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World journal of Gastroenterology 2019年第30期25卷 4092-4104页

作者： Damian jacenik ellen j.beswick Wanda M Krajewska Eric R Prossnitz Department of Cytobiochemistry Faculty of Biology and Environmental ProtectionUniversity of LodzLodz 90-236Poland Department of Internal Medicine School of Medicineand UNM Comprehensive Cancer CenterUniversity of New MexicoAlbuquerqueNM 87131United States Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineSchool of MedicineUniversity of UtahSalt Lake CityUT 84132United States

Estrogens play important roles in the development and progression of multiple tumor *** evidence points to the significance of estrogen action not only in tumors of hormonally regulated tissues such as the breast,endometrium and ovary,but also in the development of colorectal cancer(CRC).The effects of estrogens in physiological and pathophysiological conditions are mediated by the nuclear estrogen receptorsαandβ,as well as the membranebound G protein-coupled estrogen receptor(GPER).The roles of GPER in CRC development and progression,however,remain poorly *** on the functions of GPER in the colon have shown that this estrogen receptor regulates colonic motility as well as immune responses in CRC-associated diseases,such as Crohn’s disease and ulcerative *** is also involved in cell cycle regulation,endoplasmic reticulum stress,proliferation,apoptosis,vascularization,cell migration,and the regulation of fatty acid and estrogen metabolism in CRC ***,multiple lines of evidence suggest that GPER may play an important role in colorectal *** this review,we present the current state of knowledge regarding the contribution of GPER to colon function and CRC.

关键词： G protein-coupled estrogen receptor Colorectal cancer Proliferation Migration Colonic motility Inflammatory bowel disease

CD74 in antigen presentation,inflammation,and cancers of the gastrointestinal tract

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World journal of Gastroenterology 2009年第23期15卷 2855-2861页

作者： ellen j.beswick Victor E Reyes Department of Pediatrics University of Texas Medical Branch Galveston TX 77555 United States Department of Pediatrics and Microbiology and Immunology University of Texas Medical Branch Galveston TX 77555 United States

CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori （H pylon）. The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-κB and Erkl/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.

关键词： CD74 Invariant chain Cancer Inflammation Helicobacterpylori Gastrointestinal tract

Immune evasion strategies used by Helicobacter pylori

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World journal of Gastroenterology 2014年第36期20卷 12753-12766页

作者： Taslima T Lina Shatha Alzahrani jazmin Gonzalez Irina V Pinchuk ellen j.beswick Victor E Reyes Department of Microbiology and Immunology University of Texas Medical Branch Galveston TX 77555 United States MS-III School of Medicine University of Texas Medical Branch Galveston TX 77555 United States Department of Internal Medicine University of Texas Medical Branch Galveston TX 77555 United States Departments of Molecular Genetics and Microbiology University of New Mexico Health Sciences Center Albuquerque NM 87131 United States Departments of Pediatrics and Microbiology and Immunology University of Texas Medical Branch Galveston TX 77555 United Statest

Helicobacter pylori(H. pylori) is perhaps the most ubiquitous and successful human pathogen, since it colonizes the stomach of more than half of humankind. Infection with this bacterium is commonly acquired during childhood. Once infected, people carry the bacteria for decades or even for life, if not treated. Persistent infection with this pathogen causes gastritis, peptic ulcer disease and is also strongly associated with the development of gastric cancer. Despite induction of innate and adaptive immune responses in the infected individual, the host is unable to clear the bacteria. One widely accepted hallmark of H. pylori is that it successfully and stealthily evades host defense mechanisms. Though the gastric mucosa is well protected against infection, H. pylori is able to reside under the mucus, attach to gastric epithelial cells and cause persistent infection by evading immune responses mediated by host. In this review, we discuss how H. pylori avoids innate and acquired immune response elements, uses gastric epithelial cells as mediators to manipulate host T cell responses and uses virulence factors to avoid adaptive immune responses by T cells to establish a persistent infection. We also discuss in this review how the genetic diversity of this pathogen helps for its survival.

关键词： Helicobacter pylori Immune response Pattern recognition receptors Phagocytes T cells Antigen presenting cells Gastric epithelial cells Vacuolating cytotoxin T4SS

Effect of Helicobacter pylori on gastric epithelial cells

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World journal of Gastroenterology 2014年第36期20卷 12767-12780页

作者： Shatha Alzahrani Taslima T Lina jazmin Gonzalez Irina V Pinchuk ellen j.beswick Victor E Reyes Department of Microbiology and Immunology University of Texas Medical Branch Galveston TX 77555 United States MSIII School of Medicine University of Texas Medical Branch Galveston TX 77555 United States Department of Internal Medicine University of Texas Medical Branch Galveston TX 77555 United States Departments of Molecular Genetics and Microbiology University of New Mexico Health Sciences Center Albuquerque NM 87131 United States Departments of Pediatricsand and Microbiology and Immunology University of Texas Medical Branch Galves-ton TX 77555 United States

The gastrointestinal epithelium has cells with features that make them a powerful line of defense in innate mucosal immunity. Features that allow gastrointestinal epithelial cells to contribute in innate defense include cell barrier integrity, cell turnover, autophagy, and innate immune responses. Helicobacter pylori (H. pylori) is a spiral shape gram negative bacterium that selectively colonizes the gastric epithelium of more than half of the world’s population. The infection invariably becomes persistent due to highly specialized mechanisms that facilitate H. pylori’s avoidance of this initial line of host defense as well as adaptive immune mechanisms. The host response is thus unsuccessful in clearing the infection and as a result becomes established as a persistent infection promoting chronic inflammation. In some individuals the associated inflammation contributes to ulcerogenesis or neoplasia. H. pylori has an array of different strategies to interact intimately with epithelial cells and manipulate their cellular processes and functions. Among the multiple aspects that H. pylori affects in gastric epithelial cells are their distribution of epithelial junctions, DNA damage, apoptosis, proliferation, stimulation of cytokine production, and cell transformation. Some of these processes are initiated as a result of the activation of signaling mechanisms activated on binding of H. pylori to cell surface receptors or via soluble virulence factors that gain access to the epithelium. The multiple responses by the epithelium to the infection contribute to pathogenesis associated with H. pylori.

关键词： Helicobacter pylori Apoptosis Gastric epithelial cells Proinflammatory cytokines Chronic inflammation Gastric diseases Gastric cancer

Immune response to H pylori

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World journal of Gastroenterology 2006年第35期12卷 5593-5598页

作者： Giovanni Suarez Victor E Reyes ellen j.beswick Department of Pediatrics University of Texas Medical Branch Galveston TX 77555 United States Department of Microbiology and Immunology University of Texas Medical Branch Galveston TX 77555United StatesDepartment of Microbiology and Immunol-ogy University of Texas Medical Branch Galveston TX 77555 United States

The gastric mucosa separates the underlying tissue from the vast array of antigens that traffic through the stomach lumen. While the extreme pH of this environment is essential in aiding the activation of enzymes and food digestion, it also renders the gastric epithelium free from bacterial colonization, with the exception of one important human pathogen, Hpylori. This bacterium has developed mechanisms to survive the harsh environment of the stomach, actively move through the mucosal layer, attach to the epithelium, evade immune responses, and achieve persistent colonization. While a hallmark of this infection is a marked inflammatory response with the infiltration of various immune cells into the infected gastric mucosa, the host immune response is unable to clear the infection and may actually contribute to the associated pathogenesis. Here, we review the host responses involved during infection with Hpylori and how they are influenced by this bacterium.

关键词： H pylori Immune response T cell Dendritic cells

H pylori and host interactions that influence pathogenesis

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World journal of Gastroenterology 2006年第35期12卷 5599-5605页

作者： ellen j.beswick Giovanni Suarez Victor E Reyes Departments of Pediatrics Microbiology and Immunology University of Texas Medical Branch Galveston TX 77555 United States

H py/ori is probably the most prevalent human pathogen worldwide. Since it was initially suggested in 1983 by Marshall and Warren to be implicated in gastritis and peptic ulcer disease, H pylori has also been implicated in gastric carcinoma and was classified as a class I carcinogen. In the last two decades, a noteworthy body of research has revealed the multiple processes that this gram negative bacterium activates to cause gastroduodenal disease in humans. Most infections are acquired early in life and may persist for the life of the individual. While infected individuals mount an inflammatory response that becomes chronic, along with a detectable adaptive immune response, these responses are ineffective in clearing the infection. Hpylori has unique features that allow it to reside within the harsh conditions of the gastric environment, and also to evade the host immune response. In this review, we discuss the various virulence factors expressed by this bacterium and how they interact with the host epithelium to influence pathogenesis.

关键词： H pylori Gastric cancer Immune response Vacuolating cytotoxin

Challenges and prospects for consumer acceptance of cultured meat

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journal of Integrative Agriculture 2015年第2期14卷 285-294页

作者： Wim Verbeke Pierre Sans ellen j Van Loo Department of Agricultural Economics Ghent UniversityGent B-9000 Belgium INP-ENV Toulouse Toulouse 31076 France UR1303 ALISS INRA Ivry-sur-Seine 94205 France

Consumer acceptance of cultured meat is expected to depend on a wide diversity of determinants ranging from technologyrelated perceptions to product-specific expectations, and including wider contextual factors like media coverage, public involvement, and trust in science, policy and society. This paper discusses the case of cultured meat against this multitude of possible determinants shaping future consumer acceptance or rejection. The paper also presents insights from a primary exploratory study performed in April 2013 with consumers from Flanders（Belgium）（n=180）. The concept of cultured meat was only known（unaided） by 13% of the study participants. After receiving basic information about what cultured meat is, participants expressed favorable expectations about the concept. Only 9% rejected the idea of trying cultured meat, while two thirds hesitated and about quarter indicated to be willing to try it. The provision of additional information about the environmental benefits of cultured meat compared to traditional meat resulted in 43% of the participants indicating to be willing to try this novel food, while another 51% indicated to be ‘maybe＇ willing to do so. Price and sensory expectations emerged as major obstacles. Consumers eating mostly vegetarian meals were less convinced that cultured meat might be healthy, suggesting that vegetarians may not be the ideal primary target group for this novel meat substitute. Although exploratory rather than conclusive, the findings generally underscore doubts among consumers about trying this product when it would become available, and therefore also the challenge for cultured meat to mimic traditional meat in terms of sensory quality at an affordable price in order to become acceptable for future consumers.

关键词： acceptance artificial attitude consumer cultured in vitro meat synthetic

H pylori receptor MHC classⅡcontributes to the dynamic gastric epithelial apoptotic response

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World journal of Gastroenterology 2006年第33期12卷 4689-4693页

作者： David A Bland Giovanni Suarez ellen j.beswick johanna C Sierra Victor E Reyes the University of Texas Medical Branch at Galveston TX 77555-0366 United States

AIM： To investigate the role of MHC class Ⅱ in the modulation of gastric epithelial cell apoptosis induced by H pylori infection. METHODS： After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specific for MHC class Ⅱ and CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a fluorometric assay, a cytometric bead array, and confocal microscopy, respectively. RESULTS： Pretreatment of N87 cells with the anti-MHC class ⅡIgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class Ⅱ resulted in markedly reduced caspase activation, while simple ligation of MHC class Ⅱ did not. Crosslinking of MHC class Ⅱ also resulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC class Ⅱ IgM blocked the recruitment of FADD to the cell surface. CONCLUSION： The ability of MHC class Ⅱ to modulate gastric epithelial apoptosis is at least partially dependent on its crosslinking. The crosslinking of this molecule has anti-apoptotic effects during the earlier time points of Hpylori infection. This effect is possibly mediated by the ability of MHC class Ⅱ to modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by Hpylori-infected gastric epithelial cells.

关键词： Hpylori Epithelium Apoptosis Class Ⅱ MHC

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Dual-energy X-ray absorptiometry scans accurately predict differing body fat content in live sheep

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journal of Animal Science and Biotechnology 2019年第1期10卷 248-253页

作者： David W Miller ellen j Bennett joanne L Harrison Fiona Anderson Clare L Adam School of Veterinary and Life Sciences Murdoch University Scotland’s Rural College (SRUC) Peter Wilson Building The Faculty of Health University of Tasmania School of Biological Sciences University of Aberdeen Rowett Institute of Nutrition and Health University of Aberdeen

Background: There is considerable interest in implementing mobile scanning technology for on-farm body composition analysis on live *** experiments evaluated the use of dual energy X-ray absorptiometry(DXA) as an accurate method of total body fat measurement in live ***: In Exp.1,visceral and whole body fat analysis was undertaken in sheep with body condition scores(BCS)in the range 2 to 3.25(scale 1: thin to 5: fat).The relationship of BCS was moderately correlated with visceral fat depot mass(r = 0.59,P 0.05,n = 9).There was a moderate correlation between DXA body fat and BCS(r = 0.70,P < 0.01,n = 17),and DXA body fat was highly correlated with chemical body fat(r = 0.81,P < 0.001,n = 9).In Exp.3,a series of five DXA scans,at 8-week intervals,was performed on growing sheep over a 32-week *** average BCS ranged from 2.39 ± 0.07(S.E.M.) to 3.05 ± 0.11 and the DXA body fat(%) ranged from 16.8 ± 0.8 to 24.2 ± *** was a moderate correlation between DXA body fat and BCS over the 32 weeks(r = 0.61,P < 0.001,n = 24).Conclusions: Overall,these experiments indicated that there was good agreement between BCS,DXA and chemical analysis for measuring total body fat in sheep,and that DXA scanning is a valid method for longitudinal measurement of total body fat in live sheep.

关键词： BCS DEXA Fat Leptin Longitudinal Sheep