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Liver abnormalities following SARS-CoV 2 infection in children 1 to 10 years of age

Family Medicine and Community Health 2024年第1期12卷 28-35页

作者： Pauline Terebuh Veronica R Olaker ellen k kendall David C kaelber Rong Xu Pamela B Davis Center for Artificial Intelligence in Drug Discovery Case Western Reserve UniversityClevelandOHUSA The Center for Clinical Informatics Research and Education The MetroHealth SystemClevelandOHUSA Department of Medicine PediatricsDepartment of Population and Quantitative Health SciencesCase Western Reserve UniversityClevelandOHUSA Center for Community Health Integration Case Western Reserve UniversityClevelandOHUSA

Objective Beginning in October 2021 in the USA and elsewhere,cases of severe paediatric hepatitis of unknown aetiology were identified in young *** the adenovirus and adenovirus-associated virus have emerged as leading aetiological suspects,we attempted to investigate a potential role for SARS-CoV 2 in the development of subsequent liver *** We conducted a study using retrospective cohorts of deidentified,aggregated data from the electronic health records of over 100 million patients contributed by US healthcare *** Compared with propensity score matched children with other respiratory infections,children aged 1-10 years with COVID-19 had a higher risk of elevated transaminases(HR(95%CI)2.16(1.74 to 2.69))or total bilirubin(HR(95%CI)3.02(1.91 to 4.78)),or new diagnoses of liver diseases(HR(95%CI)1.67(1.21 to 2.30))from 1 to 6 months after *** with pre-existing liver abnormalities,liver abnormalities surrounding acute infection,younger age(1-4 years)or illness requiring hospitalisation all had similarly elevated *** who developed liver abnormalities following COVID-19 had more pre-existing conditions than those who developed abnormalities following other *** These results indicate that SARS-CoV 2 may prime the patient for subsequent development of liver infections or non-infectious liver *** rare(~1 in 1000),SARS-CoV 2 is a risk for subsequent abnormalities in liver function or the diagnosis of diseases of the liver.

关键词： elevated diagnosis subsequent

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New glucocerebrosidase antibodies can advance research in the field of neurodegenerative disorders

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Neural Regeneration Research 2025年第4期20卷 1085-1086页

作者： Charis Ma krystyna Rytel Yu Chen ellen Sidransky Medical Genetics Branch National Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA

In medical research,there are times when the introduction of a new tool can launch scientific discovery in new *** antibody development may be considered mundane,in the field of glucocerebrosidase(GCase)research,the dearth of validated antibodies for different applications has impeded progress in studies of disease pathogenesis and therapeutic *** recent introduction of new,rigorously evaluated antibodies can now propel research into the link between glucocerebrosidase and Parkinson’s disease(PD)as well as aspects of the pathobiology of Gaucher disease(Jong et al.,2024).

关键词： antibodies cerebro

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MicroRNAs in inflammatory bowel disease:What do we know and what can we expect?

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World Journal of Gastroenterology 2024年第16期30卷 2184-2190页

作者： ellen Cristina Souza de Oliveira Ana Elisa Valencise Quaglio Thais Gagno Grillo Luiz Claudio Di Stasi Ligia Yukie Sassaki Department of Internal Medicine Medical SchoolSão Paulo State University(Unesp)Botucatu 18618-686São PauloBrazil Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State University(Unesp)Botucatu 18618-689São PauloBrazil

MicroRNAs(miRNAs),small non-coding RNAs composed of 18–24 nucleotides,are potent regulators of gene expression,contributing to the regulation of more than 30%of protein-coding *** that miRNAs are regulators of inflammatory pathways and the differentiation of intestinal epithelial cells,there is an interest in exploring their importance in inflammatory bowel disease(IBD).IBD is a chronic and multifactorial disease of the gastrointestinal tract;the main forms are Crohn's disease and ulcerative *** studies have investigated the dysregulated expression of miRNAs in IBD,demonstrating their important roles as regulators and potential biomarkers of this *** editorial presents what is known and what is expected regarding miRNAs in *** the important regulatory roles of miRNAs in IBD are clearly established,biomarkers for IBD that can be applied in clinical practice are lacking,emphasizing the importance of further *** regarding the influence of miRNAs on the inflammatory process and the exploration of their role in gene regulation are expected to provide a basis for the use of miRNAs not only as potent biomarkers in IBD but also as therapeutic targets for the control of inflammatory processes in personalized medicine.

关键词： MicroRNAs Inflammatory bowel disease Crohn’s disease Ulcerative colitis Biomarker Therapy

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Association of Serum Folate and Vitamin B_(12) Concentrations with Obesity in Chinese Children and Adolescents

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Biomedical and Environmental Sciences 2024年第3期37卷 242-253页

作者： ZHU Qian Rang kOk E Dieuwertje BEkELE Hailu Tesfaye MANUSAMA koen ZHANG Jing Xian XIE Wei ZONG Wen Qi ZUO Hui ZHANG Jian kAMPMAN ellen DAI Yue Jiangsu Provincial Center for Disease Control and Prevention Nanjing 210009JiangsuChina Division of Human Nutrition and Health Wageningen University&ResearchWageningen 176700 AAThe Netherlands School of Public Health Medical College of Soochow UniversitySuzhou 215123JiangsuChina National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China

Objective This study aimed to evaluate the associations of serum folate and/or vitamin B12 concentrations with obesity among Chinese children and *** A cross-sectional study was conducted including 3,079 Chinese children and adolescents,aged 6 to 17 years,from Jiangsu,*** indices,such as,children's body mass index(BMI),BMI z-scores,waist circumference,and waist-to-height ratio were *** linear regression and generalized additive models were used to investigate the associations of serum folate and vitamin B12 levels with anthropometric indices and odds of *** We observed that serum vitamin B12 concentrations were inversely associated with all anthropometric indices and the odds of general obesity[odds ratio(OR)=0.68;95%confidence interval(CI)=0.59,0.78]and abdominal obesity(OR=0.68;95%CI=0.60,0.77).When compared to participants with both serum vitamin levels in the two middle quartiles,those with both serum folate and vitamin B12 levels in the highest quartile were less prone to general(OR=0.31,95%CI=0.19,0.50)or abdominal obesity(OR=0.46,95%CI=0.31,0.67).Conversely,participants with vitamin B12 levels in the lowest quartile alongside folate levels in the highest quartile had higher odds of abdominal obesity(OR=2.06,95%CI=1.09,3.91).Conclusion Higher serum vitamin B12 concentrations,but not serum folate concentrations,were associated with lower odds of childhood *** and adolescents with high levels of vitamin B12 and folate were less likely to be obese.

关键词： Folate Vitamin B12 Childhood obesity Micronutrient

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Storylines of family medicine Ⅸ:people and places—diverse populations and locations of care

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Family Medicine and Community Health 2024年第S3期12卷 79-88页

作者： William B Ventres Leslie A Stone Emad R Abou-Arab Julio Meza David S Buck Jerome W Crowder Jennifer Y C Edgoose Alexander Brown ellen J Plumb Amber k Norris Jay J Allen Lauren E Giammar John E Wood Scott M Dickson G Austin Brown Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine University of Michigan Medical SchoolAnn ArborMichiganUSA Family Medicine University of California Los AngelesDavid Geffen School of MedicineLos AngelesCaliforniaUSA Community Medicine University of HoustonTilman J Fertitta Family College of MedicineHoustonTexasUSA Social and Behavioral Sciences University of HoustonTilman J Fertitta Family College of MedicineHoustonTexasUSA Family Medicine and Community Health University of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsinUSA NH Dartmouth Family Medicine Residency ConcordNew HampshireUSA San Francisco VA Medical Center San FranciscoCaliforniaUSA Duluth Family Medicine Residency Program University of Minnesota Medical School Duluth CampusDuluthMinnesotaUSA UAMS Northeast Regional Campus Family Medicine Residency Program JonesboroArkansasUSA Cascades East Family Medicine Residency Program Oregon Health&Science University School of MedicineKlamath FallsOregonUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅸ:people and places—diverse populations and locations of care’,authors address the following themes:‘LGBTQIA+health in family medicine’,‘A family medicine approach to substance use disorders’,‘Shameless medicine for people experiencing homelessness’,“Difficult”encounters—finding the person behind the patient’,‘Attending to patients with medically unexplained symptoms’,‘Making house calls and home visits’,‘Family physicians in the procedure room’,‘Robust rural family medicine’and‘Full-spectrum family medicine’.May readers appreciate the breadth of family medicine in these essays.

关键词： illustration family dimensions

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AI有望解锁古罗马卷轴之谜

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商业周刊（中文版） 2024年第15期 52-57页

作者： Ashlee Vance ellen Huet 杨飞(译) 不详

几年前,在加利福尼亚州日益恶化的一个野火季,纳特·弗里德曼(Nat Friedman)家的房子被烧毁了。几个月后,弗里德曼因为新冠疫情被困在湾区,既煌恐又无聊。和许多中年老父亲一样,他从古罗马文化当中寻求安慰和指引。当我们中的一些人正... 详细信息

几年前,在加利福尼亚州日益恶化的一个野火季,纳特·弗里德曼(Nat Friedman)家的房子被烧毁了。几个月后,弗里德曼因为新冠疫情被困在湾区,既煌恐又无聊。和许多中年老父亲一样,他从古罗马文化当中寻求安慰和指引。当我们中的一些人正在观看《虎王》(Tiger king)或者玩孩子们的乐高积木时,他在阅读关于罗马帝国的书籍,还帮他女儿制作了罗马别墅的纸模型。他没有学着做酸面团。

关键词：古罗马文化弗里德曼加利福尼亚州纸模型乐高积木罗马帝国

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管道清洁机器人的创新应用

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现代制造 2024年第1期 27-29页

作者： Andreas Seegen ellen-Christine Rei 不详

地下排水管道需要定期的维护保养,而且最好是在不挖开地面的情况下进行维护保养。为此,Pipetronics公司开发了一种可对地下管道进行维护保养的机器人。这款机器人由Faulhaber公司研发生产的无刷直流电机来驱动机器人车轮运转,驱动机器... 详细信息

地下排水管道需要定期的维护保养,而且最好是在不挖开地面的情况下进行维护保养。为此,Pipetronics公司开发了一种可对地下管道进行维护保养的机器人。这款机器人由Faulhaber公司研发生产的无刷直流电机来驱动机器人车轮运转,驱动机器人的清洁工具完成地下管道的清洁。

关键词：机器人地下管道维护保养 Pipe 无刷直流电机创新应用清洁工具

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A chromosome-scale genome assembly of Rauvolfia tetraphylla facilitates identification of the complete ajmaline biosynthetic pathway

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Plant Communications 2024年第4期5卷 129-132页

作者： Enzo Lezin Ines Carqueijeiro Clement Cuello Mickael Durand Hans JJansen Valentin Verges Caroline Birer Williams Audrey Oudin Thomas Duge de Bernonville Julien Petrignet Noemie Celton Benoit St-Pierre Nicolas Papon Chao Sun Ron P.Dirks Sarah ellen O’Connor Michael krogh Jensen Sebastien Besseau Vincent Courdavault Biomole´cules et Biotechnologies Vegetales EA2106Universite´de Tours37200 ToursFrance Future Genomics Technologies 2333 BE Leidenthe Netherlands Laboratoire Synthe se et Isolement de Molecules BioActives(SIMBA EA 7502)Universitede Tours37200 ToursFrance Laboratoire de Cytoge´netique Constitutionnelle CHRU de Tours-Hopital Bretonneau37044 ToursFrance University Angers University BrestIRFSFR ICAT49000 AngersFrance Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 2800China Department of Natural Product Biosynthesis Max Planck Institute for Chemical Ecology07745 JenaGermany Novo Nordisk Foundation Center for Biosustainability Technical University of Denmark100193 Kgs LyngbyDenmark Present address:Limagrain Center de RechercheRoute d’EnnezatChappesFrance These authors contributed equally to this article

Dear Editor,Rauvolfia tetraphylla(aka the Devil pepper)(Supplemental Figure 1)is a well-known medicinal plant that produces monoterpenoid indole alkaloids(MIAs).This MIA biosynthesis occurs in several organs,including leaves,stems,fruit,and roots,which accumulate the famous antiarrhythmic ajmaline(kumar et al.2016a,2016b;kumara et al.,2019).MIAs are natural products notably involved in plant adaptation to the environment and defense against *** mainly results from their high biological activities,which also explain their pharmacological properties.

关键词： properties. Figure roots

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永生的信徒

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商业周刊（中文版） 2024年第2期 46-51页

作者： ellen Huet lan Loring Shiver(摄影) 王湛(译) 不详

当一个拿着夹纸写字板的人在旧金山街头热情地向你走来时,你通常可以预料到,他们的问题与某个公共政策目标有关。您有时间来谈谈堕胎权吗?住房问题?网络赌博投票倡议?然而如今,你可能会听到一个更加宏大、更加个人的问题,你怎么也想不到... 详细信息

当一个拿着夹纸写字板的人在旧金山街头热情地向你走来时,你通常可以预料到,他们的问题与某个公共政策目标有关。您有时间来谈谈堕胎权吗?住房问题?网络赌博投票倡议?然而如今,你可能会听到一个更加宏大、更加个人的问题,你怎么也想不到,那些看起来想要你签名的人会问出这句话:您想活多久?

关键词：写字板网络赌博住房问题公共政策目标旧金山

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What is the sound of fear？ Behavioral responses of white-crowned sparrows Zonotrichia leucophrys to synthesized nonlinear acoustic phenomena

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Current Zoology 2014年第4期60卷 534-541页

作者： ellen k. BLESDOE Daniel T. BLUMSTEIN The Rocky Mountain Biological Laboratory Box 519 Crested Butte CO 81224 USA Department of Ecology and Evolutionary Biology University of California 621 Young Drive South Los Angeles CA 90095-1606 USA

Fear and anxiety may be adaptive responses to life-threatening situations, and animals may communicate fear to others vocally. A fundamental understanding of fear inducing sounds is important for both wildlife conservation and management because it helps us understand how to design repellents and also how （and why） animals may be negatively impacted by anthropogenic sounds. Nonlinear phenomena--sounds produced by the desynchronization of vibrations in a sound production system-are commonly found in stress-induced animal vocalizations, such as in alarm calls, mobbing calls, and fear screams. There are several functional hypotheses for these nonlinear phenomena. One specific hypothesis is the unpredictability hypothesis, which suggests that because nonlinear phenomena are more variable and somewhat unpredictable, animals are less likely to habituate to them. Animals should, therefore, have a prolonged response to sounds with nonlinear phenomena than sounds without them. Most of the studies involving nonlinear phenomena have used mammalian subjects and conspecific stimuli. Our study fo- cused on white-crowned sparrows （Zonotrichia leucophrys ssp. oriantha） and used synthesized acoustic stimuli to investigate behavioral responses to stimuli with and without nonlinear phenomena. We predicted that birds would be less relaxed after hearing a stimulus with a nonlinear component. We calculated the difference from baseline of proportion of time spent in relaxed behaviors and performed pair-wise comparisons between a pure tone control stimulus and each of three experimental stimuli, including a frequency jump up, a frequency jump down, and white noise. These comparisons showed that in the 30q50 s after the playback experiment, birds were significantly less relaxed after hearing noise or an abrupt frequency jump down an octave but not an abrupt frequency jump up an octave or a pure tone. Nonlinear phenomena, therefore, may be generally arousing to animals and may explain why th

关键词： Nonlinear acoustic phenomena White-crowned sparrows Arousal Fear Motivation-structural rules Entropy

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