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Assessment of the effectiveness of weight-adjusted antibiotic administration,for reduced duration,in surgical prophylaxis of primary hip and knee arthroplasty

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World Journal of Orthopedics 2024年第2期15卷 170-179页

作者： Tosan Okoro Michael Wan Takura Darlington Mukabeta ella Malev Marketa Gross Claudia Williams Muhammad Manjra Jan Herman Kuiper John Murnaghan Department of Arthroplasty Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation TrustOswestry SY107AGUnited Kingdom School of Medicine Keele UniversityStaffordshire ST55BGUnited Kingdom St Joseph’s Health Centre Unity Health TorontoToronto M6R 1B5Canada Department of Arthroplasty The Royal London HospitalBarts Health NHS TrustLondon E11BBUnited Kingdom Department of Arthroplasty Sunnybrook Holland Orthopaedic and Arthritis CentreToronto M4Y 1H1Canada Institute for Science and Technology in Medicine Keele UniversityStaffordshire ST51BGUnited Kingdom

BACKGROUnD Prophylactic antibiotics have significantly led to a reduction in the risk of postoperative surgical site infections(SSI)in orthopaedic *** aim of using antibiotics for this purpose is to achieve serum and tissue drug levels that exceed,for the duration of the operation,the minimum inhibitory concentration of the likely organisms that are *** antibiotics reduce the rate of SSIs in lower limb arthroplasty from between 4%and 8%to between 1%and 3%.Controversy,however,still surrounds the optimal frequency and dosing of antibiotic *** To evaluate the impact of introduction of a weight-adjusted antibiotic prophylaxis regime,combined with a reduction in the duration of administration of post-operative antibiotics on SSI incidence during the 2 years following primary elective total hip and knee arthroplasty METHODS Following ethical approval,patients undergoing primary total hip arthroplasty(THA)/total knee arthroplasty(TKA)with the old regime(OR)of a preoperative dose[cefazolin 2 g intravenously(IV)],and two subsequent doses(2 h and 8 h),were compared to those after a change to a new regime(nR)of a weight-adjusted preoperative dose(cefazolin 2 g IV for patientsn 3g IV for patients>120 kg)and a post-operative dose at 2 *** primary outcome in both groups was SSI rates during the 2 years *** A total of n=1273 operations(THA n=534,TKA n=739)were performed in n=1264 *** was no statistically significant difference in the rate of deep(OR 0.74%(5/675)vs nR 0.50%(3/598);fishers exact test P=0.72),nor superficial SSIs(OR 2.07%(14/675)vs nR 1.50%(9/598);chi-squared test P=0.44)at 2 years *** propensity score weighting and an interrupted time series analysis,there was also no difference in SSI rates between both groups[RR 0.88(95%CI 0.61 to 1.30)P=0.46].COnCLUSIOn A weight-adjusted regime,with a reduction in number of post-operative doses had no adverse impact on S

关键词： Antibiotics Weight-adjusted Hip and knee arthroplasty Surgical site infection

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Depression and Suicidal Risk in HIV-Infected Adults at Brazzaville University Hospital: Prevalence and Associated Factors

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Advances in Infectious Diseases 2024年第1期14卷 24-33页

作者： Bienvenu Rolland Ossibi Ibara Tatia Adoua Doukaga Alain M. Mouanga André Moukouma Martin Ekat Parfait Bintsindou ella Angonga Pabota Princesse Benet Lebaho Bebene Damba Banzuzi Department of Infectious Diseases Brazzaville University Hospital Brazzaville Republic of the Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo Department of neurolgy Brazzaville University Hospital Brazzaville Republic of the Congo

Introduction: Highly active antiretroviral tritherapies have improved the quality of life of people living with HIV (PVVIH) and extended their life expectancy. However, the nervous system is faced with a neurotropic virus that evolves chronically, sometimes creating neurological disorders directly or indirectly linked to stigmatization or therapeutic effects. Objective: to determine the prevalence of depression associated with suicidal risk (SR) and identify associated factors. Patients and method: This was a prospective descriptive and analytical study from January 1 to november 30, 2022, including all HIV-positive patients receiving or not receiving antiretroviral therapy. The study took place in the infectious diseases department of Brazzaville University Hospital. This department has an inpatient capacity of 36 beds, and an outpatient capacity of 25 patients per day, three times a week. This is the largest center for PVVIH in Brazzaville. The Patient Heath Questionnaire 9 (PHQ-9) was used to assess the degree of depression and suicidal risk. Therapeutic adherence was assessed using the Morisky questionnaire. Data were analyzed using SPSS version 23 software. Qualitative variables were expressed as numbers and percentages, and quantitative variables as means and standard deviations. Statistical tests were used according to their applicability criteria. For all tests, the significance threshold was set at 0.05. Results: A total of 150 patients were consulted, constituting the sample size. The prevalence of depression and suicidal risk was 32%. These patients had an average age of 42.83 ± 10.24 years, were female (n = 101;67.3%), Christian (n = 97;64%), single (n = 68;45.3%). Stigmatization (n = 75;50%) was the reason for attempted suicide. HIV was perceived as treatable (n = 103;68.7%), unlucky (n = 62;41.3%). Patients were WHO stage 1 (n = 105;70%). RS was present in 47 cases (31.3%). Factors associated with depression and suicidal risk were age (p = 0.000), resi

关键词： Depression Suicidal Risk HIV/AIDS Prevalence Associated Factors

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The consequences of genomic architecture on ecological speciation in postglacial fishes

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Current Zoology 2013年第1期59卷 53-71页

作者： Sean M. ROGERS Jonathan A. MEE ella BOWLES Department of Biological Sciences University of Calgary 2500 University Drive NW Calgary Alberta T2N 1N4 Canada

The quest for the origin of species has entered the genomics era. Despite decades of evidence confirming the role of the environment in ecological speciation, an understanding of the genomics of ecological speciation is still in its infancy. In this review, we explore the role of genomic architecture in ecological speciation in postglacial fishes. Growing evidence for the num- ber, location, effect size, and interactions among the genes underlying population persistence, adaptive trait divergence, and re- productive isolation in these fishes reinforces the importance of considering genomic architecture in studies of ecological speci- ation. Additionally, these populations likely adapt to new freshwater environments by selection on standing genetic variation, as de novo mutations are unlikely under such recent divergence times. We hypothesize that modular genomic architectures in post- glacial fish taxa may be associated with the probability of population persistence. Empirical studies have confirmed the genic na- ture of ecological speciation, implicating surprisingly extensive linkage disequilibrium across the genome. An understanding of these genomic mosaics and how they contribute to reproductive barriers remains unclear, but migration rates and the strength of selection at these loci is predicted to influence the likelihood of population divergence. Altogether, understanding the role of ge- nomic architecture is an important component of speciation research and postglacial fishes continue to provide excellent organ- isms to test these questions, both from the perspective of variation in architectures among taxa, and with respect to the distinct environments they have colonized. However, more empirical tests of ecological speciation predictions are needed [Current Zoo- logy 59 （1）： 53-71, 2013].

关键词： Adaptation Ecological speciation Genomic architecture Modularity Postglacial fishes QTL

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Genetic basis for body size variation between an anadromous and two derived lacustrine populations of threespine stickleback Gasterosteus aculeatus in southwest Alaska

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Current Zoology 2016年第1期62卷 71-78页

作者： ella BOWLES Rebecca A. JOHnSTOn Stevi L. VAnDERZWAn Sean M. ROGERS Department of Biological Sciences University of Calgary 2500 University Dr. N.W. Calgary Alberta T2N 1N4Canada

Body size is a highly variable trait among geographically separated populations. Size-assortative reproductive isolation has been linked to recent adaptive radiations of threespine stickleback （Gasterosteus aculeatus） into freshwater, but the genetic basis of the commonly found size differ- ence between anadromous and derived lacustrine sticklebacks has not been tested. We studied the genetic basis of size differences between recently diverging stickleback lineages in southwest Alaska using a common environment experiment. We crossed stickleback within one anadromous （naknek River） and one lake （Pringle Lake） population and between the anadromous and two lake populations （Pringle and JoJo Lakes）, and raised them in a salinity of 4-6 ppt. The F1 anadromous and freshwater forms differed significantly in size, whereas hybrids were intermediate or exhibited dominance toward the anadromous form. Additionally, the size of freshwater Fls differed from their wild counterparts, with within-population Fls from Pringle Lake growing larger than their wild counterparts, while there was no size difference between lab-raised and wild anadromous fish. Sexual dimorphism was always present in anadromous fish, but not in freshwater, and not always in the hybrid crosses. These results, along with parallel changes among anadromous and fresh- water forms in other regions, suggest that this heritable trait is both plastic and may be under di- vergent and/or sexual selection.

关键词： adaptation body size common garden genetic basis threespine stickleback.

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n75：主打行车安全——虎门首测黑剑n75

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音响改装技术 2008年第4期 80-81页

作者：广南 ella

总体观感☆☆☆银声黑剑又出新导航n75,和某品牌的一款手机同一个型号,与前一款n70相比,外观有调整,黑色仍然延续.正面钢琴色烤漆,给人的感觉非常硬朗。

关键词：导航仪行车安全电子眼导航软件安全驾驶红绿灯车主实际测试功能限速

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阿尔派：便携更要专业

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音响改装技术 2007年第8期 66-67页

作者：白水 ella

去年,一句"让阿尔派导航"的口号使nVE-n900C声名远播整个汽车后装市场,阿尔派GPS导航专业、高质、经典的形象深入人心。2007年9月,一款同样继承这一精髓的阿尔派便携式导航PMD-F100即将荣耀登场,其卓尔不凡的品质已经引起大家的强烈关注。

关键词：导航便携地图专业信息点软件人性化硬件用户市场

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在路上有音乐为伴

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音响改装技术 2007年第10期 104-105页

作者：冯矛 ella

时尚在现在是个象征词,总有那么一群人在引领时代的发展和进步,而我们今天这位主人翁——余先生就是凡事都捷足先登的人,黝黑的皮肤,执拗的眼神,谈吐淡雅风趣,喜欢对未来做n种美好的设想。他爱旅行,如果有时间会买部"大切",带上老婆畅... 详细信息

时尚在现在是个象征词,总有那么一群人在引领时代的发展和进步,而我们今天这位主人翁——余先生就是凡事都捷足先登的人,黝黑的皮肤,执拗的眼神,谈吐淡雅风趣,喜欢对未来做n种美好的设想。他爱旅行,如果有时间会买部"大切",带上老婆畅游中国的大好河山,享受二人世界,路线已经定好了:西藏—内蒙古—新疆—青海。"今年儿子成绩好了会带他去韩国""工作很忙,老婆照顾家很辛苦,过年带她去澳洲"说话时,他的眼睛已经笑成了一条缝。这是个爱家的男人!他所涉足的行业很多,从建材到钢材到餐饮等等,这些看似不搭边的行业,他却都做得有声有色。

关键词：音乐象征词内蒙古行业改装车声音时间低音喇叭西藏磨合期

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新科GPS再出新品首创卫星导航与电视接收一体机

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音响改装技术 2007年第3期 73-73页

作者： ella

在方寸大小的便携式GPS上,加载TV接收功能,会是什么样?这个绝妙的创意,经过新科超越号实验室工程师的集体努力,日前,形成了两歉全新产品——GT-412、GT-3500,它们既是性能卓越的导航器,又是可移动收看的超级迷你电视。据悉,这在全世界... 详细信息

在方寸大小的便携式GPS上,加载TV接收功能,会是什么样?这个绝妙的创意,经过新科超越号实验室工程师的集体努力,日前,形成了两歉全新产品——GT-412、GT-3500,它们既是性能卓越的导航器,又是可移动收看的超级迷你电视。据悉,这在全世界范围内,属于首创。

关键词：高新科技卫星导航导航器新品电视接收兴趣点首创一体机领导者代数码

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黑剑n70就是“酷”

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音响改装技术 2007年第11期 68-68页

作者：广南 ella

初看银声黑剑n70像块瓦片,大胆采用流线行设计,局部整体以弧线形来布局,该设计能有效避免反光。前脸周身磨砂感的材质,再辅以黑色涂装,中间镶嵌一片4.3英寸宽屏,给人感觉就是一个字"酷"。

关键词：导航图目的地设计语音提示重新规划定位精度路线系统英寸设定

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阿尔派导航:有它更精彩

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音响改装技术 2006年第9期 62-62页

作者：肖必虎 ella

8月8日,阿尔派在上海举行盛大的导航产品媒体体验会,正式展出了四次获得北美汽车导航产品市场占有率第一、并荣获由***授予的2005年度导航产品质量最高奖的以阿尔派导航的先进技术为基础研发的nVE-n900C。集多种功能和先进技术于一体的n... 详细信息

8月8日,阿尔派在上海举行盛大的导航产品媒体体验会,正式展出了四次获得北美汽车导航产品市场占有率第一、并荣获由***授予的2005年度导航产品质量最高奖的以阿尔派导航的先进技术为基础研发的nVE-n900C。集多种功能和先进技术于一体的nVE-n900C受到在座媒体的热烈追捧,而接下来浦东的试驾导航体验,更让大家充分感受了阿尔派导航科技化、人性化的魅力。

关键词：导航误差导航系统显示屏人性化汽车导航用户城市道路地图数据体验目的地

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