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na,K-ATPase as a target for endogenous cardiotonic steroids:What’s the evidence?

Genes & Diseases 2021年第3期8卷 259-271页

作者： Sergei N.Orlov Artem M.Tverskoi Svetlana V.Sidorenko Larisa V.Smolyaninova Olga D.Lopina Nickolai O.Dulin elizaveta A.Klimanova MV Lomonosov Moscow State University Moscow119234Russia national Research Tomsk State University Tomsk634050Russia Siberian State Medical University Tomsk634050Russia University of Chicago IL60637USA

With an exception of few reports,the plasma concentration of ouabain and mari-nobufagenin,mostly studied cardiotonic steroids(CTS)assessed by immunoassay techniques,is less than 1 *** the last 3 decades,the implication of these endogenous CTS in the path-ogenesis of hypertension and other volume-expanded disorders is widely *** threshold for inhibition by CTS of human and rodent a1-na,K-ATPase is~1 and 1000 nM,respectively,that rules out the functioning of endogenous CTS(ECTS)as natriuretic hormones and regulators of cell adhesion,cell-to-cell communication,gene transcription and transla-tion,which are mediated by dissipation of the transmembrane gradients of monovalent *** several types of cells ouabain and marinobufagenin at concentrations corresponding to its plasma level activate na,K-ATPase,decrease the[na^(+)]i;/[K^(+)]i;-ratio and increase cell *** physiological significance and mechanism of non-canonical na^(+)/K^(+)-depen-dent and nai^(+)/Ki^(+)independent cell responses to CTS are discussed.

关键词： Cell proliferation Cellular signaling Endogenous cardiotonic steroids na+,K+-ATPase Transcription Translation

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Experimental and petrological constraints on local-scale interaction of biotite-amphibole gneiss with H_2O-CO_2-(K,na) Cl fluids at middle-crustal conditions:Example from the Limpopo Complex,South Africa

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Geoscience Frontiers 2012年第6期3卷 829-841页

作者： Oleg G.Safonov elizaveta I.Kovaleva Svetlana A.Kosova H.M.Rajesh Georgy A.Belyanin Maria A.Golunova Dirk D.Van Reenen Institute of Experimental Mineralogy RAS ChernogolovkaMoscow Region 142432.Russia Department of Petrology.Moscow State University Moscow 119899Russia Department of Geology University of JohannesburgP.O.Box 524Auckland Park 2006JohannesburgSouth Africa Labor fur Geochronologie Department fur LithospharenforschungUniversitat WienAlthanstrasse 14A-1090 ViennaAustria Institute of Experimental Mineralogy RAS ChernogolovkaMoscow Region 142432Russia Department of Geology University of JohannesburgP.O.Box 524Auckland Park 2006Johannesburg.South Africa

Reaction textures and fluid inclusions in the -2.0 Ga pyroxene-bearing dehydration zones within the Sand River biotite-hornblende orthogneisses （Central Zone of the Limpopo Complex） suggest that the formation of these zones is a result of close interplay between dehydration process along ductile shear zones triggered by H2O-CO2-salt fluids at 750--800 ℃ and 5.5--6.2 kbar, partial melting, and later exsolution of residual brine and H2O-CO2 fluids during melt crystallization at 650--700 ℃. These processes caused local variations of water and alkali activity in the fluids, resulting in various mineral assemblages within the dehydration zone. The petrological observations are substantiated by experiments on the interaction of the Sand River gneiss with the H2O-CO2-（K, na）Cl fluids at 750 and 800 ℃ and 5.5 kbar. It follows that the interaction of biotite-amphibole gneiss with H2O-CO2-（K, na）CI fluids is accompanied by partial melting at 750--800 ℃. Orthopyroxene-bearing assemblages are characteristic for temperature 800 ℃ and are stable in equilibrium with fluids with low salt concentrations, while salt-rich fluids produce clinopyroxene-bearing assemblages. These observations are in good agreement with the petrological data on the dehydration zones within the Sand River olthogneisses.

关键词： Charnockite Fluid-rock interaction CO2-rich fluids naCl-KCl brines Partial melting Experimental petrology

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