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Effects of primary glaucoma on sleep quality and daytime sleepiness of patients residing at an equatorial latitude

International Journal of Ophthalmology(English edition) 2020年第9期13卷 1451-1458页

作者： Jacob YH Chin Zhi Hong Toh Ying Tai Lo Hannah TY Wang elizabeth yw poh Chun Hau Chua Owen Kim Hee Boon Ang Lim Vernon KY Yong Augustinus Laude Hon Tym Wong Leonard WL Yip Department of Ophthalmology National Healthcare Group Eye InstituteTan Tock Seng Hospital308433Singapore Monash School of Medicine Monash UniversityVictoria 3800Australia

AIM:To investigate the impact of primary glaucoma on sleep quality and daytime sleepiness of ***:Prospective cross-sectional study with consecutive sampling in South-East Asian population was *** questionnaires:the Pittsburg Sleep Quality Index(PSQI)and Epworth Sleepiness Scale(ESS)were administered *** with nonglaucomatous optic neuropathy or concomitant retinal pathology were *** severity was based on HVF 24-2 *** single vision was represented based on the better *** of and predictive factors for poor sleep quality and excessive daytime sleepiness were ***:A total of 79 primary open angle glaucoma(POAG),27 primary angle-closure glaucoma(PACG)patients,and 89 controls were *** patients had higher median PSQI scores(P=0.004)and poorer sleep quality(P<0.001).Compared to controls,PACG patients were 3.34 times more likely to have poor sleep quality(P=0.008),which remained significant after adjustment for demographics(P=0.016)and predictive variables(P=0.013).PACG patients have poorer sleep quality when visual acuity(VA)was 6/15 or worse(P=0.009).Univariate and multivariate analysis of predictive variables for poor sleep quality and daytime sleepiness did not find statistical ***:PACG patients have poorer sleep quality but not daytime *** is important in South-East Asian population with heavy disease *** on sleep disturbances can be considered to provide more ho istic care.

关键词： sleep disturbances primary glaucoma intrinsically photosensitive retinal ganglion cells daytime sleepiness sleep quality South-East Asia

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Effect of head tilt on repeatability of optic nerve head parameters using Cirrus spectral-domain optical coherence tomography

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1170-1175页

作者： Lilian Hui Li Koh Muhammad Amir Ismail Sae Cheong Yap elizabeth poh Ying Wong Leonard Wei Leon Yip Department of Ophthalmology Tan Tock Seng HospitalNational Healthcare Group Eye Institute

AIMTo assess the repeatability of measuring optic nerve head (ONH) parameters using the Cirrus optical coherence tomography (OCT), as well as to assess the effect of head tilt on these *** healthy participants with no evidence of glaucoma were recruited for the study. Visual acuity, intraocular pressure, standard automated perimetry and ocular examination were performed for each participant. One eye was then randomly selected and scanned undilated with the Cirrus OCT in 3 positions (neutral, 30° right tilt and 30° left tilt).RESULTSData collected from 29 eyes were used for analysis. One patient was omitted due to poor scan quality. The repeatability of the ONH parameters was analyzed using analysis of variance, coefficient of variation (COV) and intraclass correlation coefficient (ICC). Analysis of variance showed no statistically significant difference between 3 scans in a single position. There was good agreement between measurements (ICC 0.919-0.996, COV 1.94%-5.48%). Even with the presence of head tilt, repeated scans in the 3 positions showed good agreement as well (ICC 0.888-0.996, COV 2.04%-5.39%).CONCLUSIONSerial measurements of ONH parameters using the Cirrus OCT are found to have good repeatability. The ONH parameters with Cirrus OCT also maintain good repeatability despite head tilt.

关键词： glaucoma imaging artifacts optical coherence tomography head movements

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Agreement of angle closure assessments between gonioscopy, anterior segment optical coherence tomography and spectral domain optical coherence tomography

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 342-346页

作者： Elton Lik Tong Tay Vernon Khet Yau Yong Boon Ang Lim Stelson Sia elizabeth poh Ying Wong Leonard Wei Leon Yip Department of Ophthalmology Tan Tock Seng Hospital Republic of Singapore Air Force Aeromedical Centre Cardinal Santos Medical Center

AIM: To determine angle closure agreements between gonioscopy and anterior segment optical coherence tomography(AS-OCT), as well as gonioscopy and spectral domain OCT(SD-OCT). A secondary objective was to quantify inter-observer agreements of AS-OCT and SD-OCT ***: Seventeen consecutive subjects(33 eyes)were recruited from the study hospital’s Glaucoma *** was performed by a glaucomatologist masked to OCT results. OCT images were read independently by 2 other glaucomatologists masked to gonioscopy findings as well as each other’s analyses of OCT ***: Totally 84.8% and 45.5% of scleral spurs were visualized in AS-OCT and SD-OCT images respectively(P <0.01). The agreement for angle closure between AS-OCT and gonioscopy was fair at k =0.31(95% confidence interval, CI: 0.03-0.59) and k =0.35(95%CI: 0.07-0.63) for reader 1 and 2 respectively. The agreement for angle closure between SD-OCT and gonioscopy was fair at k =0.21(95% CI: 0.07-0.49) and slight at k =0.17(95% CI: 0.08-0.42) for reader 1 and 2 respectively. The inter-reader agreement for angle closure in AS-OCT images was moderate at 0.51(95% CI: 0.13-0.88). The inter-reader agreement for angle closure in SD-OCT images was slight at 0.18(95% CI: 0.08-0.45).CONCLUSION: Significant proportion of scleral spurs were not visualised with SD-OCT imaging resulting in weaker inter-reader agreements. Identifying other angle landmarks in SD-OCT images will allow more consistent angle closure assessments. Gonioscopy and OCT imaging do not always agree in angle closure assessments but have their own advantages, and should be used together and not exclusively.

关键词： anterior segment imaging spectral domain imaging angle closure assessment

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Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy

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World Journal of Gastroenterology 2010年第31期16卷 3905-3910页

作者： Hoi-poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes Gastroenterology Unit Medical DepartmentHospital Tengku Ampuan AfzanJalan Tanah Putih25100 KuantanPahang Malaysia AW Morrow Gastroenter-ology and Liver Centre Royal Prince Alfred HospitalMissen-den RoadCamperdownNSW 2050Australia Gastroenterology Unit Medical DepartmentQueen Elizabeth HospitalKarung Berkunci No.202988586 Kota KinabaluMalaysia

AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003),

关键词： Cap Hood Cecum Colonoscopy Cecal intubation Colonic polyps

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ELECTROACTIVE AND NANOSTRUCTURED POLYMERS AS SCAFFOLD MATERIALS FOR NEURONAL AND CARDIAC TISSUE ENGINEERING

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Chinese Journal of Polymer Science 2007年第4期25卷 331-339页

作者： Paul Bidez elizabeth Guterman-Tretter Alan G. MacDiarmid Peter I. Lelkes 危岩 School of Biomedical Engineering Science & Health SystemsDrexel UniversityPhiladelphiaPA 19104USA School of Biomedical Engineering Science & Health SystemsDrexel UniversityPhiladelphiaPA 19104USA Department of ChemistryDrexel UniversityPhiladelphiaPA 19104USA Department of Chemistry University of PennsylvaniaPhiladelphiaPA 19104USA

Conducting polymer, polyaniline （PANI）, has been studied as a novel electroactive and electrically conductive material for tissue engineering applications. The biocompatibility of the conductive polymer can be improved by （i） covalently grafting various adhesive peptides onto the surface of prefabricated conducting polymer films or into the polymer structures during the synthesis, （ii） co-electrospinning or blending with natural proteins to form conducting nanofibers or films, and （iii） preparing conducting polymers using biopolymers, such as collagen, as templates. In this paper, we mainly describe and review the approaches of covalently attaching oligopeptides to PANI and electrospinning PANI-gelatin blend nanofibers. The employment of such modified conducting polymers as substrates for enhanced cell attachment, proliferation and differentiation has been investigated with neuronal PC-12 cells and H9c2 cardiac myoblasts. For the electrospun PANI- gelatin fibers, depending on the concentrations of PANI, H9c2 cells initially displayed different morphologies on the fibrous substrates, but after one week all cultures reached confluence of similar densities and morphologies. Furthermore, we observed, that conductive PANI, when maintained in an aqueous physiologic environment, retained a significant level of electrical conductivity for at least 100 h, even though this conductivity was decreasing over time. Preliminary data show that the application of micro-current stimulates the differentiation of PC-12 cells. All the results demonstrate the potential for using PANI as an electroactive polymer in the culture of excitable cells and open the possibility of using this material as an electroactive scaffold for cardiac and/or neuronal tissue engineering applications that require biocompatibility of conductive polymers.

关键词： Polyaniline Conductive polymer Biocompatibility Tissue engineering.

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Risk factors for ribavirin treatment failure in Asian organ transplant recipients with chronic hepatitis E infection

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World Journal of Hepatology 2019年第6期11卷 553-561页

作者： En Xian Sarah Low Edhel Tripon Kieron Lim poh Seng Tan How Cheng Low Yock Young Dan Yin Mei Lee Mark Muthiah Wai Mun Loo Calvin Jianyi Koh Wah Wah Phyo JunXiong Pang Seng Gee Lim Guan-Huei Lee Department of Medicine Ng Teng Fong General HospitalNational University Health SystemSingapore 609606Singapore Centre for Liver Disease Management and Transplant of Medical City Manila 1605Philippines Mount elizabeth Medical Centre Singapore 228510Singapore Division of Gastroenterology and Hepatology National University Health SystemSingapore 119228Singapore Department of Medicine National University of SingaporeSingapore 119077Singapore Centre for Infectious Disease Epidemiology and Research National University of SingaporeSingapore 117549Singapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore

BACKGROUND Hepatitis E virus(HEV)infection is a cause of chronic hepatitis in immunosuppressed *** virologic response rates to a 12-wk course of ribavirin therapy were reported to be>70%in the *** study describes the outcome of HEV treatment in a transplant center in *** To study the outcome of ribavirin treatment in a series of chronic HEV patients,and the cause of treatment *** We studied all of the transplant recipients who were diagnosed with HEV infection between 2012 to *** outcome of therapy and virologic relapse are monitored for three years after the end of *** Ten transplant recipients(4 liver,5 kidney,and 1 bone marrow transplantation)with positive HEV RNA were *** patients received at least 12 wk of ribavirin therapy,and the remaining patient resolved after reducing immunosuppression *** subjects had prolonged viremia that lasted more than one year,despite continuous ribavirin *** ribavirin-treated patients(44.4%)had HEV RNA relapse after achieving a virologic response by the end of *** overall failure rate is 66.7%.Being a kidney transplant recipient is the strongest risk factor for not achieving an initial sustained virologic response(0/5 treated,Chi-Square test,P<0.05).The most common side effect of ribavirin is anemia(100%)(haemoglobin reduction of 3-6.2 g/dL).Seven patients required either a blood transfusion or erythropoietin *** The sustained virologic response rate of 12-wk ribavirin therapy for HEV infection in this Asian series was lower than *** transplant recipients had a higher rate of treatment failure due to higher immunosuppression requirements and adverse effects.

关键词： Toxicity Antiviral agents Hepatitis E virus Virus classification Systemic immunity Immune responses Persistent infection

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High resolution HLA-matched unrelated donor hematopoietic stem cell transplantation may be considered a first line therapy for children with severe aplastic anemia

High resolution HLA-matched unrelated donor hematopoietic st...

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中华医学会第十七次全国儿科学术大会

作者： Yasuhiro Okamoto Godfrey Chi-fung CHAN Suradej Hongeng TAN poh Lin TAN Ah Moy Kleebsabai Sanpakit Anselm LEE Shanghai Jiao Tong University School of Medicine Shanghai Children Prince of Wales Hospital Hong Kong Kagoshima University Medical and Dental Hospital Japan Queen Mary Hospital the University of Hong Kong Faculty of Medicine Ramathibodi Hospital Mahidol University Thailand National University Health System Singapore KK Women’s and Children’s Hospital Singapore Faculty of Medicine Siriraj hospital Mahidol UniversityThailand Nanfang Hospital Southern Medical University China Mount elizabeth Hospital Singapore

From August 2000 to November 2011,127 children under the age of 18 years with acquired severe aplastic anemia(SAA) received hematopoietic stem cell transplantation(HSCT) in one of the 10 Asia Pacific institutions of the VABMT Consortium,including 53 with matched sibling donor(MSD) and 74 with alternative donor(AD).Among these 74 AD,22 were matched unrelated donor(MUD), 32 were mismatched unrelated donor(MMUD) and 20 were mismatched related donor(MMRD).

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High resolution HLA-matched unrelated donor hematopoietic stem cell transplantation may be considered a first line therapy for children with severe aplastic anemia

High resolution HLA-matched unrelated donor hematopoietic st...

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2012年江浙沪儿科学术年会暨浙江省医学会儿科学分会学术年会、儿内科疾病诊治新进展国家级学习班

作者： Jing Chen Cheng Juan Luo Chi Kong LI Yasuhiro Okamoto Godfrey Chi-fung CHAN Suradej Hongeng TAN poh Lin TAN Ah Moy Kleebsabai Sanpakit Chun Fu LI Shanghai Jiao Tong University School of Medicine Shanghai Children’s Medical Centre Prince of Wales Hospital Kagoshima University Medical and Dental Hospital Japan Queen Mary Hospital the University of Hong Kong Faculty of Medicine Ramathibodi Hospital Mahidol University Thailand National University Health System KK Women’s and Children’s Hospital Faculty of Medicine Siriraj hospital Mahidol University Nanfang Hospital Southern Medical University Mount elizabeth Hospital Singapore Anselm LEE and for Viva-Asia Blood and Marrow Transplantation (VABMT) Group

From August 2000 to November 2011, 127 children under the age of 18 years with acquired severe aplastic anemia (SAA) received hematopoietic stem cell transplantation (HSCT) in one of the 10 Asia Pacific institutions of the VABMT Consortium, including 53 with matched sibling donor (MSD) and 74 with alternative donor (AD). Among these 74 AD, 22 were matched unrelated donor (MUD), 32 were mismatched unrelated donor (MMUD) and 20 were mismatched related donor (MMRD). Although the MSD group developed less grade

关键词： HLA High resolution HLA-matched unrelated donor hematopoietic stem cell transplantation may be considered a first line therapy for children with severe aplastic anemia

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电活性导电聚合物组织工程支架材料研究进展

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中国医学科学院学报 2006年第6期28卷 845-848页

作者：李梦燕 Paul Bidez elizabeth Guterman-Tretter 郭毅 Alan G.MacDiarmid Peter I.Lelkes 原续波袁晓燕盛京李华宋存先危岩 School of Biomedical Engineering Science &Health SystemsDrexel University PhiladelphiaPA19104 School of Biomedical Engineering Science &Health Systems Drexel University PhiladelphiaPA19104 Departmentof Chemistry University of PennsylvaniaPhiladelphia PA19104 USA Departmentof Poly-mer Materials Science &Engineering School of Materials Science &EngineeringTianjin University Tianjin 300072 Tianjin Biomedical Materials KeyLaboratory Institute of Biomedical EngineeringCAMS and PUMCTianjin 300192

由于具有电活性,导电聚合物在神经和心肌等电刺激响应性细胞的培养及相关电活性组织工程支架的研究中具有潜在的应用前景,而通过键合氨基酸基团或与天然蛋白共混可以提高其生物相容性。本文主要综述两种典型的导电聚合物-聚吡咯和聚苯胺... 详细信息

由于具有电活性,导电聚合物在神经和心肌等电刺激响应性细胞的培养及相关电活性组织工程支架的研究中具有潜在的应用前景,而通过键合氨基酸基团或与天然蛋白共混可以提高其生物相容性。本文主要综述两种典型的导电聚合物-聚吡咯和聚苯胺(PANi)在组织工程支架方面的研究进展,并特别阐述短肽与PANi的共价键合和电纺PA-Ni/明胶共混纳米纤维的研究。

关键词：导电聚合物聚吡咯聚苯胺生物相容性组织工程

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