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英语沙龙（高中） 2015年第6期 42-43,58-59页

作者： Barbara elizabeth walsh

Retrospective analysis of chronic hepatitis C in untreated patients with nonlinear mixed effects model

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Journal of Biomedical Science and Engineering 2008年第2期1卷 85-90页

作者： Jian Huang Kathleen O’Sullivan John Levis elizabeth Kenny-walsh Orla Crosbie Liam Fanning Department of Gastroenterology and Hepatology University Hospital Cork Molecular Virology Department of Medicine Hospital Cork University Statistical Consultancy Unit University College Cork Statistical Consultancy Unit University College Cork Ireland

It is well known that viral load of the hepatitis C virus (HCV) is related to the efficacy of interferon therapy. The complex biological parameters that impact on viral load are essentially unknown. The current knowledge of the hepatitis C virus does not provide a mathematical model for viral load dynamics within untreated patients. We car-ried out an empirical modelling to investigate whether different fluctuation patterns exist and how these patterns (if exist) are related to host-specific factors. Data was prospectively col-lected from 147 untreated patients chronically infected with hepatitis C, each contributing be-tween 2 to 10 years of measurements. We pro-pose to use a three parameter logistic model to describe the overall pattern of viral load fluctua-tion based on an exploratory analysis of the data. To incorporate the correlation feature of longitu-dinal data and patient to patient variation, we introduced random effects components into the model. On the basis of this nonlinear mixed ef-fects modelling, we investigated effects of host-specific factors on viral load fluctuation by in-corporating covariates into the model. The pro-posed model provided a good fit for describing fluctuations of viral load measured with varying frequency over different time intervals. The aver-age viral load growth time was significantly dif-ferent between infection sources. There was a large patient to patient variation in viral load as-ymptote.

关键词： Logistic model Viral load Viral genotype Mixed effects modelling

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摇篮山游客中心

现代装饰 2021年第4期 78-85页

作者： Andrew Geeves elizabeth walsh Anjie Biair(摄影) Rob Burnett(摄影) 范嘉苑(编译) 不详

凌厉几何形态与亲和洞穴的对话,摇篮山游客中心坐落于澳大利亚塔斯马尼亚州的摇笵山(Cradle Mountain)景区内.建筑以其恢弘尺度而又和谐统一的特征形成鲜明对比.称得上是对自然的抽象诠释,极具现代感的设计使建筑能经受住时间考验.而最... 详细信息

凌厉几何形态与亲和洞穴的对话,摇篮山游客中心坐落于澳大利亚塔斯马尼亚州的摇笵山(Cradle Mountain)景区内.建筑以其恢弘尺度而又和谐统一的特征形成鲜明对比.称得上是对自然的抽象诠释,极具现代感的设计使建筑能经受住时间考验.而最为让人惊叹的或许是那粗犷的金属立面与温轚、柔和而又楨美的木饰面内部空间的融合,由此形成独一无二的体验空间。

关键词：几何形态现代感澳大利亚和谐统一内部空间体验空间游客摇篮

Semantic Segmentation of Lumbar Vertebrae Using Meijering U-Net(MU-Net)on Spine Magnetic Resonance Images

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 733-757页

作者： Lakshmi S V V Shiloah elizabeth Darmanayagam Sunil Retmin Raj Cyril Department of Computer Science and Engineering College of Engineering GuindyAnna UniversityChennai600025India Department of Information Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

Lower back pain is one of the most common medical problems in the world and it is experienced by a huge percentage of people *** to its ability to produce a detailed view of the soft tissues,including the spinal cord,nerves,intervertebral discs,and vertebrae,Magnetic Resonance Imaging is thought to be the most effective method for imaging the *** semantic segmentation of vertebrae plays a major role in the diagnostic process of lumbar *** is difficult to semantically partition the vertebrae in Magnetic Resonance Images from the surrounding variety of tissues,including muscles,ligaments,and intervertebral discs.U-Net is a powerful deep-learning architecture to handle the challenges of medical image analysis tasks and achieves high segmentation *** work proposes a modified U-Net architecture namely MU-Net,consisting of the Meijering convolutional layer that incorporates the Meijering filter to perform the semantic segmentation of lumbar vertebrae L1 to L5 and sacral vertebra ***-colour mask images were generated and used as ground truth for training the *** work has been carried out on 1312 images expanded from T1-weighted mid-sagittal MRI images of 515 patients in the Lumbar Spine MRI Dataset publicly available from Mendeley *** proposed MU-Net model for the semantic segmentation of the lumbar vertebrae gives better performance with 98.79%of pixel accuracy(PA),98.66%of dice similarity coefficient(DSC),97.36%of Jaccard coefficient,and 92.55%mean Intersection over Union(mean IoU)metrics using the mentioned dataset.

关键词： Computer aided diagnosis(CAD) magnetic resonance imaging(MRI) semantic segmentation lumbar vertebrae deep learning U-Net model

岩石下的珍宝澳大利亚摇篮山游客中心及穿梭巴士停靠站

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室内设计与装修 2021年第9期 64-69页

作者： [澳大利亚]Cumulus Studio(设计) 小麦(编译) Peter Walker(设计) Andrew Geeves(设计) elizabeth walsh(设计) Luke Waldron(设计) Todd Henderson(设计) Matt Green(设计) Claire Austin(设计) Jason Licht(设计) Gary Fleming(设计) Anjie Blair(摄影) 不详

摇篮山游客中心坐落于澳大利亚摇篮山国家森林公园(Cradle Mountain)。这里有原始雨林和连绵草原,还有被称为“塔斯马尼亚魔鬼”的珍稀动物袋獾,近年来正吸引着越来越多的游客前来。如何在满足游客接待量的同时又为游客带来独具特色的... 详细信息

摇篮山游客中心坐落于澳大利亚摇篮山国家森林公园(Cradle Mountain)。这里有原始雨林和连绵草原,还有被称为“塔斯马尼亚魔鬼”的珍稀动物袋獾,近年来正吸引着越来越多的游客前来。如何在满足游客接待量的同时又为游客带来独具特色的游览体验和高质量的服务,更要保护生态环境不被破坏,成为摇篮山管理者考量的重中之重。因此建立一个有针对性的总体规划刻不容缓,而本案即是这一规划中最先启动的项目,也是该地区的地标性建筑。

关键词：游客接待量塔斯马尼亚地标性建筑停靠站国家森林公园原始雨林澳大利亚总体规划

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护理学校归属感量表的汉化及信效度检验

护理学杂志 2025年第2期40卷 5-8页

作者：崔元耀张琳张迪房洁 Patel Sarah elizabeth 德州学院健康医学院山东德州253023 山东大学齐鲁医院德州医院健康管理中心 School of Nursing and Health Studies University of Missouri-Kansas City

目的汉化护理学校归属感量表,并检验中文版护理学校归属感量表的信效度。方法依据Brislin原则翻译护理学校归属感量表,由8名专家评价中文版护理学校归属感量表的内容效度。2022年8月至2023年10月,采用中文版护理学校归属感量表调查330... 详细信息

目的汉化护理学校归属感量表,并检验中文版护理学校归属感量表的信效度。方法依据Brislin原则翻译护理学校归属感量表,由8名专家评价中文版护理学校归属感量表的内容效度。2022年8月至2023年10月,采用中文版护理学校归属感量表调查330名护理本科生以检验其信效度。结果中文版护理学校归属感量表包含4个分量表共19个条目。量表水平的内容效度指数为0.947,条目水平的内容效度指数为0.875~1.000,量表的Cronbach′sα系数为0.965。探索性因子分析提取4个公因子,累计方差贡献率为83.766%;验证性因子分析结果显示,χ^(2)/df=2.672,RMSEA=0.088,CFI=0.938,RMR=0.027,NFI=0.906,IFI=0.939。结论中文版护理学校归属感量表信效度良好,可用于测评护理专业学生的学校归属感水平。

关键词：护理本科生归属感学校归属感临床实践评估工具信度效度护理教育

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科学家怎么用DeepSeek

科学大观园 2025年第5期 32-33页

作者： elizabeth gibney

科研人员正在测试这个开源模型执行科研任务的能力——从数学一直到认知科学。两周前，一家中国公司推出的DeepSeek-R1让美国股市大幅震荡——DeepSeek-R1是一款平价但强大的人工智能（AI）“推理”模型。经过反复测试，DeepSeek-R1回...

科研人员正在测试这个开源模型执行科研任务的能力——从数学一直到认知科学。两周前，一家中国公司推出的DeepSeek-R1让美国股市大幅震荡——DeepSeek-R1是一款平价但强大的人工智能（AI）“推理”模型。经过反复测试，DeepSeek-R1回答数学和科学问题的能力与o1模型不相上下——o1是由加州旧金山OpenAI公司去年9月推出的一款模型，OpenAI的推理模型一直被视为行业顶尖水准。

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应用CRISP清单,提升我国全科医学和基本医疗研究报告的质量

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中国全科医学 2025年第4期28卷 393-401页

作者：杨辉汪洋陈庆奇刘晨曦顾杰赵洋秦江梅曹新阳 elizabeth Sturgiss William R.Phillips 许岩丽 Monash大学公共卫生与预防医学学院澳大利亚墨尔本市VIC 3168 上海市全科医学与社区卫生发展研究中心 200090 同济大学附属杨浦医院全科医学科上海市200090 香港大学家庭医学及基层医疗学系中国香港特别行政区999077 华中科技大学同济医学院医药卫生管理学院湖北省武汉市430000 复旦大学附属中山医院全科医学科上海市200032 复旦大学附属中山医院国际医疗部上海市200032 新南威尔士大学乔治全球健康研究院澳大利亚悉尼2050 墨尔本大学人口与全球健康学院澳大利亚墨尔本3010 国家卫生健康委卫生发展研究中心北京市100044 《中国全科医学》杂志社有限公司北京市100053 School of Primary and Allied Health Care Monash UniversityMelbourneVictoriaAustraliaVIC 3168 University of Washington SeattleWashington98195

基本医疗(初级保健)研究报告内容的条目共识(CRISP)工作组于2023年提出了CRISP清单,以支持改善上述领域研究报告的质量、实用性和传播性。《中国全科医学》英文版的学术编辑团队对CRISP清单进行了中文翻译,并通过这篇述评,在回顾我国全... 详细信息

基本医疗(初级保健)研究报告内容的条目共识(CRISP)工作组于2023年提出了CRISP清单,以支持改善上述领域研究报告的质量、实用性和传播性。《中国全科医学》英文版的学术编辑团队对CRISP清单进行了中文翻译,并通过这篇述评,在回顾我国全科医学和基本医疗研究的内涵和发展现状的基础上,归纳了该领域的科研报告中目前存在的主要问题,如“以作者为中心”“过度重视塑造权威性”“盲目生搬国际经验”“缺乏对方法学的透明报告”“在论文中压入大量冗繁信息”以及“遮蔽关键信息”等。最后,编辑团队推荐和鼓励中国的全科医学和基本医疗服务研究的作者、编辑和学术评议专家尝试使用CRISP清单,在改善中国全科医学和基本医疗研究报告质量的同时,进一步完善该工具在学科发展研究、临床研究、卫生服务研究、卫生政策研究、教育和培训研究以及社区流行病学研究等亚领域中的应用。

关键词：全科医学基本医疗研究报告内容共识

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Plasticity as panacea？ Nerves, hormones, and the currencies of trade-offs

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Current Zoology 2015年第2期61卷 251-264页

作者： elizabeth BASTIAANS elizabeth SWANGER Department of Ecology Evolution and Behavior University of Minnesota MN 55108 USA

Phenotypic plasticity is nearly universal among organisms, and evidence indicates that plasticity can exhibit additive genetic variation and respond to selection. These findings have important implications for our understanding of how plasticity may be constrained and how its mechanistic structure may affect its evolution. Many life history trade-offs may be conceptua- lized as plastic traits, with individuals varying in their position along trade-off axes due to genetic differences, developmental plasticity, or short-term plasticity occurring throughout an individual＇s lifetime. Behavioral plasticity is key to understanding when organisms are likely to encounter trade-offs, whether those trade-offs can be mitigated, and how the tradc-offs affect the ecology and evolution of populations. In this review, we discuss hormonal and neural mechanisms that may influence how plastic behavioral traits are expressed and evolve. We also outline a classification of life history trade-offs and their mechanistic bases and discuss the currencies most likely to mediate each category of trade-off and bow they are tied to the mechanisms by which animals express their behaviors.

关键词： Phenotypic plasticity Life history trade-offs Hormones Neural tissue

The effectiveness of eyespots and masquerade in protecting artificial prey across ontogenetic and seasonal shifts

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Current Zoology 2022年第4期68卷 451-458页

作者： elizabeth G Postema Department of Entomology and Nematology University of CaliforniaDavisCA 95616USA

When constraints on antipredator coloration shift over the course of development,it can be advantageous for animals to adopt different color strategies for each life *** caterpillars in the genus Papilio exhibit unique ontogenetic color sequences:for example,early instars that masquerade as bird feces,with later instars possessing eyespots.I hypothesize that larvae abandon feces masquerade in favor of eyespots due to ontogenetic changes in signaler *** ontogenetic pattern also occurs within broader seasonal shifts in background color and predator activity.I conducted predation experiments with artificial prey to determine how potential signaling constraints(specifically size and season)shape predation risk,and consequently the expression of ontogenetic color change in Papilio ***,both predation and background greenness declined significantly from July to September,though there was little evidence that these patterns impacted the effectiveness of either color *** size and color strongly affected the attack rate of avian predators:attacks increased with prey size regardless of color,and eyespotted prey were attacked more than masquerading prey *** results may reflect a key size-mediated tradeoff between conspicuousness and intimidation in eyespotted prey,and raise questions about how interwoven aspects of behavior and signal environment might maintain the prevalence of large,eyespotted larvae in nature.

关键词： ontogenetic color change eyespots masquerade predator-prey dynamics season