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Pseudomelanosis duodeni associated with chronic renal failure

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World Journal of Gastroenterology 2012年第12期18卷 1414-1416页

作者： Marcia Henriques de Magalhes costa Maria da Gloria Fernandes Pegado cleber Vargas Maria elizabeth c castro Kalil Madi Tiago Nunes cyrla Zaltman Gastroenterology Section Department of Internal MedicineClementino Fraga Filho University HospitalUniversidade Federal do Rio de JaneiroRio de Janeiro 21941-913Brazil Department of Pathology Clementino Fraga Filho University HospitalUniversidade Federal do Rio de JaneiroRio de Janeiro 21941-913Brazil Hospital clínic i Provincial/IDIBAPS Barcelona 08036Spain

Pseudomelanosis duodeni (PD) is a rare dark speckled appearance of the duodenum associated with gastrointestinal bleeding,hypertension,chronic heart failure,chronic renal failure and consumption of different *** report four cases of PD associated with chronic renal failure admitted to the gastroenterology outpatient unit due to epigastric pain,nausea,melena and progressive reduction of hemoglobin *** endoscopy revealed erosions in the esophagus and stomach,with no active bleeding at the *** addition,the duodenal mucosa presented marked signs of melanosis;later confirmed by histopathological *** though PD is usually regarded as a benign condition,its pathogenesis and clinical significance is yet to be defined.

关键词： Pseudomelanosis duodeni chronic renal fail-ure Diabetes mellitus Anti hypertensive drugs Gastro-duodenal endoscopy

Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status

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Bone Research 2023年第4期11卷 876-894页

作者： Ananya Nandy Ron c.M.Helderman Santosh Thapa Shobana Jayapalan Alison Richards Nikita Narayani Michael P.czech clifford J.Rosen elizabeth Rendina-Ruedy Department of Medicine Division of Clinical PharmacologyVanderbilt University Medical CenterNashvilleTN 37232USA Program in Molecular Medicine University of Massachusetts Chan Medical SchoolWorcesterMA 01605USA Maine Medical center Research Institute ScarboroughMEUSA Molecular Physiology and Biophysics Vanderbilt UniversityNashvilleTN 37232USA

Bone formation is a highly energy-demanding process that can be impacted by metabolic *** has been considered the principal substrate for osteoblasts,although fatty acids are also important for osteoblast ***,we report that osteoblasts can derive energy from endogenous fatty acids stored in lipid droplets via lipolysis and that this process is critical for bone *** such,we demonstrate that osteoblasts accumulate lipid droplets that are highly dynamic and provide the molecular mechanism by which they serve as a fuel source for energy generation during osteoblast *** cytoplasmic lipolysis leads to both an increase in lipid droplet size in osteoblasts and an impairment in osteoblast *** fatty acids released by lipolysis from these lipid droplets become critical for cellular energy production as cellular energetics shifts towards oxidative phosphorylation during nutrient-depleted *** vivo,conditional deletion of the ATGL-encoding gene Pnpla2 in osteoblast progenitor cells reduces cortical and trabecular bone parameters and alters skeletal lipid ***,our data demonstrate that osteoblasts store fatty acids in the form of lipid droplets,which are released via lipolysis to support cellular bioenergetic status when nutrients are *** in this process result in impairment of bone formation,specifically reducing ATP production and overall osteoblast function.

关键词： endogenous maintain osteoblast

Assessing the accuracy of patient report of the 5As (ask,assess,advise,assist,and arrange) for smoking cessation counseling

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Family Medicine and community Health 2017年第3期5卷 164-169页

作者： Susan A.Flocke elizabeth Antognoli Department of Family Medicine and community Health Case Western Reserve Univer-sityClevelandOHUSA

Objective:The 5As framework(ask,advise,assess,assist,arrange)is a recommended strat-egy for smoking cessation counseling in primary *** study compares patient report with direct observation to assess the degree of recall bias for each of the ***:Primary care visits by 107 adult smokers and 16 physicians were *** 48 hours after the visit,patients completed a survey assessing whether or not smoking was discussed and items specific to each of the *** audio recordings were evaluated to assess the presence of each *** sensitivity,specificity,positive predictive value,and negative predictive value of patient report versus direct observation were ***:The frequency of the 5As based on evaluation of the audio recording ranged from 13% (arrange)to 98% (ask).The sensitivity and specificity of patient report were 92% and not applicable for ask,90% and 50% for assess,94% and 33% for advise,90% and 50% for assist,and 85% and 67% for arrange *** predictive values ranged from 28% to 98%;negative predictive values ranged from 0% to 97% .conclusion:compared with the gold standard of direct observation,patient report of each of the 5As is reasonably sensitive but not *** overreport the occurrence of each of the 5As.

关键词： 5As(ask,assess,advise,assist,arrange) smoking cessation primary care

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在发病前,拯教青少年抑郁

环球科学 2024年第3期 50-57页

作者：伊丽莎白·斯沃博达张胜楠(译) 不详中国科学院心理研究所

当埃丝特·奥拉德乔(Esther Oladejo)连续好几天都想不起来吃饭时,她意识到自已已经越过了一条无形的边界。作为一名颇有天赋的橄榄球运动员,忙碌的学校日程也不曾停下她成长的脚步。

关键词：橄榄球运动员青少年抑郁发病前

cell adhesion in renal tubular epithelial cells:Biochemistry,biophysics or both

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BIOcELL 2022年第4期46卷 937-940页

作者： cLAIRE elizabeth HILLS ELEFTHERIOS SIAMANTOURAS PAUL EDWARD SQUIRES Diabetes Metabolism&Inflammation GroupSchool of Life SciencesJoseph Banks LaboratoriesUniversity of LincolnLincolnLN67DLUK

changes in cell-cell and cell-substrate adhesion markers are increasingly used to characterize disease onset and ***,these relationships depend on both the biochemical and molecular association between cells and between cells and their extracellular matrix,as well as the biophysical and mechanical properties orchestrated by cytoskeletal,membrane and matrix *** fully appreciate the role of cell adhesion when determining normal physiology and the impact of disease on cellular function,it is important to consider both biochemical and biophysical attributes of the system being *** this short viewpoint we reflect on our experiences assessing cell-cell and/or cell-matrix interactions in renal tubular epithelial cells.

关键词： cell-adhesion cadherin cytoskeleton AFM Kidney Epithelium

Linking the health data system in the U.S.:challenges to the benefits

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International Journal of Nursing Sciences 2017年第4期4卷 410-417页

作者： Huixin Wu elizabeth M.LaRue chatham University Eastside CampusRoom#2166585 Penn Avenue PittsburghPA 15201United States University of Pittsburgh 3500 Victoria StreetPittsburghPA 15213United States

In order to improve patient care in the United States there,the government made a mandate called HIE(Health Information Exchange).This order was created from the belief that sharing digital health in-formation between,across,and within health communities will improve one's healthcare experience across their *** health information,*** personal health record,should be shareable between healthcare providers;such as private practice physicians,home health agencies,hospitals and nursing care *** of the *** now have electronic health records,however,with a lack of standards for structuring health information and unified communication protocols to share health information across providers,only a small percentage of *** engage in computerized *** order to understand barriers and facilitators in the *** HIE adoption,we reviewed the published research literature between 2010 and *** search yielded 664 articles from Medline,PsychInfo,Global health,InSpec,Scopus and Business Source complete ***-nine articles met our inclusion *** article presents the compiled organizational and end user barriers and facilitators along with suggested methods to achieve continuity of care through HIE.

关键词： Electronic health records Health information exchange United States Hospitals

Impact of source tissue and ex vivo expansion on the characterization of goat mesenchymal stem cells

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Journal of Animal Science and Biotechnology 2015年第2期6卷 230-251页

作者： Nuradilla Mohamad-Fauzi Pablo J Ross elizabeth A Maga James D Murray Department of Animal Science University of California Institute of Ocean and Earth Sciences University of Malaya Department of Population Health and Reproduction University of California

Background： There is considerable interest in using goats as models for genetically engineering dairy animals and also for using stem cells as therapeutics for bone and cartilage repair. Mesenchymal stem cells （MScs） have been isolated and characterized from various species, but are poorly characterized in goats. Results： Goat MScs isolated from bone marrow （BM-MScs） and adipose tissue （AScs） have the ability to undergo osteogenic, adipogenic and chondrogenic differentiation. cytochemical staining and gene expression analysis show that AScs have a greater capacity for adipogenic differentiation compared to BM-MScs and fibroblasts. Different methods of inducing adipogenesis also affect the extent and profile of adipogenic differentiation in MScs. Goat fibroblasts were not capable of osteogenesis, hence distinguishing them from the MScs. Goat MScs and fibroblasts express cD90, cD105, cD73 but not cD45, and exhibit cytoplasmic localization of OcT4 protein. Goat MScs can be stably transfected by Nucleofection, but, as evidenced by colony-forming efficiency （cFE）, yield significantly different levels of progenitor cells that are robust enough to proliferate into colonies of integrants following G418 selection. BM-MScs expanded over increasing passages in vitro maintained karyotypic stability up to 20 passages in culture, exhibited an increase in adipogenic differentiation and cFE, but showed altered morphology and amenability to genetic modification by selection. conclusions： Our findings provide characterization information on goat MScs, and show that there can be significant differences between MScs isolated from different tissues and from within the same tissue. Fibroblasts do not exhibit trilineage differentiation potential at the same capacity as MScs, making it a more reliable method for distinguishing MScs from fibroblasts, compared to cell surface marker expression.

关键词： Adipose Bone marrow characterization Differentiation Goat Mesenchymal stem cells

Diagnostic utility of IgG and IgM immunohistochemistry in autoimmune liver disease

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World Journal of Gastroenterology 2010年第4期16卷 453-457页

作者： Roger Klein Moreira Frank Revetta elizabeth Koehler Mary Kay Washington Department of Pathology Columbia University College of Physicians & SurgeonsNew YorkNY 10038United States Department of Pathology Vanderbilt UniversityNashvilleTN 37232United States Department of Biostatistics Vanderbilt UniversityNashvilleTN 37232United States

AIM:To assess the role of IgM and IgG immunohistochemistry(IHc) in the evaluation of autoimmune liver conditions-autoimmune hepatitis(AIH),primary biliary cirrhosis(PBc),and primary sclerosing cholangitis(PSc).METHODS:Forty one biopsies from untreated patients diagnosed with autoimmune liver disease(AIH,n = 20;PBc,n = 13;PSc,n = 8) and fourteen biopsies of patients with chronic hepatitis c were *** and IgG-positive plasma cells were counted in each ***:A predominance of IgG-positive plasma cells was seen in AIH(90% of cases),PSc(75% of cases),and chronic hepatitis c(100% of cases),while IgMpositive plasma cells predominated in PBc(92.8% ofcases).The IgM /IgG ratio(ccurately distinguished PBc from AIH in 90.9% of cases(sensitivity = 92.3%,specificity = 90%),and PBc from either AIH or PSc in 87.8% of cases(sensitivity = 92.3%,specificity = 85.7%).cONcLUSION:Plasmacytic infiltrates expressing predominantly IgM are characteristic of PBc,while other forms of liver disease analyzed in this study,including AIH,typically show an IgG-predominant plasma cell *** data indicate that IgM and IgG IHc may be a useful tool when PBc is a diagnostic consideration.

关键词： Autoimmune hepatitis Primary sclerosing cholangitis Primary biliary cirrhosis Immunoglobulin Immunohistochemistry

Effects of resveratrol and other polyphenols in hepatic steatosis

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World Journal of Gastroenterology 2014年第23期20卷 7366-7380页

作者： Leixuri Aguirre Maria Puy Portillo elizabeth Hijona Luis Buja Nutrition and Obesity Group Department of Nutrition and Food ScienceUniversity of Basque Country (UPV/EHU) and Centro de Investigación Lucio Lascaray01006 VitoriaSpain centro de Investigación Biomédica en Fisiopatología de la Obesidad y Nutrición (cIBERobn) Instituto de Salud Carlos Ⅲ01006 VitoriaSpain Department of Gastroenterology University of the Basque Country (UPV/EHU)Donostia Hospital and Biodonostia Institute20014 San SebastiánSpain centro de Investigación Biomédica en Enfermedades Hepáticas (cIBERehd) Instituto de Salud Carlos Ⅲ20014 San SebastianSpain

Non-alcoholic fatty liver disease covers a wide spectrum of liver pathologies which range from simple steatosis to non-alcoholic *** are members of a very large family of plant-derived compounds that can have beneficial effects on human health,and thus their study has become an increasingly important area of human nutrition *** aim of the present review is to compile published data concerning the effects of both isolated polyphenols as well as polyphenol extracts,on hepatocyte and liver fat accumulation under different steatosis-inducing *** results reported clearly show that this group of biomolecules is able to reduce fat accumulation,but further studies are needed to establish the optimal dose and treatment period *** regard to the potential mechanisms of action,there is a good *** anti-lipidogenic effect of polyphenols is mainly due to reduced fatty acid and triacylglycerol synthesis,increased in fatty acid oxidation,and reduced of oxidative stress and *** a general conclusion,it can be stated that polyphenols are biomolecules which produce hepatoprotective *** date,these beneficial effects have been demonstrated in cultured cells and animal ***,studies performed in humans are needed before these molecules can be considered as truly useful tools in the prevention of liver steatosis.

关键词： Polyphenols Resveratrol Quercetin liver Steatosis Non-alcoholic fatty liver disease