检索结果-南通市图书馆

CHO cell cytotoxicity and genotoxicity analyses of disinfection by-products： An updated review

Journal of Environmental Sciences 2017年第8期29卷 64-76页

作者： elizabeth D.Wagner Michael J.Plewa Safe Global Water Institute University of Illinois at Urbana-Champaign 1101 W Peabody Dr. Urbana IL 61801 United States Department of Crop Sciences University of Illinois at Urbana-Champaign 1101 W Peabody Dr. Urbana IL 61801 United States

The disinfection of drinking water is an important public health service that generates high quality, safe and palatable tap water. The disinfection of drinking water to reduce waterborne disease was an outstanding public health achievement of the 20 th *** unintended consequence is the reaction of disinfectants with natural organic matter,anthropogenic contaminants and bromide/iodide to form disinfection by-products（DBPs）.A large number of DBPs are cytotoxic, neurotoxic, mutagenic, genotoxic, carcinogenic and teratogenic. Epidemiological studies demonstrated low but significant associations between disinfected drinking water and adverse health effects. The distribution of DBPs in disinfected waters has been well defined by advances in high precision analytical chemistry. Progress in the analytical biology and toxicology of DBPs has been *** objective of this review was to provide a detailed presentation of the methodology for the quantitative, comparative analyses on the induction of cytotoxicity and genotoxicity of103 DBPs using an identical analytical biological platform and endpoints. A single Chinese hamster ovary cell line was employed in the assays. The data presented are derived from papers published in the literature as well as additional new data and represent the largest direct quantitative comparison on the toxic potency of both regulated and emerging *** data may form the foundation of novel research to define the major forcing agents of DBP-mediated toxicity in disinfected water and may play an important role in achieving the goal of making safe drinking water better.

关键词： DBPs Mammalian cell cytotoxicity Mammalian cell genotoxicity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modelling mitochondrial dysfunction in Alzheimer’s disease using human induced pluripotent stem cells

引用

World Journal of Stem Cells 2019年第5期11卷 236-253页

作者： Kate elizabeth Hawkins Michael Duchen Cell and Developmental Biology Division of Biosciences University College London

Alzheimer’s disease (AD) is the most common form of dementia. To date, only five pharmacological agents have been approved by the Food and Drug Administration for clinical use in AD, all of which target the symptoms of the disease rather than the cause. Increasing our understanding of the underlying pathophysiology of AD will facilitate the development of new therapeutic strategies. Over the years, the major hypotheses of AD etiology have focused on deposition of amyloid beta and mitochondrial dysfunction. In this review we highlight the potential of experimental model systems based on human induced pluripotent stem cells (iPSCs) to provide novel insights into the cellular pathophysiology underlying neurodegeneration in AD. Whilst Down syndrome and familial AD iPSC models faithfully reproduce features of AD such as accumulation of Aβ and tau, oxidative stress and mitochondrial dysfunction, sporadic AD is much more difficult to model in this way due to its complex etiology. Nevertheless, iPSC-based modelling of AD has provided invaluable insights into the underlying pathophysiology of the disease, and has a huge potential for use as a platform for drug discovery.

关键词： Induced pluripotent stem cells Alzheimer's disease Mitochondria

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intestinal antigen-presenting cells in mucosal immune homeostasis:Crosstalk between dendritic cells,macrophages and B-cells

引用

World Journal of Gastroenterology 2014年第29期20卷 9653-9664页

作者： elizabeth R Mann Xuhang Li Division of Gastroenterology Department of MedicineThe Johns Hopkins University School of Medicine

The intestinal immune system maintains a delicate balance between immunogenicity against invading pathogens and tolerance of the commensal microbiota. Inflammatory bowel disease (IBD) involves a breakdown in tolerance towards the microbiota. Dendritic cells (DC), macrophages (MΦ) and B-cells are known as professional antigen-presenting cells (APC) due to their specialization in presenting processed antigen to T-cells, and in turn shaping types of T-cell responses generated. Intestinal DC are migratory cells, unique in their ability to generate primary T-cell responses in mesenteric lymph nodes or Peyer’s patches, whilst MΦ and B-cells contribute to polarization and differentiation of secondary T-cell responses in the gut lamina propria. The antigen-sampling function of gut DC and MΦ enables them to sample bacterial antigens from the gut lumen to determine types of T-cell responses generated. The primary function of intestinal B-cells involves their secretion of large amounts of immunoglobulin A, which in turn contributes to epithelial barrier function and limits immune responses towards to microbiota. Here, we review the role of all three types of APC in intestinal immunity, both in the steady state and in inflammation, and how these cells interact with one another, as well as with the intestinal microenvironment, to shape mucosal immune responses. We describe mechanisms of maintaining intestinal immune tolerance in the steady state but also inappropriate responses of APC to components of the gut microbiota that contribute to pathology in IBD.

关键词： Antigen presenting cells Dendritic cells Macrophages B cells Inflammatory bowel disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of liver biopsy in nonalcoholic fatty liver disease

引用

World Journal of Gastroenterology 2014年第27期20卷 9026-9037页

作者： ILKe Nalbantoglu elizabeth M Brunt Department of Pathology and Immunology Washington University School of MedicineSaint Louis MO 63110 United States

Nonalcoholic fatty liver disease (NAFLD), defined as abnormal accumulation (> 5%) of hepatic triglyceride without excess alcohol intake, is the most common form of chronic liver disease in adults and children in the United States. NAFLD encompasses a spectrum of histologic findings including uncomplicated steatosis, steatosis with inflammation and steatohepatitis [nonalcoholic steatohepatitis (NASH)]; the latter can advance to cirrhosis and hepatocellular carcinoma. NASH is currently accepted as the hepatic manifestation of the set of cardiovascular risk factors collectively known as metabolic syndrome. In 1999 a system for histologic grading and staging for NASH was proposed; this was revised by the NASH Clinical Research Network in 2005 for the entire spectrum of lesions in NAFLD, including the lesions and patterns of pediatric NAFLD, and for application in clinical research trials. Diagnosis remains distinct from grade and stage. A recent European proposal separates steatosis from activity to derive a numeric diagnosis of NASH. Even though there have been promising advancements in non-invasive testing, these tests are not yet detailed enough to replace the full range of findings provided by liver biopsy evaluation. Limitations of biopsy are acknowledged, but liver biopsy remains the “gold standard” for diagnosis and determination of amounts of necroinflammatory activity, and location of fibrosis, as well as remodeling of the parenchyma in NASH. This review focuses on the specific histologic lesions of NAFLD and NASH, grading and staging, differential diagnoses to be considered, and the continuing role of the liver biopsy in this important liver disease.

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Liver biopsy Histopathology Grading and staging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Consequences of fractal grade distribution for bulk sorting of a copper porphyry deposit

引用

Geoscience Frontiers 2015年第4期6卷 477-480页

作者： Peter Coghill David Miljak elizabeth Williams CSIRO Mineral Resources Flagship

We show the presence of fractal ordering of copper grade in bore core data at short range in the Cadia Ridgeway porphyry deposit and measure its persistence after mining by monitoring the output of the mine every 20 s for a month using a large scale, zero field magnetic resonance sensor. A simple model is used to investigate this connection and its consequences for sorting of the ore. Fractal distributions, and their associated power laws, have two features highly favourable for segregating ore： a large proportion of low-grade pods and the large scale spatial clustering of grade.

关键词： FractalMagnetic resonanceCopperPorphyry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Distribution of bleeding gastrointestinal angioectasias in a Western population

引用

World Journal of Gastroenterology 2012年第43期18卷 6235-6239页

作者： elizabeth Bollinger Daniel Raines Patrick Saitta Department of Medicine Section of Gastroenterology Louisiana State University Health Sciences Center New Orleans LA 70112 United States Division of Gastroenterology Lenox Hill Hospital New York NY 10075 United States

AIM:To define which segments of the gastrointestinal tract are most likely to yield angioectasias for ablative therapy. METHODS:A retrospective chart review was performed for patients treated in the Louisiana State University Health Sciences Center Gastroenterology clinics between the dates of July 1, 2007 and October 1, 2010. The selection of cases for review was initiated by use of our electronic medical record to identify all patients with a diagnosis of angioectasia, angiodysplasia, or arteriovenous malformation. Of these cases, chart reviews identified patients who had a complete evaluation of their gastrointestinal tract as defined by at least one upper endoscopy, colonoscopy and small bowel capsule endoscopy within the past three years. Patients without evidence of overt gastrointestinal bleeding or iron deficiency anemia associated with intestinal angioectasias were classified as asymptomatic and excluded from this analysis. Thirty-five patients with confirmed, bleeding intestinal angioectasias who had undergone complete endoscopic evaluation of the gastrointestinal tract were included in the final analysis. RESULTS:A total of 127 cases were reviewed. Sixtysix were excluded during subsequent screening due to lack of complete small bowel evaluation and/or lack of documentation of overt bleeding or iron deficiency anemia. The 61 remaining cases were carefully examined with independent review of endoscopic images as well as complete capsule endoscopy videos. This anal- ysis excluded 26 additional cases due to insufficient records/images for review, incomplete capsule examination, poor capsule visualization or lack of confirmation of typical angioectasias by the principal investigator on independent review. Thirty-five cases met criteria for final analysis. All study patients were age 50 years or older and 13 patients (37.1%) had chronic kidney disease stage 3 or higher. Twenty of 35 patients were taking aspirin (81 mg or 325 mg), clopidogrel, and/or warfarin, w

关键词： Intestinal angioectasias Intestinal angiodysplasias Intestinal arteriovenous malformations Obscure gastrointestinal bleeding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hyporheic Zone Flow Disruption from Channel Linings： Implications for the Hydrology and Geochemistry of an Urban Stream, St. Louis, Missouri, USA

引用

Journal of Earth Science 2016年第1期27卷 98-109页

作者： elizabeth a.hasenmueller heather k.robinson Department of Earth and Atmospheric Sciences Saint Louis University St. Louis MO 63108 USA

Cement channel linings in an urban stream in St. Louis, Missouri increase event water contributions during flooding, shorten transport times, and magnify geochemical variability on both short and seasonal timescales due to disruption of hyporheic flowpaths. Detailed analyses of water isotopes, major and trace elements, and in situ water quality data for an individual flood event reveal that baseflow contributions rise by 8% only 320 m downstream of the point where this particular channel changes from cement-lined to unlined. However, additional hydrograph separations indicate baseflow contributions are variable and can be much higher（average baseflow increase is 16%）. Stream electrical conductivity（EC） and solute concentrations in the lined reach were up to 25% lower during peak flow than in the unlined channel, indicating a greater event flow fraction. In contrast, during low flow, stream EC and solute concentrations in the lined reach were up to 30% higher due to the restricted inflow of more dilute groundwater. Over longer timescales, EC, solute concentrations, turbidity, and bacterial loads decrease downstream signifying increasing contributions of dilute baseflow. The decreased connectivity of surface waters and groundwaters along the hyporheic zone in lined channels increases the hydrologic and geochemical variability of urban streams.

关键词： stream channel linings hyporheic zone groundwater-surface water interactions,flood hydrograph urban geochemistry urban streams.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genetics and pathophysiology of mammalian sulfate biology

引用

Journal of Genetics and Genomics 2017年第1期44卷 7-20页

作者： Rachel Langford elizabeth Hurrion Paul A. Dawson Mater Research Institute University of Queensland Woolloongabba 4102 Queensland Australia Mater Mothers' Hospital South Brisbane 4101 Queensland Australia

Nutrient sulfate is essential for numerous physiological functions in mammalian growth and development. Accordingly, disruptions to any of the molecular processes that maintain the required biological ratio of sulfonated and unconjugated substrates are likely to have detrimental consequences for mammalian physiology. Molecular processes of sulfate biology can be broadly grouped into four categories： firstly, intracellular sulfate levels are maintained by intermediary metabolism and sulfate transporters that mediate the transfer of sulfate across the plasma membrane; secondly, sulfate is converted to 3＇-phosphoadenosine 5＇-phosphosulfate （PAPS）, which is the universal sulfonate donor for all sulfonation reactions; thirdly, sulfotransferases mediate the intracellular sulfonation of endogenous and exogenous substrates; fourthly, sulfate is removed from substrates via sulfatases. From the literature, we curated 91 human genes that encode all known sulfate transporters, enzymes in pathways of sulfate generation, PAPS synthetases and transporters, sulfotransferases and sulfatases, with a focus on genes that are linked to human and animal pathophysiology. The predominant clinical features linked to these genes include neurological dysfunction, skeletal dysplasias, reduced fecundity and reproduction, and cardiovascular pathologies. Collectively, this review provides reference information for genetic investigations of perturbed mammalian sulfate biology.

关键词： Sulfate Pathogenetics Transport Sulfotransferase Sulfatase PAPS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Oxidative stress battles neuronal Bcl-xL in a fight to the death

引用

Neural Regeneration Research 2021年第1期16卷 12-15页

作者： Han-A Park Katheryn Broman elizabeth A.Jonas Department of Human Nutrition and Hospitality Management College of Human Environmental SciencesThe University of AlabamaTuscaloosaALUSA Department of Internal Medicine Section of EndocrinologyYale UniversityNew HavenCTUSA

Bcl-xL is a pro-survival protein of the Bcl2 family found in the mitochondrial ***-xL supports growth,development,and maturation of neurons,and it also prevents neuronal death during neurotoxic *** article reviews the mechanisms and upstream signaling that regulate the activity and abundance of *** team and others have reported that oxidative stress is a key regulator of intracellular Bcl-xL balance in *** stress regulates synthesis,degradation,and activity of Bcl-xL and therefore neuronal *** apoptosis,pro-apoptotic Bcl2 proteins such as Bax and Bak translocate to and oligomerize in the mitochondrial *** of oligomers causes release of cytochrome c and activation of caspases that lead to neuronal ***-xL binds directly to pro-apoptotic Bcl2 proteins to block apoptotic *** anti-apoptotic roles of Bcl-xL have been well documented,an increasing number of studies in recent decades show that protein binding partners of Bcl-xL are not limited to Bcl2 ***-xL forms a complex with F1Fo ATP synthase,DJ-1,DRP1,IP3R,and the ryanodine *** proteins support physiological processes in neurons such as growth and development and prevent neuronal damage by regulating mitochondrial ATP production,synapse formation,synaptic vesicle recycling,neurotransmission,and calcium ***,under conditions of oxidative stress,Bcl-xL undergoes proteolytic cleavage thus lowering the abundance of functional Bcl-xL in ***,oxidative stress alters formation of Bcl-xL-mediated multiprotein complexes by regulating post-translational ***,oxidative stress regulates transcription factors that target the Bcl-x gene and alter accessibility of microRNA to mRNA influencing mRNA levels of *** this review,we discussed how Bcl-xL supports the normal physiology of neurons,and how oxidative stress contributes to pathology by manipulating the dynamics of Bcl

关键词： ATP Bcl-xL F1Fo ATP synthase mitochondria neuroprotection oxidative stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of organic acids—essential oils blend and oat fiber combination on broiler chicken growth performance, blood parameters, and intestinal health

引用

Animal Nutrition 2021年第4期7卷 1039-1051页

作者： Deborah I.Adewole Samson Oladokun elizabeth Santin Department of Animal Science and Aquaculture Faculty of AgricultureDalhousie UniversityTruroNSB2N 5E3Canada b JEFO Nutrition Inc.Saint-HyacintheQC J2R 2E7Canada

This study evaluated the effect of organic acids-essential oils blend with or without oat hulls(OH)on growth performance,organ weights,blood parameters,gut morphology,microbiota,and short-chain fatty acids(SC FA)in ***-old broiler chickens were randomly allocated to 4 dieta ry treatments consisting of 1)a corn-soybean meal-wheat based diet(BAS),2)BAS+0.05%bacitracin methylene disalicylate(BMD),3)BAS+protected organic acids-essential oils at 300 g/1,000 kg of feed(OE),and 4)BAS+protected organic acids-essential oils at 300 g/1,000 kg of feed+3%OH(OEOH),in 8 replicate *** was in starter(d0 to 14),grower(d 14 to 24),and finisher(d 24 to 36)*** weight(BW),feed intake(FI),feed conversion ratio(FCR),and mortality were determined *** d 36,8 chickens per treatment were sampled for blood biochemistry,organ weights,cecal SCFA production,and *** had no effect on FI and FCR at all *** OE and OEOH treatments reduced(P<0.001)the body weight gain of birds at the starter *** fed the OEOH treatment had higher(P<0.001)gizzard weight,while those offered the BMD diet showed a tendency(P=0.08)to have higher cecal *** in the OEOH treatment recorded increased ileal villus height and villus height-to-crypt depth ratio,as well as reduced duodenal crypt depth,while birds in the OE treatment had increased j ej unal villus height and villus height-to-crypt depth *** OEOH and OE treatments increased the number of goblet cells produced in the duodenum and *** had no effecton SCFA *** in the OE treatment recorded the lowest concentration of blood urea(P=0.05)and cholesterol(P<0.05).Both OE and OEOH treatments increased(P<0.05)the relative abundance of potentially beneficial bacteria in the genus Firmicutesunclassified,Ruminococcus,Turicibacter,and Erysipelotrichaceaeunclassified,while reducing(P<0.001)the relative abundance of potentially harmful ***,bo

关键词： Organic acid Essential oil Oat hull Broiler chicken Ceca microbiota

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：