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The computerized LASSI-BC Test versus the Standard LASSI-L Paper-and-Pencil Version in Community-Based-Samples

Advances in Alzheimer's Disease 2024年第1期13卷 11-25页

作者： Rosie E. Curiel Cid Alexandra Ortega Ubbo Visser Marcela Kitaigorodsky D. Diane Zheng Diana Hincapie Kirsten Horne Crenshaw Ashleigh Beaulieu Brooke Bosworth Liz Gallardo Emory Neer Sofia Ramirez elizabeth A. Crocco Mike Georgiou Efrosyni Sfakianaki David A. Loewenstein Center for Cognitive Neuroscience and Aging and Department of Psychiatry and Behavioral Sciences Miller School of Medicine University of Miami Miami FL USA Department of Computer Sciences University of Miami Coral Gables FL USA Nova Southeastern University Fort Lauderdale FL USA Department of Radiology and Nuclear Medicine Miller School of Medicine University of Miami Miami FL USA

Proactive Semantic Interference (PSI) and failure to recover from PSI (frPSI), are novel constructs assessed by the LASSI-L. These measures are sensitive to cognitive changes in early Mild Cognitive Impairment (MCI) and preclinical AD determined by Aβ load using PET. The goal of this study was to compare a new computerized version of the LASSI-L (LASSI-Brief Computerized) to the standard paper-and-pencil version of the test. In this study, we examined 110 cognitively unimpaired (CU) older adults and 79 with amnestic MCI (aMCI) who were administered the paper-and-pencil form of the LASSI-L. Their performance was compared with 62 CU older adults and 52 aMCI participants examined using the LASSI-BC. After adjustment for covariates (degree of initial learning, sex, education, and language of evaluation) both the standard and computerized versions distinguished between aMCI and CU participants. The performance of CU and aMCI groups using either form was relatively commensurate. Importantly, an optimal combination of Cued B2 recall and Cued B1 intrusions on the LASSI-BC yielded an area under the ROC curve of .927, a sensitivity of 92.3% and specificity of 88.1%, relative to an area under the ROC curve of .815, a sensitivity of 72.5%, and a specificity of 79.1% obtained for the paper-and-pencil LASSI-L. Overall, the LASSI-BC was comparable, and in some ways, superior to the paper-and-pencil LASSI-L. Advantages of the LASSI-BC include a more standardized administration, suitability for remote assessment, and an automated scoring mechanism that can be verified by a built-in audio recording of responses.

关键词： Mild Cognitive Impairment Proactive Semantic Interference LASSI-L Computerized Cognitive Assessment

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On the potential of iPhone significant location data to characterize individual mobility for air pollution health studies

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Frontiers of Environmental Science & Engineering 2022年第5期16卷 109-113页

作者： Eastman elizabeth A.Stevens Kelly Ivey Cesunica Haofei Yu Department of Civil Environmentaland Construction EngineeringUniversity of Central FloridaOrlandoFL 32816USA School of Public Administration University of Central FloridaOrlandoFL 32801USA Department of Civil and Environmental Engineering University of California-BerkeleyBerkeleyCA 94720USA

In many air pollution health studies,the time-activity pattern of individuals is often ignored largely due to lack of ***,a better understanding of this location-based information is expected to decrease uncertainties in exposure ***,we showcase the potential of iPhone’s Significant Location(iSL)data in capturing the user’s historical time-activity patterns in order to estimate exposure to ambient air *** this study,one subject carried an iPhone in tandem with a reference GPS tracking device for one *** GPS device recorded locations in 10 second intervals while the iSL recorded the time spent in locations the subject visited *** GPS data as a reference,we then evaluated the accuracy of iSL data in capturing the subject’s time-activity patterns and time-weighted air pollution concentration within the study time *** found the iSL data accurately captured the time the subject spent in 16 microenvironments(*** the subject visited more than once),which was 93%of the time during the study *** average error of time-weighted aerosol optical depth value,a surrogate of particle pollution,is only 0.012%.To explore the availability of iSL data among iPhone users,an online survey was *** the 349 surveyed participants,72%of them have iSL data *** the popularity of iPhones,iSL data may be available for a significant portion of the general *** results suggest iSL data have great potential for characterizing historical time-activity patterns to improve air pollution exposure estimation.

关键词： Air pollution exposure Human mobility iPhone Significant Location Smartphone data

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Increased presence of effector lymphocytes during Helicobacter hepaticus-induced colitis

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World Journal of Gastroenterology 2012年第13期18卷 1459-1469页

作者： Sarah J McCaskey elizabeth A Rondini Jonathan F Clinthorne Ingeborg M Langohr elizabeth M Gardner Jenifer I Fenton Department of Food Science and Human Nutrition College of Osteopathic MedicineMichigan State UniversityEast LansingMI 48824United States Department of Food Science Human Nutrition Michigan State UniversityEast LansingMI 48824United States Department of Pathobiology and Diagnostic Investigation Michigan State UniversityEast Lansing MI 48824United States

AIM： To identify and characterize drosophila mothers against decapentaplegic （SMAD）3-dependent changes in immune cell populations following infection with He- Iicobacter hepaticus （H. hepaticus）. METHODS： SMAD3/ （n = L9） and colitis-resistant SMAD3＋/ （n = 24） mice （8-10 wk of age） were in- fected with/-/, hepaticus and changes in immune cell populations [T lymphocytes, natural killer （NK） cells, T regulatory cells] were measured in the spleen and mesenteric lymph nodes （MsLNs） at 0 d, 3 d, 7 d and 28 d post-infection using flow cytometry. Genotype-dependent changes in T lymphocytes and granzyme B＋ cells were also assessed after 28 d in proximal colon tissue using immunohistochemistry. RESULTS： As previously observed, SMAD3＋, but not SMAD3＋/- mice, developed colitis, peaking at 4 wk post-infection. No significant changes in T cell subsets were observed in the spleen or in the MsLNs between genotypes at any time point. However, CD4＋ and CD8＋/ CD62L＋＋ cells, an effector T lymphocyte population, as well as NK cells （NKp46/DX5＋） were significantly higher in the MsLNs of SMAD3/ mice at 7 d and 28 d post-in- fection. In the colon, a higher number of CD3＋ cells were present in SMAD3＋ compared to SMAD3＋/- mice at base- line, which did not significantly change during infection. However, the number of granzyme B＋ cells, a marker of cytolytic lymphoo/tes, significantly increased in SMAD3＋ mice 28 d post-infection compared to both SMAD3＋/- mice and to baseline values. This was consistent with more severe colitis development in these animals. CONCLUSION： Data suggest that defects in SMAD3 signaling increase susceptibility to H. hepaticus-induced colitis through aberrant activation and/or dysregulation of effector lymphoo/tes.

关键词： Transforming growth factor-J3 Colitis Dro-sophila mothers against decapentaplegic Colon cancer T lymphocytes

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Current and near-term advances in Earth observation for ecological applications

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Ecological Processes 2021年第1期10卷 1-57页

作者： Susan L.Ustin elizabeth M.Middleton John Muir Institute of the Environment University of CaliforniaDavisCA 95616USA NASA/Goddard Space Flight Center(Emerita) GreenbeltMD 20771USA.

There is an unprecedented array of new satellite technologies with capabilities for advancing our understanding of ecological processes and the changing composition of the Earth’s biosphere at scales from local plots to the whole *** identified 48 instruments and 13 platforms with multiple instruments that are of broad interest to the environmental sciences that either collected data in the 2000s,were recently launched,or are planned for launch in this *** have restricted our review to instruments that primarily observe terrestrial landscapes or coastal margins and are available under free and open data *** focused on imagers that passively measure wavelengths in the reflected solar and emitted thermal *** suite of instruments we describe measure land surface characteristics,including land cover,but provide a more detailed monitoring of ecosystems,plant communities,and even some species then possible from historic *** newer instruments have potential to greatly improve our understanding of ecosystem functional relationships among plant traits like leaf mass area(LMA),total nitrogen content,and leaf area index(LAI).They provide new information on physiological processes related to photosynthesis,transpiration and respiration,and stress detection,including capabilities to measure key plant and soil biophysical *** include canopy and soil temperature and emissivity,chlorophyll fluorescence,and biogeochemical contents like photosynthetic pigments(e.g.,chlorophylls,carotenoids,and phycobiliproteins from cyanobacteria),water,cellulose,lignin,and nitrogen in foliar *** data will enable us to quantify and characterize various soil properties such as iron content,several types of soil clays,organic matter,and other *** of these satellites are in low Earth orbit(LEO),but we include a few in geostationary orbit(GEO)because of their potential to measure plant physiological traits over diurnal periods,impro

关键词： Terrestrial ecosystems Earth Observing Satellites Ecosystem processes Physiological functions Multispectral Hyperspectral Thermal LiDAR Radar imagers Biochemistry Soil properties Species mapping Change detection 3D canopy structure Topography

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Characterization of the D" beneath the Galapagos Islands using SKKS and SKS waveforms

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Earthquake Science 2011年第1期24卷 87-99页

作者： elizabeth Vanacore Fenglin Niu Department of Earth Science Rice University Houston TX 77005 USA Research School of Earth Sciences The Australian National University Canberra ACT 0200 Australia

SKS and SKKS waveforms from 16 events occurring between 2003 and 2005 in the Tonga Trench that were recorded by the BOLIVAR array are analyzed to determine the structure of the D＂ layer beneath the Galapagos Islands. 248 differential travel-time residuals of SKKS-SKS are measured and reveal a region of positive residuals of differential travel times in the northeast portion of the sampled region. Analyzing correlation statistics between the measured SKKS-SKS residuals and the observed absolute travel time delay of the individual SKS and SKKS phases for two events with high data quality, we determine that the residual differential travel time is due to excess low velocity along the SKKS raypaths. First order modeling of three potential low velocity structures, ultra-low velocity zones （ULVZ）, plume conduit, D＂ structure, indicates that the observed SKKS-SKS residuals can be best explained by a low velocity anomaly within the D＂ layer. To determine the presence of lower mantle anisotropy, amplitude ratios of the radial and transverse component of SKS and SKKS waveform are calculated and compared. Regions with significant presence of seismic anisotropy are interpreted as the edge of the flow field associated with a hypothetical mantle upwelling.

关键词： SKKS-SKS D" structure plume formation anisotropy differential travel-time residuals

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疗愈花园类型的概念界定

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风景园林 2024年第5期31卷 75-90页

作者：伊丽莎白·R·M·黛尔姜博(译) 程宇(译) 佛罗里达大学环境园艺学院哈尔滨工业大学建筑与设计学院哈尔滨工业大学寒地城乡人居环境科学与技术工业和信息化部重点实验室

【目的】随着疗愈花园研究的不断深入,相关描述性术语也越来越多,很难区分不同类型的疗愈花园。通过明确疗愈花园类型,设计师和其他相关专业人员能更好地为客户和其他利益相关者提供信息,创造出更具针对性和响应性的设计,有效促进新项... 详细信息

【目的】随着疗愈花园研究的不断深入,相关描述性术语也越来越多,很难区分不同类型的疗愈花园。通过明确疗愈花园类型,设计师和其他相关专业人员能更好地为客户和其他利益相关者提供信息,创造出更具针对性和响应性的设计,有效促进新项目的开发。【方法】建立疗愈花园类型层次框架,并以现有花园为例,分析每种类型疗愈花园的设计目的、设计重点和潜在用户。【结果】将疗愈花园类型层次框架的基本结构分为主动型(使能型)和被动型(恢复型)的双轨结构,明确了不同类型疗愈花园的区别和联系。【结论】“疗愈花园”一词常被用于描述医疗机构中的花园,而不同类型的疗愈花园之间存在一些重要区别。这些区别为疗愈花园的设计提供了依据,有助于在花园空间中开展高质量的活动,同时兼顾使用者的需求。疗愈花园的设计必须满足使用人群的特定需求,包括居民/患者、员工和家庭成员。

关键词：疗愈花园恢复花园使能花园治疗花园感官花园

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Significance of long non-coding RNA AGPG for the metabolism of esophageal cancer

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Cancer Communications 2020年第7期40卷 313-315页

作者： Rebecca elizabeth Vargas Wenqi Wang Department of Developmental and Cell Biology University of CaliforniaIrvineCalifornia92697USA

Over the years,thousands of long non-coding RNAs(lncRNAs)have been identified to be exclusively expressed in specific cancer types and for their unique functions in *** has led to an increasing interest in elucidating the vital roles[1]and underlying mechanism[2,3]of such non-coding genome in driving cancerous phenotypes.A number of studies have pinpointed the key functions of lncRNAs in diverse biological events including chromatin interactions,transcriptional regulation,RNA processing,mRNA stabilization,signal transduction,and metabolic regulation;highlighting their essential roles in both physiology and diseases such as cancer[4].

关键词： metabolism esophageal cancer

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Cryptomycota: the missing link

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Protein & Cell 2012年第3期3卷 161-162页

作者： Krishna Bolla elizabeth Jane Ashforth Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100190China􀀍

Fungi have been well studied for 150 years and it was thought that there was a good understanding of the major evolutionary groups,but new findings by UK researchers from the University of Exeter have radically changed this *** a local pond near the Exeter University,UK,they discovered a diverse and deep evolutionary branch of fungi named Cryptomycota(Greek:crypto,hidden;mycota,fungi)that has now doubled our knowledge of fungal diversity.

关键词： doubled branch Cry

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Prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma:Review and bibliometric

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iLIVER 2024年第1期3卷 52-61页

作者： Pamela Scarlett Espinoza Loyola Diana Laura Muratalla Bautista Karen Adela Hernández Bautista elizabeth Gil White JoséAntonio González Moreno Daniel Angel Torres del Real Víctor Manuel Páez Zayas Carla Escorza-Molina Fernando Mondragón Rodríguez Omar Vásquez Gómez Luis Jorge Fernández López Paul Santiago Mogrovejo Vázquez Isidoro Aczel Sánchez-Cedillo Víctor Jose Visag Castillo Social Service Internship Universidad Nacional Autónoma de MéxicoMexico City 04510Mexico Social Service Internship Universidad AnahuacMexico City 04510Mexico Department of Surgery Division of Transplantation Surgery Hospital General de MéxicoMexico City 06720Mexico Departament of Gastroenterology Division of HepatologyHospital General de MéxicoMexico City 06720Mexico Departmanet of Anesthesiology Hospital General de MéxicoMexico City 06720Mexico

Hepatocellular carcinoma(HCC)is one of the most common cancers in the world and is one of the leading indications for liver transplantation,liver transplantation is the gold standard treatment for end stage liver *** is based up on radiological characteristics and rarely biopsy *** treatment must be individualized to each patient to improve recurrences and *** this article,we focus on the different selection criteria for liver *** study aimed to investigate the distribution laws and research frontiers of international literature,so as to present holistic bibliometric evaluation of the studies on 5-year survival and disease-free recurrence in 5 years,according to hepatocarcinoma criteria for liver *** paper aims to review and analyze 5-year survival and disease-free recurrence based on hepatocarcinoma criteria for liver *** systematically examines and summarizes distribution characteristics and research frontiers through bibliometric analysis.A bibliographic search was implemented in PubMed/Medline,Clinical Key,Science Direct and Index Medicus with MESH terms,from the year 1996–*** selected for transplantation using the Metroticket 2.0(MT2)criteria had the highest overall survival along with patients selected for transplantation using the Milan Criteria had the best 5-year disease-free *** Metroticket 2.0 criteria(MT2)and Milan Criteria(MC)have shown the most favorable post-transplant outcomes for patients with hepatocellular carcinoma(HCC).However,MC demonstrated the best 5-year disease-free recurrence rate,underscoring the significance of taking into account tumor morphology and biology when determining the eligibility of HCC patients for liver *** distribution characteristics and research frontiers by bibliometrics concerning prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma the collaboration

关键词： Hepatocellular carcinoma Liver transplantation Survival Criteria Recurrence Bibliometrics

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Fate of polyphenols in pili(Canarium ovatum Engl.) pomace after in vitro simulated digestion

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Asian Pacific Journal of Tropical Biomedicine 2017年第1期7卷 53-58页

作者： elizabeth Hashim Arenas Trinidad Palad Trinidad Department of Food Technology College of EducationUniversity of Santo TomasEspanaManila 1015Philippines The Graduate School University of Santo TomasEspanaManila 1015Philippines

Objective: To evaluate the stability and bioavailability of polyphenols in pili(Canarium ovatum Engl.) pomace during simulated in vitro ***: Freeze-dried pili pomace was subjected to in vitro digestion simulating conditions in the stomach, small intestine and colon. Total polyphenols, anthocyanins, fl avonoids and condensed tannins, and its antioxidant activity – 1,1-diphenyl-2-picrylhydrazyl, 2,20-azinobis-3-ethylbenzothiozoline-6-sulfonic acid, and ferric reducing antioxidant power were measured using standard spectrophotometric ***: In vitro digestion of pili pomace resulted in reduction of phenolic *** tannins and anthocyanins were released in the gastric and intestinal stages,while total polyphenols and flavonoids after fermentation simulating colonic *** values of the bioavailable fractions showed that more than 90% of activity was lost during simulated ***: Findings indicate that pili pomace is a promising functional ingredient for food and dietary supplements which can furnish potentially bioavailable phenolic antioxidants to the body.

关键词： Antioxidant In vitro digestion Phenolics Bioavailability Canarium ovatum Pili

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