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Effects of Gas1 on gliomas:a review on current preclinical studies

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 101-111页

作者： jose Segovia elizabeth Bautista Manuel Lara-Lozano Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios Avanzados del IPN07360 Distrito FederalMexico

Glioblastoma multiforme(GBM)is the most common and lethal brain *** prognosis remains very poor,despite the use of combined treatments such as surgical resection,radiation and *** major limitations for the treatment of GBM are its high invasiveness,tumor recurrence and resistance to ***,gene therapy appears as a relevant strategy for its ***,we have investigated the use of growth-arrest-specific 1(Gas1)for the treatment of ***1 is a tumor suppressor protein that inhibits glioma growth by inducing arrest and apoptosis of tumor ***,we have shown that a soluble form of Gas1 acting in both autocrine and paracrine manners is also effective inhibiting tumor growth in animal models,indicating its potential as an adjuvant for the treatment of GBM.

关键词： Growth arrest specific 1 glioma serine-threonine protein kinase glial cell-derived neurotrophic factor extracellular signal-regulated kinases and tumor

Helicobacter pylori and upper gastrointestinal diseases: A review

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Health 2014年第4期6卷 263-273页

作者： Bruna Maria Roesler elizabeth Maria Afonso Rabelo-Goncalves jose Murilo Robilotta Zeitune Department of Clinical Medicine Center of Diagnosis of Digestive DiseasesFaculty of Medical SciencesState University of CampinasCampinasBrazil

Since its first isolation by Marshall and Warren, Helicobacter pylori (H. pylori) has been recognized to have a causal role in the upper gastrointestinal diseases development, especially in chronic gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT lymphoma) and gastric adenocarcinoma. H. pylori is a spiral-shaped gram-negative flagellate bacterium that has a high genetic diversity, which is an important factor in its adaptation to the host stomach and also for the clinical outcome of the infection, an aspect that remains unclear. However, it is thought to involve a interplay among the virulence of the infecting strain, host genetics and environmental factors. This review chapter brings the principal characteristics of the diseases associated with H. pylori infection and summarizes some important characteristics concerning the virulence of bacterium strain, host genetics and external environment.

关键词： Helicobacter Pylori Gastritis Peptic Ulcer Disease MALT Lymphoma Gastric Cancer

Analysis of Percolation of the Stabilized Suspensions of TiO2 and SiO2 Nanoparticles in Soil Columns Simulating Landfill Layers

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Journal of Mechanics Engineering and Automation 2016年第1期6卷 47-52页

作者： elizabeth Mendes de Oliveira Daniele Aparecida Nogueira Luis CarlosRolim Lopes jose Flavio Silveira Feiteira jose Adilson de Castro Escola de Engenharia de Alimentos Centro Federal de Educaao Tecnologica Celso Suckow da Fonseca Valenca 27600-000Rio de Janeiro Brasil Escola de Engenharia Industrial Metalurgica Universidade Federal Fluminense Volta Redonda 27255-125 Rio de Janeiro Brasil

It studied the behavior of transport and stability of TiO2 and SiO2 nanoparticles suspensions percolating through soil columns aiming at simulating municipal waste landfills covering soil layers performance. Experimental columns were constructed with landfill soils and water suspensions with nanoparticles percolation runs were carried out. The experimental columns were constructed with 100 mm and 200 mm of diameter and height, respectively. Outlet concentrations were measured along the percolation time using ICP-OES and nanoparticles tracking analyzer. It was observed that SiO2 nanoparticles acts as a stabilizer of TiO2 nanoparticles suspensions and promotes its transport through the soil columns, which simulates the conditions of the controlled landfills layers. The interaction of the suspensions of SiO2 nanoparticles with nanoparticles of TiO2, promote a high stability of the emulsions, which confers the high zeta potential present in SiO2 suspensions, promoting greater mobility and transport through the soil columns. The experimental results demonstrated that TiO2 nanoparticles were kept suspended, even after 10 days, which indicates good stability. It was observed that both TiO2 and SiO2 were kept in suspensions with negligible nanoparticles clustering and decantation. It was confirmed that the TiO2 and SiO2 of the outflow of soil columns are strongly affected by the soil pH, organic carbon and clay content of the soils. It was observed that the soil columns behave as a retention barrier for both TiO2 and SiO2 nanoparticles.

关键词： Stabilization column experiment and nanofluids.

Sub-Epithelial Connective Tissue Graft to Increase the Volume of Residual Alveolar Bone in the Upper Anterior Sector and Fixed Rehabilitation with Zirconia

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Open Journal of Stomatology 2018年第6期8卷 189-195页

作者： Minor Enrique Zuniga Araya Rita elizabeth Martínez Martínez jose Honorio Olvera Delgado Jaime Alejandro Nieto Ramirez Elena A.Popoca Hernandez jose Luis Ayala Herrera San Luis Potosi University San Luis PotosiMexico Universidad Autónoma de San Luis Potosí San Luis PotosíMéxico

Background: The collapse of the alveolar ridge in an edentulous area in patients who will undergo oral rehabilitation impedes the harmonic relationship between pontic and ridge. To correct this type of defect there are several surgical techniques that aim to achieve soft tissue augmentation, allowing the conformation of an ideal profile with the use of a pontic. The aim was to demonstrate how the technique of tissue modification in an area with a class b defect of Allen allows the correction of aesthetics in the anterior dental sector. Case presentation: A 41-year-old Mexican woman. Extra and intraoral examination was performed, the dental treatment included connective tissue graft and rehabilitation with Zirconia. Conclusion: Surgery of residual alveolar ridge augmentation with connective tissue graft gives the patient favorable aesthetic results in the anterior area when it will be rehabilitated.

关键词： Esthetic Zone Zirconia Class B Defect of Allen

Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases

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World Journal of Hepatology 2015年第30期7卷 2968-2979页

作者： elizabeth MA Rabelo-Goncalves Bruna M Roesler jose MR Zeitune Laboratory of Gastroenterology and Hepatology Center of Diagnosis of Digestive DiseasesState University of CampinasCampinasSao Paulo 13083-878Brazil Department of Internal Medicine Faculty of Medical SciencesState University of CampinasCampinasSao Paulo13083-887Brazil

Helicobacter pylori(H. pylori) is an ancient microorganism that has co-evolved with humans for over 60000 years. This bacterium typically colonizes the human stomach and it is currently recognized as the most common infectious pathogen of the gastroduodenal tract. Although its chronic infection is associated with gastritis, peptic ulcer, dysplasia, neoplasia, MALT lymphoma and gastric adenocarcinoma, it has been suggested the possible association of H. pylori infection with several extragastric effects including hepatobiliary and pancreatic diseases. Since a microorganism resembling H. pylori was detected in samples from patients with hepatobiliary disorders, several reports have been discussed the possible role of bacteria in hepatic diseases as hepatocellular carcinoma, cirrhosis and hepatic encephalopathy, nonalcoholic fatty liver disease and fibrosis. Additionally, studies have reported the possible association between H. pylori infection and pancreatic diseases, especially because it has been suggested that this infection could change the pancreatic physiology. Some of them have related a possible association between the microorganism and pancreatic cancer. H. pylori infection has also been suggested to play a role in the acute and chronic pancreatitis pathogenesis, autoimmune pancreatitis, diabetes mellitus and metabolic syndrome. Considering that association of H. pylori to liver and pancreas diseases needs further clarification, our work offers a review about the results of some investigations related to the potential pathogenicity of H. pylori in these extragastric diseases.

关键词： Hepatocellular carcinoma Cirrhosis Hepaticencephalopathy Helicobacter pylori Nonalcoholic fattyliver disease Fibrosis Pancreatitis Pancreatic cancer Diabetes mellitus Metabolic syndrome

Photoluminescence Response of HfO<sub>2</sub>:Eu<sup>3+</sup>Obtained by Hydrothermal Route

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Open Journal of Synthesis Theory and Applications 2013年第2期2卷 73-77页

作者： elizabeth Navarro Cerón Geonel Rodríguez Gattorno jose Guzmán-Mendoza Manuel García-Hipólito Ciro Falcony Centro de Investigación de Ciencia Aplicada y Tecnología Avanzada Instituto Politécnico Nacional México D. F. México Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional México D. F. México Departamento de Física Aplicada Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Mérida México Instituto de Investigaciones en Materiales Universidad Nacional Autónoma de México México D. F. México

In this work, the synthesis and photoluminescence response of HfO2 doped with Eu3+ (HfO2:Eu3+) are reported. The synthesis was carried out by the hydrothermal route of HfCl4 and EuCl3?.6H2O with NH4OH dissolved in deionized water. To perform the hydrolysis, the precursors were subjected to hydrothermal treatment at 120°C, under autogenously pressure at reaction times of 24, 40, 52 and 72 hours. The synthesized nanoparticles were characterized by mean of X- ray diffraction (XRD), high resolution transmission electron microscope (HRTEM), and energy dispersive spectroscopy (EDS). Samples excited with 395 nm radiation show photoluminescence emission lines corresponding to the electronic transitions 5D0 → 7FJ (J = 0 → 4), characteristics of the Eu3+ ion. The photoluminescence emission intensity increases with the increasing of the reaction time, reaching a maximum at 72 hours. The excitation band peaked at 395 nm, makes this material an excellent candidate for applications in solid state white lamps.

关键词： Photoluminescence Hafnium Oxide Hydrothermal Method Earth Rare Trivalent Ions

Neurological manifestations with jugular vein thrombosis linked to an inflammatory profile may be a sequela of long COVID

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Neuroprotection 2023年第2期1卷 170-175页

作者： elizabeth Mendoza-Portillo Estefania Aleman-Navarro G.Aleph Prieto Yvonne Rosenstein jose J.Lozano-Nuevo Araceli Perez-Lopez Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez Ciudad de MéxicoMéxico Instituto de Biotecnología Universidad Nacional Autónoma de México(UNAM)CuernavacaMorelosMéxico Instituto de Neurobiología UNAM-JuriquillaQuerétaroMéxico Institute for Memory Impairments and Neurological Disorders University of California-IrvineIrvineCaliforniaUSA Hospital General de Ticomán Secretaría de Salud de la Ciudad de MéxicoCiudad de MéxicoMéxico Unidad de Investigación en Biomedicina Facultad de Estudios Superiores IztacalaUNAMTlalneplantlaEstado de MéxicoMéxico

More than 670 million cases of coronavirus disease 2019(COVID-19)have been recorded worldwide in the 3 years since the start of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** 45%of survivors of COVID-19 develop a syndrome known as long-term COVID,in which symptoms persist even months after the acute *** 76%of patients with long COVID experience neurological ***,patients who have survived COVID-19 have an increased risk of cerebral venous *** case report describes a 41-year-old woman who developed neurological manifestations associated with jugular vein thrombosis 24 h after administration of the Oxford–AstraZeneca(ChAdOx1 nCoV-19)vaccine(AstraZeneca-Serum Institute of India).She had been infected with SARS-CoV-2 three months before *** initially suspected to be a case of vaccine-induced immune thrombotic thrombocytopenia(VITT)in view of her recent vaccination,the patient did not have any hallmarks of VITT,such as thrombocytopenia,an increased D-dimer level,or antibodies against platelet ***,the neurological manifestations were associated with a high concentration of inflammatory cytokines,including interleukin(IL)-6,IL-17A,and IL-21,and elevated neutrophil levels in cerebrospinal fluid,suggesting that inflammatory immune components had a role in the development of thrombotic events and pointing to an alternative *** this case,the laboratory results indicated that the neurological manifestations associated with jugular vein thrombosis were not associated with ***,we propose that the thrombosis of the left jugular vein was a sequela of SARS-CoV-2 infection.

关键词： cerebral venous thrombosis long COVID vaccine

Influences of Amazonian White and Black Waters on the Hematological and Biochemical Plasma Features of Arapaima gigas （Osteoglossiformes）

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Journal of Life Sciences 2014年第3期8卷 252-261页

作者： Cleverson Agner Ramos jose Carlos Nunes Raulino Glauber Cruz de Menezes Iracimar Batista do Carmo Elenice Martins Brasil elizabeth Gusmao Affonso Oscar Tadeu Ferreira da Costa Marisa Narciso Femandes Departament of Morphology Federal University of Amazon Manaus Amazon 69077-000 Brazil Department of Aquaculture INPA (National Institute of Amazonian Research) Manaus Amazon 69060-001 Brazil Departament of Physiological Sciences Federal University of Sao Carlos Sao Carlos Sao Paulo 13565-905 Brazil

The Arapaima gigas, despite being an air breather, its gill structure is quite close to water breathers, especially in early stages of development. The effects of Amazonian waters is well notices in other Teleostei expose to BW （black water）, and WW （white water）. However, information about hematological adjustments and its implications to ionic regulation patters are scarce. Therefore, our aim was to analyzed A. gigas hematological parameters when exposed to BW and WW providing suitable hematological data concerning about physiological responses in Amazonian waters. Fish were acclimated in three separated ponds containing BW, WW and well water as control （C）. Blood samples were taken from the caudal vessel in order to perform measurement assays on levels of hemoglobin, hematocrit, mean corpuscular volume, corpuscular hemoglobin, corpuscular hemoglobin concentration, glucose, cholesterol and protein. Our findings corroborate the hypothesis stating that BW does interfere on fish adaptation specialy in smallfish （-100 g）. However in largefish （-1,000 g） neither WW or BW can interfere on plasma profile of analysed fish. Despite black water systems being considered a barrier constraining the dispersion of several species, this seems not to be a problem for this specie which has kept its ion-regulatory mechanisms even in black waters.

关键词： Amazon fish blood parameters Amazonian waters Pirarucu.

A WW Domain-Containing Protein Forms Immune Nuclear Bodies against Begomoviruses

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Molecular Plant 2018年第12期11卷 1449-1465页

作者： lara P. Calil lana P.S. Quadros Thais C. Araujo Christiane E.M. Duarte Bianca C. Gouveia-Mageste jose Cleydson F. Silva Otavio J.B. Brustolini Ruan M. Teixeira Caue N. Oliveira Rafael W.M.M. Milagres Gilberto S. Martins Joanne Chory Pedro A.B. Reis Joao Paulo B. Machado elizabeth P.B. Fontes Departament of Biochemistry and Molecular Biology Universidade Federal de Vigosa Vigosa Minas Gerais 36570-000 Brazil Nati onal In stitute of Science and Tech no logy in Plant-Pest Interactions Bioagro Universidade Federal de Vicosa Vinosa Minas Gerais 36570-000 Brazil Departament of Genetics Universidade Federal do Rio de Janeiro Rio de Janeiro Rio de Janeiro Brazil Howard Hughes Medical Institute and Plant Biology Laboratory The Salk Institute of Biological Studies La Jolla CA 92037 USA Agronomy Institute Universidade Federal de Vigosa Campus Florestal Florestal Minas Gerais 35690-000 Brazil These authors contributed equally to this article

The bipartite begomoviruses (Geminiviridae family), which are DNA viruses that replicate in the nucleus of infected cells, encode the nuclear shuttle protein (NSP) to facilitate the translocation of viral DNA from the nucleus to the cytoplasm via nuclear pores. This intracellular trafficking of NSP-DNA complexes is accessorized by the NSP-interacting guanosine triphosphatase (NIG) at the cytosolic side. Here, we report the nuclear redistribution of NIG by AtWWPI, a WW domain-containing protein that forms immune nuclear bodies (NBs) against begomoviruses. We demonstrated that AtWWPI relocates NIG from the cytoplasm to the nucleus where it is confined to AtWWP1-NBs, suggesting that the NIG-AtWWP1 interaction may interfere with the NIG pro-viral function associated with its cytosolic localization. Consistent with this assumpti on joss AtWWPI functi on cuased plants more susceptible to begomovirus infection, whereas overexpression of AWWP1 enhaneed plant resistance to begomovirus. Furthermore, we found that a mutant versi on of AtWWPI defective for NB formatio n was noIonger capable of interacti ng with and relocating NIG to the nucleus and lost its immune function against begomovirus. The antiviral function of AtWWP1-NBs, however, could be antagonized by viral infection that induced either the disruption or a decrease in the number of AtWWP1-NBs. Collectively, these results led us to propose that AtWWPI organizes nuclear structures into nuclear foci, which provide intrinsic immunity against begomovirus infection.

关键词： nuclear bodies antiviral immunity begomovirus NIG AtWWP1