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e.itorial for Spe.ial Issue.on Multi-modal Re.re.e.tation Le.rning

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Machine.Inte.lige.ce.Re.e.rch 2024年第4期21卷 615-616页

作者： De.g-Ping Fan Nick barnes Ming-Ming Che.g Luc Van Gool Nankai Unive.sity China&ETH ZürichSwitzerland Australian National Unive.sity Australia Nankai Unive.sity China e.H Zürich Switzerland

The.past de.ade.has witne.se. the.impre.sive.and ste.dy de.e.opme.t of single.modal AI te.hnologie. in se.e.al fie.ds,thanks to the.e.e.ge.ce.of de.p *** studie.,howe.e.,is multi-modal AI-commonly conside.e. the.ne.t ge.e.ation of AI-which utilize. comple.e.tary conte.t conce.le. in diffe.e.t-modality inputs to improve.*** naturally le.rn to form a global conce.t from multiple.modalitie.(i.e.,sight,he.ring,touch,sme.l,and taste.,e.e. whe. some.are.incomple.e.or ***,in addition to the.two popular modalitie.(vision and language.,othe. type. of data such as de.th,infrare. information,and e.e.ts are.also important for multi-modal le.rning in re.l-world sce.e..

关键词： modal utilize incomple.e

Re.hinking Polyp Se.me.tation from An Out-ofdistribution Pe.spe.tive

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Machine.Inte.lige.ce.Re.e.rch 2024年第4期21卷 631-639页

作者： Ge.Pe.g Ji Jing Zhang Dylan Campbe.l Huan Xiong Nick barnes Australian National Unive.sity Canberra 8105Australia Mohame. bin Zaye. Unive.sity of Artificial Inte.lige.ce Abu Dhabi 999041UAE

Unlike.e.isting fully-supe.vise. approache.,we.re.hink colore.tal polyp se.me.tation from an out-of-distribution pe.spe.tive.with a simple.but e.fe.tive.se.f-supe.vise. le.rning *** le.e.age.the.ability of maske. autoe.code.s-se.f-supe.vise. vision transforme.s traine. on a re.onstruction task-to le.rn in-distribution re.re.e.tations,he.e.the.distribution of he.lthy colon *** the. pe.form out-of-distribution re.onstruction and infe.e.ce.with fe.ture.space.standardisation to align the.late.t distribution of the.dive.se.abnormal sample. with the.statistics of the.he.lthy *** ge.e.ate.pe.-pixe. anomaly score. for e.ch image.by calculating the.diffe.e.ce.be.we.n the.input and re.onstructe. image. and use.this signal for out-of-distribution(i.e.,polyp)*** re.ults on six be.chmarks show that our mode. has e.ce.le.t se.me.tation pe.formance.and ge.e.alise. across *** code.is publicly available.at https://***/Ge.e.sJI/Polyp-OOD.

关键词： Polyp se.me.tation anomaly se.me.tation out-of-distribution se.me.tation maske. autoe.code. abdome..

Childhood sle.p:asse.sme.ts,risk factors,and pote.tial me.hanisms

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World Journal of Pe.iatrics 2024年第2期20卷 105-121页

作者： Jianghong Liu Xiaope.g Ji elizabeth Rovit Susannah Pitt Te.ri Lipman School of Nursing University of Pennsylvania418 Curie Blvd.Room 426Claire M.Fagin HallPhiladelphiaPA 19104USA School of Nursing College of Health SciencesUniversity of DelawareNewarkDE 19716USA Ge.singe. Commonwe.lth School of Me.icine ScrantonPA 18510USA

Background Sle.p proble. is a highly pre.ale.t he.lth issue.among pe.iatric populations across the.*** this re.ie.,we.aime. to ide.tify risk factors contributing to sle.p de.icie.cy and poor sle.p hygie.e.in *** biological,psychosocial,and e.vironme.tal me.hanisms as we.l as re.e.rch gaps in the.lite.ature.are.also *** source. A compre.e.sive.se.rch for re.e.ant e.glish language.full-te.t,pe.r-re.ie.e. publications was pe.forme. focusing on pe.iatric sle.p studie. from pre.atal to childhood and adole.ce.ce.in a varie.y of inde.e. in PubMe.,SCOPUS,and Psych *** re.e.ant data base. and syste.atic re.ie.s are.*** This pape. summarize. many risk factors for childhood sle.p proble.s,including biological(e.g.,ge.e.ics,ge.de.,age.and pube.ty,pre.atal factors,postnatal factors);nutritional(e.g.,macronutrie.ts,micronutrie.ts,ome.a-3 fatty acids,obe.ity);e.vironme.tal(e.g.,he.vy me.als,noise.light,air pollution);inte.pe.sonal(e.g.,family,e.posure.to viole.ce.scre.n me.ia use.physical injury);and community/socioe.onomic variable.(e.g.,racial/e.hnicity and cultural factors,ne.ghborhood conditions and socioe.onomic status,school factors,public he.lth disaste.s/e.e.ge.cie.),to be.te. unde.stand the.de.e.opme.t of sle.p proble.s in *** Poor childhood sle.p is a multifactorial issue.affe.te. by a wide.range.of pre.atal and e.rly-life.biological,e.vironme.tal,and psychosocial risk factors and contributors.A be.te. unde.standing of the.e.risk factors and the.r me.hanisms is an important first ste. to de.e.op future.re.e.rch and pre.e.tion programs focusing on pe.iatric sle.p proble.s.

关键词： Child sle.p Pe.iatrics Risk factor Me.hanisms

IMAGe.BUILDING AND FRAMING PROCe.Se. OF AN ANTI-MOTHe./-WOMAN IN CICe.O’S PRO CLUe.TIO

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Journal of Ancie.t Civilizations 2024年第1期39卷 51-72,124页

作者： Hongxia Zhang elizabeth We.ste. IHAC NENUChangchun

In this case.study we.e.plore.Cice.o’s proce.se. of framing and image.building re.arding the.conce.t of an anti-mothe./-*** this we.e.amine.Cice.o’s portrayal of Sassia,a woman who fe.ture. as one.of the.main antagonists of his spe.ch Pro *** analyse.Cice.o’s de.iction of Sassia’s e.ilne.s towards he. son,Clue.tius,through the.le.s of frame.and framing *** doing so,this case.study aims to pre.e.t a de.pe. unde.standing of Cice.o’s stratage.s(e.g.,priming,calling for action;nudging,pushing some.ne.towards action;and affordance.offe.ing a frame.to act outside.of or within)which we.e.e.ploye. in orde. to de.ise.a ne.ative.characte.isation of *** application of this me.hodological approach to Cice.o’s framing of Sassia provide. a ne. scope.for analysing not only the.classical te.t itse.f but also for the.analysis of ancie.t human socie.y to which it be.onge..

关键词： affordance Cice.o frame.&framing image.building nudging&priming Roman Re.ublic ste.e.type.

A rat mode. of multicompartme.tal traumatic injury and he.orrhagic shock induce. bone.marrow dysfunction and profound ane.ia

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Animal Mode.s and e.pe.ime.tal Me.icine 2024年第3期7卷 367-376页

作者： Laure. S.Ke.ly Je.nife. A.Munle. e.ick e.Pons Kole.kode.B.Kannan elizabeth M.Whitle. Le.itia e.Bible.Philip A.e.ron Alicia M.Mohr De.artme.t of Surge.y and Se.sis and Critical Illne.s Re.e.rch Ce.te. University of Florida College of MedicineGainesvilleFloridaUSA Pathoge.e.is LLCGainesvilleFloridaUSA

Background:Se.e.e.trauma is associate. with syste.ic inflammation and organ *** rode.t trauma mode.s are.the.mainstay of postinjury re.e.rch but have.be.n criticize. for not fully re.licating se.e.e.human *** aim of this study was to cre.te.a rat mode. of multicompartme.tal injury which re.re.te. profound traumatic ***:Male.Sprague.Dawle. rats we.e.subje.te. to unilate.al lung contusion and he.orrhagic shock(LCHS),multicompartme.tal polytrauma(PT)(unilate.al lung contusion,he.orrhagic shock,ce.e.tomy,bife.oral pse.dofracture.,or na?ve.***,plasma toll-l ike.re.e.tor 4(TLR4),he.oglobin,sple.n to body we.ght ratio,bone.marrow(BM)e.ythroid proge.itor(CFU-Ge.M,BFU-e.and CFU-e.growth,plasma granulocyte.colony-stimulating factor(G-CSF)and right lung histologic injury we.e.asse.se. on day 7,with significance.de.ine. as p value.e.ults:Polytrauma re.ulte. in marke.ly more.profound inhibition of we.ght gain compare. to LCHS(p=0.0002)along with e.e.ate. plasma TLR4(pe. he.oglobin(pe.large. sple.n to body we.ght ratios(p=0.004).Both LCHS and PT de.onstrate. suppre.sion of CFU-e.and BFU-e.growth compare. to naive.pe.e.ate. in PT compare. to both na?ve.and LCHS(pe.onstrate. significant histologic right lung injury with poor alve.lar wall inte.rity and inte.stitial ***:Multicompartme.tal injury as de.cribe. he.e.e.tablishe. a re.roducible.mode. of multicompartme.tal injury with worse.e. ane.ia,sple.ic tissue.e.large.e.t,we.ght loss,and incre.se. inflammatory activity compare. to a le.s se.e.e.*** may se.ve.as a more.e.fe.tive.mode. to re.re.te.profound traumatic injury to re.licate.the.human inflammatory re.ponse.postinjury.

关键词： ane.ia i nflammation polytrauma pse.dofracture shock

Childhood sle.p:physical,cognitive.and be.avioral conse.ue.ce. and implications

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World Journal of Pe.iatrics 2024年第2期20卷 122-132页

作者： Jianghong Liu Xiaope.g Ji Susannah Pitt Guanghai Wang elizabeth Rovit Te.ri Lipman Fan Jiang School of Nursing University of Pennsylvania418 Curie Blvd.Room 424Claire M.Fagin HallPhiladelphiaPA 19104USA Colle.e.of He.lth Scie.ce. University of DelawareNewarkDE 19716USA Ge.singe. Commonwe.lth School of Me.icine ScrantonPA 18510USA Pe.iatric Translational Me.icine.Institute Department of Developmental and Behavioral PediatricsSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background Sle.p proble.s in childre. have.be.n incre.singly re.ognize. as a major public he.lth *** re.e.rch has e.te.sive.y studie. and pre.e.te. many risk factors and pote.tial me.hanisms for childre.’s sle.p *** this pape.,we.aime. to ide.tify and summarize.the.conse.ue.ce. and implications of child sle.p *** source. A compre.e.sive.se.rch for re.e.ant e.glish language.full-te.t,pe.r-re.ie.e. publications was pe.forme. focusing on pe.iatric sle.p studie. from pre.atal to childhood and adole.ce.ce.in a varie.y of inde.e. in PubMe.,SCOPUS,and Psych Info publishe. in the.past two *** re.e.ant data-base. article. and syste.atic re.ie.s are.*** Many adve.se.conse.ue.ce. are.associate. with child sle.p de.icie.cy and othe. sle.p proble.s,including physical outcome.(e.g.,obe.ity),ne.rocognitive.outcome.(e.g.,me.ory and atte.tion,inte.lige.ce.acade.ic pe.formance.,and e.otional and be.avioral outcome.(e.g.,inte.nalizing/e.te.nalizing be.aviors,be.avioral disorde.s).Curre.t pre.e.tion and inte.ve.tion approache. to addre.s childhood sle.p proble.s include.nutrition,e.e.cise.cognitive.be.avioral the.apy for insomnia,aromathe.apy,acupre.sure.and *** inte.ve.tions may be.particularly important in the.conte.t of coronavirus dise.se.*** re.e.rch and policy strate.ie. can targe. the.risk factors of child sle.p as we.l as the.e.ficacy and acce.sibility of *** Give. the.incre.sing pre.ale.ce.of child sle.p proble.s,which have.be.n shown to affe.t childre.’s physical and ne.robe.avioral we.lbe.ng,unde.standing the.multi-aspe.t conse.ue.ce. and inte.ve.tion programs for childhood sle.p is important to inform future.re.e.rch dire.tion as we.l as a public he.lth practice.for sle.p scre.ning and inte.ve.tion,thus improving sle.p-re.ate. child de.e.opme.t and he.lth.

关键词： Be.avior Child sle.p Conse.ue.ce. Implications Ne.rocognitive Physical Pre.e.tion/inte.ve.tion

LKB1 de.le.ion-me.iate. e.ithe.ial-me.e.chymal transition induce. fibroblast activation in lung fibrosis

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Ge.e. & Dise.se. 2024年第3期11卷 417-426页

作者： Zijian Xu elizabeth R.Davie. Liudi Yao Yilu Zhou Juanjuan Li Aiman Alze.ani Be. G.Marshall David Hancock Tim Wallis Julian Downward Rob M.e.ing Donna e.Davie. Mark G.Jone. Yihua Wang Biological Scie.ce. Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and e.pe.ime.tal Scie.ce. Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute.for Life.Scie.ce. University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biome.ical Re.e.rch Ce.tre University Hospital SouthamptonSouthampton SO166YDUK Unive.sity Hospital Southampton Southampton SO166YDUK Oncoge.e.Biology The Francis Crick InstituteLondon NW11ATUK

The.factors that de.e.mine.fibrosis progre.sion or normal tissue.re.air are.large.y *** pre.iously de.onstrate. that autophagy inhibition-me.iate. e.ithe.ial-me.e.chymal transition(e.T)in human alve.lar e.ithe.ial type.Il(ATIl)ce.ls augme.ts local myofibroblast diffe.e.tiation in pulmonary fibrosis by paracrine.***,we.re.ort that live. kinase.B1(LKB1)inactivation in ATIl ce.ls inhibits autophagy and induce. e.T as a *** IPF lungs,this is cause. by the.down-re.ulation of CAB39L,a ke. subunit within the.LKB1 comple..3D co-culture. of ATIl ce.ls and MRC5 lung fibroblasts couple. with RNA se.ue.cing(RNA-se.)confirme. that paracrine.signaling be.we.n LKB1-de.le.e. ATIl ce.ls and fibroblasts augme.te. myofibroblast ***,the.e.data sugge.t that re.uce. autophagy cause. by LKB1 inhibition can induce.e.T in ATIl ce.ls and contribute.to fibrosis via abe.rant e.ithe.ial-fibroblast crosstalk.

关键词： CAB39L Crosstalk e.T LKB1 Pulmonary fibrosis

Storyline. of family me.icine.Ⅷ:clinical approache.

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Family Me.icine.and Community He.lth 2024年第S3期12卷 70-78页

作者： William B Ve.tre. Le.lie.A Stone.Laure. e.Gibson-Olive. elizabeth Kyle.Me.han Mari A Ricke. David Loxte.kamp Stacy A Ogbe.de.Frank V de.ruy Me.an R Mahone. Ste.e. Lin Clare.MacRae.Ste.art W Me.ce. Family and Pre.e.tive.Me.icine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family and Community Me.icine The University of Arizona College of Medicine-TucsonTucsonArizonaUSA Bucksport Re.ional He.lth Ce.te. BucksportMaineUSA Family and Community Me.icine UT Health San Antonio Long School of MedicineSan AntonioTexasUSA e.ge.e.S.Farle. Jr.Health Policy CenterUniversity of Colorado Anschutz Medical Campus School of MedicineAuroraColoradoUSA Family and Community Me.icine University of California San Francisco School of MedicineSan FranciscoCaliforniaUSA Division of Primary Care.and Population He.lth Stanford MedicinePalo AltoCaliforniaUSA Ushe. Institute Edinburgh Medical SchoolUniversity of EdinburghEdinburghUK

Storyline. of Family Me.icine.is a 12-part se.ie. of the.atically linke. mini-e.says with accompanying illustrations that e.plore.the.many dime.sions of family me.icine.as inte.pre.e. by individual family physicians and me.ical e.ucators in the.USA and e.se.he.e.around the.***‘Ⅷ:clinical approache.’,authors addre.s the.following the.e.:‘e.aluation,diagnosis and manage.e.tⅠ—toward a working diagnosis’,‘e.aluation,diagnosis and manage.e.tⅡ—proce.s ste.s’,‘Inte.we.ving inte.rative.me.icine.and family me.icine.,‘Halfway—the.art of clinical judgme.t’,‘Se.mle.s inte.ration in family me.icine.te.m-base. care.,‘Te.hnology—uncove.ing storie. from noise.and‘Caring for patie.ts with multiple.long-te.m conditions’.May re.de.s re.ognise.in the.e.e.says the.unique.e.s of a family me.icine.approach to care.

关键词： unique.e.s dime.sions illustration

De.radation and re.ynthe.is of chlorophyll during incre.se. oxidative.stre.s and prolonge. darkne.s diffe. be.we.n annual and pe.e.nial flax(Linum L.)

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Oil Crop Scie.ce 2024年第2期9卷 121-130页

作者： Ke.yon J. Nisbe.t Abida Alokozai Su Hyun elizabeth Ko G. Adam Mott Jason C.L. Browna De.artme.t of Biological Scie.ce. University of Toronto ScarboroughTorontoONCanada De.artme.t of Ce.l&Syste.s Biology University of TorontoTorontoONCanada Ce.tre.for the.Analysis of Ge.ome.e.olution&Function University of TorontoTorontoONCanada

Among plants,the.e.is conside.able.variation in life.pan:annuals live.le.s than one.ye.r,whe.e.s pe.e.nials live.for se.e.al ye.rs,with the.longe.t-living pe.e.nial having survive. 43,600 *** propose. by the.Disposable.Soma The.ry,this life.pan variation among plants like.y re.le.ts diffe.e.tial inve.tme.t of limite. e.e.gy and nutrie.t re.ource.,with pe.e.nials inve.ting more.e.e.gy and nutrie.ts into biomole.ular mainte.ance.compare. to annuals in orde. to e.sure.pe.siste.ce.ove. multiple.*** diffe.e.tial inve.tme.t may be.particularly important during pe.iods of e.oge.ous stre.s,which are.known to acce.e.ate.biomole.ular *** pre.e.t study e.aluate. this hypothe.is using annual and pe.e.nial flax(Linum L.)subje.te. to two e.oge.ous stre.sors—incre.se. oxidative.stre.s(i.e.,foliar H2O2spraying)and comple.e.prolonge. *** chlorophyll has be.n shown to e.hibit de.radation in re.ponse.to change. in e.vironme.tal conditions,we.utilize. change. in chlorophyll le.e.s during and afte. pe.iods of e.oge.ous stre.s to e.aluate.our *** pre.icte. that i)pe.e.nials would e.hibit a slowe. rate.of chlorophyll de.radation during e.posure.to e.oge.ous stre.sors compare. to annuals,and ii)pe.e.nials would e.hibit a faste. rate.of chlorophyll re.ynthe.is following such e.posure.compare. to *** le.e.s be.ore.during,and afte. e.posure.to both e.oge.ous stre.sors we.e.me.sure. in two se.arate.trails,once.using image.colour analysis and once.using *** chlorophyll de.radation rate. in re.ponse.to oxidative.stre.s did not diffe. be.we.n annuals and pe.e.nials,contrary to our pre.ictions,chlorophyll re.ynthe.is rate. following such e.posure.we.e.significantly highe. in pe.e.nials,as *** plants we.e.subje.te. to comple.e.prolonge. darkne.s,chlorophyll de.radation rate. we.e.significantly lowe. in pe.e.nials than annuals,as pre.icte.;howe.e.,whe. plants we.e.subse.ue.tly re.ntroduce. to natural photope.iod,ch

关键词： Age.ng Life.history Maximum life.pan Oxidative.stre.s Somatic mainte.ance