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The Association of Diet-Modulated Gut Microbiota on Development and Treatment of Colorectal Cancer

Journal of Nutritional Oncology 2021年第4期6卷 152-158页

作者： elizabeth clinger Lei Hao Indiana University of Pennsylvania IndianaPA 15705USA Nutrition with elizabeth LLCBrookvillePA 15825USA Department of Nursing and Allied Health Professions Indiana University of PennsylvaniaIndianaPA 15705USA

Colorectal cancer is the third most common cancer *** of colon cancer continues to be investigated with research findings ranging from environment to diet to inherited gene *** factors associated with colon cancer include familial history of colon cancer and inflammatory bowel disease,as well as lifestyle-related modifiable influences like diet,weight,and *** findings point to the connection between diet and gut microbiota,which is highly affected by changes in diet promoting either an environment of beneficial bacteria or *** effects on the microbiome can impact health outcomes,including an increased risk for colorectal *** the mechanisms behind the effect of gut microbiota on the development of colorectal cancer continues to evolve,its effect on both inflammation and immune response may play a key ***,after development of colorectal cancer diagnosis,the changes to gut microbiota have a potential to continue to influence the effectiveness of therapy and *** review presents the current knowledge around the diet-modulated gut microbiome and its association with,risk for,development of,and treatment of colorectal ***,further research on dietary elements that affect the gut microbiome and its subsequent effect on development and treatment of colorectal cancer is needed for applicable recommendations that can be made for dietary modulation of the gut microbiota for improved health outcomes.

关键词： Diet Gut microbiota Microbiome Colorectal cancer Cancer treatment

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The Roles of Obesity in the Development of Cancer

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Journal of Nutritional Oncology 2021年第1期6卷 1-15页

作者： Md Shahjalal Khan elizabeth clinger Lei Hao Department of Nutritional Sciences Texas Tech UniversityLubbockTX 79409USA Department of Food and Nutrition Indiana University of PennsylvaniaIndianaPA 15701USA

Cancer is one of the leading causes of death in the *** evidence indicates that obesity is strongly associated with the development of *** review aims to understand the underpinning mechanism of how obesity contributes to the development of *** obesity is an exaggeration of normal adiposity associated with extreme chronicity and co-existing conditions,true causality and underlying mechanisms are difficult to ***,the exact causal relationship is yet to be ***,it will be unlikely to outline a"one system fits all"mechanism for this obesity-cancer axis;however,the biological processes linking obesity and cancer need to be better *** this review,we tried to portray the postulated mechanisms considering common pathophysiology associated with obesity,leading to cancer ***-mediated insulin metabolism,sustained low-grade inflammatory signaling,elevated estrogen metabolism,and abnormal microbiome diversity and dysbiosis are among those mechanisms that can lead to tumor and cancer progression.

关键词： Cancer Obesity Cytokine Insulin Inflammation Gut microbiota

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