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Cohort contributions to trends in the incidence and mortality of intrahepatic cholangiocarcinoma

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Hepatobiliary Surgery and Nutrition 2018年第4期7卷 270-276页

作者： eliza w.beal Dmitry Tumin Dimitrios Moris Xu-Feng Zhang Jeffery Chakedis Mary Dilhoff Carl M.Schmidt Timothy M.Pawlik Department of Surgery Division of Surgical OncologyThe Ohio State University Wexner Medical Center and James Cancer Hospital and Solove Research InstituteColumbusOHUSA Department of Anesthesiology and Pain Medicine Nationwide Children’s HospitalColumbusOHUSA Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710000China

Background: The incidence and mortality of intrahepatic cholangiocarcinoma (ICC) are increasing worldwide. we used age-period-cohort (APC) modeling to evaluate the contribution of cohort effects to trends in ICC incidence and mortality in the US. Methods: Incidence data were acquired from the Surveillance, Epidemiology and End-Results (SEER) program. Mortality data were obtained from the Centers for Disease Control and Prevention wONDER Database. APC models using restricted cubic splines were fitted to estimate change in incidence and mortality risk over age, and modification of incidence and mortality risks according to birth cohort and period of diagnosis or death. Likelihood ratio tests were used to summarize improvement in model fit with APC modeling. Results: There were 4,053 cases of ICC at SEER registry sites between 1973–2012. ICC incidence increased with older age and across all birth cohorts examined. Inclusion of cohort effects tended to improve model fit relative to an age-period model (likelihood ratio test P=0.082). The national crude ICC-related mortality rate increased from 2.9 to 5.0 per 100,000 among males and 2.7 to 4.6 per 100,000 among females. Among males, ICC mortality risk varied across birth cohorts, and inclusion of cohort effects in a model predicting ICC mortality risk improved model fit (likelihood ratio test P=0.001), but cohort effects did not alter model fit among females (P=0.223). Conclusions: ICC incidence and mortality have increased over time in the United States. Birth cohort effects influenced increased ICC incidence and ICC mortality among males, but were not evident in the trend of ICC mortality among females.

关键词： Intrahepatic cholangiocarcinoma (ICC) incidence mortality cohort effect age-period-cohort model (APC model)

Radiographic characteristics of neuroendocrine liver metastases do not predict clinical outcomes following liver resection

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Hepatobiliary Surgery and Nutrition 2020年第1期9卷 1-12,中插1页

作者： Emily A.Armstrong eliza w.beal Manisha Shah Bhavana Konda Sherif Abdel-Misih Aslam Ejaz Mary E.Dillhoff Timothy M.Pawlik Jordan M.Cloyd The Ohio State University College of Medicine ColumbusOHUSA Department of Surgery Division of Surgical OncologyThe Ohio State University Wexner Medical CenterColumbusOHUSA Department of Internal Medicine Division of Medical OncologyThe Ohio State University Wexner Medical CenterColumbusOHUSA

Background: Previous research has demonstrated that specific radiographic criteria, including the presence of calcifications and the enhancement pattern on computed tomography (CT) imaging, correlates with clinicopathologic features and outcomes of patients with gastroenteropancreatic neuroendocrine tumors (NET). we sought to investigate whether these radiographic characteristics were prognostic among patients with neuroendocrine liver metastases (NELM) undergoing surgical resection. Methods: The preoperative contrast-enhanced CT scans of all patients who underwent resection of NELM at a single institution between 2000-2015 were retrospectively reviewed. The presence of calcifications was determined on non-contrast phase imaging. Enhancement on the arterial phase scan was categorized as hyperenhancing, hypoenhancing, or mixed. Relevant clinicopathologic characteristics as well as recurrence-free survival (RFS) and overall survival (OS) were compared between groups. Results: Among 82 patients who underwent resection of NELM, 57 had available data on calcifications while 51 had data available on arterial enhancement patterns. Among all patients, median age was 58 (IQR:47-63) and the majority were female (N=48, 59.5%). The most common primary tumor locations were pancreas (N=25, 30.5%) and small bowel (N=27, 32.9%). The most commonly performed operations were right hepatectomy (N=29, 35.4%), bisegmentectomy (N=15, 18.3%), and segmentectomy (N=14, 17.1%). Median tumor number was 4 (IQR: 2-9), median Ki-67 was 5% (IQR: 2-10%), and median size of the largest liver metastasis was 4.5 (IQR: 2.8-7.7) cm. Twelve (21%) patients had tumor calcifications. Among patients with and without calcifications there were no differences in demographics, clinicopathologic characteristics, RFS (P=0.772) or OS (P=0.095). Arterial enhancement was hypoenhancing in 23 (45.1%), hyperenhancing in 10 (19.6%), and mixed in 18 (35.3%). Similarly, there were no differences between arterial enhancemen

关键词： Neuroendocrine tumor (NET) carcinoid hepatectomy radiomics prognosis

Magnetopause properties at the dusk magnetospheric flank from global magnetohydrodynamic simulations,the kinetic Vlasov equilibrium,and in situ observations--Potential implications for SMILE

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Earth and Planetary Physics 2024年第1期8卷 222-233页

作者： Marius Echim Costel Munteanu Gabriel Voitcu eliza Teodorescu Institute of Space Science Măgurele 077125Romania Royal Belgian Institute for Space Aeronomy 1180 BrusselsBelgium Solar-Terrestrial Centre of Excellence(STCE) 1180 BrusselsBelgium

we derived the properties of the terrestrial magnetopause(MP)from two modeling approaches,one global–fluid,the other local–kinetic,and compared the results with data collected in situ by the Magnetospheric Multiscale 2(MMS2)*** used global magnetohydrodynamic(MHD)simulations of the Earth’s magnetosphere(publicly available from the NASA-CCMC[National Aeronautics and Space Administration–Community Coordinated Modeling Center])and local Vlasov equilibrium models(based on kinetic models for tangential discontinuities)to extract spatial profiles of the plasma and field variables at the Earth’s *** global MHD simulations used initial solar wind conditions extracted from the OMNI database at the time epoch when the MMS2 observes the *** kinetic Vlasov model used asymptotic boundary conditions derived from the same in situ MMS measurements upstream or downstream of the *** global MHD simulations provide a three-dimensional image of the magnetosphere at the time when the MMS2 crosses the *** Vlasov model provides a one-dimensional local view of the MP derived from first principles of kinetic *** MMS2 experimental data also serve as a reference for comparing and validating the numerical simulations and *** found that the MP transition layer formed in global MHD simulations was generally localized closer to the Earth(roughly by one Earth radius)from the position of the real MP observed by the *** also found that the global MHD simulations overestimated the thickness of the MP transition by one order of magnitude for three analyzed variables:magnetic field,density,and tangential *** MP thickness derived from the local Vlasov equilibrium was consistent with observations for all three of these *** overestimation of density in the Vlasov equilibrium was reduced compared with the global MHD *** discuss our results in the context of future SMILE(Solar wind Magnetosphere Ionosphere Link Explorer)campaigns for observing

关键词： magnetopause magnetohydrodynamic numerical simulations Vlasov equilibrium Magnetospheric Multiscale observations

High Impact Polylactide Based on Organosilicon Nucleation Agent

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Chinese Journal of Polymer Science 2024年第6期42卷 787-797页

作者： Daria Pakuła Bogna Sztorch eliza Romańczuk-Ruszuk Bogdan Marciniec Robert E.Przekop Faculty of Chemistry Adam Mickiewicz University in PoznańUniwersytetu Poznańskiego 861-614PoznańPoland Centre for Advanced Technologies Adam Mickiewicz University in PoznańUniwersytetu Poznańskiego 1061-614PoznańPoland Institute of Biomedical Engineering Faculty of Mechanical EngineeringBialystok University of TechnologyWiejska 45C15-351BialystokPoland

Various sectors of the industry are searching for new materials with specific requirements,providing improved *** study presents novel composite materials based on polylactide that have been modified with the organosilicon compound,(3-thiopropyl)polysilsesquioxane(SSQ-SH).The SSQ-SH compound is a mixture of cage structures and not fully condensed random *** composite materials were obtained through injection *** study includes a comprehensive characterization of the new materials that analyze their functional properties,such as rheology(MFR),mechanical strength(tensile strength,Charpy impact strength),and thermal *** microscopic photos were also taken to analyze the microstructure of the *** addition of a 5%by-weight organosilicon compound to polylactide resulted in a significant increase in MFR by 73.8%compared to the neat *** greatest improvement in impact strength was achieved for the 5%SSQ-SH/PLA composite,increasing it by 32.0 kJ/m^(2)compared to PLA,which represents an increase of up to 187%.The conducted research confirms the possibility of modifying the properties of the polymer by employing organosilicon compounds.

关键词： Octa(3-thiopropyl)silsesquioxane 8SH-POSS Polylactide(PLA) Injection moulding Composites

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需要内容证明的选举之年

科技纵览 2024年第1期 24-27页

作者： eliza Strickland 不详

媒体组织利用数字清单,防止深度伪造和虚假信息。2023年4月,一则竞选广告出现在美国共和党全国委员会的You Tube频道,广告显示了一系列画面:庆祝连任L的美国总统拜登,在美国城市街道上护窗紧闭的银行和防暴警察,以及从美墨边境涌入的移... 详细信息

媒体组织利用数字清单,防止深度伪造和虚假信息。2023年4月,一则竞选广告出现在美国共和党全国委员会的You Tube频道,广告显示了一系列画面:庆祝连任L的美国总统拜登,在美国城市街道上护窗紧闭的银行和防暴警察,以及从美墨边境涌入的移民。广告的文案这样写道:“人工智能生成的‘国家未来展望’:假如2024年拜登连任。”

关键词：竞选广告人工智能美国共和党防暴警察虚假信息未来展望

Hepatocellular carcinoma locoregional therapies:Outcomes and future horizons

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world Journal of Gastroenterology 2021年第43期27卷 7462-7479页

作者： Mina S Makary Stuart Ramsell Eric Miller eliza w.beal Joshua D Dowell Department of Radiology The Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Radiation Oncology The Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Radiology Northwest RadiologySt.Vincent HealthIndianapolisIN 46260United States

Hepatocellular carcinoma(HCC)is the most common primary cancer of the liver and has an overall five-year survival rate of less than twenty *** patients with unresectable disease,evolving liver-directed locoregional therapies provide efficacious treatment across the spectrum of disease stages and via a variety of catheter-directed and percutaneous *** of locoregional therapies in HCC may include curative intent in early-stage disease,bridging or downstaging to surgical resection or transplantation for early or intermediate-stage disease,and local disease control and palliation in advanced-stage *** review explores the outcomes of chemoembolization,bland embolization,radioembolization,and percutaneous ablative *** is also given to prognostic factors related to each of the respective techniques,as well as future directions of locoregional therapies for HCC.

关键词： Hepatocellular carcinoma Bland embolization Chemoembolization Radioembolization Transarterial embolization Thermal ablation Locoregional therapy

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2024年人工智能现状

科技纵览 2024年第7期 8-9页

作者： eliza Strickland 不详

每年,人工智能指数都迎来更令人咋舌的数据,让人感到惊诉。2024年,502页的报告证明我们正处于人工智能蓬勃发展的时期。该报告由斯坦福大学以人为本人工智能研究所(HAI)于4月发布,涵盖了研发、技术性能、负责任的人工智能、经济、教育... 详细信息

每年,人工智能指数都迎来更令人咋舌的数据,让人感到惊诉。2024年,502页的报告证明我们正处于人工智能蓬勃发展的时期。该报告由斯坦福大学以人为本人工智能研究所(HAI)于4月发布,涵盖了研发、技术性能、负责任的人工智能、经济、教育、政策和监管、多样性和舆论等方面的趋势。在此,我们编制了4个图表来说明2024年人工智能的现状。

关键词：人工智能斯坦福大学以人为本多样性图表现状

Effect of transplant center volume on post-transplant survival in patients listed for simultaneous liver and kidney transplantation

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world Journal of Hepatology 2018年第1期10卷 134-141页

作者： Rohan M Modi Dmitry Tumin Andrew J Kruger eliza w.beal Don Hayes Jr James Hanje Anthony J Michaels Kenneth washburn Lanla F Conteh Sylvester M Black Khalid Mumtaz Department of Internal Medicine Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Anesthesiology and Pain Medicine Nationwide Children’s HospitalColumbusOH 43205United States Department of General Surgery Division of TransplantationOhio State University Wexner Medical CenterColumbusOH 43210United States Comprehensive Transplant Center Ohio State University Wexner Medical CenterColumbusOH 43210United States Section of Pulmonary Medicine Nationwide Children’s HospitalColumbusOH 43205United States Department of Internal Medicine Division of GastroenterologyHepatology and NutritionOhio State University Wexner Medical CenterColumbusOH 43210United States

AIM To examine the effect of center size on survival differences between simultaneous liver kidney transplantation(SLKT) and liver transplantation alone(LTA) in SLKT-listed *** The United Network of Organ Sharing database was queried for patients ≥ 18 years of age listed for SLKT between February 2002 and December 2015. Posttransplant survival was evaluated using stratified Cox regression with interaction between transplant type(LTA vs SLKT) and center *** During the study period, 393 of 4580 patients(9%) listed for SLKT underwent a LTA. Overall mortality was higher among LTA recipients(180/393, 46%) than SLKT recipients(1107/4187, 26%). The Cox model predicted a significant survival disadvantage for patients receiving LTA vs SLKT [hazard ratio, hazard ratio(HR) = 2.85; 95%CI: 2.21, 3.66; P was modestly attenuated as center SLKT volume increased, with a 3% reduction(HR = 0.97; 95%CI: 0.95, 0.99; P = 0.010) for every 10 SLKs *** In conclusion, LTA is associated with increased mortality among patients listed for SLKT. This difference is modestly attenuated at more experienced centers and may explain inconsistencies between smaller-center and larger registry-wide studies comparing SLKT and LTA outcomes.

关键词： Kidney transplantation Center volume Mortality Liver transplantation United network for organ sharing

Hydraulic energy indices reveal spatial dependence in a subtropical soil under maize crop in Southern Brazil

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Pedosphere 2021年第5期31卷 771-782页

作者： Maria eliza TUREK Robson Andre ARMINDO Ole wENDROTH Graduate Program of Environmental Engineering(PPGEA) Federal University of Paraná(UFPR)Curitiba 81531980(Brazil) Department of Physics(DFI) Federal University of Lavras(UFLA)Mailbox 3037Lavras 37200900(Brazil) Department of Plant&Soil Sciences University of Kentucky(UK)Lexington 40546-0091(USA)

Soil physical quality(SPQ)assessment is an important part in the evaluation of soil use,management,and *** can be assessed using several physical properties,hydraulic indices,and *** from tropical and temperate regions represent different physical behaviors,and the quantification of their physical properties is important to support soil evaluation and *** objective of this study was to evaluate the SPQ in a subtropical field under maize crop cultivation according to its physical properties,hydraulic indices,and functions in an attempt to infer the spatial variability and to determine the behavior of soil physical structure across a spatial *** used soil key physical variables,such as texture,bulk density,total porosity,saturated hydraulic conductivity,and organic carbon content,were measured in a regular grid with a soil sampling density of 30 points per hectare,covering an area of0.5 *** hydraulic conductivity varied strongly between subsamples and in the field,suggesting the heterogeneity of the soil structure regarding water *** physical variables were combined with other indicators,which were based on the soil water retention curve and the pore size distribution(PSD)*** analysis was performed to verify the relationship between the measured and calculated variables,and some strong linear correlations were revealed,such as between aeration energy index and microporosity(r=0.608)and water retention energy index with microporosity(r=0.532)and with bulk density(r=0.541).For most sampled locations,the shape and location parameters of PSD showed results outside of the optimum ranges,whereas the hydraulic energy indices and cumulative hydraulic energy functions presented values that were similar to those found for some tropical soils described in the *** spatial variability of these indices was described using semivariograms and kriged maps,indicating the variability of the SPQ i

关键词： geostatistics integral energy pore size distribution soil physical indicators soil physical quality soil water retention curve