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Statins for primary cardiovascular prevention in the elderly

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Journal of Geriatric Cardiology 2015年第4期12卷 431-438页

作者： Juan Pedro-Botet elisenda Climent Juan J Chillarón Rocio Toro David Benaiges Juana A Flores-Le Roux Lipid and Vascular Risk Unit Endocrinology department Hospital del Mar. Spain Department of Medicine School of Medicine. Cáldiz University Cádiz Spain

老人口全球正在增加，与题目 >；组成快成长的年龄组的 65 岁。而且，老脸心血管的疾病死亡和病态的最大的风险和负担。尽管老病人，特别地那些更旧的 >；75，很好没在评估类脂化合物阴沉的治疗的使随机化的临床的审判被... 详细信息

老人口全球正在增加，与题目 >；组成快成长的年龄组的 65 岁。而且，老脸心血管的疾病死亡和病态的最大的风险和负担。尽管老病人，特别地那些更旧的 >；75，很好没在评估类脂化合物阴沉的治疗的使随机化的临床的审判被代表，在更老的个人在主要预防支持 statin 治疗的使用的可得到的证据主要从亚群分析和 hoc 以后的数据被导出。在另一方面，老病人经常有要求并发的药的一个高数字的多重合作病态；这可以为药药相互作用增加风险，从而减少 statin 的潜在的好处治疗。这评论的目的是关于 statin 使用介绍相关文学在为他们的主要心血管的疾病老，与治疗的联系风险和好处。

关键词：心血管疾病他汀类药物中老年人预防药物相互作用药物治疗年龄组世界范围

Complications of Monochorionic Diamniotic Twins: Stepwise Approach for Early Identification, Differential Diagnosis, and Clinical Management

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Maternal-Fetal Medicine 2021年第1期3卷 42-52页

作者： Taita Micheletti elisenda Eixarch Mar Bennasar Josep Maria Martinez Eduard Gratacos BCNatal-Fetal Medicine Research Center(Hospital Clinic and Hospital Sant Joan de Deu) University of BarcelonaBarcelona 08028Spain Institut d'Investigacions Biomediques August Pi iSunyer(IDIBAPS) Barcelona 08036Spain Centre for Biomedical Research on Rare Diseases(CIBER-ER)Madrid 28029 Spain Institut de Recerca Sant Joan de Deu Esplugues de Llobregat 08950Spain

One in three monochorionic twins may develop complications during pregnancy. Monochorionic twins, especially monochorionic diamniotic (MCDA), present specific problems caused by the presence of interfetal placental anastomoses. The first critical step in the management of MCDA twins is identification in the first trimester. Secondly, close follow-up every 2 weeks is mandatory to allow early diagnosis and timely treatment of twin-twin transfusion syndrome. Other potentially severe complications include selective fetal growth restriction, twin anemia polycythemia syndrome or single fetal death. Thirdly, a correct differential diagnosis is critical to establish the best therapy. This may represent a clinical challenge since MCDA twin complications often overlap. A simple diagnostic algorithm may be of great help to establish the right diagnosis and management option. In this review we summarize the main steps for the clinical follow-up, differential diagnosis, and targeted management of MCDA twins complications.

关键词： Acute feto-fetal transfusion Discordant malformation Monochorionic diamniotic twin pregnancy Pregnancy twin Selective fetal growth restriction Single intrauterine fetal death Twin anemia-polycythemia sequence Twin-twin transfusion syndrome

Treatment Response in Behaviour Disorders in Rett Syndrome

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Journal of Behavioral and Brain Science 2013年第2期3卷 217-224页

作者： Ana Roche Martínez Marc Turon Laura Callejón-Póo elisenda Sole Judith Armstrong Mercé Pineda Child Cardiology Department Sant Joan de Déu Children’s Hospital Barcelona Spain Child Neurology Department Sant Joan de Déu Children’s Hospital Barcelona Spain Child Neuropsychology Department Sant Joan de Déu Children’s Hospital Barcelona Spain Molecular Genetics Laboratory Sant Joan de Déu Children’s Hospital Barcelona Spain

RTT girls suffer periods of abnormal behavior from early infancy, including irritability and sleep disorders or anxiety in the first years of life, and a more depressed mood after adolescence, all of which influences their quality of life. An association between emotional and behavioral disorders and various neurochemical changes in the synapses of cortical and subcortical brain regions has been established;also, cortisol levels in the blood vary during stress. The main purpose of this study was to improve mood and behavior disorders in RTT patients with venlafaxine (SNRI), and compare the results with citalopram (SSRIs) during 6 - 8 weeks, to determine which drug offered greater efficacy and fewer side effects, as well as to compare them to risperidone, and to correlate cortisol levels in saliva with stress and drug response. Eleven patients, aged 5 to 26 years old, agreed to participate in this study;neuropsychological tests (Mullen and Vineland scales), quality of life and quality of sleep scales, blood tests, EKG and EEG were performed before and after treatment. Only 2 patients completed the three months trial. Improvement in mood and behavior was not statistically significant for patients;differences in neurodevelopment and quality of life or sleep scales were not significant either;no serious adverse effects were observed. Cortisol levels in saliva decreased in 50% of the patients after the first month of treatment, although this was not statistically significant.

关键词： Cortisol Mood and Behavior Rett Syndrome SSRI SNRI

Degradation and Detoxification of Banana Postharvest Treatment Water Using Advanced Oxidation Techniques

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Green and Sustainable Chemistry 2011年第3期1卷 39-46页

作者： Dunia E.Santiago elisenda Pulido Melian Cristina Fernandez Rodriguez Jose A.Ortega Mendez Sebastian O.Perez-Baez Jose M.Dona-Rodriguez Grupo de Photocatalisis y Espectroscopia Aplicada al Medioambiente-FEAM(Unidad Asociada al Instituto de Ciencia de Materiales de Sevilla C.S.I.C.)CIDIA-Depto.de QuimicaEdificio del Parque Cientifico TecnologicoUniversidad De Las Palmas De Gran CanariaLas PalmasSpain

The elimination and detoxification of water contaminated with the principal commercial fungi-cides—thia- bendazole (Textar 60 T) and imazalil sulphate (Fruitgard IS 7.5)—used in the postharvest treatment of bananas was successfully achieved through the use of advanced oxidation processes (AOPs). The techniques tested were heterogeneous photocatalysis with TiO2 and TiO2-activated carbon (TiO2-CA) and Fenton and photo-Fenton processes. The evolution of fungicide concentration during degradation was studied together with mineralization and toxicity levels. When treated with any of the methods under study, the water meets the conditions stipulated by the legislation currently in force for its reuse in irrigation. However, this study proposes that the Fenton process is the best option for treatment of this type of water due to the efficiency of its reactions and its low economic cost.

关键词： Thiabendazole Imazalil Sulphate Photocatalysis Fenton Photo-Fenton Banana Postharvest