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Influence of Proxies on the Reported Frequency of Falls, Fear of Falling and Activity Restriction in Older People

Health 2014年第12期6卷 1512-1521页

作者： elise mendes da costa Isabelle Godin Thierry Pepersack Michèle Dramaix Yves Coppieters Martine Bantuelle Alain Levêque Educa-Santé Non-Profit Organisation Charleroi Belgium Geriatrics Erasme University Hospital Université Libre de Bruxelles (U.L.B.) Bruxelles Belgium Research Centre in Epidemiology Biostatistics and Clinical Research School of Public Health Université Libre de Bruxelles (U.L.B.) Bruxelles Belgium Research Centre in Social Approaches to Health School of Public Health Université Libre de Bruxelles (U.L.B.) Bruxelles Belgium

Introduction: In older populations, the help of a third person may be necessary for a certain number of individuals in order to fill in questionnaires. The influence of this assistance on the collected information can raise questions, among others concerning the concordance between the information provided by the persons themselves and by their proxies, or the introduction of a potential bias. Our study’s objective is to examine, among older people, the differences in the reported frequency of falls, fear of falling and activity restriction due to fear of falling, according to the fact that people had filled in a questionnaire with or without the help of a third person. Methods: The data used come from the secondary analysis of a cross-sectional survey using a self-administered questionnaire and conducted in 2006 in a Belgian semi-rural town among non-institutionalised persons aged 65 years and over. Results: Among the 501 questionnaires, 16.4% were filled in with the help of another person. In bivariate analysis, the persons who needed help reported fall history, fear of falling and activity restriction significantly more often. In multivariable analysis, when considering concurrently the covariates (sex, age, living alone and fall history for fear of falling and for activity restriction), the influence of having received help to fill in the survey was only significant for activity restriction. Conclusion: Our study shows that it is important to know whether or not a person has received help to fill in a questionnaire. This can actually influence the reported frequency of certain outcomes, even, for activity restriction, when considering simultaneously the effect of other covariates. Given the current and future ageing of our populations, it seems that more extensive exploration is needed of the influence of proxies on the collected information about falls, fear of falling and activity restriction among older people.

关键词： Accidental Falls Fear of Falling Activity Restriction Proxies Older People

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Performance of masonry enclosure walls:lessons learned from recent earthquakes

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Earthquake Engineering and Engineering Vibration 2012年第1期11卷 23-34页

作者： Romeu Silva Vicente Hugo Rodrigues Humberto Varum Aníbal costa Jos António Raimundo mendes da Silva University of Aveiro Civil Engineering Department Campus Universitario de SantiagoAveiroPT3810-193Portugal University of Coimbra Civil Engineering Pinhal de MarrocosPolo ⅡCoimbraPT3030Portugal

This paper discusses the issue of performance requirements and construction criteria for masonry enclosure and infill walls. Vertical building enclosures in European countries are very often constituted by non-load-bearing masonry walls, using horizontally perforated clay bricks. These walls are generally supported and confined by a reinforced concrete frame structure of columns and beams/slabs. Since these walls are commonly considered to be nonstructural elements and their influence on the structural response is ignored, their consideration in the design of structures as well as their connection to the adjacent structural elements is frequently negligent or insufficiently detailed. As a consequence, nonstructural elements, as for wall enclosures, are relatively sensitive to drift and acceleration demands when buildings are subjected to seismic actions. Many international standards and technical documents stress the need for design acceptability criteria for nonstructural elements, however they do not specifically indicate how to prevent collapse and severe cracking, and how to enhance the overall stability in the case of moderate to high seismic loading. Furthermore, a review of appropriate measures to improve enclosure wall performance and both in-plane and out-of-plane integrity under seismic actions is addressed.

关键词： RC structures masonry enclosure walls infill walls in-plane out-of-plane cracking performanceimprovement

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Formation of DNA Strand Breaks in Peripheral Lymphocytes of Rats After Exposure to Natural Sunlight

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Biomedical and Environmental Sciences 2012年第2期25卷 245-249页

作者： Dorival mendes RODRIGUES-JUNIOR Ana Amélia de CARVALHO MELO Benedito Borges da SILVA Pedro Vitor LOPES-costa Department of Biology Federal University of Piaui-TeresinaPiauiBrazil Department of Gynecology Federal University of Piaui-TeresinaPiauiBrazil

Objective This paper aims to evaluate the genotoxicity in peripheral blood lymphocytes of rats after exposure to sunlight at different time points of day in a tropical region of Brazil（5oS,42oW）.Materials and Methods Thirty Wistar-Hannover rats,three months old,were randomly divided into three groups of 10 animals each：Group I [control,without exposure to ultraviolet（UV） radiation],Group II（exposed to sunlight during 08：00 a.***.to 10：00 a.m.）,and Group III（exposed to sunlight during 10：00 a.***.to 12：00 a.m.）.After a week of exposure,peripheral blood samples were taken from the tail of these animals to prepare smears on two slides per animal.In 24 h after exposure to sunlight in Group III,a new collection was obtained to observe the repair activity.The alkaline comet assay was used in this study to evaluate the genotoxic activity of sunlight（P0.05）.Results There was no statistical difference between Group I and II（P=0.672）.On the other hand,the exposure to sunlight in Group III showed genotoxic action in comparison to the other groups（P0.0001）.Also,there was no significant repair in Group III R（P=0.407）.Conclusion This study has shown a genotoxic potential of sunlight（UVA-B） in lymphocytes of mammals from 10：00 a.***.to 12：00 a.m.,due to a higher intensity of UV in this tropical region.

关键词： Comet assay DNA damage Rats Sunlight Ultraviolet radiation

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Microbial enzymatic stoichiometry and the acquisition of C, N,and P in soils under different land-use types in Braziliansemiarid

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Soil Ecology Letters 2023年第3期5卷 101-108页

作者： Erika Valente de Medeiros Érica de Oliveira Silva Gustavo Pereira Duda Mario Andrade Lira Junior Uemeson Josédos Santos Claude Hammecker Diogo Paes da costa Fabio Fernando Araujo Arthur Prudêncio de Araujo Pereira Lucas William mendes Ademir Sergio Ferreira Araujo Laboratory of Microbiology and Enzymology-LEMA Federal University of Agreste PernambucoGaranhuns 55292-270Brazil Federal Rural University of Pernambuco Rua Dom Manuel de Medeiross/nDois Irmãos52171-900RecifeBrazil Soil-Agrosystem-Hydrosystem Interaction Lab-LISAH Place Pierre Viala234060 MontpellierFrance Universidade do Oeste Paulista Presidente PrudenteSPBrazil Departamento de Ciência Do Solo Universidade Federal Do CearáFortalezaCEBrazil Center for Nuclear Energy in Agriculture University of Sao PauloPiracicabaSPBrazil Soil Quality Lab Agricultural Science CenterFederal University of PiauíTeresinaPI 60049-550Brazil

This study hypothesized that different land-use affect the microbial enzymatic stoichiometry and C-,N-,and P-acquisition in Brazilian semiarid soils.Thus,the enzymesβ-glucosidase(C-acquiring enzyme),urease(N-acquiring enzyme),and acid phosphatase(P-acquiring enzyme)were assessed in soil samples collected at 0−5 and 5−10 cm depth from a tropical dry forest,a protected area with Angico,a protected area with Ipê,scrub area,and an agricultural area with maize.The values of C-,N-,and P-acquiring enzymes were used to calculate the enzymatic C:N,C:P,and N:P ratios.The values of C:P and N:P ratios were higher at 0−5 cm depth,while no significant variation,between soil depth,was observed for C:N ratio.The values of C-and N-acquiring enzymes were higher at 0−5 cm in tropical dry forest areas and Angico forest,respectively.In all land use types,the values of vectors L and A were higher than 1°and 45°,respectively.This study showed that both land-use and soil depth influence the enzymatic stoichiometry,showing higher values of C-and N-acquiring enzymes in native and protected forests at soil surface.

关键词： C:N:P stoichiometry tropical forests soil depth Luvisols

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Risk Governance,Assessment,and Economic Impacts

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International Journal of Disaster Risk Science 2017年第3期8卷 235-236页

作者： Paula Teves-costa JoséManuel mendes Instituto Dom Luiz Faculdade de Ciências Universidade de Lisboa European Center on Urban Risks (CERU) Center for Social Studies Faculty of Economics University of Coimbra

Due to climate change,growing urbanization,and population migration the social and economic impacts of natural hazards have been increasing worldwide.The challenge for risk science,both methodologically and conceptual... 详细信息

关键词： Risk Governance,Assessment,and Economic Impacts

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Light weighting opportunities and material choice for commercial vehicle frame structures from a design point of view

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Advances in Manufacturing 2015年第1期3卷 19-26页

作者： Peter Seyfried Ed Juarez mendes Taiss Alexandre costa Calijorne Fei-Peng Li Qi-Feng Song Hamburg University of Applied Sciences Hamburg Germany Companhia Brasileira de Metalurgia e Mineracao Villa NovaMGBrazil Caltra Projetos & Consultoria Belo HorizonteMGBrazil Dongfeng Commercial Vehicle Technology Center FAW Technology Center

This paper focuses on an estimation of light weighting opportunities for the frame structure of com- mercial road vehicles. This estimation is based on simpli- fied static load cases which play a predominant role for the dimensioning of a frame structure and therefore these simplifications are not putting the general validity of the conclusions into question. A comparison of different ma- terials under this scenario shows that light metals do not show any weight reduction advantage in comparison to steel while a material-independent topology optimization has more weight reduction potential for the frame structure than a simple change of materials. Considering the con- straints of part complexity which is directly linked with production and assembly cost, the ladder frame structure has become the current state of the art design. Thus the paper also puts a spotlight on basic rules of node design and vertical load induction in order to keep the weight of such a design as low as possible. Practical examples from manufacturers show that the weight of a commercial vehicle could be reduced by 10%, and main parts of the frame structure could be reduced by 30% using high strength steel in combination with innovative production methods like roll forming.

关键词： Ladder frame . Light weighting.Commercialvehicle .Node design - High strength steel - Profilesection . Vertical bending .Topology optimization

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Optical Microscopy as a Tool to Correlate Morphology and Thermal Properties of Extruded PET/PC Reactive Blends

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Materials Sciences and Applications 2011年第8期2卷 1033-1040页

作者： Luis Claudio mendes Patricia Soares da costa Pereira Instituto de Macromoléculas Professora Eloisa Mano-IMA Universidade Federal do Rio de Janeiro-UFRJ Centro de Tecnologia Bloco J P.O.Box 68525 Avenida Horácio Macedo 2030 -21941-598 Rio de Janeiro RJ Brasil

Catalysed and uncatalysed reactive extruded poly(ethylene terephthalate)/poly(bisphenol-A carbonate) (PET/PC) blends phase structure at compositional range containing 0-100 wt% of both parent polymers were evaluated. Phase separation was supported by TG/DTG, DMA and DSC. The changes on Tg and Tm of the parent polymers were associated to the esterification and transesterification reactions inside the phases and into the interfacial region. According to optical observations, not yet published in this matter, the blend morphology was dictated, either composition or melt flow rate and in the whole composition range, a matrix-droplet morphology was noticed. PET was only able to be crystallized in blends in which it was the matrix. Mostly, the PET/PC blends revealed to be partially miscible systems in which the level of the transesterification/esterification reactions was driven by the kind of matrix. The latter showed great influence on the thermal properties.

关键词： PET/PC Phase Structure Morphology OM DMA DSC TG/DTG

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Immunotherapy in glioblastoma treatment:Current state and future prospects

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World Journal of Clinical Oncology 2023年第4期14卷 138-159页

作者： Samuel Luca Rocha Pinheiro Fabian Fellipe Bueno Lemos Hanna Santos Marques Marcel Silva Luz Luís Guilherme de Oliveira Silva Clara Faria Souza mendes dos Santos Karolaine da costa Evangelista Mariana Santos Calmon Matheus Sande Loureiro Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094BahiaBrazil

Glioblastoma remains as the most common and aggressive malignant brain tumor,standing with a poor prognosis and treatment prospective.Despite the aggressive standard care,such as surgical resection and chemoradiation,median survival rates are low.In this regard,immunotherapeutic strategies aim to become more attractive for glioblastoma,considering its recent advances and approaches.In this review,we provide an overview of the current status and progress in immunotherapy for glioblastoma,going through the fundamental knowledge on immune targeting to promising strategies,such as Chimeric antigen receptor T-Cell therapy,immune checkpoint inhibitors,cytokine-based treatment,oncolytic virus and vaccine-based techniques.At last,it is discussed innovative methods to overcome diverse challenges,and future perspectives in this area.

关键词： Glioblastoma Immunotherapy Tumor microenvironment Chimeric antigen receptor T cell Oncolytic viruses Immune-checkpoint inhibitors Brain cancer

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Benign retroperitoneal schwannoma presenting as colitis:A case report

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World Journal of Gastroenterology 2007年第41期13卷 5521-5524页

作者： Gary Fass Didier Hossey Michel Nyst Dirk Smets Esmail Najar Saligheh Ruth Duttmann Kathleen Claes Pierre mendes da costa Department of Digestive Laparoscopic and Thoracic SurgeryBrugmann University HospitalBrusselsBelgium Department of Radiology Brugmann University HospitalBrusselsBelgium Department of Pathology Brugmann University HospitalBrusselsBelgium Laboratory of Molecular Genetics Centre for Medical GeneticsGhent University HospitalGhentBelgium

We report a case of a patient presenting with clinical,radiological and endoscopic features of colitis due to a compressive left para-aortic mass. Total open surgical excision was performed,which resulted in complete resolution of colitis. Histopathology and immunohistochemistry revealed benign retroperitoneal schwannoma. These neural sheath tumors rarely occur in the retroperitoneum. They are usually asymptomatic but as they enlarge they may compress adjacent structures,which leads to a wide spectrum of non-specific symptoms,including lumbar pain,headache,secondary hypertension,abdominal pain and renal colicky pain. CT and MR findings show characteristic features,but none are specific. Schwannoma can be isolated sporadic lesions,or associated with schwannomatosis or neurofibromatosis type Ⅱ (NF2). Although they vary in biological and clinical behavior,their presence is,in nearly every case,due to alterations or absence of the NF2 gene,which is involved in the growth regulation of Schwann cells. Both conditions were excluded by thorough mutation analysis. Diagnosis is based on histopathological examination and immunohistochemistry. Total excision is therapeutic and has a good prognosis. Schwannomatosis and NF2 should be excluded through clinical diagnostic criteria. Genetic testing of NF2 is probably not justified in the presence of a solitary retroperitoneal schwannoma.

关键词：大肠炎神经纤维瘤腹膜后腔症状

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Experimental salt cavern in offshore ultra-deep water and well designevaluation for CO_(2) abatement

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International Journal of Mining Science and Technology 2019年第5期29卷 641-656页

作者： Alvaro Maia da costa Pedro V.M.costa Antonio C.O.Miranda Mariana B.R.Goulart Okhiria D.Udebhulu Nelson F.F.Ebecken Ricardo C.Azevedo Sérgio M.de Eston Giorgio de Tomi Andre B.mendes Julio R.Meneghini Kazuo Nishimoto Claudio Mueller Sampaio Camila Brandao Alexandre Breda University of Sao Paulo(USP) Sao Paulo 01000-000Brazil Modecom-Technology in Geomechanics and Computing Modeling Rio de Janeiro 27570-000Brazil Department of Civil and Environment Engineering University of Brasília(UnB)Brasília 70000-000Brazil COPPE Federal University of Rio de JaneiroRio de Janeiro 27570-000Brazil Technology Division of Shell Shell BrazilRio de Janeiro 27570-000Brazil

This paper presents a proposal for an experimental salt cavern in offshore ultra-deep water for CO2 abatement,including the instrumentation plan and well conceptual design evaluated for carbon capture and storage(CCS)application.These studies are based on applied computational mechanics associated with field experimentation that has contributed to the technical feasibility of the underground potash mine at the State of Sergipe in Brazil.This knowhow allowed the stability analysis of several salt caverns for brine production at the State of Alagoas in Brazil and to the drilling through stratified thick layers of salt of the pre-salt reservoirs in Santos Basin.Now,this knowledge has been applied in the design of onshore and offshore salt caverns opened by dissolution for storage of natural gas and CO2.The geomechanical study,through the application of computational mechanics,of offshore giant salt caverns of 450 m high by 150 m in diameter,shows that one cavern can store about 4 billion Sm3 or 7.2 million tons of CO2.Before the construction of the giant cavern,which will be the first gas storage offshore in the world,it has been decided to develop an experimental one,with smaller size,to obtained field parameters.The experimental cavern will allow the calibration of parameters to be used in the structural integrity analysis of the cavern and well for storage of natural gas which is rich in CO2 under high pressure.

关键词： Salt cavern Pre-salt reservoir Geomechanical study Carbon capture and storage

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