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Excess body weight, liver steatosis, and early fibrosis progression due to hepatitis C recurrence after liver transplantation

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World Journal of Gastroenterology 2005年第38期11卷 5944-5950页

作者： Pierluigi Toniutto Carlo Fabris Claudio Avellini Rosalba Minisini Davide Bitetto elisabetta Rossi Carlo Smirne Mario Pirisi Liver Transplantation Unit Pathology Department of Medical Sciences

AIM: To investigate how weight gain after OLT affects the speed of fibrosis progression (SFP) during recurrent hepatitis C virus (HCV) infection of the ***: Ninety consecutive patients (63 males,median age 53 years; 55 with HCV-related liver disease),transplanted at a single institution, were studied. All were followed for at least 2 years after OLT and had at least one follow-up graft biopsy, performed not earlier than 1 year after the transplant operation. For each biopsy, a single,experienced pathologist gave an estimate of both the staging according to Ishak and the degree of hepatic *** SFP was quantified in fibrosis units/month (FU/mo).The lipid metabolism status of patients was summarized by the plasma triglycerides/cholesterol (T/C) ratio. Body mass index (BMI) was measured before OLT, and 1 and 2 years after ***: In the HCV positive group, the highest SFP was observed in the first post-OLT year. At that time point,a SFP ≤0.100 FU/mo was observed more frequently among recipients who had received their graft from a young donor and had a pre-transplant BMI value ＞26.0 kg/m2. At completion of the first post-transplant year, a BMI value ＞26.5 kg/m2 was associated with a T/C ratio ≤1. The proportion of patients with SFP ＞0.100 FU/mo descended in the following order: female recipients with a high T/C ratio, male recipients with high T/C ratio, and recipients of either gender with low T/C ratio. Hepatic steatosis was observed more frequently in recipients who, in the first post-transplant year, had increased their BMI ≥1.5 kg/m2 in comparison to the pre-transplant value. Hepatic steatosis was inversely associated with the staging ***: Among HCV positive recipients, excessweight gain post-OLT does not represent a factor favoring early liver fibrosis development and might even be protective against it.

关键词： Liver transplantation Hepatitis C infection Liver fibrosis Liver steatosis Body mass index

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No correlation between X chromosome inactivation pattern and autistic spectrum disorders in an Italian cohort of patients

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Open Journal of Genetics 2011年第3期1卷 34-37页

作者： Natalia Cannelli elisabetta Tabolacci Claudia Rendeli Giovanni Neri Fiorella Gurrieri 不详

Autistic spectrum disorders (ASD) occur more frequently in males, suggesting a major pathogenic role for genes located on the X-chromosome. The analysis of X chromosome inactivation (XCI) pattern may help to identify XCI skewing in those families in which such genes are involved, even without identifying the specific genetic mutation. In order to identify such families, we determined the XCI pattern in 40 females with ASD and 58 mothers of children with ASD, as well as in 80 matched control females. The X inactivation assay was carried out on genomic DNA extracted from peripheral blood. XCI was calculated for informative heterozygous individuals as the ratio of the peak area of two alleles of the highly polymorphic CAG repeat of the androgen receptor (AR) gene (Xq11-12). Our results indicate that there is no difference in XCI pattern both in ASD females and in the mothers of ASD patients when compared with the appropriate controls. These findings suggest that the contribution of X-linked genes to the etiology of ASD is still likely but it is not supported by X-inactivation patterns on peripheral blood cells.

关键词： Autism X Chromosome Inactivation

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Treatment of Supraventricular Arrhythmias by Transcatheter Radiofrequency Ablation： The Experience of the Electrophysiology Unit of the University Hospital

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Journal of Pharmacy and Pharmacology 2017年第1期5卷 5-8页

作者： Zecchin Massimo Porto Andrea Bianco elisabetta Gianfranco Sinagra Stroili Manuela Cardiovascular Department ASU1 of Trieste Trieste 34149 Italy Department of Technology Assessment ASU1 of Trieste Trieste 34125Italy

TC-RF （transcatheter radiofrequency） ablation has an important role in the treatment ofSVA （supraventricular arrhythmias）. The indication to TC-RF ablation is usually made to improve the patient＇s quality of life through the elimination of the arrhythmic substrate. The objective of this study is to make a brief review of the literature and to report the Electrophysiology Unit experience of the Cardiovascular Department of the University Hospital of Trieste. From the study, it can be found that about one thousand of patients are visited annually in the Cardiovascular Department of the University Hospital of Trieste （1,019 ± 71/year over the past five years）. The acute success rate of atrial fibrillation and flutter ablation procedures was respectively 93.9% and 97.9% with a relapse rate of 30% and 10% at 12 month. Accessory pathways and nodal atrio ventricular re-entry tachycardia ablation procedures had an acute success rate of respectively 91.1% and 96.6% with a relapse rate of 10% at 12 months. The overall complication rate was 5%. Catheter ablation is an effective therapy for SVA treatment. It can often be definitive, and it is generally superior to drug therapy, with a low complication rate. The improvement in patients＇ quality of life is associated with a reduced need for access to health services.

关键词： TC-RF (transcatheter radiofrequency) ablation SVA (supraventricular arrhythmias) atrial fibrillation atrial flutter atrio-ventricular re-entry tachycardia atrio-ventricular nodal re-entry tachycardia technology assessment.

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Integrin-targeting with peptide-bioconjugated semiconductor-magnetic nanocrystalline heterostructures

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Nano Research 2016年第3期9卷 644-662页

作者： Gianpiero Valente Nicoletta Depalo Ivan de Paola Rosa Maria lacobazzi Nunzio Denora Valentino Laquintana Roberto Comparelli Emiliano Altamura Tiziana Latronico Michele Altomare elisabetta Fanizza Marinella Striccoli Angela Agostiano Michele Saviano Annarita Del Gatto Laura Zaccaro Maria Lucia Curri Universita degli Studi di Bari Aldo Moro Dipartimento di Chimica Via Orabona 4 70125 - Bari Italy Istituto per i Processi Chimico-Fisici-CNR UOS Bari Via Orabona 4 70125 - Bari Italy Istituto di Biostrutture e Bioimmagini-CNR Via Mezzocannone 16 80134 - Napoli Italy Universita degli Studi di Bari Aldo Moro Dipartimento di Farmacia - Scienze del Farmaco Via Orabona 4 70125 - Bari Italy Universita degli Studi di BariAIdo Moro Dipartimento di Bioscienze Biotecnologie e Biofarmaceutica Via Orabona 4 70125 - Bari Italy lstituto di Cristallografia-CNR Via Amendola 122/0 70126 Bari Italy

Binary asymmetric nanocrystals （BNCs）, composed of a photoactive TiO2 nanorod joined with a superparamagnetic γ-Fe203 spherical domain, were embedded in polyethylene glycol modified phospholipid micelle and successfully bioconjugated to a suitably designed peptide containing an RGD motif. BNCs represent a relevant multifunctional nanomaterial, owing to the coexistence of two distinct domains in one particle, characterized by high photoactivity and magnetic properties, that is particularly suited for use as a phototherapy and hyperthermia agent as well as a magnetic probe in biological imaging. We selected the RGD motif in order to target integrin expressed on activated endothelial cells and several types of cancer cells. The prepared RGD-peptide/BNC conjugates, comprehensively monitored by using complementary optical and structural techniques, demon- strated a high stability and uniform dispersibility in biological media. The cytotoxicity of the RGD-peptide/BNC conjugates was studied in vitro. The cellular uptake of RGD-peptide conjugates in the cells, assessed by means of two distinct approaches, namely confocal microscopy analysis and emission spectroscopy determination in cell lysates, displayed selectivity of the RGD-peptide-BNC conjugate for the cw]33 integrin. These RGD-peptide-BNC conjugates have a high potential for theranostic treatment of cancer.

关键词： nanocrystallineheterostructures photoactive semiconductor magnetic nanostructure cyclic RGD peptide αvβ3 integrin active targeting

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The experience performing extended abdominoplasty in massive weight loss patients

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Plastic and Aesthetic Research 2017年第4期4卷 57-63页

作者： Maria A.Bocchiotti elisabetta Adelaide Baglioni Stefano Bruschi Luca Spaziante Erind Ruka Department of Reconstructive and Aesthetic Plastic Surgery Cittadella Salute e dellaScienza HospitalUniversity of Turin10100 TurinItaly

Aim: The post-bariatric patients who undergo torsoplasty often incur postoperative complications that dilate their recovery time. The authors propose the technique of extended abdominoplasty, described in 2012 for aesthetic torso remodeling, in post-bariatric patients in order to reduce complications and hospitalization time. Methods: The authors performed 21 extended abdominoplasties and compared them with 21 torsoplasties in post-bariatric patients during a 1-year period. Data studied was age, gender, duration of the procedure, blood loss, complications and hospitalization duration. Results: Peri and postoperative bleeding led to 3 cases of anemia necessitating blood transfusions in 14.3% of the second group;no blood transfusion was needed in the first group. No other major complications occurred during the postoperative period in both groups. Conclusion: The authors believe that extended abdominoplasty is a viable alternative to the torsoplasty in selected patients presenting a severe adipocutaneous circumferential laxity, as occurs in post-bariatric patients with a significant weight loss.

关键词： Post-bariatric abdominoplasty torsoplasty complications body contouring body reshaping

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New strategies for colorectal cancer screening

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World Journal of Gastroenterology 2013年第12期19卷 1855-1860页

作者： Maria Di Lena elisabetta Travaglio Donato F Altomare Department of Emergency and Organ Transplantation University Aldo Moro of Bari

Colorectal cancer (CRC) is still one of the leading causes of cancer-related death in Western countries, despite major improvements in its treatment. The dramatically high social and economic impact of CRC on human health makes the identification of a reliable screening tool of paramount importance. Current screening methods, such as the fecal occult blood test and colonoscopy do not adequately meet the ideal requisites of a screening test because, even if they are effective, they are limited first by too low specificity and sensitivity, or second by high invasiveness, costs and risk. Nowadays extended efforts are made by researchers to look for more reliable and effective screening tests based on a systems biology approach, using biological samples easily available, such as urine, breath, serum and feces. The effectiveness and reliability of several new attempts to screen these patients by non-invasive analysis of their biological samples using genomic (genetic and epigenetic alteration), transcriptomic (miRNA), proteomic (cancer-related antigens, new antibodies against tumor-associated antigens, mutated proteins) and metabolomic (volatile organic metabolites) methods are discussed in this review. Among the most interesting new screening tools, fecal fluorescent long-DNA, fecal miRNA and metabolomic evaluation in breath and/ or serum seem to be most promising.

关键词： Colorectal cancer Screening Fecal occult blood test Systems biology Metabolomics Proteomic microRNA Volatile organic compounds

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Effects of music and music therapy on mood in neurological patients

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World Journal of Psychiatry 2015年第1期5卷 68-78页

作者： Alfredo Raglio Lapo Attardo Giulia Gontero Silvia Rollino elisabetta Groppo Enrico Granieri Department of Public Health Experimental and Forensic MedicineUniversity of Pavia Department of Biomedical and Specialistic Surgical Sciences Section of NeurologyUniversity of Ferrara

Mood disorder and depressive syndromes represent a common comorbid condition in neurological disorders witha prevalence rate that ranges between 20% and 50% of patients with stroke, epilepsy, multiple sclerosis, and Parkinson's disease. Notwithstanding, these conditions are often under-diagnosed and under-treated in the clinical practice and negatively affect the functional recovery, the adherence to treatment, the quality of life, and even the mortality risk. In addition, a bidirectional association between depression and neurological disorders may be possible being that depressive syndromes may be considered as a risk factor for certain neurological diseases. Despite the large amount of evidence regarding the effects of music therapy(MT) and other musical interventions on different aspects of neurological disorders, no updated article reviewing outcomes such as mood, emotions, depression, activity of daily living and so on is actually available; for this reason, little is known about the effectiveness of music and MT on these important outcomes in neurological patients. The aim of this article is to provide a narrative review of the current literature on musical interventions and their effects on mood and depression in patients with neurological disorders. Searching on Pub Med and Psyc Info databases, 25 studies corresponding to the inclusion criteria have been selected; 11 of them assess the effects of music or MT in Dementia, 9 explore the efficacy on patients with Stroke, and 5 regard other neurological diseases like Multiple Sclerosis, Amyotrophic Lateral Sclerosis/motor neuron disease, Chronic quadriplegia, Parkinson's Disease, and Acquired Brain dysfunctions. Selected studies are based on relational and rehabilitative music therapy approaches or concern music listening interventions. Most of the studies support the efficacy of MT and other musical interventions on mood, depressive syndromes, and quality of life on neurological patients.

关键词： Music Listening Music therapy Epilepsy Narrative review Stroke Mood Amyotrophic lateral sclerosis Depression Parkinson Dementia Multiple sclerosis Neurological disease Neurological disorders Acquired brain injury

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S100b protects IMR-32 cells against Ab(1-42) induced neurotoxicity via modulation of apoptotic genes expression

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Advances in Alzheimer's Disease 2013年第3期2卷 99-108页

作者： M. elisabetta Clementi Beatrice Sampaolese Doriana Triggiani Antonio Tiezzi Bruno Giardina 1CNR-ICRM Institute of Chimica del Riconoscimento Molecolare Department for Innovation in Biological Agro-food and Forest Systems (DIBAF) Tuscia University Viterbo Italy Institute of Biochemistry and Clinical Biochemistry Catholic University School of Medicine Rome Italy

Amyloid beta (1-42) peptide is considered responsible for the formation of senile plaques that accumulate in the brain of patients with Alzheimer’s disease (AD). In the past years considerable attention has been focused on identifying new protective substances that prevent or almost retard the appearance of amyloid beta (1-42)-related neurotoxic effects. In this study, human neuroblastoma cells (IMR-32) was used as system model to evaluate the protective role of S100b, a neurotrophic factor and neuronal survival protein, that is highly expressed by reactive astrocytes in close vicinity of beta-amyloid deposits, against amyloid beta (1-42)-dependent toxicity. Our results show that at nanomolar concentrations, S100b protects cells against Aβmediated cytotoxicity, as assessed by MTS vitality test. The protective mechanism seems to be related to the effect on bcl-2 (an anti-apoptotic gene) expression, which is highly down-regulated by amyloid beta (1-42) treatment, while resulted more expressed in the presence of S100b. On the contrary, Bax, a proapoptotic gene, resulted down-regulated by the treatment with S100 compared with the results obtained in the presence of amyloid beta (1-42) peptide. However, at micromolar doses, S100b is toxic for IMR-32 cells and its toxicity adds to that of the Aβpeptide, suggesting that additional molecular mechanisms may be involved in theneurotoxic process.

关键词： S100b Neurodegeneration Oxidate Methionine Apoptotic Genes Expression

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Chemotherapy-induced neurotoxicity in the treatment of gynecological cancers:State of art and an innovative approach for prevention

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World Journal of Clinical Oncology 2021年第6期12卷 458-467页

作者： Ester Oneda Chiara Abeni Laura Zanotti elisabetta Zaina Sara Bighè Alberto Zaniboni Department of Clinical Oncology Fondazione PoliambulanzaBrescia 25124Italy

Chemotherapy-induced peripheral neuropathy(CIPN)is a common side effect that occurs in 20%of ovarian cancer patients treated with the combination of carboplatin/paclitaxel(CP).This toxicity is directly correlated with the dose of paclitaxel *** studies have investigated whether different formulations of taxane can induce this side effect at a lower rate,but,unfortunately,no significant improvement was *** can be disabling in the daily lives of patients and can cause dose reduction or early termination of the *** can last for months and even years after its ***,patients responsive to CP treatment are candidates for a reintroduction of the same drugs when disease relapse occurs,and residual neuropathy can affect the continuation of *** are no approved drugs that mitigate or prevent the onset of *** this review,we summarize the evidence regarding the incidence of CIPN with different taxane formulations,regimen schedules and prevention *** particular,the Hilotherm®Chemo care device is a regional cooling system that lowers the temperature of the hands and feet to reduce the flow of chemotherapy into the *** used hilotherapy during chemotherapy infusion to prevent the onset of *** data from 44 ovarian cancer patients treated with 6 cycle of CP show that hilotherapy was well tolerated;only two patients(4.5%)stopped hilotherapy because of cold intolerance,and only one patient(2.2%)experienced grade≥2 CIPN.

关键词： Peripheral neuropathy Ovarian cancer Paclitaxel Chemotherapy-induced peripheral neuropathy prevention Hilotherapy

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意大利计算机

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科技纵览 2019年第6期 44-51页

作者： elisabetta Mori 不详

“我决定报废我们的第一版计算机,然后从头开始。”1957年秋天,一位年轻有为的意大利华裔电子工程师马里奥侏(Mario Tchou),在好利获得(Olivetti)电子研究实验室对他的团队这样说。这座实验室位于比萨郊区一座改建的别墅里,距离比萨斜... 详细信息

“我决定报废我们的第一版计算机,然后从头开始。”1957年秋天,一位年轻有为的意大利华裔电子工程师马里奥侏(Mario Tchou),在好利获得(Olivetti)电子研究实验室对他的团队这样说。这座实验室位于比萨郊区一座改建的别墅里,距离比萨斜塔不远。

关键词：计算机意大利比萨斜塔实验室工程师电子

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