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Lactobacilli,bifi dobacteria and *** nissle induce pro-and anti-inflammatory cytokines in peripheral blood mononuclear cells

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World Journal of Gastroenterology 2006年第37期12卷 5978-5986页

作者： Ulf Helwig Karen M Lammers Fernando Rizzello Patricia Brigidi Verena Rohleder elisabetta caramelli Paolo Giochetti Juergen Schrezenmeir Ulrich R Foelsch Stefan Schreiber Massimo Campieri University Hospital Schleswig-Holstein Campus Kiel 1~(st) Medical Department Schittenhelmstr.12 24105 Kiel Germany University of Bologna Department of Internal Medicine and Gastroenterology Policlinico S. Orsola Via Massarenti 9 40138 Bologna Italy University of Bologna Department of Internal Medicine and Gastroenterology Policlinico S. Orsola Via Massarenti 9 40138 Bologna Italy University of Bologna Institute for Microbiology Via Bellmeloro 9 40138 Bologna Italy University Hospital Schleswig-Holstein Campus Kiel 1~(st) Medical Department Schittenhelmstr.12 24105 Kiel Germany University of Bologna Histology and General Embryology and Pharmaceutical Science Via Bellmeloro 9 40138 Bologna Italy Federal Research Center for Nutrition and Food Location Kiel Institute for Physiology and Bioche- mistry of Nurtition Hermann-Weigmann-Str.1 24103 Kiel Germany

AIM： To investigate whether the stimulation of peripheral blood mononuclear cells （PBMNC） with the cell debris and cell extraction of different probiotic strains is similar or species specific. METHODS： Three strains of bifidobacteria, 4 strains of lactobacilli, and E. coli nissle were sonicated and centrifuged in order to divide them into cell extract and cell debris. PBMNC were separated by density gradient and incubated for 36 h with either the cell debris or the cell extract of single strains of probiotic bacteria in doses from 10^2 to 10^8 CFU/mL. Cell supernatants were taken and interleukin （IL）-10, IL-1β, and tumor necosis factor （TNF）-α were determined by ELISA. RESULTS： Depending on the species super-family, the strains had different stimulation patterns. Except for both L. casei strains, the cell extract of bitTdobacteria and/actobacilli had less stimulating capacity than cell debris, whereas the cell extract of E. coli nissle had similar stimulating properties to that of the cell debris of the strain and significantly more stimulating capacity than that of bifidobacteria and lactobacilli. The cell debris of bifidobacteria stimulated more cytokine release than the cell debris of lactobacilli. The cell debris of lactobacilli did not have a stimulating capacity when lower concentrations were used. Neither cell extraction nor cell debris had an inhibitory effect on the production of the tested cytokines by stimulated PBMNC. CONCLUSION： The incubation of probiotic strains, which have been used in clinical trials for inflammatory diseases, with immunocompetent cells leads to different species specific reactions. High IL-10 response to cell debris of bifidobacteria and E. coli nissle can be found. This corresponds to positive effects of bihdobacteria and E. coli nissle in clinical trials for inflammatory bowel disease compared to negative outcomes obtained with lactobacilli.

关键词： Lactobacilli Bifidobacteria Probiotics Interleukin-l0 Tumor necrosis factor-α Interleukin-1β Peripheral blood mononuclear cells

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Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

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Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria Martinelli Jessica Mandrioli Andrea Ghezzi elisabetta Zucchi Giulia Gianferrari Cecilia Simonini Francesco Cavallieri Franco Valzania Department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental Medicine Ph.D.Program University of Modena and Reggio EmiliaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory SOD1 superoxide dismutase 1 urinary vocal cord palsy

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Stressed axons craving for glial sugar: links to regeneration?

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Neural Regeneration Research 2022年第2期17卷 304-306页

作者： elisabetta Babetto Bogdan Beirowski Hunter James Kelly Research Institute Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloNYUSA Department of Biochemistry Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloNYUSA Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloNYUSA

Extract The contrary but interrelated processes of axon degeneration and regeneration are the yin and yang of many neurodegenerative conditions. Here we discuss recent evidence for metabolic cross-talk between glia and injured axons regulating these processes. We especially focus on potential bioenergetic mechanisms as to how axon-flanking glia may promote regeneration.

关键词： degeneration conditions. processes.

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Diabetic retinopathy: a matter of retinal ganglion cell homeostasis

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Neural Regeneration Research 2020年第7期15卷 1253-1254页

作者： elisabetta Catalani Davide Cervia Department for Innovation in Biological Agro-food and Forest systems (DIBAF) Università degli Studi della Tuscialargo dell’Università snc

Diabetic retinopathy(DR)is the most common complication of diabetes and the leading cause of visual impairment in the working-age population in the Western world(http://***/).One of the earliest events observed in DR is the impairment of retinal perfusion,caused by the constriction of retinal blood vessels,inducing biochemical and metabolic alterations,perycites/endothelial degeneration,and retina ischemia(Wong et al.,2016).Severe stages of DR include proliferative DR,caused by the abnormal growth of new vessels,and diabetic macular oedema in the central part of the *** is strongly associated with a prolonged duration of diabetes,hypertension,and hyperglycaemia but it can persist even after replacement of normal glycaemic status(Wong et al.,2016).

关键词： homeostasis alterations impairment

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ON THE CONVERGENCE OF PROJECTOR-SPLINES FOR THE NUMERICAL EVALUATION OF CERTAIN TWO-DIMENSIONAL CPV INTEGRALS

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Journal of Computational Mathematics 2002年第2期20卷 113-120页

作者： Santi, elisabetta Cimoroni, M.G. Department of Energetica University of L'Aquila-67040 Roio Poggio-L'Aquila 意大利

Focuses on a study that proposed product formulas based on projector-splines for the numerical evaluation of two-dimensional Cauchy principal value integrals. Preliminaries; Convergence of quadrature rules using proje... 详细信息

关键词： D Cauchy principal value integral Tensor product projector-splines.

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Playing together,laughing together:rapid facial mimicry and social sensitivity in lowland gorillas

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Current Zoology 2022年第5期68卷 560-569页

作者： Chiara Bresciani Giada Cordoni elisabetta Palagi Natural History Museum University of PisaVia Roma 79Calci(Pisa)56011Italia Department of Biology Unit of EthologyUniversity of PisaVia A.Volta 6Pisa 56126Italia

n nonhuman animals,the phenomenon of rapid facial mimicry(RFM)—the automatic,involuntary,and rapid(<1 s)replication of others’facial expressions—has been mainly investigated in the playful *** immature lowland gorillas Gorilla gorilla gorilla both play face(PF)and full PF(FPF)are rapidly mimicked between the *** makes the species suitable to test hypotheses on the factors influencing RFM during *** observations on 3 captive groups of lowland gorillas(N=27)revealed that contrary to expectations,the closeness of social bond negatively influenced the occurrence of RFM but it did not affect either RFM latency or its overlapping index(OVERLAP).RFM was affected by the degree of symmetry of play fighting:the more balanced the session,the higher the occurrence of *** of the same sex class responded faster than players of different *** findings suggest that RFM may help synchronizing behaviors of playmates matching in size(same-sex)and promote symmetric playful interactions.“Laughing together”(measured by the RFM OVERLAP)lasted longer when the responder perfectly mirrored the partner expression(PF→PF;FPF→FPF).If PF and FPF convey information on the different play roughness degree,through“laughing together”the players could coordinate their actions and share positive moods and playful *** the perfect congruency in the motor resonance,also known as social sensitivity,can foster a possible emotional dialogue between gorillas remains to be investigated.

关键词： emotional resonance facial overlapping Gorilla gorilla gorilla matching playmates mirror response play communication

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Melt migration and melt-rock reaction in the Alpine-Apennine peridotites:Insights on mantle dynamics in extending lithosphere

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Geoscience Frontiers 2020年第1期11卷 151-166页

作者： elisabetta Rampone Giulio Borghini Valentin Basch DISTAV University of GenovaCorso Europa 26I-16132 GenovaItaly Dipartimento di Scienze della Terra University of Milanovia Botticelli 2320133 MilanoItaly

The compositional variability of the lithospheric mantle at extensional settings is largely caused by the reactive percolation of uprising melts in the thermal boundary layer and in lithospheric *** Alpine-Apennine(A-A)ophiolites are predominantly constituted by mantle peridotites and are widely thought to represent analogs of the oceanic lithosphere formed at ocean/continent transition and slow-to ultraslow-spreading *** and geochemical studies on the A-A mantle peridotites have revealed that they preserve significant compositional and isotopic heterogeneity at variable scale,reflecting a long-lived multi-stage melt migration,intrusion and melt-rock interaction history,occurred at different lithospheric depths during progressive *** A-A mantle peridotites thus constitute a unique window on mantle dynamics and lithosphere-asthenosphere interactions in very slow spreading *** this work,we review field,microstructural and chemical-isotopic evidence on the major stages of melt percolation and melt-rock interaction recorded by the A-A peridotites and discuss their consequences in creating chemical-isotopic heterogeneities at variable scales and enhancing weakening and deformation of the extending *** will be on three most important stages:(i)old(pre-Jurassic)pyroxenite emplacement,and the significant isotopic modification induced in the host mantle by pyroxenite-derived melts,(ii)melt-peridotite interactions during Jurassic mantle exhumation,*** open-system reactive porous flow at spinel facies depths causing bulk depletion(origin of reactive harzburgites and dunites),and the shallower melt impregnation which originated plagioclase-rich peridotites and an overall mantle *** infer that migrating melts largely originated as shallow,variably depleted,melt fractions,and acquired Si-rich composition by reactive dissolution of mantle pyroxenes during upward *** melt-rock reaction processes

关键词： Mantle peridotite Pyroxenite Melt migration Melt impregnation Melt-rock reaction Alpine-Apennine ophiolites

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Novel emphasis on somatostatinergic system in retinal ganglion cell neuroresilience

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Neural Regeneration Research 2024年第1期19卷 148-149页

作者： elisabetta Catalani Davide Cervia Department for Innovation in Biological Agro-food and Forest Systems(DIBAF)Universitàdegli Studi della Tuscialargo dell’UniversitàsncViterboItaly

The neuromodulatory peptide somatostatin(somatotropin release inhibiting factor,SRIF)-14 acts at multiple levels through five SRIF receptor subtypes(sst1 to sst5).SRIF-28 is also derived from a common propeptide translated from a single SRIF gene,although SRIF-14 is the predominant form in the mammalian nervous *** to its short half-life,synthetic SRIF analogs have been developed over the years and are available for therapeutic approaches.

关键词： life system predominant

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Nuclear sphingomyelin in neurodegenerative diseases

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Neural Regeneration Research 2021年第10期16卷 2028-2029页

作者： elisabetta Albi Alice V.Alessenko Department of Pharmaceutical Science University of PerugiaPerugiaItaly Emanuel Institute of Biochemical Physics Russian Academy of SciencesMoscowRussia

Introduction:Recently,sphingolipids(SphLs)have become increasingly appreciated as a family of molecules involved in the growth,differentiation,and death of the central nervous system *** disequilibrium among the different SphLs leads to changes in the neuronal cell physiology and induces the development of neurodegenerative diseases(Alessenko and Albi,2020).Sphingomyelin(SM),sphinganin(Sphn),sphingosine(Sph),sphingosine-1-phosphate(S1P)and ceramide(Cer)are the most well-studied group of SphLs responsible for neurodegeneration,as well as derived molecules such as glucosylceramide or cerebroside(GCer)and galactosylceramide(GalCer)and finally more complex molecules such as as gangliosides.

关键词： finally system sine

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A Drosophila perspective on retina functions and dysfunctions

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Neural Regeneration Research 2022年第2期17卷 341-343页

作者： elisabetta Catalani Federica Silvestri Davide Cervia Department for Innovation in Biological Agro-food and Forest Systems(DIBAF)Universitadegli Studi della Tuscialargo dell’UniversitasncViterboItaly

Due to the high degree of conservation of genes and mechanisms, the fruit fly Drosophila melanogaster is a powerful experimental in vivo tool to investigate complex diseases, thus complementing traditional vertebrate systems. Drosophila is also an advantageous system regarding the animal husbandry and the short generation time and lifespan.

关键词： Drosophila husbandry functions

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