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Plant Cell Wall Proteomics： Mass Spectrometry Data, a Trove for Research on Protein Structure/Function Relationships

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Molecular Plant 2009年第5期2卷 977-989页

作者： Cecile Albenne Herve Canut Georges Boudart Yu Zhang Helene San Clemente Rafael Pont-Lezica elisabeth Jamet Surfaces Cellulaires et Signalisation chez les Vegetaux UMR 5546 CNRS-UPS-Universite de Toulouse Pole de Biotechnologie Vegetale 24 chernin de Borde- Rouge BP 42617 Auzeville 31326 Castanet-Tolosan France

Proteomics allows the large-scale study of protein expression either in whole organisms or in purified organelles. In particular, mass spectrometry （MS） analysis of gel-separated proteins produces data not only for protein identification, but for protein structure, location, and processing as well. An in-depth analysis was performed on MS data from etiolated hypocotyl cell wall proteomics ofArabidopsis thaliana. These analyses show that highly homologous members of multigene families can be differentiated. Two lectins presenting 93% amino acid identity were identified using peptide mass fingerprinting. Although the identification of structural proteins such as extensins or hydroxyproline/proline-rich proteins （H/PRPs） is arduous, different types of MS spectra were exploited to identify and characterize an H/PRP. Maturation events in a couple of cell wall proteins （CWPs） were analyzed using site mapping. N-glycosylation of CWPs as well as the hydroxylation or oxidation of amino acids were also explored, adding information to improve our understanding of CWP structure/function relationships. A bioinformatic tool was developed to locate by means of MS the N-terminus of mature secreted proteins and N-glycosylation.

关键词： Cell wall protein MALDI-TOF mass spectrometry post-translational modification protein structure proteomics.

Waist circumference thresholds and cardiorespiratory fitness

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Journal of Sport and Health Science 2019年第1期8卷 17-22页

作者： Sindre M.Dyrstad elisabeth Edvardsen Bj?rge H.Hansen Sigmund A.Anderssen Department of Education and Sport Science University of Stavanger Department of Sports Medicine Norwegian School of Sport Sciences Department of Pulmonary Medicine Oslo University Hospital

Purpose: This study's purpose was to examine whether established risk categories of waist circumference(WC)—normal, high risk, and very high health risk—reflected significant differences in cardiorespiratory fitness(CRF) and physical activity(PA) ***: CRF was directly measured as maximal oxygen uptake during a progressive graded treadmill test to exhaustion in 722 individuals(349 women) aged 20à85 years. WC was measured between the lower rib and the iliac crest. Objectively measured PA was assessed using an ***: Men in the normal risk group(WC 102 cm). Corresponding numbers for women within normal(WC 88 cm) were 25% and 18%(p < 0.05). There was a high negative correlation between CRF and WC in men(r = ?0.68), and a moderate correlation for women(r = ?0.49; p < 0.001). For each cm increase in WC, CRF was reduced by 0.48 and 0.27 mL/kg/min in men and women,respectively(p < 0.001).Conclusion: The recommended WC thresholds for abdominal obesity reflected significant differences in CRF for both men and women, and could serve as a useful instrument for estimating health-related differences in CRF.

关键词： Abdominal obesity Fit fat Maximal oxygen uptake Obesity Public health Waist circumference

Nickel ferrite spinel as catalyst precursor in the dry reforming of methane:Synthesis,characterization and catalytic properties

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Journal of Natural Gas Chemistry 2012年第5期21卷 595-604页

作者： Rafik Benrabaa Hamza Boukhlouf Axel Lfberg Annick Rubbens Rose-Nelle Vannier elisabeth Bordes-Richard Akila Barama Laboratoire de Matériaux Catalytiques & Catalyse en Chimie Organique Faculté de ChimieUSTHBBP32 El Alia16111 Bab EzzouarAlgerAlgérie Unité de Catalyse et de Chimie du Solide UMR CNRS 8181Ecole Nationale Supérieure de Chimie de LilleUniversitédes Sciences et Technologies de LilleCité Scientif ique59655 Villeneuve d'AscqFrance

Dry reforming of methane by CO2 using nickel ferrite as precursor of catalysts was *** ferrite crystalline particles were prepared by coprecipitation of nitrates with NaOH or ammonia followed by calcination,or by hydrothermal synthesis without calcination *** textural and structural properties were determined by a number of analysis methods,including X-ray diffraction （XRD）,Raman spectroscopy and X-ray photoelectron spectroscopy （XPS）,among which X-ray diffraction （XRD） was at room and variable *** synthesized oxides showed the presence of micro or nanoparticles of NiFe2O4 inverse spinel,but Fe2O3 （hematite） was also present when ammonia was used for *** reducibility by hydrogen was studied by temperature-programmed reduction （TPR） and in situ XRD,which showed the influence of the preparation *** surface area （BET）,particle size （Rietveld refinement）,as well as surface Ni/Fe atomic ratio （XPS） and the behavior upon reduction varied according to the synthesis *** catalytic reactivity was investigated using isopropanol decomposition to determine the acid/base *** catalytic performance of methane reforming with CO2 was measured with and without the pre-treatment of catalysts under H2 in 650-800 C *** catalytic conversions of methane and CO2 were quite low but they increased when the catalysts were pre-reduced.A significant contribution of reverse water gas shift reaction accounted for the low values of H2 /CO *** coking was observed as shown by the reoxidation step performed after the catalytic *** possible formation of nickel-iron alloy observed during the study of reducibility by hydrogen was invoked to account for the catalytic behavior.

关键词： dry reforming of methane NiFe2O4 spinel hydrothermal synthesis coprecipitation isopropanol decomposition

Orchestration of antiviral responses within the infected central nervous system

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Cellular & Molecular Immunology 2024年第9期21卷 943-958页

作者： Andreas Pavlou Felix Mulenge Olivia Luise Gern Lena Mareike Busker elisabeth Greimel Inken Waltl Ulrich Kalinke Institute for Experimental Infection Research TWINCORECentre for Experimental and Clinical Infection Researcha joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School30625HannoverGermany Department of Pathology University of Veterinary Medicine HannoverFoundation30559HannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical School30625HannoverGermany

Many newly emerging and re-emerging viruses have neuroinvasive potential,underscoring viral encephalitis as a global research *** entry of the virus into the CNS,severe neurological life-threatening conditions may manifest that are associated with high morbidity and *** currently available therapeutic arsenal against viral encephalitis is rather limited,emphasizing the need to better understand the conditions of local antiviral immunity within the infected *** this review,we discuss new insights into the pathophysiology of viral encephalitis,with a focus on myeloid cells and CD8^(+)T cells,which critically contribute to protection against viral CNS *** illuminating the prerequisites of myeloid and T cell activation,discussing new discoveries regarding their transcriptional signatures,and dissecting the mechanisms of their recruitment to sites of viral replication within the CNS,we aim to further delineate the complexity of antiviral responses within the infected ***,we summarize the current knowledge in the field of virus infection and neurodegeneration and discuss the potential links of some neurotropic viruses with certain pathological hallmarks observed in neurodegeneration.

关键词： Virus infection Virus control within the brain T cell recruitment to the brain Microglia activation

Ensure preparation and capsule endoscopy:A two-center prospective study

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World Journal of Gastroenterology 2013年第8期19卷 1264-1270页

作者： Eva Niv Baruch Ovadia Yulia Ron Ervin Santo elisabeth Mahajna Zamir Halpern Zvi Fireman Department of Gastroenterology Tel Aviv Sourasky Medical CenterTel Aviv 64239Israel Department of Gastroenterology Hillel Yaffe Medical CenterHadera 38100Israel

AIM:To compare small bowel(SB) cleanliness and capsule endoscopy(CE) image quality following Ensure,polyethylene glycol(PEG) and standard ***:A preparation protocol for CE that is both efficacious and acceptable to patients remains *** the physiological function of the SB as a site for the digestion and absorption of food and not as a stool reservoir,preparation consisting of a liquid,fiber-free formula ingested one day before a CE study might have an advantage over other kinds of *** conducted a prospective,blind-topreparation,two-center study that compared four types of *** participants' demographic and clinical data were *** and SB transit times were *** presence of bile in the duodenum was scored by a single,blinded-to-preparation gastroenterologist expert in CE,as was cleanliness within the proximal,middle and distal part of the SB.A four-point scale was used(grade 1 = no bile or residue,grade 4 ≥ 90% of lumen full of bile or residual material).RESULTS:The 198 consecutive patients who were referred to CE studies due to routine medical reasons were divided into four *** all observed a 12-h overnight fast before undergoing *** the 24 h preceding the fast,control group 1(n = 45 patients) ate light unrestricted meals,control group 2(n = 81) also ate light meals but free of fruits and vegetables,the PEG group(n = 50) ate unrestricted light meals and ingested the PEG preparation,and the Ensure group(n = 22) ingested only the Ensure *** with Ensure improved the visualization of duodenal mucosa(a score of 1.76) by decreasing the bile content compared to preparation with PEG(a score of 2.9)(P = 0.053).Overall,as expected,there was less residue and stool in the proximal part of the SB than in the middle and distal parts in all *** total score of cleanliness throughout the length of the SB showed some benefit for Ensure(a score of 1.8) over control g

关键词： Capsule endoscopy Preparation Polyethylene glycol Ensure Fiber-free diet Image quality

Association between vitamin D and hepatitis C virus infection: A meta-analysis

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World Journal of Gastroenterology 2013年第35期19卷 5917-5924页

作者： Livia Melo Villar José Antonio Del Campo Isidora Ranchal elisabeth Lampe Manuel Romero-Gomez Laboratory of Viral Hepatitis Oswaldo Cruz Institute Fiocruz Rio de Janeiro RJ 210360-040 Brazil Unit for the Clinical Management of Digestive Diseases and CIBERehd Hospital Universitario de Valme41014 SevillaSpain

AIM:To evaluate the association between 25-hydroxyvitamin D[25(OH)D]and sustained virological response(SVR)in hepatitis C virus(HCV)infected ***:Relevant studies were identified by systematically searching MEDLINE databases up to March2012 and abstracts of the European and American Congress of Hepatology conducted in *** must provide information on SVR and the levels of 25(OH)D3and/or 25(OH)D2[henceforth referred to as 25(OH)D]in sera samples from HCV infected *** inclusion criteria were:clinical studies that included HCV infected patients aged older than 18 years regardless of HCV genotype or ethnic group;provided information on SVR rates;and were reported in the English languageas full *** to the heterogeneity of studies in categorizing serum vitamin D levels,a cut-off value of30 ng/mL of serum 25(OH)D was *** was assessed using *** summary odds ratios with their corresponding 95%CI were calculated based on a random-effects ***:Overall,11 studies(8 observational and 3interventional)involving 1575 individuals were included and 1117 HCV infected individuals(71%)showed low vitamin D *** of the studies included monoinfected HCV individuals with the mean age ranging from 38 to 56 *** studies were conducted in human immunodeficiency virus/HCV infected *** vitamin D measurement,most of the studies employed radioimmunoassays(n=5)followed by chemiluminescence(n=4)and just one study employed high performance/pressure liquid chromatography(HPLC).Basal vitamin D levels varied from 17 to43 ng/mL in the studies selected,and most of the HCV infected individuals had genotype 1(1068/1575)with mean viral load varying from log 4.5-5.9 UI/*** regard to HCV treatment,most of the studies(n=8)included HCV individuals without previous treatment,where the pooled SVR rate was 46.4%.High rates of SVR were observed in HCV individuals with vitamin D levels above 30 ng/mL(OR=1

关键词： Vitamin D Hepatitis C Therapy Metaanalysis Sustained virological response

Evidence of Linkages between Patient Safety and Person-Centred Care in the Maternity and Obstetric Context—An Integrative Review

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Open Journal of Nursing 2017年第3期7卷 378-398页

作者： elisabeth Severinsson Megumi Haruna maria Ronnerhag Anne Lise Holm Britt S.Hansen Ingela Berggren Centre for Women’s Family&Child HealthDepartment of Nursing and Health SciencesFaculty of Health and Social SciencesUniversity College of Southeast-NorwayKongsbergNorway Department of Midwifery and Women’s Health Division of Health Sciences&NursingGraduate School of MedicineThe University of TokyoTokyoJapan Department of Health Sciences University WestTrollhattanSweden Department of Health Sciences Western Norway University of Applied SciencesHaugesundNorway Department of Health Studies Faculty of Social SciencesUniversity of StavangerStavangerNorway

The aim was to evaluate the current state of knowledge pertaining to patient safety and its link to person-centred care. The international relevance of patient safety has expanded, as have the models of person-centred care. Inspired by this new trend, we collated and summarized the literature for evidence of the two topics. The study was guided by Russell, Whittemore and Knafl’s integrative review framework. An electronic database search was conducted for relevant articles from 2005 to 2016. This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The structure and process of the evaluation of the evidence are described and the findings interpreted by means of a thematic synthesis. One theme emerged: trustful, safe communication in the relationship between the patient, family members and healthcare professionals and two domains;safety culture and multidisciplinary capacity building. The dominant dimension in the safety culture domain is respectful communication, which implies sharing experiences that lead to a sense of control during labour and birth and is related to the women’s feeling of personal capacity. The dominant dimensions in the multidisciplinary capacity building domain are collaborative teamwork, coordination and risk management, knowledge sharing and patient-centred communication. In conclusion, to enhance patient safety, it is necessary to develop patient-focused, evidence-based skills and guidelines as well as a supportive organization. Due to their interaction with patients, midwives’ communication competence on the part of midwives is essential for supporting the birth and fulfilling the women’s needs and expectations.

关键词： Communication Integrative Review Midwifery Nursing Patient Safety Person-Centred Care Maternity Obstetric Care

‘New’unintentionally produced PCBs in the Arctic

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Emerging Contaminants 2019年第1期5卷 9-14页

作者： Paul W.Bartlett elisabeth Isaksson Mark H.Hermanson Fordham University 113 West 60th Street-Rm 813mNew YorkNY10023USA John Jay College of Criminal Justice City University of New York524 West 59th St.Rm.NB 9.63.25New YorkNY10019USA Norwegian Polar Institute Fram Centre Postboks 6066NO-9296TromsøNorway Hermanson&Associates LLC 2000W.53rd St.MinneapolisMN55419USA

Contamination of the Arctic by legacy polychlorinated biphenyls(PCB)is well documented,but the more recent discovery of unintentionally produced(UP)PCBs in the Arctic is a cause for *** PCBs are covered by existing international conventions and regular monitoring,and the UP congeners are covered by the Stockholm Convention and the *** Substances Control Act,but systematic monitoring and regulatory enforcement of UP-PCBs are *** of UP-PCB are by-products of manufacturing(***)and from thermal sources(***).Estimates of PCB emissions in China now show UP-PCB eclipsing emissions of legacy *** we discuss the 209 PCB-congener results from surface snow samples from Lomonosovfonna in 2010 and 2014,a glacial site on Svalbard which,in 2014,shows presence of PCB5,PCB11,and an unusually high amount of *** PCB5 and PCB11 may not be found in legacy PCB mixtures,PCB52 is in many PCB mixtures,yet dominates none of them as in the 2014 snow *** it possible that these congeners are from UP-PCB processes?A search of the literature shows that PCB5,PCB11 and PCB52 are co-synthesis products of pigment production and that PCB5 and PCB11 are found in flue gas and ash from hazardous waste *** these,PCB11 has received greater attention in the *** has recently been consistently detected in the air,snow,soil and biota in the Arctic,evidence that PCB11 and possibly other UP-PCB congeners are global *** core measurements dating from 1957 to 2009 of PCBs in Svalbard reveal PCB11 presence throughout that period,indicating historic presence in the Arctic before being a focus of research *** UP-PCB need to be more fully investigated,especially from thermal sources.

关键词： PCB Polychlorinated biphenyls Arctic PCB5 PCB11 PCB52 Emerging chemicals Assessment

Epidemiology of burns and scalds in children presenting to the emergency department of a regional burns unit: a 7-year retrospective study

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Burns & Trauma 2016年第3期4卷 245-250页

作者： Ceri elisabeth Battle Vanessa Evans Karen James Katherine Guy Janet Whitley Phillip Adrian Evans Department of Emergency Medicine NISCHR Haemostasis Biomedical Research UnitMorriston HospitalSwanseaUK Department of Physiotherapy Morriston HospitalSwanseaUK Department of Emergency Medicine NISCHR Haemostasis Biomedical Research UnitMorriston HospitalSwanseaUK Department of Physiotherapy Morriston HospitalSwanseaUK Department of Emergency Medicine Morriston HospitalSwanseaWales SA66NLUK

Background:Variation in the incidence and mechanism of thermal injury has been reported in different age groups in *** aim of this study was to report the incidence,mechanisms,and environmental factors of all burns presentations to the emergency department(ED)of a regional burns centre over a 7-year ***:A retrospective,chart review study of all burns presentations to the ED of a regional burns centre in South Wales was *** children recorded as having sustained a burn or scald,aged less than 16 years were included in the ***’demographics were analysed using descriptive statistics,and comparisons were made between patients aged less than 5 and patients aged 5-16 using chi-square test and Mann-Whitney U ***:A total of 1387 cases were included in the final *** were the most common thermal injury with 569(41.0%)reported,followed by contact burns in 563(40.6%)*** patients requiring hospitalisation were significantly younger(2 vs 3 years;p<0.001)and had a higher rate of non-accidental injury(10 vs 4;p<0.001).The most commonly injured site in both age groups was a hand or ***:Scalds and contact burns were the most commonly reported thermal injury in children aged less than *** mechanisms were hot beverages,hobs and hair straighteners,highlighting further burn prevention strategies are needed and good-quality prospective studies that investigate the effectiveness of such strategies.

关键词： Burns epidemiology Paediatrics Emergency department