CONTEXT:Reduced expression of somatostatin receptors(SSTRs)in somatotroph adenomas and their potential down-regulation after medical treatment may explain the unsatisfactory response to octreotide in particular acrome...
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CONTEXT:Reduced expression of somatostatin receptors(SSTRs)in somatotroph adenomas and their potential down-regulation after medical treatment may explain the unsatisfactory response to octreotide in particular acromegalic *** expression of SSTRs other than SSTR2a has not been studied in large,unselected cohorts using novel rabbit monoclonal ***:We aimed to determine the expression of SSTRs 1,2a,3,and 5 in somatotroph adenomas,to correlate expression with clinical characteristics and the response to octreotide,and to ascertain whether preoperative octreotide treatment affected SSTR ***,SETTING,PATIENTS:The study included 75 adenomas from patients operated on consecutively during 2000 to *** exclusion of 13 patients,immunohistochemical analysis with rabbit monoclonal antibodies against SSTRs 1,2a,3,and
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