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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria jim.nez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano Sergei A.Kirov Jesús M.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

Origin of light emission and enhanced Eu^(3+) photoluminescence in tin-containing glass

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Journal of Rare Earths 2015年第1期33卷 27-32页

作者： José A.jim.nez Esteban Rosim Fachini Department of Chemistry University of North FloridaJacksonville FL 32224 USA Department of Physical Sciences General Studies Faculty University of Puerto RicoRío Piedras PR 00931 USA

A barium-phosphate glass matrix was co-doped with Sn O and Eu2O3 for investigating on material luminescent properties. Optical absorption and X-ray photoelectron spectroscopy（XPS） were employed in the characterization of tin species. The prevalence of divalent tin was indicated by the XPS data in accord with a conspicuous absorption band detected around 285 nm ascribed to twofold-coordinated Sn centers（isoelectronic with Sn^2＋）. Photoluminescence（PL） excitation spectra obtained by monitoring Eu^3＋ emission from the 5D0 state revealed a broad excitation band from about 250 to 340 nm, characteristic of donor/acceptor energy transfer. Under excitation of such at 290 nm, the co-doped material exhibited a bright whitish luminescence, and a four-fold enhanced Eu3＋ emission relative to a purely Eu-doped reference. Time-resolved PL spectra recorded under the excitation at 290 nm exposed a broad band characteristic of the twofold-coordinated Sn centers and emission bands of Eu^3＋ ions, which appeared well separated in time in accord with their emission decay dynamics. The data suggested that light absorption took place at the Sn centers（donors） followed by energy transfer to Eu^3＋ ions（acceptors） which resulted in populating the 5D0 emitting state. Energy transfer pathways likely resulting in the enhanced Eu3＋ photoluminescence and the consequential light emission were discussed.

关键词： energy transfer glasses luminescence optical materials rare earths

A DYNAMICS APPROACH TO THE COMPUTATION OF EIGENVECTORS OF MATRICES

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Journal of Computational Mathematics 2005年第6期23卷 657-672页

作者： S. jim.nez L. Vézquez Colaborador honorifico Dept. Matemátiea AplicadaUniversidad Complutense de Madrid 28040 Madrid Spain Dept. Matemdtica Aplicada Facultad de Informática Universidad Complutense de Madrid 28040 Madrid Spain Centro de Astrobiologla CSIC/INTA 28850 Torrejón de Ardoz Madrid Spain

We construct a family of dynamical systems whose evolution converges to the eigenvectors of a general square matrix, not necessarily symmetric. We analyze the convergence of those systems and perform numerical tests. ... 详细信息

关键词： Smallest real eigenvalue Iterative method

Effect of rhenium on the microstructure and mechanical behavior of Fe–2.25Cr–1.6W–0.25V-0.1C bainitic steels

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Journal of Materials Science & Technology 2017年第12期33卷 1487-1493页

作者： José Antonio jim.nez Manuel Carsí Oscar Antonio Ruano Department of Physical Metallurgy Centro Nacional de lnvestigaciones MetalurgicasC.S.I.CAvda.Gregorio del Amo 828040 MadridSpain

A new ferritic creep resistant steel has been developed by eliminating Nb and adding 1.5 mass % Re to a ferritic steel grade T/P23 with the aim of enhancing its mechanical properties at high *** ingots of both steels, new grade and ASTM T/P 23, were hot rolled at 900℃ and then submitted to a thermal treatment consisting of solubilization at 1050℃ and tempering at 700℃. Tempered bainitic microstructures obtained contain second phases reinforcing carbide particles, mainly M_6C and M_（23）C_6 at the boundaries of both, prior austenite grains and bainitic ferrite laths, as well as MC within the grains. Mechanical properties at temperatures ranging from 540 to 600℃ were studied by strain-ratechange tests in compression at strain rates between 10^（-7） and 10^（-4）s^（-1）. These tests showed high stress exponents（n ≥ 20） and activation energies（Q ≈ 400 k J/mol） for both alloys, which were associated with a dislocation movement mechanism with a strong interaction between dislocations and precipitates. On the other hand, a creep exponent of 5 was derived for the stress dependence of minimum creep rate from conventional-type creep tests at 600℃. Although this stress exponent is usually related to a dislocation climb controlled creep mechanism, remarkable microstructural degradation observed with increasing creep time makes difficult to elucidate the true deformation mechanism controlling creep.

关键词： Creep resistant steel T/P23 Thermal treatment Tempered bainite High temperature mechanical properties Creep

Attaching CF_(3) groups to organic molecules using trifluoroacetates via ion-shielding photoelectrocatalysis

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Science China Chemistry 2024年第11期67卷 3495-3497页

作者： Paula Visiedo-jim.nez Francisco Juliá-Hernández Departamento de Química Inorgánica Facultad de QuímicaUniversidad de MurciaCampus de EspinardoMurcia 30100Spain

Fluorinated molecules play a protagonist role in pharmaceuticals, agrochemicals, and materials. The incorporation of fluoroalkyl groups into organic compounds provides them with unique chemical properties that are key... 详细信息

关键词： materials groups compounds

Eventual Leader Election with Weak Assumptions on Initial Knowledge,Communication Reliability,and Synchrony

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Journal of Computer Science & Technology 2010年第6期25卷 1267-1281页

作者： Antonio Fernndez Anta Ernesto jim.nez Michel Raynal Institute IMDEA Networks Avenida del Mar Mediterraneo EUI Universidad Politcnica de Madrid IRISA Universit de Rennes

This paper considers the eventual leader election problem in asynchronous message-passing systems where an arbitrary number t of processes can crash（t〈n,where n is the total number of processes）.It considers weak assumptions both on the initial knowledge of the processes and on the network *** precisely,initially,a process knows only its identity and the fact that the process identities are different and totally ordered（it knows neither n nor t）.Two eventual leader election protocols and a lower bound are *** first protocol assumes that a process also knows a lower bound α on the number of processes that do not *** protocol requires the following behavioral properties from the underlying network：the graph made up of the correct processes and fair lossy links is strongly connected,and there is a correct process connected to（n〈f）-α other correct processes（where f is the actual number of crashes in the considered run） through eventually timely paths（paths made up of correct processes and eventually timely links）.This protocol is not communication-efficient in the sense that each correct process has to send messages *** second protocol is communication-efficient：after some time,only the final common leader has to send messages *** protocol does not require the processes to know α,but requires stronger properties from the underlying network：each pair of correct processes has to be connected by fair lossy links（one in each direction）,and there is a correct process whose n〈f-1 output links to the rest of correct processes have to be eventually timely.A matching lower bound result shows that any eventual leader election protocol must have runs with this number of eventually timely links,even if all processes know all the processes *** addition to being communication-efficient,the second protocol has another noteworthy efficiency property,namely,be the run finite or infinite,all the local variables and message fields have

关键词： eventually timely and fair lossy links eventual leader election failure detector omega leader oracle process initial knowledge

Natural sediment at a dam and its inorganic materials as adsorbents of praseodymium(Pr(Ⅲ))

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International Journal of Sediment Research 2023年第4期38卷 566-575页

作者： Melania jim.nez-Reyes Jaime jim.nez-Becerril Marcos Solache-Ríos Perla Tatiana Almazán-Sánchez Departamento de Química Instituto Nacional de Investigaciones Nucleares Carretera México-Toluca S/N CONACy T-Instituto Nacional de Investigaciones Nucleares

The sediment deposited behind a dam(DS) and its inorganic materials(IM-DS) were characterized and used for the removal of praseodymium(Pr) from aqueous solutions. Quartz, albite, and kaolinite were found in the sediment by X-ray diffraction. Kinetic data fit well to a pseudo second-order model, the equilibrium time for DS and IM-DS was 2 h and 3 min, respectively, and the adsorption capacity was higher for Pr/DS(qe= 4.91 mg/g) than for Pr/IM-DS(qe= 3.01 mg/g) in these conditions. Pr/DS and Pr/IM-DS data isotherms were in agreement with the Langmuir-Freundlich model and the maximum adsorption capacities were 4.95 and 4.01 mg/g, respectively. Both processes are exothermic(enthalpy change, ΔH0=-22.8 and-21.8 k J/mol for DS and IM-DS, respectively), the increase of the randomness is small, and the feasibility and spontaneity are low. Praseodymium was desorbed by ethylenediaminetetraacetic acid disodium(EDTA-Na2), sodium chloride, nitric, citric, and humic acids solutions, and one hundred percent of praseodymium was desorbed by the EDTA-Na2solution. The Pr2(EDTA)3(praseodymium ethylenediaminetetraacetate) complex was completely desorbed from both materials(DS and IM-DS). Distribution coefficients(KD) depend upon praseodymium concentration,temperature, p H, and the kind of adsorbent. Chemical reactions of praseodymium with kaolinite and iron minerals could explain the adsorption.

关键词： Praseodymium Sediment Adsorption process parameters Desorption

Sex differences in Alzheimer's disease:an urgent research venue to follow

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Neural Regeneration Research 2024年第12期19卷 2569-2570页

作者： Raquel jim.nez-Herrera Ana Contreras Juan D.Navarro-López Lydia jim.nez-Díaz Neurophysiology&Behavior Lab University of Castilla-La ManchaSchool of Medicine of Ciudad RealCiudad RealSpain

Due to increasing life expectancy,the amount of people with dementia worldwide is expected to experience a substantial rise,with estimates indicating a growth from 55 million in 2019 to a staggering 139 million by the... 详细信息

关键词： Alzheimer predominant estimates

Processing of Aerosol Particles in Convective Cumulus Clouds:Cases Study in the Mexican East Pacific

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Advances in Atmospheric Sciences 2010年第6期27卷 1331-1343页

作者： José C.jim.nez-ESCALONA Oscar PERALTA ESIME UP Ticomán National Polytechnic Institute Chemistry Faculty National Autonomous University of MexicoCiudad Universitaria

In the Mexican Intertropical Convergence Zone, particle size distributions within 500 m of cloud boundaries at altitudes of 1000, 2500, and 4200 m, were compared against size distributions at the same levels but 1500 m away from the clouds. The differences in the distributions near and far from the cloud are related to processes that may change particle properties inside the cloud. Chemical changes in the aerosols are deduced from the particles＇ refractive index, as derived from comparisons with the scattering coeflcient measured by a nephelometer. An analysis of ten cloud systems indicates that vertical transport of cloud base aerosol followed by entrainment/detrainment is the cloud processing signature most frequently observed in the comparisons （65%）. Changes in the chemical composition are observed in approximately 20% of the cases and another 20% of the cases showed removal by precipitation. About 5% of the comparisons showed clear evidence of changes by coalescence. The principal effect of these cloud-processed aerosols is observed in the increase of optical depth in the layer from 30 m to 4200 m in the near-cloud regions, in comparison with the atmosphere further from clouds.

关键词： cloud processing cloud interaction scattering redistribution entrainment