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Diagnostic delay in inflammatory bowel diseases in a German population

World Journal of Gastroenterology 2024年第29期30卷 3465-3478页

作者： elisabeth blüthner Annalena Dehe Carsten Büning Britta Siegmund Matthias Prager Jochen Maul Alexander Krannich Jan Preiß Bertram Wiedenmann Florian Rieder Raneem Khedraki Frank Tacke Andreas Sturm Anja Schirbel Department of Hepatology and Gastroenterology Campus Virchow-Klinikum and Campus CharitéMitteCharité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Vivantes Klinikum im FriedrichshainBerlin 10249Germany Department of Internal Medicine Krankenhaus WaldfriedeBerlin 14163Germany Department of Gastroenterology Infectious Diseases and RheumatologyCharité-Universitätsmedizin BerlinBerlin 12203Germany Praxis für Gastroenterologie Berlin Zehlendorf Berlin 14195Germany Gastroenterologie am Bayrischen Platz Berlin 10825Germany Clinical Trial Office Charité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Diabetology and HepatologyVivantes Klinikum NeuköllnBerlin 10117Germany Department of Gastroenterology Hepatology and NutritionDigestive Diseases and Surgery InstituteThe Cleveland Clinic FoundationClevelandOH 44195United States Department of Internal Medicine DRK Kliniken Berlin WestendBerlin 14050Germany Gastroenterologie im Havelland Straße der EinheitFalkensee 14612Germany

BACKGROUND Early diagnosis is key to prevent bowel damage in inflammatory bowel disease(IBD).Risk factor analyses linked with delayed diagnosis in European IBD patients are scarce and no data in German IBD patients *** To identify risk factors leading to prolonged diagnostic time in a German IBD *** Between 2012 and 2022,430 IBD patients from four Berlin hospitals were enrolled in a prospective study and asked to complete a 16-item questionnaire to determine features of the path leading to IBD *** diagnostic time was defined as the time from symptom onset to consulting a physician(patient waiting time)and from first consultation to IBD diagnosis(physician diagnostic time).Univariate and multivariate analyses were performed to identify risk factors for each time *** The total diagnostic time was significantly longer in Crohn’s disease(CD)compared to ulcerative colitis(UC)patients(12.0 vs 4.0 mo;P<0.001),mainly due to increased physician diagnostic time(5.5 vs 1.0 mo;P<0.001).In a multivariate analysis,the predominant symptoms diarrhea(P=0.012)and skin lesions(P=0.028)as well as performed gastroscopy(P=0.042)were associated with longer physician diagnostic time in CD *** UC,fever was correlated(P=0.020)with shorter physician diagnostic time,while fatigue(P=0.011)and positive family history(P=0.046)were correlated with longer physician diagnostic *** We demonstrated that CD patients compared to UC are at risk of long diagnostic *** efforts should focus on shortening the diagnostic delay for a better outcome in these patients.

关键词： Diagnostic time Diagnostic delay Crohn’s disease Ulcerative colitis Germany

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ARCHIMEDES'PRINCIPLE OF FLOTATION AND FLOATING BODIES:CONSTRUCTION,EXTENSIONS AND RELATED PROblEMS

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Acta Mathematica Scientia 2025年第1期45卷 237-256页

作者： Chunyan LIU elisabeth M.WERNER Deping YE 张宁 School of Mathematics and Computer Science Wuhan Polytechnic UniversityWuhan430048China Department of Mathematics Case Western Reserve UniversityClevelandOH44106USA Department of Mathematics and Statistics Memorial University of NewfoundlandSt.John’sNewfoundlandCanadaA1C 5S7 Department of Mathematics and Statistics Memorial University of NewfoundlandSt.John’sSchool of Mathematics and StatisticsHuazhong University of Science and Technology1037 Luoyu RoadWuhan430074China

In this article,we explain how the famous Archimedes’principle of flotation can be used to construct various floating *** survey some of the most important results regarding the floating bodies,including their relations with affine surface area and projection body,their extensions in different settings such as space forms and log-concave functions,and mention some associated open problems.

关键词： flfoating body affine surface area log-concave functions

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Effect of Modulen vs budesonide on clinical response and mucosal healing in Crohn’s patients

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World Journal of Gastroenterology 2025年第5期31卷 84-93页

作者： Baruch Ovadia Eva Niv Sara Stern Katie elisabeth Mahajna Oren Gal Yael Kopelman Department of Gastroenterology Hillel Yaffe Medical CenterHadera 38100HaifaIsrael Faculty of Medicine Technion-Israel Institute of TechnologyHadera 38100HaifaIsrael Department of Gastroenterology Meuhedet Health ServicesHadera 38100HaifaIsrael

BACKGROUND Mucosal healing has become an important goal of Crohn’s disease(CD)***,enriched with transforming growth factor-beta 2,and budeso-nide are commonly accepted treatments for mild-moderate ***,their effects on the small bowel(SB)mucosa remain *** To prospectively assess clinical and mucosal responses to Modulen vs budesonide in adults with CD,using SB capsule *** Thirty patients were divided into two groups:Modulen+home-based diet(21 patients)and budesonide(9 patients)for an eight-week intervention followed by four weeks of ***,laboratory,and endoscopic responses were *** mucosal changes were assessed through SB capsule *** Results indicated significant clinical improvement in the Modulen group with reduced CD activity index(P=0.041)and improved inflammatory bowel disease questionnaire score(P=0.016).Moreover,Modulen was associated with a signifi-cant SB mucosal improvement,evidenced by a decrease in Lewis score(P=0.027).No significant changes were observed in calprotectin or other laboratory ***,budesonide exhibited more modest clinical effects,but it improved calprotectin,hemoglobin,and C-reactive protein levels(P=0.051,P=0.014,and P=0.038,respectively).The capsule endoscopy did not reveal a significant mucosal response in the budesonide *** Both interventions have a role in CD ***,their effects differ and may complement each other:Modulen yields clinical and mucosal improvements,while budesonide primarily leads mainly to laboratory improvements.

关键词： Crohn’s disease Modulen oral polymeric diet Transforming growth factor-beta 2 Budesonide Mucosal healing Clinical response Capsule endoscopy Small bowel capsule

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3-Dimensional Skew-symmetric Algebras and the Variety of Horn-Lie Algebras

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Algebra Colloquium 2018年第4期25卷 547-566页

作者： elisabeth Remm LMIA Universite de Hante-A1sace (LMIAEA 3993)F-68100 MulhouseFrance

An algebra is called skew-symmetric if its multiplication operation is a skew-symmetric bilinear *** determine all these algebras in dimension 3 over a field of characteristic different from *** an application,we dete... 详细信息

关键词： 3-dimensional skew-symmetric algebras variety of Hom-Lie algebras

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MicroTAS 2011:Microfluidics in Seattle

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Science China Chemistry 2012年第4期55卷 550-551页

作者： VERPOORTE elisabeth Pharmaceutical Analysis Department of Pharmacy University of Groningen Antonius Deusinglaan 1 9713AV Groningen The Netherlands

Though the labonachip or microfluidics field can nov be considered well established and perhaps even maturafter more than two decades, it continues to grow. Type il ＂lab chip＂ or ＂microfluidics＂ into the Web of ScienceTM ant you＇ll see what I mean. At the time of writing this article there were 8029 published items, which had been citer 100,676 times altogether. An astounding number in fact ＂lab chip＂ or ＂microfluidics＂ has an Hindex of 131, asta tistic that many chemists, analytical or otherwise, have con tributed to over the years. The number of published paper continues to increase with each successive year, with mort than 1400 of the 8029 articles mentioned above appearin in 2011 alone. We are offto a good start in 2012, with mort than 150 papers published in January. At this rate, the tota number of papers in 2012 will easily surpass that of 2011 Clearly, more and more researchers continue to enter tht labonachip field, ensuring a healthy and dynamic re search climate internationally.

关键词：微流体西雅图实验室芯片芯片实验室化学家论文 THT

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Use of Total Precipitable Water Classification of A Priori Error and Quality Control in Atmospheric Temperature and Water Vapor Sounding Retrieval

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Advances in Atmospheric Sciences 2012年第2期29卷 263-273页

作者： Eun-Han KWON elisabeth WEISZ School of Earth and Environmental Sciences Seoul National University Seoul 151-747 Korea Cooperative Institute for Meteorological Satellite Studies University of Wisconsin-Madison1225 West Dayton Street Madison WI 53706 USA

This study investigates the use of dynamic a priori error information according to atmospheric moistness and the use of quality controls in temperature and water vapor profile retrievals from hyperspectral infrared （IR） sounders. Temperature and water vapor profiles are retrieved from Atmospheric InfraRed Sounder （AIRS） radiance measurements by applying a physical iterative method using regression retrieval as the first guess. Based on the dependency of first-guess errors on the degree of atmospheric moistness, the a priori first-guess errors classified by total precipitable water （TPW） are applied in the AIRS physical retrieval procedure. Compared to the retrieval results from a fixed a priori error, boundary layer moisture retrievals appear to be improved via TPW classification of a priori first-guess errors. Six quality control （QC） tests, which check non-converged or bad retrievals, large residuals, high terrain and desert areas, and large temperature and moisture deviations from the first guess regression retrieval, are also applied in the AIRS physical retrievals. Significantly large errors are found for the retrievals rejected by these six QCs, and the retrieval errors are substantially reduced via QC over land, which suggest the usefulness and high impact of the QCs, especially over land. In conclusion, the use of dynamic a priori error information according to atmospheric moistness, and the use of appropriate QCs dealing with the geographical information and the deviation from the first-guess as well as the conventional inverse performance are suggested to improve temperature and moisture retrievals and their applications.

关键词： atmospheric sounding AIRS total precipitable water a priori error quality control

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Renal dysfunction in cirrhosis: acute kidney injury and the hepatorenal syndrome

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Gastroenterology Report 2017年第2期5卷 127-137,I0002页

作者： Theresa Bucsics elisabeth Krones Division of Gastroenterology and Hepatology Department of Internal Medicine IIIMedical University of ViennaViennaAustria Vienna Hepatic Hemodynamic Laboratory Medical University of ViennaViennaAustria Division of Gastroenterology and Hepatology Department of Internal MedicineMedical University of GrazGrazAustria

Renal dysfunction is a common complication of liver cirrhosis and of utmost clinical and prognostic *** with cirrhosis are more prone to developing acute kidney injury(AKI)than the non-cirrhotic ***-renal AKI,the hepatorenal syndrome type of AKI(HRS-AKI,formerly known as‘type 1’)and acute tubular necrosis represent the most common causes of AKI in *** differentiation is imperative,as treatment differs *** pre-renal AKI usually responds well to plasma volume expansion,HRS-AKI and ATN require different specific approaches and are associated with substantial *** paradigms,such as the threshold of 2.5 mg/dL for diagnosis of HRS-AKI,have recently been abolished and novel urinary biomarkers are being investigated in order to facilitate early and correct diagnosis and treatment of HRS-AKI and other forms of AKI in patients with *** review summarizes the current diagnostic criteria,as well as pathophysiologic and therapeutic concepts for AKI and HRS-AKI in cirrhosis.

关键词： liver cirrhosis acute kidney injury hepatorenal syndrome

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Missing and murdered indigenous women and girls in Canada:a new population affinity assessment technique to aid in identification using 3D technology

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Forensic Sciences Research 2022年第3期7卷 427-439页

作者： elisabeth Cuerrier-Richer Department of Anthropology University of TorontoTorontoOntarioCanada

As of 2015,204 cases of missing and murdered Indigenous women and girls(MMIWG)remained unsolved in Canada,making it a major concern for Canadian Indigenous communities,who are still pressing for the resolution of these *** forensic anthropology,the assessment of population affinity can be useful to help identify *** affinity,previously referred to as ancestry,is evaluated based on morphological analyses,which examine the size and shape of skeletal features,and metric analyses,which utilise skeletal ***,morphological analyses strongly depend on an anthropologist’s experience with human variation,which makes the analyses particularly challenging to reproduce and *** purpose of this study is to improve the rigour of morphological analyses by using 3D technology to quantify relevant cranial nonmetric population affinity *** there is currently little morphological data available for the Canadian Indigenous population,this research aims to develop a new technique that could aid in the identification of *** study comprised a total of 87 adult female crania,including 24 of Canadian Inuit origin,50 of European descent and 13 of African *** samples were imaged using photogrammetry,then analysed using a 3D shape analysis in 3DS *** show that this method is satisfactory in correctly evaluating population affinity with an accuracy of 87.36%(jackknifed:80.46%)and an average repeatability of 97%.Unfortunately,the small Canadian Indigenous sample size impacted the applicability of the results and further research will be required before the technique can be used to aid in the identification of MMIWG in Canada.

关键词： Forensic sciences forensic anthropology population affinity assessment Canadian Indigenous morphological analyses cranial traits 3D shape analysis

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Solid dispersions of quercetin-PEG matrices:Miscibility prediction,preparation and characterization

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Food Bioscience 2022年第5期49卷 236-245页

作者： elisabeth Van Hecke Mohammed Benali Universite de Technologie de Compiegne ESCOMTIMR(Integrated Transformations of Renewable Matter)Centre de Recherche RoyallieuCEDEX CS 6031960203CompiegneFrance

Quercetin is a bioflavonoid compound with low water solubility in both foods and the gastrointestinal tract,which limits the exploitation of its health-promoting *** study aims to formulate solid dispersions(SDs)of quercetin with hydrophilic polyethylene glycol PEG matrices,using the melt-mixing method,to improve the dissolution and antioxidant activity of ***,the total Gibbs free energy for different binary mixtures was modelled to predict the miscibility of the ***,the physicochemical properties of the formulated SDs were characterised and dissolution tests and antioxidant activity measurements were performed in vitro to evaluate the improved profiles and antioxidant activity of the SDs *** group contribution methods of Hoy and Van Krevelen and Hoftyzer,used for PEG solubility parameter calculations,presented a suitable prediction of interaction and miscibility *** results suggested the presence of amorphous quercetin precipitates in the crystalline matrix of PEG 4000 and PEG 6000,and the formation of an amorphous SD between quercetin and PEG *** formulations achieved good radical scavenging activity and better dissolution,especially the quercetin-PEG 1000 SDs.

关键词： Solid dispersion Quercetin PEG Solubility parameters Miscibility Radical scavenging activity

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From Academic Nitpicking to a =New Culture Movement＇： How Newspapers Turned Academic Debates into the Center of ~May Fourth＂

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Frontiers of History in China 2014年第4期9卷 534-557页

作者： elisabeth Forster Faculty of History University of Oxford Oxford OX 1 2RL United Kingdom

Abstract In early 1919, people like Hu Shi and Chen Duxiu were regarded as members of an ivory-tower ＂academic faction＂（xuepai）, embroiled in a debate with an opposing ＂faction.＂ After the May Fourth demonstrations, they were praised as the stars of a ＂New Culture Movement.＂ However, it was not obvious how the circle around Hu Shi and Chert Duxiu was associated with the May Fourth demonstrations. This link hinged on the way in which newspapers like Shenbao reported about the academic debates and the political events of May Fourth. After compartmentalizing the debating academics into fixed xuepai, Shenbao ascribed warlord-political allegiances to them. These made the Hu-Chen circle look like government victims and their ＂factional＂ rivals like the warlords＇ allies. When the atmosphere became hostile to the government during May Fourth, Hu Shi＇s ＂faction＂ became associated with the equally victimized May Fourth demonstrators. Their ideas were regarded as （now popular） expressions of anti-government sentiment, and soon this was labeled the core of the ＂New Culture Movement.＂ The idea and rhetoric of China＇s ＂New Culture Movement＂ in this way emerged out of the fortuitous concatenation of academic debates, newspaper stories, and political events.

关键词： May Fourth Movement New Culture Movement Shenbao academicfactions (xuepai) Chinese newspapers

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