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Energy and AI 2024年第2期16卷 269-276页

作者： Daniel Vila elisabeth Hornberger Christina Toigo STOFF2 GmbH–Gebäude H/Flughafen Tegel 1 13405 BerlinGermany University of Applied Sciences Upper Austria Stelzhamerstraße 23A-4600 WelsAustria Centre for Economic Research on Inclusivity and Sustainability at the University of Galway University RoadGalwayIreland

The intermittency of renewable energy is a key limiting factor for the successful decarbonization of both energy producing and consuming sectors. Green hydrogen has the potential to act as the central energy vector connecting hard-to-abate sectors to renewable power. However, combining energy storage and conversion for a holistic electrolyzer system remains challenging. Here, we show the innovative Zink-Zwischenschritt Elektrolyseur (ZZE), or Zinc Intermediate step Electrolyzer in English, that temporarily decouples the water splitting reaction and uses zinc to store electrical energy in chemical form. To perform optimal operation of a ZZE system, machine learning models were applied to predict the state of charge of a lab scale ZZE system. Using various models, we were able to determine the effectiveness of the prediction and contrast it to state of charge predictions of other energy storage systems. We show that a bi-directional long short-term memory neural network approach has the lowest error within the testing environment. This work serves to perform further ZZE development as well as state of charge prediction for other novel energy storage technologies.

关键词： Electrolyzer Battery ZZE Energy storage State of charge Machine learning Sequence-to-sequence model

Fluid-rock interaction experiments with andesite at 100℃ for potential carbon storage in geothermal reservoirs

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Deep Underground Science and Engineering 2024年第3期3卷 369-382页

作者： Grace E.Belshaw elisabeth Steer Yukun Ji Herwin Azis Benyamin Sapiie Bagus Muljadi Veerle Vandeginste School of Chemistry University of NottinghamNottinghamUK GeoEnergy Research Centre University of NottinghamNottinghamUK British Geological Survey KeyworthUK State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhouChina PT Supreme Energy JakartaIndonesia Faculty of Earth Sciences and Technology Institut Teknologi BandungBandungIndonesia Faculty of Engineering University of NottinghamNottinghamUK Department of Materials Engineering KU LeuvenCampus BrugesBrugesBelgium

Geothermal energy extraction often results in the release of naturally occurring carbon dioxide(CO_(2))as a *** on carbon storage using volcanic rock types other than basalt under both acidic and elevated temperature conditions has been limited so *** study uses batch reactor experiments at 100℃ to investigate the dissolution of andesite rock samples obtained from an active geothermal reservoir in Sumatra(Indonesia).The samples are subjected to reactions with neutral-pH fluids and acidic fluids,mimicking the geochemical responses upon reinjection of geothermal fluids,either without or with dissolved acidic gases,*** elemental analysis reveals the release of Ca^(2+)ions into the fluids through the dissolution of *** overall dissolution rate of the rock samples is 2.4×10^(–11)to 4.2×10^(–11)mol/(m^(2)·s),based on the Si release during the initial 7 h of the *** dissolution rates are about two orders of magnitude lower than those reported for basaltic rocks under similar reaction *** study offers valuable insights into the potential utilization of andesite reservoirs for effective CO_(2) storage via mineralization.

关键词： andesite carbon sequestration geothermal reservoirs plagioclase dissolution

What makes residents participate in the rural toilet revolution?

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Environmental Science and Ecotechnology 2024年第3期19卷 23-25页

作者： Yong Li Shikun Cheng Xingyu Chen Mingjun Gao Cong Chen elisabeth-Maria Huba Zifu Li John Crittenden Tianxin Li School of Energy and Environmental Engineering Beijing Key Laboratory of Resource-oriented Treatment of Industrial PollutantsUniversity of Science and Technology BeijingXueyuan Road No.30Haidian DistrictBeijing100083PR China School of Economics and Management University of Science and Technology BeijingXueyuan Road No.30Haidian DistrictBeijing100083PR China German Toilet Organization Paulsenstr.2312163BerlinGermany Brook Byers Institute for Sustainable Systems Georgia Institute of TechnologyAtlanta30332GAUnited States

Recent data reveals a staggering reality:as of 2020,approximately 3.6 billion individuals across the globe remain devoid of proper sanitation services[1].Worldwide governmental and nongovernmental organisations are dedicatedly engaged in the arduous task of ameliorating living standards by providing secure sanitation ***,a recurring challenge persists,with these initiatives frequently encountering setbacks,especially in rural areas.

关键词： services governmental rural

Rumen microbial degradation of bromoform from red seaweed(Asparagopsis taxiformis)and the impact on rumen fermentation and methanogenic archaea

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Journal of Animal Science and Biotechnology 2024年第1期15卷 412-426页

作者： Pedro Romero Alejandro Belanche elisabeth Jiménez Rafael Hueso Eva Ramos-Morales Joan King Salwen Ermias Kebreab David R.Yáñez-Ruiz Estacion Experimental del Zaidin Consejo Superior de Investigaciones Cientificas(CSIC)Profesor Albareda 1Granada 18008Spain Department of Animal Production and Food Sciences University of ZaragozaMiguel Servet 177Saragossa 50013Spain Blue Ocean Barns Inc. Redwood CityCAUSA Department of Animal Science University of CaliforniaDavisCA 95618USA

Background The red macroalgae Asparagopsis is an effective methanogenesis inhibitor due to the presence of halogenated methane(CH_(4))analogues,primarily bromoform(CHBr_(3)).This study aimed to investigate the degradation process of CHBr3 from A taxiformis in the rumen and whether this process is *** in vitro batch culture system was used according to a 2×2 factorial design,assessing two A taxiformis inclusion rates[0(CTL)and 2%DM diet(AT)]and two diets[high-concentrate(HC)and high-forage diet(HF)].Incubations lasted for 72 h and samples of headspace and fermentation liquid were taken at 0,0.5,1,3,6,8,12,16,24,48 and 72 h to assess the pattern of degradation of CHBr_(3) into dibromomethane(CH_(2)Br_(2))and fermentation ***,an in vitro experiment with pure cultures of seven methanogens strains(Methanobrevibacter smithii,Methanobrevibacter ruminantium,Methanosphaera stadtmanae,Methanosarcina barkeri,Methanobrevibacter millerae,Methanorhermobacter wolfei and Methanobacterium mobile)was conducted to test the effects of increasing concentrations of CHBr3(0.4,2,10and 50μmol/L).Results The addition of AT significantly decreased CH_(4) production(P=0.002)and the acetate:propionate ratio(P=0.003)during a 72-h *** concentrations of CHBr_(3) showed a rapid decrease with nearly 90%degraded within the first 3 h of *** the contrary,CH_(2)Br_(2) concentration quickly increased during the first 6 h and then gradually decreased towards the end of the *** CHBr_(3) degradation nor CH_(2)Br_(2) synthesis were affected by the type of diet used as substrate,suggesting that the fermentation rate is not a driving factor involved in CHBr_(3)*** in vitro culture of methanogens showed a dose-response effect of CHBr3 by inhibiting the growth of ***,***,***,***,***,***,and *** The present work demonstrated that CHBr_(3) from *** is quickly degrad

关键词： Bromoform metabolism Dibromomethane metabolism Methane mitigation Methanogens Rumen microbiota Seaweed

Integrated adsorption and photocatalytic removal of methylene blue dye from aqueous solution by hierarchical Nb_(2)O_(5)@PAN/PVDF/ANO composite nanofibers

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Nano Materials Science 2024年第1期6卷 96-105页

作者： Aditya Rianjanu Kurniawan Deny Pratama Marpaung elisabeth Kartini Arum Melati Rizky Aflaha Yudha Gusti Wibowo I Putu Mahendra Nursidik Yulianto Januar Widakdo Kuwat Triyana Hutomo Suryo Wasisto Tarmizi Taher Department of Materials Engineering Institut Teknologi SumateraTerusan RyacuduWay HuiJati AgungLampung Selatan35365Indonesia Center for Green and Sustainable Materials Institut Teknologi SumateraTerusan RyacuduWay HuiJati AgungLampung Selatan35365Indonesia Department of Environmental Engineering Institut Teknologi SumateraTerusan RyacuduWay HuiJati AgungLampung Selatan35365Indonesia Department of Physics Faculty of Mathematics and Natural SciencesUniversitas Gadjah MadaSekip Utara PO Box BLS 21Yogyakarta55281Indonesia Department of Mining Engineering Institut Teknologi SumateraTerusan RyacuduWay HuiJati AgungLampung Selatan35365Indonesia Department of Chemistry Institut Teknologi SumateraTerusan RyacuduWay HuiJati AgungLampung Selatan35365Indonesia Research Center for Photonics National Research and Innovation Agency(BRIN)Kawasan Puspitek SerpongTangerang Selatan15314Indonesia Department of Physics Faculty of Mathematics and Natural SciencesUniversitas IndonesiaDepok16424Indonesia PT Nanosense Instrument Indonesia UmbulharjoYogyakarta55167Indonesia Department of Chemical Engineering Faculty of EngineeringUniversitas Gadjah MadaJl Grafika No.2Yogyakarta55281Indonesia

This work presents the development of hierarchical niobium pentoxide(Nb_(2)O_(5))-based composite nanofiber membranes for integrated adsorption and photocatalytic degradation of methylene blue(MB)pollutants from aqueous *** Nb_(2)O_(5) nanorods were vertically grown using a hydrothermal process on a base electrospun nanofibrous membrane made of polyacrylonitrile/polyvinylidene fluoride/ammonium niobate(V)oxalate hydrate(Nb_(2)O_(5)@PAN/PVDF/ANO).They were characterized using field-emission scanning electron microscopy(FE-SEM),X-ray diffraction(XRD)analysis,and Fourier transform infrared(FTIR)*** composite nanofibers possessed a narrow optical bandgap energy of 3.31 eV and demonstrated an MB degradation efficiency of 96%after 480 min contact *** pseudo-first-order kinetic study was also conducted,in which Nb_(2)O_(5)@PAN/PVDF/ANO nanofibers have kinetic constant values of 1.29×10^(-2) min^(-1) and 0.30×10^(-2) min^(-1) for adsorption and photocatalytic degradation of MB aqueous solutions,*** values are 17.7 and 7.8 times greater than those of PAN/PVDF/ANO nanofibers without Nb_(2)O_(5) *** their outstanding photocatalytic performance,the developed membrane materials exhibit advantageous characteristics in recycling,which subsequently widen their practical use in environmental remediation applications.

关键词： Hierarchical nanostructure Composite nanofiber Niobium pentoxide Dye degradation Synergetic adsorption and photocatalysis

Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2233-2240页

作者： Joaquina Martínez-Galán Cristina Jiménez-Luna Isabel Rodriguez elisabeth Maza Carlos García-Collado Antonio Rodríguez-Fernández Javier Luis López-Hidalgo Octavio Caba Department of Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain Instituto de Investigación Biosanitaria Ibs.GranadaGranada 18012Spain Institute of Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain Pharmacogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain Department of Medicina Nuclear Virgen de las Nieves University HospitalGranada 18014Spain Department of Anatomía Patológica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGROUND Metastatic pancreatic ductal adenocarcinoma(PDAC)is a lethal malignancy with dispiriting survival *** is a promising approach to many cancer types,but achieves poor outcomes in advanced PDAC due to its immunosuppressive tumor *** describe a case of metastatic PDAC effectively treated with *** SUMMARY We report the case of a 67-year-old woman with unresectable locally advanced PDAC,treated with gemcitabine plus nab-paclitaxel followed by radiotherapy plus *** nine months,pancreatic tumor progression was observed at the level of the hepatic hilum with the appearance of a new pulmonary nodule suggestive of a second primary,confirmed by left lung *** immunotherapy was then initiated with pembrolizumab,an immune checkpoint inhibitor targeting programmed cell death protein-1 that covers the two tumor *** patient showed a complete metabolic response that was maintained throughout the *** patient continues to be disease-free at 5.6 years since the start of *** These results suggest that the administration of pembrolizumab after chemoradiotherapy has a beneficial effect in patients with metastatic *** our knowledge,this is the first reported case of a patient with metastatic PDAC and metastatic lung cancer showing such a long-lasting complete response after pembrolizumab treatment without curative *** studies are required to determine biomarkers that identify PDAC patients most likely to benefit from this immunotherapy.

关键词： Pancreatic ductal adenocarcinoma Lung cancer Immunotherapy Pembrolizumab Programmed cell death protein-1 Case report

Diagnostic delay in inflammatory bowel diseases in a German population

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World Journal of Gastroenterology 2024年第29期30卷 3465-3478页

作者： elisabeth Blüthner Annalena Dehe Carsten Büning Britta Siegmund Matthias Prager Jochen Maul Alexander Krannich Jan Preiß Bertram Wiedenmann Florian Rieder Raneem Khedraki Frank Tacke Andreas Sturm Anja Schirbel Department of Hepatology and Gastroenterology Campus Virchow-Klinikum and Campus CharitéMitteCharité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Vivantes Klinikum im FriedrichshainBerlin 10249Germany Department of Internal Medicine Krankenhaus WaldfriedeBerlin 14163Germany Department of Gastroenterology Infectious Diseases and RheumatologyCharité-Universitätsmedizin BerlinBerlin 12203Germany Praxis für Gastroenterologie Berlin Zehlendorf Berlin 14195Germany Gastroenterologie am Bayrischen Platz Berlin 10825Germany Clinical Trial Office Charité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gastroenterology Diabetology and HepatologyVivantes Klinikum NeuköllnBerlin 10117Germany Department of Gastroenterology Hepatology and NutritionDigestive Diseases and Surgery InstituteThe Cleveland Clinic FoundationClevelandOH 44195United States Department of Internal Medicine DRK Kliniken Berlin WestendBerlin 14050Germany Gastroenterologie im Havelland Straße der EinheitFalkensee 14612Germany

BACKGROUND Early diagnosis is key to prevent bowel damage in inflammatory bowel disease(IBD).Risk factor analyses linked with delayed diagnosis in European IBD patients are scarce and no data in German IBD patients *** To identify risk factors leading to prolonged diagnostic time in a German IBD *** Between 2012 and 2022,430 IBD patients from four Berlin hospitals were enrolled in a prospective study and asked to complete a 16-item questionnaire to determine features of the path leading to IBD *** diagnostic time was defined as the time from symptom onset to consulting a physician(patient waiting time)and from first consultation to IBD diagnosis(physician diagnostic time).Univariate and multivariate analyses were performed to identify risk factors for each time *** The total diagnostic time was significantly longer in Crohn’s disease(CD)compared to ulcerative colitis(UC)patients(12.0 vs 4.0 mo;P<0.001),mainly due to increased physician diagnostic time(5.5 vs 1.0 mo;P<0.001).In a multivariate analysis,the predominant symptoms diarrhea(P=0.012)and skin lesions(P=0.028)as well as performed gastroscopy(P=0.042)were associated with longer physician diagnostic time in CD *** UC,fever was correlated(P=0.020)with shorter physician diagnostic time,while fatigue(P=0.011)and positive family history(P=0.046)were correlated with longer physician diagnostic *** We demonstrated that CD patients compared to UC are at risk of long diagnostic *** efforts should focus on shortening the diagnostic delay for a better outcome in these patients.

关键词： Diagnostic time Diagnostic delay Crohn’s disease Ulcerative colitis Germany

空气质量改善与肺功能下降减缓:在SAPALDIA队列中肥胖的影响

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环境与职业医学 2013年第12期30卷 962-962页

作者： Tamara Schikowski Emmanuel Schaffner Flurina Meier Harish C.Phuleria Andrea Vierktter Christian Schindler Susi Kriemler elisabeth zemp Ursula Krmer Pierre-Olivier Bridevaux Thierry Rochat Joel Schwartz Nino Künzli Nicole Probst-Hensch

[背景]假设随着年龄的增长,空气污染和肥胖通过致炎特性加速肺功能减退。[目的]先前公布的以人口为基础的SAPALDIA队列研究中,空气质量改善与肺部健康之间是否存在关联。本文探讨肥胖是否会改变这一关联。[方法]使用校正的混合模型分析... 详细信息

[背景]假设随着年龄的增长,空气污染和肥胖通过致炎特性加速肺功能减退。[目的]先前公布的以人口为基础的SAPALDIA队列研究中,空气质量改善与肺部健康之间是否存在关联。本文探讨肥胖是否会改变这一关联。[方法]使用校正的混合模型分析,评估在10年的随访期间,平均身体质量指数(BMI)和空气动力学直径≤10μm的颗粒物变化(PM10;ΔPM10)与肺功能减退之间的关联。[结果]共获得4664人的肺功能数据和完整信息。与低或正常平均BMI者相比,高平均BMI者年龄相关的肺功能减退,其FVC(用力肺活量)指标下降得更快,而FEV1/FVC(1秒用力呼气量/FVC)和FEF25-75(在25%～75%肺活量时的用力呼气流量)下降的速度较慢。在低和正常BMI者中,空气质量改善与随着时间推移的FEV1/FVC、FEF25-75、FEF25-75/FVC下降减缓相关,但在超重或肥胖者中无相关性。这种减缓作用在ΔFEF25-75/FVC上最为明显:在低或正常体质量者中,PM10每下降10μg/m3,ΔFEF25-75/FVC下降分别为30%和22%。[结论]上述研究结果指出并列考虑空气污染暴露和肥胖对健康的影响的重要性。今后需要进一步研究所观察到的相互作用的机制。

关键词：肺功能减退空气污染质量改善队列研究肥胖者身体质量指数用力肺活量用力呼气流量

iGlarLixi与甘精胰岛素100 U/ml或利司那肽用于口服降糖药血糖控制不佳的亚太地区2型糖尿病患者的疗效和安全性:LixiLan-O-AP随机对照试验

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中国糖尿病杂志 2024年第1期32卷 76-80页

作者：杨文英(译) 董晓林(译) 李青菊(译) 成志锋(译) 袁国跃(译) 刘铭(译) 肖建中(译) elisabeth Niemoeller(译) elisabeth Souhami(译) 中日友好医院内分泌科北京100029 济南市中心医院内分泌科郑州大学第二附属医院内分泌科哈尔滨医科大学附属第四医院内分泌代谢病科江苏大学附属医院内分泌代谢科天津医科大学总医院内分泌代谢科清华大学附属北京清华长庚医院内分泌与代谢科赛诺菲

LixiLan-O-AP是一项开放性、随机、多中心、治疗24周的3期临床研究,在接受二甲双胍联合或不联合第二种口服降糖药治疗控制不佳的亚太地区T2DM患者中,比较甘精胰岛素/利司那肽固定比例复方制剂(iGlarLixi)与100 U/ml的甘精胰岛素和利司... 详细信息

LixiLan-O-AP是一项开放性、随机、多中心、治疗24周的3期临床研究,在接受二甲双胍联合或不联合第二种口服降糖药治疗控制不佳的亚太地区T2DM患者中,比较甘精胰岛素/利司那肽固定比例复方制剂(iGlarLixi)与100 U/ml的甘精胰岛素和利司那肽的疗效和安全性(临床研究注册号:NCT03798054)。该研究于2022年发表于《Diabetes,Obesity and Metabolism》(Diabetes Obes Metab2022 Apr 19),现将其主要结果摘译成中文。

关键词：口服降糖药疗效和安全性甘精胰岛素血糖控制不佳随机对照试验二甲双胍注册号复方制剂

Superficial Angiomyxoma of the Vulva: A Case Report

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Open Journal of Pathology 2024年第2期14卷 64-68页

作者： Zo Irène Raivoherivony Herilalao elisabeth Razafindrafara Vahatra Joëlle Razafimahefa Romuald Randriamahavonjy Nantenaina Soa Randrianjafisamindrakotroka Department of Pathology Joseph Ravoahangy Andrianavalona University Hospital Antananarivo Madagascar Department of Pathology Soavinandriana University Hospital Antananarivo Madagascar Department of Pathology Andrainjato University Hospital Fianarantsoa Madagascar Gyneco-Obstetrics Department Soavinandriana University Hospital Antananarivo Madagascar

Superficial angiomyxoma is a rare benign mesenchymal tumor that mainly occurs in the genital region. We report the case of a 51-year-old woman with a painless vulvar mass, well circumscribed on ultrasound. On gross finding, it was a polypoid and bilobed mass, partially encapsulated. On histological examination, it was a proliferation of non-atypical spindle cells with an abundant, myxoid stroma and numerous medium-sized blood vessels. The diagnosis was superficial angiomyxoma. The clinical features do not often lead to the diagnosis of superficial vulvar angiomyxoma. It is based on histological examination and immunohistochemistry is helpful to differentiate it from other myxoid tumors.

关键词： Angiomyxoma Mesenchymal Tumor Myxoïd Stromal Tumor of Vulva