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Neuroimmunology and Neuroinflammation 2018年第12期5卷 54-59页

作者： George P. Paraskevas Vasilios C. Constantinides elisabeth kapaki Cognitive and Movement Disorders Clinic and Neurochemistry Unit 1st Department of Neurology National and Kapodistrian University of Athens School of Medicine Eginition Hospital Athens 11528 Greece

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL), is the most common cause of inherited cerebral small vessel disease, inherited stroke and inherited vascular dementia. It is not infrequent for CADASIL to be mistaken and mistreated for multiple sclerosis (MS). A much less frequent but existing scenario is the co-occurrence of CADASIL and MS (or MS-like inflammatory condition). Such patients may present with spinal cord lesions, brain or spinal cord enhancing lesions, positive oligoclonal bands and high IgG index in the cerebrospinal fluid and good response to corticosteroids or immunomodulating treatments. CADASIL through various mechanisms may trigger or modulate autoimmune reactions, and either be complicated by an inflammatory component or cause an MS-like disorder.

关键词： Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy multiple sclerosis autoimmunity NOTCH3

The emerging TDP-43 proteinopathy

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Neuroimmunology and Neuroinflammation 2018年第5期5卷 4-6页

作者： George P.Paraskevas Mara Bourbouli Ioannis Zaganas elisabeth kapaki Cognitive and Movement Disorders Clinic and Neurochemistry Unit 1st Department of NeurologySchool of MedicineNationaland Kapodistrian University of AthensAthens11528Greece Neurology Laboratory of the Department of Neurology School of MedicineUniversity of CreteCrete71003Greece

Currently, neurodegenerative diseases are viewed as proteinopathies. In this context, a specific protein or peptide is involved in the pathogenesis of the disease by missfolding, polymerization, reduced degradation and final accumulation in the form of insoluble inclusions leading to neurodegeneration by various interacting mechanisms[1,2].

关键词： The emerging TDP-43 neurodegenerative diseases

Biomarker-based diagnosis of cognitive disorders in a case series

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Neuroimmunology and Neuroinflammation 2020年第4期7卷 319-329页

作者： elisabeth kapaki Vasilios C.Constantinides Efstratios-Stylianos Pyrgelis Panagiotis G.Paraskevas John D.Papatriantafyllou George P.Paraskevas Neurodegenerative Disorders and Neurochemistry and Biological Markers Units 1st Department of NeurologyNational and Kapodistrian University of AthensSchool of MedicineEginition HospitalAthens 11528Greece Department of Nursing Technological Educational Institute of CreteSchool of Health and Welfare ServicesHeraklionStauromenos 71004CreteGreece Third Age Day Care Center IASIS Athens-Glyfada&Memory ClinicMedical Center Athens-MarousiMaroussiAthens 15125Greece

The classical cerebrospinal fluid biomarkers of Alzheimer's Disease (namely total tau, phospho-tau and amyloid beta peptide) have received much attention, since they can detect the biochemical fingerprint of Alzheimer's disease and serve as a diagnostic aid for correct diagnosis of cognitive disorders during life. In this case series, we present 6 examples of patients with cognitive impairment of various types and severities and how biomarker data were helpful in every day diagnostic approach, combined with clinical, neuropsychological and imaging data and based on the most recent guidelines and recommendations.

关键词： Cerebrospinal fluid tau phospho-tau amyloid-beta Alzheimer’s disease frontotemporal dementia vascular cognitive impairment

Cerebrospinal fluid amyloid beta and tau proteins in atypical Parkinsonism: a review

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Neuroimmunology and Neuroinflammation 2020年第2期7卷 120-131页

作者： Vasilios C.Constantinides George P.Paraskevas Fotini Boufidou Mara Bourbouli Panagiotis G.Paraskevas Leonidas Stefanis elisabeth kapaki 1st Department of Neurology National and Kapodistrian University of AthensAthensP.C.11528Greece Department of Neurology University of CreteHeraklion 70013Greece Department of Nursing Technological Educational Institute of CreteHeraklion 71500Greece

Progressive supranuclear palsy,corticobasal degeneration,multiple system atrophy and dementia with Lewy bodies are the most common causes of atypical Parkinsonism and enter the differential diagnosis of Parkinson's *** system atrophy,dementia with Lewy bodies and Parkinson's disease are synucleinopathies,whereas progressive supranuclear palsy and corticobasal degeneration are *** cerebrospinal fluid markers have been applied on cohorts of patients with Parkinsonism,with the aim to develop biomarkers for these *** tau(τΤ),phosphorylated tau at threonine 181(τP-181)and amyloid-beta with 42 amino acids(Aβ42)are considered classical biomarkers for Alzheimer's *** aim of the present study is to review the literature regarding these classical cerebrospinal fluid biomarkers in cohorts with Parkinsonism,as well as present data on novel approaches regarding analysis of these proteins.

关键词： Biomarkers cerebrospinal fluid progressive supranuclear palsy corticobasal degeneration multiple system atrophy dementia with Lewy bodies tau protein phosphorylated tau protein amyloid beta