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Analysis of the in vitro degradation and the in vivo tissue response to bi-layered 3D-printed scaffolds combining PLA and biphasic PLA/bioglass components--Guidance of the inflammatory response as basis for osteochondral regeneration

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Bioactive Materials 2017年第4期2卷 208-223页

作者： Mike Barbeck Tiziano Serra Patrick Booms Sanja Stojanovic Stevo Najman elisabeth engel Robert Sader Charles James Kirkpatrick Melba Navarro Shahram Ghanaati Private Office BerlinGermany Institute for Bioengineering of Catalonia(IBEC) Biomaterials for Regenerative MedicineBarcelonaSpain Clinic of Oro-Maxillofacial and Plastic Surgery FORM-LabGoethe University FrankfurtFrankfurtGermany University of Ni's Faculty of MedicineDepartment for Cell and Tissue EngineeringInstitute of Biology and Human GeneticsNi'sSerbia Technical University of Catalonia(UPC) Dpt.Materials Science and MetallurgySpain CIBER en Bioingenieria Biomateriales y Nanomedicina(CIBER-BBN)Spain

The aim of the present study was the in vitro and in vivo analysis of a bi-layered 3D-printed scaffold combining a PLA layer and a biphasic PLA/bioglass G5 layer for regeneration of osteochondral defects in vivo Focus of the in vitro analysis was on the(molecular)weight loss and the morphological and mechanical variations after immersion in *** in vivo study focused on analysis of the tissue reactions and differences in the implant bed vascularization using an established subcutaneous implantation model in CD-1 mice and established histological and histomorphometrical *** scaffold parts kept their structural integrity,while changes in morphology were observed,especially for the PLA/G5 *** properties decreased with progressive degradation,while the PLA/G5 scaffolds presented higher compressive modulus than PLA *** tissue reaction to PLA included low numbers of BMGCs and minimal vascularization of its implant beds,while the addition of G5 lead to higher numbers of BMGCs and a higher implant bed *** revealed that the use of a bi-layered scaffold shows the ability to observe distinct in vivo response despite the physical proximity of PLA and PLA/G5 ***,the results showed that the addition of G5 enables to reduce scaffold weight loss and to increase mechanical ***,the addition of G5 lead to a higher vascularization of the implant bed required as basis for bone tissue regeneration mediated by higher numbers of BMGCs,while within the PLA parts a significantly lower vascularization was found optimally for chondral ***,this data show that the analyzed bi-layered scaffold may serve as an ideal basis for the regeneration of osteochondral tissue ***,the results show that it might be able to reduce the number of experimental animals required as it may be possible to analyze the tissue response to more than one implant in one experimental animal.

关键词： Bioactive glass Polylactic acid(PLA) Bi-layer scaffold Multinucleated giant cells Bone substitute Vascularization Calcium phosphate glass

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Biomolecular functionalization for enhanced cell–material interactions of poly(methyl methacrylate)surfaces 5th China-Europe Symposium on Biomaterials in Regenerative Medicine(CESB 2015)Hangzhou,China April 7–10,2015

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Regenerative Biomaterials 2015年第3期2卷 167-175页

作者： Xavier Punet Rodolphe Mauchauffe´ Jose´C.Rodrı´guez-Cabello Matilde Alonso elisabeth engel Miguel A.Mateos-Timoneda Biomaterials for Regenerative Therapies Group Institute for Bioengineering of Catalonia(IBEC)Barcelona 08028Spain CIBER en Bioingenerı´a Biomateriales y Nanomedicina(CIBER-BBN)Spain G.I.R.Bioforge Universidad Valladolid(UVA)Valladolid 47011Spain Department of Material Science and Metallurgical Engineering Technical University of Catalonia(UPC)Barcelona 08028Spain

The integration of implants or medical devices into the body tissues requires of good cell–material ***,most polymeric materials used for these applications lack on biological cues,which enhanced mid-and long-term implant failure due to weak integration with the surrounding *** used strategies for tissue–material integration focus on functionalization of the material surface by means of natural proteins or short ***,the use of these biomolecules involves major drawbacks such as immunogenic problems and oversimplification of the ***,designed elastin-like recombinamers(ELRs)are used to enhance poly(methyl methacrylate)surface properties and compared against the use of short *** this study,cell response has been analysed for different functionalization conditions in the presence and absence of a competing protein,which interferes on surface–cell interaction by unspecific adsorption on the *** study has shown that ELRs can induce higher rates of cell attachment and stronger cell anchorages than short peptides,being a better choice for surface functionalization.

关键词： cell adhesion elastin-like recombinamer poly(methyl methacrylate) PMMA RGD peptide surface modification

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