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Gastroenterology Report 2023年第1期11卷 563-565页

作者： Peter Heinz-Erian Andreas RJanecke Thomas Muller Peter Rehder elisabeth bruder Thomas Menter Heinz Zoller Markus Pirklbauer Michael Rieger Department of Pediatric and Adolescent Medicine Medical University of InnsbruckInnsbruckTyrolAustria Department of Urology Medical University of InnsbruckInnsbruckTyrolAustria Institute of Pathology University Hospital BaselBaselBaselSwitzerland Department of Internal Medicine I Medical University of InnsbruckInnsbruckTyrolAustria Department of Internal Medicine IV Medical University of InnsbruckInnsbruckTyrolAustria Department of Radiology District Hospital HallHallTyrolAustria

Introduction Chronic intestinal pseudo-obstruction(CIPO),defined as chronic constipation without mechanical obstruction of the gastrointestinal tract[1,2],often presents with a truly chameleon-like symptomatology including irregular defecation,abdominal pain and distension,nausea,vomiting,and sometimes fluid/electrolyte *** diarrhea was found in17%of CIPO cases,its nature,however,has not been precisely *** deviations of electrolyte and acid–base status,to the best of our knowledge,have not been reported.

关键词： obstruction diarrhea chronic

Route, origin & valence matter: towards sophisticated nextgeneration vaccines to cope with the COVID-19 pandemic

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2123-2125页

作者： Julia Volckmar Lars Melcher Dunja bruder Infection Immunology Group Institute of Medical MicrobiologyInfection Prevention and ControlHealth Campus ImmunologyInfectiology and InflammationOtto-vonGuericke University MagdeburgMagdeburgGermany Immune Regulation Group Helmholtz Centre for Infection ResearchBraunschweigGermany

In a recent study published in Cell,Afkhami and colleagues systematically compared different routes of vaccine delivery,origin of the vaccine platform as well as valence of the vaccine and demonstrated that the respiratory mucosal delivery of a trivalent chimpanzee’s adenovirus(Ad)-vectored vaccine is superior to any other of the tested conditions in inducing broadlyacting immunity and protection against current severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and possibly future variants of concern(VOC).1 The ongoing global coronavirus disease 2019(COVID-19)pandemic caused by SARS-CoV-2 has forced an uniquely fast development of novel mRNA-and vector-based vaccines.

关键词： vaccine vaccines immunity

Prediction-based load balancing and resolution tuning for interactive volume raycasting

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Visual Informatics 2017年第2期1卷 106-117页

作者： Valentin bruder Steffen Frey Thomas Ertl University of Stuttgart Germany

We present an integrated approach for real-time performance prediction of volume raycasting that we employ for load balancing and sampling resolution *** volume rendering,the usage of acceleration techniques such as empty space skipping and early ray termination,among others,can cause significant variations in rendering performance when users adjust the camera configuration or transfer *** variations in rendering times may result in unpleasant effects such as jerky motions or abruptly reduced responsiveness during interactive *** avoid those effects,we propose an integrated approach to adapt rendering parameters according to performance *** assess performancerelevant data on-the-fly,for which we propose a novel technique to estimate the impact of early ray *** the basis of this data,we introduce a hybrid model,to achieve accurate predictions with minimal computational *** hybrid model incorporates aspects from analytical performance modeling and machine learning,with the goal to combine their respective *** show the applicability of our prediction model for two different use cases:(1)to dynamically steer the sampling density in object and/or image space and(2)to dynamically distribute the workload among several different parallel computing *** approach allows to reliably meet performance requirements such as a user-defined frame rate,even in the case of sudden large changes to the transfer function or the camera orientation.

关键词： Volume raycasting Performance prediction Load balancing

IL-33: a jack of all trades in the orchestration of respiratory antibacterial immunity

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Cellular & Molecular Immunology 2017年第11期14卷 875-877页

作者： Julia D Boehme Dunja bruder Infection Immunology Group Institute of Medical Microbiology and Hospital HygieneOtto-von-Guericke UniversityMagdeburgGermany Immune Regulation Group Department of Immune ControlHelmholtz Centre for Infection ResearchBraunschweigGermany

Influenza A virus(IAV)is the causative agent of mostly mild to moderate seasonal respiratory infections and several pandemic outbreaks,the most recent of which was reported in *** IAV pandemics were associated with an enormous death toll;for example,the 1918 H1N1 pandemic affected hundreds of millions of people globally and resulted in~50 million deaths.1 Microbiologic analyses of patient samples revealed a strong incidence of bacterial pathogens in fatal complications of viral infection.2 To date,many pieces of epidemiologic and experimental evidence reveal pronounced susceptibility to detrimental bacterial superinfection in IAVinfected individuals.

关键词： immunity respiratory hundreds

Beware the intruder:gasodermin A as molecular guardian preventing systemic dissemination of group A streptococci following local skin infection

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Cellular & Molecular Immunology 2022年第7期19卷 761-763页

作者： Mahyar Aghapour Surender Surender Dunja bruder Infection Immunology Group Institute of Medical MicrobiologyInfection Control and PreventionHealth Campus ImmunologyInfectiology and InflammationOtto-von-Guericke UniversityMagdeburgGermany Immune Regulation Group Helmholtz Centre for Infection ResearchBraunschweigGermany

Pyroptosis represents a host-protective mechanism that promotes clearance of pathogens by initiating the recruitment of immune cells to the site of *** a study recently published in Nature,Deng et *** outlined a hitherto unknown role of the group A Streptococcus(GAS)-derived cysteine protease streptococcal pyrogenic exotoxin B(SpeB)in gasodermin A(GSDMA)cleavage as the primary step in induction of *** clearly shown in GSDMA-deficient mice infected with SpeBproducing GAS,this cleavage event is key to preventing the systemic spread and fatal course of GAS following local skin infection[1].

关键词： protective infection local

Negative elongation factor:a key factor in the maintenance of intestinal epithelial barrier integrity

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Cellular & Molecular Immunology 2022年第4期19卷 453-455页

作者： Elif Gelmez Andreas Jeron Dunja bruder Infection Immunology Group Institute of Medical MicrobiologyInfection Control and PreventionHealth Campus ImmunologyInfectiology and InflammationOtto-von-Guericke UniversityMagdeburgGermany Immune Regulation Group Helmholtz Centre for Infection ResearchBraunschweigGermany

In addition to its physiological function in the uptake of dietary nutrients,the intestinal epithelium constitutes an essential mechanical barrier separating luminal gut content and mucosal microbiota from the inner *** epithelial cells(IEC)comprise the frontline of this barrier,the maintenance of which critically depends on the expression of cell-cell junction protein structures,including tight junctions,adherence junctions,desmosomes,and gap junctions,which physically bridge and seal the intercellular niche within the IEC layer.

关键词： epithelium barrier separating

Good and bad outcomes of respiratory viral infections—influenza A virus trains sustained antitumor immunity of macrophages in the lung

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Cellular & Molecular Immunology 2023年第8期20卷 861-863页

作者： Sabine Stegemann-Koniszewski Sarah Frentzel Dunja bruder Experimental Pneumology Department of PneumologyUniversity Hospital Magdeburg/Medical FacultyHealth Campus ImmunologyInfectiology and InflammationOtto-von-Guericke University MagdeburgMagdeburgGermany Institute of Medical Microbiology and Hospital Hygiene Infection Immunology GroupHealth Campus ImmunologyInfectiology and InflammationOtto-von-Guericke University MagdeburgMagdeburgGermany Immune Regulation Group Helmholtz Centre for Infection ResearchBraunschweigGermany

In their recent article in Nature Immunology, Wang et al. showed that influenza A virus (IAV) infection trained alveolar macrophages (AMs) for sustained antitumor immunity in the lung [1], extending the concept of trained immunity and pointing out benefits of viral respiratory infection in the context of pulmonary antitumor immune surveillance.

关键词： immunity sustained respiratory

Starch Digestibility and Functional Properties of Rice Starch Subjected to Gamma Radiation

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Rice science 2018年第1期25卷 42-51页

作者： Luís Fernando POLESI Silene bruder Silveira SARMENTO Solange Guidolin CANNIATTI-BRAZACA Center for Nuclear Energy in Agriculture University of Sao Paulo Department of Food Engineering Federal University of Rondonia Department of Agri-Food Industry Food and NutritionLuiz de Queiroz College of AgricultureUniversity of Sao Paulo

This study investigated the effect of gamma radiation on the digestibility and functional properties of rice *** cultivars IRGA417 and IAC202 were used for isolation of starch by the alkaline *** samples were irradiated with 1,2 and 5 k Gy doses of ^(60)Co at a rate of 0.4 k Gy/h.A control sample,which was not irradiated,was used for *** and control starches were characterized by in vitro starch digestibility,total dietary fiber,color,water absorption index,water solubility index,syneresis,swelling factor,amylose leaching,pasting properties and gel *** changed starch digestibility differently in either *** radiation doses promoted increase in the color parameter b*(yellow),elevation in the capacity to absorb water,and solubility in water as well as the amylose leached from granules for both *** properties showed a decrease that was proportional to the dose applied,caused by the depolymerization of starch *** firmness of the starch from IAC202 was inversely proportional to the radiation dose applied,whereas for IRGA417,there was a reduction at 5 k Gy *** starches can be modified by irradiation to exhibit different functional characteristics and they can be used by the food industries in products such as soups,desserts,flans,puddings and others.

关键词： Oryza sativa irradiation viscosity swelling amylose starch digestibility

Influence of High-Speed Milling Process on Mechanical and Microstructural Properties of Ultrafine Grained Profiles Produced by Linear Flow Splitting

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Transactions of Nanjing University of Aeronautics and Astronautics 2017年第4期34卷 349-356页

作者： Abele Eberhard Müller Clemens Turan Emrah Niehuesbernd Joern bruder Enrico Falk Florian Institute of Production Management Technology and Machine Tools(PTW)Technische Universitt Darmstadt Physical Metallurgy(PhM) Technische Universitt Darmstadt

The effects of milling parameters on the surface quality,microstructures and mechanical properties of machined parts with ultrafine grained(UFG)gradient microstructures are *** effects of the cutting speed,feed per tooth,cutting tool geometry and cooling strategy are *** has been found that the surface quality of machined grooves can be improved by increasing the cutting ***,cryogenic cooling with CO_2 exhibits no significant improvement of surface *** and hardness investigations revealed similar microstructure and hardness variations near the machined groove walls for both utilized tool ***,cryogenic cooling can decrease more far-ranging hardness reductions due to high process temperatures,especially in the UFG regions of the machined parts,whilst it cannot prevent the drop in hardness directly at the groove walls.

关键词： high-speed milling ultrafine grained microstructure linear flow splitting hardness

Starch Digestibility and Physicochemical and Cooking Properties of Irradiated Rice Grains

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Rice science 2017年第1期24卷 48-55页

作者： Luís Fernando POLESI Manoel Divino da MATTA JUNIOR Silene bruder Silveira SARMENTO Solange Guidolin CANNIATTI-BRAZACA Department of Food Engineering Federal University of RondoniaAriquemes 76872-848RondoniaBrazil Department of Agroindustry Food and NutritionCollege of Agriculture Luiz de QueirozUniversity of Sao PauloPiracicaba 13418-900Sao PauloBrazil

This study evaluated the starch digestibility, physicochemical properties and cooking characteristics of polished rice（varieties IRGA417 and IAC202） subjected to the doses of 0（as the control）, 1, 2 and 5 k Gy of gamma radiation. The highest dose decreased the apparent amylose content, peak viscosity, water absorption and volume expansion. Irradiation increased the solid loss by 119% and 187% for IAC202 and IRGA417, respectively, when comparing the higher dose with the control. For IAC202, irradiation decreased the rapidly digestible starch and increased the slowly digestible starch（SDS） and resistant starch（RS）. IRGA417 showed an elevation of SDS and a reduction in RS. And 1 k Gy dose of gamma radiation generated the highest level of RS for both the two varieties and presented the smallest changes in other physicochemical and cooking properties.

关键词： starch cooking viscosity gamma irradiation grains Starch granules chains physiological