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Effects of Adjunctive Daily Blue Light Toothbrushing on Dental Plaque and Gingival Inflammation—A Randomized Controlled Study

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Open Journal of Stomatology 2018年第10期8卷 287-303页

作者： Nadja Bjurshammar Sebastian Malmqvist Gunnar Johannsen elisabeth bostrom Jonas Fyrestam Conny Ostman Annsofi Johannsen Department of Dental Medicine Division of Oral DiseasesKarolinska InstitutetHuddingeSweden Department of Chemistry-BMC Uppsala UniversityUppsalaSweden Department of Environmental Science&Analytical Chemistry Division of Analytical ChemistryStockholm UniversityStockholmSweden

Phototherapy with blue light emitting diodes (LEDs) is gaining interest because of the efficient antimicrobial benefits reported in several studies in the last decade. The aim in this study was to investigate if a toothbrush with incorporated blue light used in daily oral care can reduce dental plaque and gingival inflammation. An 8-week single-blinded randomized controlled clinical study including 48 subjects compared effects of toothbrushes with/without 450 nm blue LED light emission, on clinical parameters (plaque index, gingival index, bleeding on probing), and on inflammatory markers in saliva and gingival crevicular fluid. Significant reductions in dental plaque and gingival inflammation (p < 0.001), and in some inflammatory markers (p ≤ 0.05), matrix metalloproteinase (MMP)-8, tissue inhibitor metalloproteinase inhibitor (TIMP)-1, interleukin (IL)-1β and interleukin (IL)-8, were detected within both groups from baseline to follow-up. For all subjects dental plaque was reduced with 57%, and a reduction in gingival inflammation was demonstrated by a decrease in gingival index (GI) with 46% and in bleeding on probing (BOP) with a decrease of 15%. No significant differences were found between the groups at a level of p = 0.05. However, the amount of plaque was reduced by 62% in the blue light group and 51% in the control group, a difference established at a level of p = 0.058. A toothbrush with a 450 nm LED did not show any statistical significant adjunctive effect of toothbrushing regarding reduction in measurements of dental plaque and gingival inflammation.

关键词： Phototherapy Antimicrobial Blue Light Dental Plaque Gingival Inflammation Toothbrushing

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Polymeric Structure and Solid ^(31)P, ^(113)Cd NMR Spectra of Cadmium(II) Dialkyldithiophosphate (Alkyl = n-butyl and i-butyl)

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Chinese Chemical Letters 2003年第2期14卷 188-190页

作者： Ye Gao YIN Willis FORSLING Dan bostrom Oleg ANTZUTKIN Mats LINDBERG Alexander IVANOV Department of Chemistry Faculty of ScienceThe University of ShantouShantou 515063 Division of Inorganic Chemistry Department of Chemical and Metallurgical Engineering Lule?University of Technology.Lule?se-97187Sweden Department of Chemistry Ume UniversityUme se-90187-Sweden

Two polymeric complexes, [Cd(BTP)2]n 1 and [Cd(i-BTP)2]n 2, were prepared and investigated by solid 31P and 113Cd NMR spectroscopies. The crystal structure of 2 was determined by X-ray diffraction.

关键词： Cadmium(II) complex dialkyldithiophosphate crystal structure solid NMR.

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基于归纳学习的结构损伤识别方法研究

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西安交通大学学报 2005年第2期39卷 142-145页

作者：饶文碧谈怀江 bostrom Henrik 武汉理工大学计算机科学与技术学院武汉430070 斯特哥尔摩大学与瑞典皇家工学院计算机与系统科学系

采用归纳学习方法来识别结构损伤. 首先,通过对经典的决策树算法和序列覆盖算法进行结合与改进,得到一种高效且代价又小的归纳学习算法(RAC),同时引入装袋算法产生多个分类法,并用它们进行类预测,而且使用选票策略得出最佳类预测.其次,... 详细信息

采用归纳学习方法来识别结构损伤. 首先,通过对经典的决策树算法和序列覆盖算法进行结合与改进,得到一种高效且代价又小的归纳学习算法(RAC),同时引入装袋算法产生多个分类法,并用它们进行类预测,而且使用选票策略得出最佳类预测.其次,用正交最小二乘迭代算法作为径向基函数(RBF)神经网络的学习方法,通过“信息贡献”准则进行正交变换来优选中心.最后,对上述归纳学习方法用于梁结构损伤定位的效果进行了实验评估.结果表明,对于 RAC算法和生成分类法的数目分别为 10 和 50 情况下的装袋算法,当损伤样本被噪声污染程度在100% 时,识别精度均可达到 90% 以上,而对于 RBF神经网络算法, 只有当损伤样本被噪声污染程度小于70% 时,识别精度才可达到90%以上.

关键词：结构损伤识别规则归纳学习装袋学习算法神经网络

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Periodontitis-induced systemic inflammation exacerbates atherosclerosis partly via endothelial–mesenchymal transition in mice

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International Journal of Oral Science 2019年第3期11卷 201-212页

作者： Jin Sook Suh Sol Kim Kristina I.bostrom Cun-Yu Wang Reuben H.Kim No-Hee Park The Shapiro Family Laboratory of Viral Oncology and Aging Research UCLA School of DentistryLos AngelesCAUSA Department of Medicine David Geffen School of Medicine at UCLALos AngelesCAUSA Division of Oral Biology and Medicine UCLA School of DentistryLos AngelesCAUSA UCLA Jonsson Comprehensive Cancer Center Los AngelesCAUSA Department of Bioengineering UCLA Samueli School of EngineeringLos AngelesCAUSA

Growing evidence suggests close associations between periodontitis and *** further understand the pathological relationships of these associations,we developed periodontitis with ligature placement around maxillary molars or ligature placement in conjunction with Porphyromonas gingivalis lipopolysaccharide injection at the ligature sites (ligature/***) in Apolipoprotein E knock out mice and studied the atherogenesis process in these *** mice were fed with high fat diet for 11 weeks and sacrificed for analyzing periodontitis,systemic inflammation,and *** did not develop periodontitis or systemic inflammation and had minimal lipid deposition in the aortas,but mice receiving ligature or ligature/*** showed severe periodontitis,systemic inflammation,and aortic plaque *** aortic plaque contained abundant macrophages and cells expressing both endothelial and mesenchymal cell *** severity of periodontitis was slightly higher in mice receiving ligature/*** than ligature alone,and the magnitude of systemic inflammation and aortic plaque formation were also notably greater in the mice with ligature/*** observations indicate that the development of atherosclerosis is due to systemic inflammation caused by severe *** vitro,*** enhanced the secretion of pro-inflammatory cytokines from macrophages and increased the adhesion of monocytes to endothelial cells by upregulating the expression of adhesion molecules from endothelial ***,secretory proteins,such as TNF-α,from macrophages induced endothelial–mesenchymal transitions of the endothelial *** together,systemic inflammation induced by severe periodontitis might exacerbate atherosclerosis via,in part,causing aberrant functions of vascular endothelial cells and the activation of macrophages in mice.

关键词： via aortic cells TNF-α did had but was

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Polymorph Control of Felodipine Form Ⅱ in an Attempted Cocrystallization

Polymorph Control of Felodipine Form Ⅱ in an Attempted Cocr...

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第二届中国晶型药物研发技术研讨会

作者： Dan bostrom SitaramP.Velaga Department of Health Science Lulea University of Technology Lule S-971 87Sweden Energy Technology and Thermal Process Chemistry Ume University Ume S-901 87Sweden

The metastable formⅡof racemic felodipine was obtained in an attempted cocrystallization with *** lowtemperature crystal structure was characterized by a 1D hydrogen-bonded chain consisting of four independent felodi...

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Dedifferentiated fat cells:A cell source for regenerative medicine

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World Journal of Stem Cells 2015年第10期7卷 1202-1214页

作者： Medet Jumabay Kristina I bostrom Division of Cardiology David Geffen School of Medicine at UCLA the Molecular Biology Institute at UCLA

The identification of an ideal cell source for tissue regeneration remains a challenge in the stem cell field. The ability of progeny cells to differentiate into other cell types is important for the processes of tissue reconstruction and tissue engineering and has clinical, biochemical or molecular implications. The adaptation of stem cells from adipose tissue for use in regenerative medicine has created a new role for adipocytes. Mature adipocytes can easily be isolated from adipose cell suspensions and allowed to dedifferentiate into lipidfree multipotent cells, referred to as dedifferentiated fat(DFAT) cells. Compared to other adult stem cells, the DFAT cells have unique advantages in their abundance, ease of isolation and homogeneity. Under proper condition in vitro and in vivo, the DFAT cells have exhibited adipogenic, osteogenic, chondrogenic, cardiomyogenc, angiogenic, myogenic, and neurogenic potentials. In this review, we first discuss the phenomena of dedifferentiation and transdifferentiation of cells, and then dedifferentiation of adipocytes in particular. Understanding the dedifferentiation process itself may contribute to our knowledge of normal growth processes, as well as mechanisms of disease. Second, we highlight new developments in DFAT cell culture and summarize the current understanding of DFAT cell properties. The unique features of DFAT cells are promising for clinical applications such as tissue regeneration.

关键词： Adipocytes Dedifferentiated fat cells Adult stem cells Pluripotent stem cells Differentiation

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Promoting sense of security in old-age care

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Health 2013年第6期5卷 56-63页

作者： Martina bostrom Marie Ernsth Bravell Dan Lundgren Anita Bjorklund Institute of Gerontology School of Health SciencesJonkoping UniversityJonkopingSweden Department of Organizational Development Division of Social ServicesThe Research School Health and WelfareSchool of Health SciencesJonkoping UniversityJonkopingSweden Department of Rehabilitation School of Health SciencesJonkoping UniversityJonkopingSweden

Purpose: The concept of security is related to the experience of health but has ever so often been argued from a risk perspective rather than from a promotional perspective. The experience of older persons’ sense of security in private homes and in nursing homes seems to be missing when it comes to promote aging well throughout the life span. This study aimed to describe and analyze factors related to the sense of security of older persons receiving care in nursing homes in Sweden. Design and Methods: The study was based on a questionnaire from a total of 495 persons aged ≥ 65 in private homes (n = 350) or nursing homes (n = 145) in Sweden. Results: Secure relationships, sense of control, and perceived health were significantly related to the subjects’ sense of security. No significant relationships were found between sense of security and having a personal emergency response alarm. Implications: Experience of sense of security from the older person perspective differs depending on the context. To promote the sense of security within the care of older persons, methods on how to establish secure relations as well as the sense of control and knowledge need to be further tested, developed and analyzed together with older persons.

关键词： Sense of Security Nursing Homes Regression Analysis Health Promotion

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如果我们的电脑比我们更聪明?

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疯狂英语（新悦读） 2016年第7期 30-33页

作者： Nick bostrom T Boy

“电脑战胜人类”“人类完败”——3月15日，谷歌开发的围棋人工智能程序阿尔法狗（AlphaGo）以4：1的成绩结束了与世界围棋冠军李世石的比赛后，这是众多媒体新闻标题中出现率颇高的两条。

关键词：电脑战聪明智慧人工智能新闻标题李世石出现率多媒体

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Combining computer vision and deep learning to enable ultra-scale aerial phenotyping and precision agriculture:A case study of lettuce production

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Horticulture Research 2019年第1期6卷 906-917页

作者： Alan Bauer Aaron George bostrom Joshua Ball Christopher Applegate Tao Cheng Stephen Laycock Sergio Moreno Rojas Jacob Kirwan Ji Zhou Earlham Institute Norwich Research ParkNorwich NR47UZUK Plant Phenomics Research Center China-UK Plant Phenomics Research CentreNanjing Agricultural UniversityNanjing 210095 JiangsuChina School of Computing Sciences University of East AngliaNorwich Research ParkNorwich NR47TJUK National Engineering and Technology Center for Information Agriculture MARA Key Laboratory for Crop System Analysis and Decision MakingJiangsu Key Laboratory for Information AgricultureNanjing Agricultural UniversityNanjing 210095 JiangsuChina G’s Growers Limited ElyCambridgeshire CB75TZUK

Aerial imagery is regularly used by crop researchers,growers and farmers to monitor crops during the growing *** extract meaningful information from large-scale aerial images collected from the field,high-throughput phenotypic analysis solutions are required,which not only produce high-quality measures of key crop traits,but also support professionals to make prompt and reliable crop management ***,we report AirSurf,an automated and open-source analytic platform that combines modern computer vision,up-to-date machine learning,and modular software engineering in order to measure yield-related phenotypes from ultra-large aerial *** quantify millions of in-field lettuces acquired by fixed-wing light aircrafts equipped with normalised difference vegetation index(NDVI)sensors,we customised AirSurf by combining computer vision algorithms and a deep-learning classifier trained with over 100,000 labelled lettuce *** tailored platform,AirSurf-Lettuce,is capable of scoring and categorising iceberg lettuces with high accuracy(>98%).Furthermore,novel analysis functions have been developed to map lettuce size distribution across the field,based on which associated global positioning system(GPS)tagged harvest regions have been identified to enable growers and farmers to conduct precision agricultural practises in order to improve the actual yield as well as crop marketability before the harvest.

关键词： computer analysis equipped

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Virtual Synchronous Generator Based Current Synchronous Detection Scheme for a Virtual Inertia Emulation in SmartGrids

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Energy and Power Engineering 2019年第3期11卷 99-131页

作者： Arvind Parwal Martin Fregelius Dalmo Cardosa Silva Tatiana Potapenko Johannes Hjalmarsson James Kelly Irina Temiz Janaina Goncalves de Oliveira Cecilia bostrom Mats Leijon Division of Electricity Department of Engineering SciencesUppsala UniversityUppsalaSweden Department of Electrical Engineering Universidade Federal de Juiz de ForaJuiz de ForaBrazil MaREI—Centre for Marine and Renewable Energy Ireland University College CorkCorkIreland Department of Electrical Engineering Chalmers University of TechnologyGothenburgSweden

Renewable energy sources, such as photovoltaic wind turbines, and wave power converters, use power converters to connect to the grid which causes a loss in rotational inertia. The attempt to meet the increasing energy demand means that the interest for the integration of renewable energy sources in the existing power system is growing, but such integration poses challenges to the operating stability. Power converters play a major role in the evolution of power system towards SmartGrids, by regulating as virtual synchronous generators. The concept of virtual synchronous generators requires an energy storage system with power converters to emulate virtual inertia similar to the dynamics of traditional synchronous generators. In this paper, a dynamic droop control for the estimation of fundamental reference sources is implemented in the control loop of the converter, including active and reactive power components acting as a mechanical input to the virtual synchronous generator and the virtual excitation controller. An inertia coefficient and a droop coefficient are implemented in the control loop. The proposed controller uses a current synchronous detection scheme to emulate a virtual inertia from the virtual synchronous generators. In this study, a wave energy converter as the power source is used and a power management of virtual synchronous generators to control the frequency deviation and the terminal voltage is implemented. The dynamic control scheme based on a current synchronous detection scheme is presented in detail with a power management control. Finally, we carried out numerical simulations and verified the scheme through the experimental results in a microgrid structure.

关键词： Current Synchronous Detection Dynamic Droop Control Energy Storage Virtual Inertia Virtual Synchronous Generator

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