检索结果-南通市图书馆

Comparison of 2D and 4D Flow MRI Measurements for Hemodynamic Evaluation of the Fontan Palliation

Congenital Heart Disease 2023年第6期18卷 627-638页

作者： elisa Listo Nicola Martini Stefano Salvadori elisa valenti Nicola Stagnaro Gianluca Trocchio Chiara Marrone Alberto Clemente Francesca Raimondi Pierluigi Festa Lamia Ait Ali Department of Radiology IRCCS Istituto Giannina GasliniGenovaItaly U.O.C.Bioingegneria Gabriele Monasterio CNR-Tuscany FoundationPisaItaly Institute of Clinical Physiology CNR PisaItaly Cardiology Unit IRCCS Istituto Giannina GasliniGenovaItaly Pediatric Cardiology and GUCH Unit Massa Gabriele Monasterio CNR-Tuscany FoundationMassaItaly Gabriele Monasterio CNR-Tuscany Foundation PisaItaly Department of Cardiology Azienda Ospedaliero-Universitaria MeyerFlorenceItaly Institute of Clinical Physiology CNR MassaItaly

Background:The assessment of Fontan circuit’sﬂow is traditionally evaluated by multiple through-plane phase-contrast MRI acquisitions(2Dﬂow),while recently,a single volumetric 4D-ﬂow MRI acquisition is emerging as a comprehensive tool for the hemodynamic evaluation in congenital heart ***:To compare 2D and 4D-ﬂow MRI measurements in patients after Fontan palliation and to evaluate parameters affecting potential ***:39 patients after Fontan palliation(23 males,age 22±11 years)who underwent cardiac MRI with 2D and 4D-ﬂow MRI acquisition were included in the *** all patients,bloodﬂow quantiﬁcation in the Fontan circuit and aorta by 2Dﬂow and by 4Dﬂow MRI acquisition blinding to the 2D results was *** agreement between 2D and 4D-ﬂow MRI was calculated as the intraclass correlation coefﬁcient(ICC).The mean absolute differences between 4D and 2Dﬂows were analyzed using linear regression ***:4D-ﬂow MRI acquisition time was slightly lower than 2D(7.6±1.8 min vs.9.4±3.3 min,p=0.03).Flow was slightly predominant in the right pulmonary artery(58%of total pulmonaryﬂow).Conduit/tunnel-pul-monary arteriesﬂow accounted for 60%of the Fontan *** between 2D and 4D was overall good-to-excellent from ICC:0.81795%CI:0.637–0.907 to 0.93295%CI:0.866–*** was no signiﬁcant inﬂu-ence of evaluated parameters on the agreement on 4D and 2Dﬂ***:4D-ﬂow MRI represents a valid tool in Fontan’sﬂow quantiﬁ*** larger studies are needed to conﬁrm our results and to evaluate the impact of advanced 4D-ﬂow MRI parameters on the prognostic stratiﬁcation in patients after Fontan palliation.

关键词： Fontan palliation fontanﬂows 4Dﬂow MRI 2Dﬂow MRI cardiac magnetic resonance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multi-family therapy for veteran and refugee families: a Delphi study

引用

Military Medical Research 2019年第1期6卷 39-44页

作者： elisa van Ee Psychotraumacentrum Zuid Nederland Behavioural Science Institute Radboud University

Background: Research indicates that Posttraumatic stress disorder(PTSD) has an extensive impact on family relationships. Nevertheless, there is a dearth of empirically supported interventions addressing family functioning and PTSD. In the Netherlands, it is considered good clinical practice to offer multi-family therapy(MFT) to veteran and refugee families. MFT for traumatized families aims to address the dysfunctional family patterns that have evolved to address the consequences with ***: The aim of this study is to generate a common framework for the practical impact and active ingredients of MFT in families confronted with trauma. The Delphi method was used to study the expert opinion of 11 therapists in Dutch expert trauma ***: The results indicate that MFT is a promising treatment for families dealing with the consequences of trauma. According to experts, positive outcomes include an increased understanding between family members,particularly visible in the de-escalation of conflicts within the family, and improved parenting. One explanation for the effectiveness of MFT with these target groups is its defining feature of therapy with several ***: The findings support the importance of considering family relationships and the family context in interventions for traumatized individuals.

关键词： PTSD Veteran Refugee Multi-family therapy Parenting Expert opinion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Importance and performance of streetscapes at a tourism destination in Indonesia:The residents’perspectives

引用

Frontiers of Architectural Research 2020年第3期9卷 641-655页

作者： Marly valenti Patandianan Hiroyuki Shibusawa Department of Architecture and Civil Engineering Toyohashi University of TechnolosvToyohoshiJapan

The present study examined the importance and performance of streetscapes at a tourism destination in Makassar,Indonesia,from the residents’perspectives using the importance-performance analysis ***,six attributes of the streetscapes in four segments of the old city district were identified and presented to 400 *** participants were then asked to rate the perception and preference of each *** of the attribute values were illustrated in a Cartesian *** indicate notable discrepancies between the perceptions and preferences of the ***,these attributes were inconsistent with their ***,the results showed that each segment should have different priorities for specific attributes to improve the performance of the ***,such data can be used by stakeholders,such as tourism developers and government policymakers,to make appropriate and informed decisions that will improve the attractiveness of this tourism destination and increase the number of visitors.

关键词： Streetscapes Tourism destination Importance-performance analysis Residents’perspectives

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatocellular carcinoma in nonalcoholic fatty liver: Role of environmental and genetic factors

引用

World Journal of Gastroenterology 2014年第36期20卷 12945-12955页

作者： Paola Dongiovanni Stefano Romeo Luca valenti Internal Medicine 1B Fondazione IRCCS Ca’ Granda Ospedale Policlinico 20122 Milano Italy Department of Pathophysiology and Transplantation Università degli Studi di Milano 20122 Milano Italy Wallenberg Laboratory Department of Molecular and Clinical Medicine University of Gothenburg 40530 Gothenburg Sweden Clinical Nutrition Unit Department of Medical and Surgical Sciences University Magna Graecia 88100 Catan-zaro Italy

Hepatocellular carcinoma(HCC) is the fourth cause of cancer related mortality, and its incidence is rapidly increasing. Viral hepatitis, alcohol abuse, and exposure to hepatotoxins are major risk factors, but nonalcoholic fatty liver disease(NAFLD) associated with obesity, insulin resistance, and type 2 diabetes, is an increasingly recognized trigger, especially in developed countries. Older age, severity of insulin resistance and diabetes, and iron overload have been reported to predispose to HCC in this context. Remarkably, HCCs have been reported in non-cirrhotic livers in a higher proportion of cases in NAFLD patients than in other etiologies. Inherited factors have also been implicated to explain the different individual susceptibility to develop HCC, and their role seems magnified in fatty liver, where only a minority of affected subjects progresses to cancer. In particular, the common I148 M variant of the PNPLA3 gene influencing hepatic lipid metabolism influences HCC risk independently of its effect on the progression of liver fibrosis. Recently, rare loss-of-function mutations in Apolipoprotein B resulting in very low density lipoproteins hepatic retention and in Telomerase reverse transcriptase influencing cellular senescence have also been linked to HCC in NAFLD. Indeed, hepatic stellate cells senescence has been suggested to bridge tissue aging with alterations of the intestinal microbiota in the pathogenesis of obesity-related HCC. A deeper understanding of the mechanisms mediating hepatic carcinogenesis during insulin resistance, and the identification of its genetic determinants will hopefully provide new diagnostic and therapeutic tools.

关键词： Nonalcoholic fatty liver disease Steatosis Hepatocellular carcinoma Cirrhosis Fibrogenesis Liver disease Genetics Single nucleotide polymorphism Patatin-like phospholipase domain-containing 3

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

NGM282: a step forward in the nonalcoholic steatohepatitis treatment landscape?

引用

Hepatobiliary Surgery and Nutrition 2018年第6期7卷 484-486页

作者： Luca valenti Valerio Nobili Internal Medicine and Metabolic Diseases Fondazione IRCCS Ca’Granda Ospedale Policlinico MilanoDepartment of Pathophysiology and TransplantationUniversitàdegli Studi di MilanoMilanItaly Hepatology Gastroenterology and Nutrition UnitIRCCS“Bambino Gesù”Children’s HospitalRomeItaly Department of Pediatric University“La Sapienza”RomeItaly

Nonalcoholic fatty liver disease(NAFLD)is becoming the leading cause of liver disease worldwide,and the prevalence is still increasing,especially during the developmental age(1-3).NAFLD is defined in the presence of increased hepatic fat content not explained by at risk alcohol intake,and is epidemiologically associated with obesity,insulin resistance and metabolic disorders.

关键词： NAFLD intake hepatic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Building mass to prevent non-alcoholic fatty liver disease?

引用

Hepatobiliary Surgery and Nutrition 2019年第2期8卷 173-176页

作者： Serena Pelusi Luca valenti Department of Pathophysiology and Transplantation Università degli Studi di MilanoMilan Italy Translational Medicine Department of Transfusion Medicine and HematologyFondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico MilanoMilanItaly

While increased adiposity,generally estimated by high body mass index(BMI)is the major risk factor for non-alcoholic fatty liver disease(NAFLD),several studies have now reported an association between low skeletal muscle mass and this condition(1,2).In particular,sarcopenia has been associated with NAFLD in the general population,and with disease severity in patients who underwent liver biopsy(3-5).

关键词： NAFLD liver skeletal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Over-specialization versus synergy in neuroscience:professionals’integration is more than the sum of its parts

引用

Neural Regeneration Research 2021年第11期16卷 2232-2233页

作者： elisa Cainelli Luca Vedovelli Department of General Psychology University of PadovaPadovaItaly Unit of Biostatistics Epidemiology and Public HealthDepartment of CardiacThoracicVascular Sciencesand Public HealthUniversity of PadovaPadovaItaly

Health care systems in industrialized countries are built around acute health problems(Etzwiler,1997).This approach is successful when the goal is to improve or overcome pathologies that result in severe health issues or *** the recent tremendous improvement of the treatments of life-threatening conditions,the clinical focus has moved from short term results to the overall expected quality of life and longterm ***,the new objectives imply to consider a multitude of interacting processes and *** fact,a complex interplay of biological systems(nervous,immune,and endocrine)works together in an integrated and synergistic way to deal with a constantly evolving environment,determining our physical,behavioral,and psychological/subjective *** interplay is the mechanism that allows us to adapt promptly and appropriately to circumstances,the key feature for successful living.

关键词： overcome synergistic determining

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

How do stream processes affect hazard exposure on alluvial fans? Insights from an experimental study

引用

Journal of Mountain Science 2020年第4期17卷 753-772页

作者： Bruno MAZZORANA elisa GHIANDONI Lorenzo PICCO Universidad Austral de Chile Faculty of SciencesInstituto de Ciencias de la Tierra5090000 ValdiviaChile Universidad Austral de Chile RINA–Natural and Anthropogenic Risks Research Center5090000 ValdiviaChile Universidad Austral de Chile Laboratory of HydromorphologyFaculty of Forest Sciences and Natural Resources5090000 ValdiviaChile University of Padova Department of LandEnvironmentAgriculture and Forestry35020 LegnaroItaly

Alluvial fans are among the most privileged settlement areas in many mountain regions. These landforms are particularly dynamic being episodically affected by distributary processes generated by extreme flood events. Addressing risk assessment entails determining hazard exposure and unravelling how it might be related to process loading and to process dynamics once the flow becomes unconfined on the surface of alluvial fans. By following a ‘similarity of process concept’, rather than by attempting to scale a real-world prototype, we performed a set of 72 experimental runs on an alluvial fan model. Thereby, we considered two model layouts, one without a guiding channel and featuring a convex shape and the other one with a guiding channel, a bridge, and inclined but planar overland flow areas as to mirror an anthropic environment. Process magnitude and intensity parameters were systematically varied, and the associated biphasic distributary processes video recorded. For each experiment, the exposure was detected by mapping the exposed area in a GIS, thereby discerning between areas exposed to biphasic flows and the associated depositional phenomena or to the liquid flow phase only. Our results reveal that total event volume, sediment availability and stream power in the feeding channel, as well as depositional effects, avulsion, and channelization on the alluvial fan concur to determine the overall exposure. Stream process loading alone, even when rigorously defined in terms of its characterizing parameters, is not sufficient to exhaustively determine exposure. Hence, further developing reliable biphasic simulation models for hazard assessment on settled alluvial fans is pivotal.

关键词： Alluvial fan Hazard Exposure Flood risk Experimental model Process similarity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biomarkers for pancreatic cancer:Recent achievements in proteomics and genomics through classical and multivariate statistical methods

引用

World Journal of Gastroenterology 2014年第37期20卷 13325-13342页

作者： Emilio Marengo elisa Robotti Department of Sciences and Technological Innovation University of Piemonte Orientale

Pancreatic cancer(PC) is one of the most aggressive and lethal neoplastic diseases. A valid alternative to the usual invasive diagnostic tools would certainly be the determination of biomarkers in peripheral fluids to provide less invasive tools for early diagnosis. Nowadays, biomarkers are generally investigated mainly in peripheral blood and tissues through high-throughput omics techniques comparing control vs pathological samples. The results can be evaluated by two main strategies:(1) classical methods in which the identification of significant biomarkers is accomplished by monovariate statistical tests where each biomarker is considered as independent from the others; and(2) multivariate methods, taking into consideration the correlations existing among the biomarkers themselves. This last approach is very powerful since it allows the identification of pools of biomarkers with diagnostic and prognostic performances which are superior to single markers in terms of sensitivity, specificity and robustness. Multivariate techniques are usually applied with variable selection procedures to provide a restricted set of biomarkers with the best predictive ability; however, standard selection methods are usually aimed at the identification of the smallest set of variables with the best predictive ability and exhaustivity is usually neglected. The exhaustive search for biomarkers is instead an important alternative to standard variable selection since it can provide information about the etiology of the pathology by producing a comprehensive set of markers. In this review, the most recent applications of the omics techniques(proteomics, genomics and metabolomics) to the identification of exploratory biomarkers for PC will be presented with particular regard to the statistical methods adopted for their identification. The basic theory related to classical and multivariate methods for identification of biomarkers is presented and then, the most recent applications in this f

关键词： Pancreatic cancer Biomarker identification Multivariate analysis Principal component analysis Ranking principal component analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Methods to produce induced pluripotent stem cell-derived mesenchymal stem cells: Mesenchymal stem cells from induced pluripotent stem cells

引用

World Journal of Stem Cells 2021年第8期13卷 1094-1111页

作者： Victoria Dupuis elisa Oltra Facultédes Sciences et d’Ingénierie Sorbonne UniversitéParis 75252France Department of Pathology Universidad Católica de Valencia San Vicente MártirValencia 46001Spain Centro de Investigación Traslacional San Alberto Magno Universidad Católica de Valencia San Vicente MártirValencia 46001Spain

Mesenchymal stem cells(MSCs)have received significant attention in recent years due to their large potential for cell ***,they secrete a wide variety of immunomodulatory factors of interest for the treatment of immune-related disorders and inflammatory *** can be extracted from multiple tissues of the human ***,several factors may restrict their use for clinical applications:the requirement of invasive procedures for their isolation,their limited numbers,and their heterogeneity according to the tissue of origin or *** addition,MSCs often present early signs of replicative senescence limiting their expansion in vitro,and their therapeutic capacity in *** to the clinical potential of MSCs,a considerable number of methods to differentiate induced pluripotent stem cells(iPSCs)into MSCs have *** represent a new reliable,unlimited source to generate MSCs(MSCs derived from iPSC,iMSCs)from homogeneous and well-characterized cell lines,which would relieve many of the above mentioned technical and biological ***,the use of iPSCs prevents some of the ethical concerns surrounding the use of human embryonic stem *** this review,we analyze the main current protocols used to differentiate human iPSCs into MSCs,which we classify into five different categories:MSC Switch,Embryoid Body Formation,Specific Differentiation,Pathway Inhibitor,and Platelet *** also evaluate common and method-specific culture components and provide a list of positive and negative markers for MSC *** guidance on material requirements to produce iMSCs with these methods and on the phenotypic features of the iMSCs obtained is *** information may help researchers identify protocol options to design and/or refine standardized procedures for large-scale production of iMSCs fitting clinical demands.

关键词： Mesenchymal stem cells Induced pluripotent stem cells Mesenchymal stem cells derived from induced pluripotent stem cells Differentiation methods Culture components Mesenchymal stem cell markers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：