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Effectiveness and safety of antithrombotic strategies in elderly patients with acute myocardial infarction

World Journal of Cardiology 2020年第11期12卷 513-525页

作者： elisa rondano Marzia Bertolazzi Alessandro Galluzzo Ludovica Maltese Paolo Caccianotti Sergio Macciò Stefano Mazza Maria Virginia Di Ruocco Serena Favretto Eraldo Occhetta Francesco Rametta Cardiology Department St.Andrea HospitalVercelli 13100Italy

BACKGROUND Elderly patients represent a rapidly growing part of the population more susceptible to acute coronary syndromes and their ***,literature evidence is lacking in this clinical *** To describe the clinical features,in-hospital management and outcomes of“elderly”patients with myocardial infarction treated with antiplatelet and/or anticoagulation *** This study was a retrospective analysis of all consecutive patients older than 80 years admitted to the Division of Cardiology of *** Hospital of Vercelli from January 2018 to December 2018 due to ST-elevation myocardial infarction(STEMI)or non-ST elevation myocardial infarction(NSTEMI).Clinical and laboratory data were collected for each patient,as well as the prevalence of previous or in-hospital atrial fibrillation(AF).In-hospital management,consisting of an invasive or conservative strategy,and the anti-thrombotic therapy used are *** evaluated at 1 year follow-up included an efficacy ischemic endpoint and a safety bleeding *** Of the 105 patients enrolled(mean age 83.9±3.6 years,52.3%males),68(64.8%)were admitted due to NSTEMI and 37(35.2%)due to *** the STEMI patients,34(91.9%)underwent coronary angiography and all of them were treated with percutaneous coronary intervention(PCI);among the NSTEMI patients,42(61.8%)were assigned to an invasive strategy and 16(38.1%)of them underwent a *** significant difference between the groups was found concerning the prevalence of previous or in-hospital de-novo AF.10.5%of the whole population received triple antithrombotic therapy and 9.5%single antiplatelet therapy plus oral anticoagulation(OAC),with no significant difference between the subgroups,although a higher number of STEMI patients received dual antiplatelet therapy without OAC as compared with NSTEMI patients.A low rate of in-hospital death(5.7%)and 1-year cardiovascular death(3.3%)was ***(7.8%)patients experienced

关键词： Antiplatelet therapy Anticoagulant therapy Elderly patients Safety Acute myocardial infarction

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Statistical evaluation of fluoride contamination in groundwater resources of Santiago del Estero Province, Argentina

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Geoscience Frontiers 2020年第6期11卷 2197-2205页

作者： K.rondano Gómez C.E.López Pasquali G.Paniagua González P.Fernández Hernando R.M.Garcinuño Martínez Departamento de Ciencias Básicas Facultad de Ciencias ForestalesUniversidad Nacional de Santiago Del EsteroArgentina Departamento de Ciencias Analíticas Facultad de CienciasUniversidad Nacional de Educación a DistanciaSpain Departamento de Química Analítica Facultad de Agronomía y AgroindustriasUniversidad Nacional de Santiago Del EsteroArgentina

This study investigates the suitability of statistical techniques for evaluating the fluoride content and the groundwater quality from Robles Department(RD)and Banda Department(BD)in Santiago del Estero(Argentina).For the original statistical study,evaluation of nine parameters(fluoride,pH,conductivity,atmospheric and water temperature,total dissolved solids,chloride,hardness,and alkalinity)of 110 collected underground water samples from 23 dispersed rural areas was *** samples were obtained by sampling taken from wells at different *** levels were determined by a standard colorimetric method in two seasonal periods,the dry(from April to September)and rainy(from October to March)*** analytical results obtained for physicochemical parameters such as pH,total dissolved solids(TDS),and temperature does not reveal any notable difference between the rainy and dry seasons *** both seasons,the atmospheric temperature average was 22℃.With respect to fluoride content,approximately 50%of the analysed groundwater samples exceeded the limit established by current legislation(1.0 mg/L),obtaining concentration levels in the range of 0.01-2.80 mg/*** study demonstrates the usefulness of the univariate statistical method(quartiles calculation,interquartile range IQR),multivariate principal component analysis(PCA),and cluster analysis to establish a better understanding of the state of the contamination of the waters in the region studied.

关键词： Source water protection Santiago del Estero Multivariate statistical analysis Fluoride Spectrophotometry

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