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Direct carotid puncture in acute ischaemic stroke intervention

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Stroke & Vascular Neurology 2020年第1期5卷 71-79页

作者： elisa Colombo Lorenzo Rinaldo Giuseppe Lanzino Neurologic Surgery Mayo ClinicRochesterMinnesotaUSA

Endovascular intervention for acute ischaemic stroke care is mostly performed in older patients,often with unfavourable aortic and supra-aortic anatomy,as well as cardiovascular comorbidities.A significant subset of them may benefit from transcervical access as the initial approach for mechanical *** fact,direct carotid artery puncture in these cases has the advantage to bypass the anatomical obstacles and achieve faster *** is advised when common carotid artery access is pursued in order to avoid adverse events,including haematoma formation,iatrogenic arterial dissection and sheath *** spite of potential complications,direct carotid puncture in acute ischaemic stroke intervention overcomes challenging angioarchitecture and may reduce the rate of poor clinical outcomes associated with delayed revascularisation in certain cases.

关键词： carotid puncture anatomy

CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3519-3532页

作者： Alvaro Quintanal-Villalonga Kenta Kawasaki Esther Redin Fathema Uddin Swanand Rakhade Vidushi Durani Amin Sabet Moniquetta Shafer Wouter R.Karthaus Samir Zaidi Yingqian A.Zhan Parvathy Manoj Harsha Sridhar Dennis Kinyua Hong Zhong Barbara P.Mello Metamia Ciampricotti Umesh K.Bhanot Irina Linkov Juan Qiu Radhika A.Patel Colm Morrsey Sanjoy Mehta Jesse Barnes Michael C.Haffner Nichlas D.Socci Richard P.Koche elisa de Stanchina Sonia Molina-Pinelo Sohrab Salehi Helena A.Yu Joseph M.Chan Charles M.Rudin Department of Medicine Thoracic Oncology ServiceMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Cancer Biology and Genetics Program Sloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Vagelos College of Physicians and Surgeons Columbia UniversityNew YorkNYUSA Weill Cornell Graduate School of Medical Sciences Weill Cornell MedicineNew YorkNYUA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Center for Epigenetics Research Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Pathology Core Facilty Department of Pathology and Laboratory MedicineMSKCCNew YorkNYUSA Antitumor Assessment Core Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Divisionsof Human Biology and Clinical Research Fred Hutchinon Cancer CenterSeattleWAUSA Deparmentof Urology University of WashingtonSeattleWAUSA Gene Editing&Screening Core Facility Memorial Sloan Kettering Cancer Center New YorkNYUSA Department of Laboratory Medicine and Pathology University of WashingtonSeattleWAUSA Bioinfomatics CoreFacility Memorial Soan Kettering Cancer CenterNew YorkNYUSA Institute of Biomedicine of Seille(Bis) HURCSCUniversidad de SevillaSevilleSpain Computational Oncology Department of Epidemiology and BiostatisticsMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Well Cornell Medical College New York NYUSA Present address:Swiss Institute for Experimental Cancer Research(ISREC) School of Life SciencesEPFLLausanneSwitzerland

Neuroendocrine(NE)transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor *** to date,even if patients at high risk of transformation can be identified by the occurrence of Tumor Protein P53(TP53)and Retinoblastoma Transcriptional Corepressor 1(RB1)mutations in their tumors,no therapeutic strategies are available to prevent or delay histological *** of the cell cycle kinase Cell Division Cycle 7(CDC7)occurred in tumors during the initial steps of NE transformation,already after TP53/RB1 co-inactivation,leading to induced sensitivity to the CDC7 inhibitor ***7 inhibition suppressed NE transdifferentiation and extended response to targeted therapy in in vivo models of NE transformation by inducing the proteasome-mediated degradation of the MYC Proto-Oncogen(MYC),implicated in stemness and histological *** overexpression of a degradation-resistant MYC isoform reestablished the NE transformation phenotype observed on targeted therapy,even in the presence of ***7 inhibition also markedly extended response to standard cytotoxics(cisplatin,irinotecan)in lung and prostate small cell carcinoma *** results nominate CDC7 inhibition as a therapeutic strategy to constrain lineage plasticity,as well as to effectively treat NE tumors de novo or after *** simurosertib clinical efficacy trials are ongoing,this concept could be readily translated for patients at risk oftransformation.

关键词： tumors markedly transformation

Celiac disease:From genetics to epigenetics

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World Journal of Gastroenterology 2022年第4期28卷 449-463页

作者： elisa Gnodi Raffaella Meneveri Donatella Barisani School of Medicine and Surgery University of Milano-BicoccaMonza 20900Italy

Celiac disease(CeD)is a multifactorial autoimmune disorder spread *** exposure to gluten,a protein found in cereals like wheat,barley and rye,is the main environmental factor involved in its *** if the genetic predisposition represented by HLA-DQ2 or HLA-DQ8 haplotypes is widely recognised as mandatory for CeD development,it is not enough to explain the total predisposition for the ***,the onset of CeD comprehend a wide spectrum of symptoms,that often leads to a delay in CeD *** overcome this deficiency and help detecting people with increased risk for CeD,also clarifying CeD traits linked to disease familiarity,different studies have tried to make light on other predisposing *** were in many cases genetic variants shared with other autoimmune *** inherited traits can be regulated by epigenetic modifications,also induced by environmental factors,the most recent studies focused on the potential involvement of epigenetics in *** factors can in fact modulate gene expression with many mechanisms,generating more or less stable changes in gene expression without affecting the DNA *** we analyze the different epigenetic modifications in CeD,in particular DNA methylation,histone modifications,non-coding RNAs and RNA *** attention is dedicated to the additional predispositions to CeD,the involvement of epigenetics in developing CeD complications,the pathogenic pathways modulated by epigenetic factors such as microRNAs and the potential use of epigenetic profiling as biomarker to discriminate different classes of patients.

关键词： Celiac disease Epigenetics DNA methylation Histone modifications Long non-coding RNAs MicroRNAs

Herbivore performance and plant defense after sequential attacks by inducing and suppressing herbivores

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Insect Science 2019年第1期26卷 108-118页

作者： elisa Faria de Oliveira Angelo Pallini Arne Janssen Department of Entomology Federal University of VicosaVicosaMGBrazil Department of Entomology Federal University of Lavras LavrasMGBrazil Section Population Biology Institute for Biodiversity and Ecosystem DynamicsUniversity of Amsterdam Amsterdamthe Netherlands

It is well known that herbivore-induced plant defenses alter host plant quality and can affect the behavior and performance of later arriving *** of sequential attacks by herbivores that either suppress or induce plant defenses are less well *** sequentially infested leaves of tomato plants with a strain of the phytophagous spider mite Tetranychus urticae that induces plant defenses and the closely related Tetranychus evansi, which suppresses plant *** quality was quantified through oviposifion of both spider mite species and by measuring proteinase inhibitor activity using plant material that had been sequentially attacked by both herbivore ***-mite oviposifion data show that *** could suppress an earlier induction of plant defenses by ***,and *** could induce defenses in plants previously attacked by *** in 1 *** attacks by the second species did not result in further changes in *** inhibitor activity levels showed that *** suppressed the high activity levels induced by *** to constitutive levels in 1 day,and further suppressed activity to levels similar to those in plants attacked by *** *** by *** induced proteinase inhibitor activity in plants previously attacked by ***,eventually to similar levels as induced by *** ***,plant quality and plant defenses were significantly affected by sequential attacks and the order of attack does not affect subsequent performance,but does affect proteinase inhibitor activity *** on our results,we discuss the evolution of suppression of plant defenses.

关键词： plant defense plant-herbivore interactions plant quality sequential attack Tetranychus evansi Tetranychus urticae

Wolf predation on wild ungulates:how slope and habitat cover influence the localization of kill sites

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Current Zoology 2018年第3期64卷 271-275页

作者： elisa TORRETTA Luca CAVIGLIA Matteo SERAFINI Alberto MERIGGI Di.S.T.A. Universita degli Studi di PaviaVia Ferrata 1Pavia 27100Italy

Based on data collected along the Ligurian Apennines and Alps(N-W Italy),we analysed the main environmental and human-related factors influencing the distribution of kill sites of the wolf Canis *** mapped and digitized 62 kill sites collected during *** each kill site,we defined a buffer corresponding to the potential hunting area of *** compared kill site plots and an equal number of random *** formulated a model of kill site distribution following an approach presence versus availability by binary logistic regression analysis;we tested the hypothesis that wolf choice of kill sites is influenced by the physiography and the land use of the *** the preyed wild ungulates,we identified 23 roe deer Capreolus capreolus,18 fallow deer Dama dama,16 wild boars Sus scrofa,and 5 chamois Rupicapra *** logistic regression analysis showed a negative effect of the road density,the urban areas,the mixed forests,and a positive effect of steep slopes and open *** are more vulnerable to predators under certain conditions and predators are capable of selecting for these *** achieved this by selecting particular habitats in which to kill their prey:they preferred steep,open habitats far from human presence,where wild ungulates are more easily detectable and chasable.

关键词： Canis lupus hunting habits kill site distribution modeling predator-prey interaction wild ungulates.

Is autophagy an elective strategy to protect neurons from dysregulated cholesterol metabolism?

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Neural Regeneration Research 2019年第4期14卷 582-587页

作者： elisa Piscianz Liza Vecchi Brumatti Alberto Tommasini Annalisa Marcuzzi Department of Medicine Surgery and Health Sciences University of Trieste Institute for Maternal and Child Health-IRCCS "Burlo Garofolo"

The balance of autophagy, apoptosis and necroptosis is crucial to determine the outcome of the cellular response to cholesterol dysregulation. Cholesterol plays a major role in regulating the properties of cell membranes, especially as regards their fluidity, and the regulation of its biosynthesis influences the shape and functions of these membranes. Whilst dietary cholesterol can easily be distributed to most organs, the central nervous system, whose membranes are particularly rich in cholesterol, mainly relies on de novo synthesis. For this reason, defects in the biosynthesis of cholesterol can variably affect the development of central nervous system. Moreover, defective synthesis of cholesterol and its intermediates may reflect both on structural cell anomalies and on the response to inflammatory stimuli. Examples of such disorders include mevalonate kinase deficiency, and Smith-Lemli-Opitz syndrome, due to deficiency in biosynthetic enzymes, and type C Niemann-Pick syndrome, due to altered cholesterol trafficking across cell compartments. Autophagy, as a crucial pathway dedicated to the degradation of cytosolic proteins and organelles, plays an essential role in the maintenance of homeostasis and in the turnover of the cytoplasmic material especially in the presence of imbalances such as those resulting from alteration of cholesterol metabolism. Manipulating the process of autophagy can offer possible strategies for improving neuronal cell viability and function in these genetic disorders.

关键词： cholesterol inflammation apoptosis autophagy neurons inherited disease necroptosis neuronal dysfunction

High levels of arbuscular mycorrhizal fungus colonization on Medicago truncatula reduces plant suitability as a host for pea aphids (Acyrthosiphon pisum)

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Insect Science 2020年第1期27卷 99-112页

作者： elisa Garzo Eric Rizzo Alberto Fereres S.Karen Gomez nstituto de Ciencias Agrarias-Consejo Superior de Investigaciones Cientificas(ICA-CSIC) MadridSpain School of Biological Sciences University of Northern ColoradoGreeleyColoradoUSA

This study sheds light on a poorly understood area in insect-plant-microbe interactions,focusing on aphid probing and feeding behavior on plants with varying levels of arbuscular mycorrhizal(AM)fungus root *** investigates a commonly occurring interaction of three species:pea aphid Acyrthosiphon pisum,barrel medic Medicago truncatula,and the AM fungus Rhizophagus irregularis,examining whether aphid-feeding behavior changes when insects feed on plants at different levels of AM fungus colonization(42% and 84% root length colonized).Aphid probing and feeding behavior was monitored throughout 8 h of recording using the electrical penetration graph(EPG)technique,also,foliar nutrient content and plant growth were ***,aphids took longer to reach their 1st sustained phloem ingestion on the 84% AM plants than on the 42% AM plants or on *** aphids showed phloem ingestion on the 84% AM plants relative to the 42% AM *** of the 84% AM plants had higher percent carbon(43.7%)relative to controls(40.5%),and the 84% AM plants had reduced percent nitrogen(5.3%)relative to the 42% AM plants(6%).In conclusion,EPG and foliar nutrient data support the hypothesis that modifications in plant anatomy(e.g.,thicker leaves),and poor food quality(reduced nitrogen)in the 84% AM plants contribute to reduced aphid success in locating phloem and ultimately to differences in phloem sap *** work suggests that *** plants benefit from AM symbiosis not only because of increased nutrient uptake but also because of reduced susceptibility to aphids.

关键词： Aphididae arbuscular mycorrhizal fungus electrical penetration graph(EPG) Fabaceae Glomeraceae insect-plant-microbe interactions symbiosis

Effect of different starch sources in a raw meat-based diet on fecal microbiome in dogs housed in a shelter

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Animal Nutrition 2020年第3期6卷 353-361页

作者： Misa Sandri Sandy Sgorlon elisa Scarsella Bruno Stefanon Department of AgriFood Environmental and Animal ScienceUniversity of UdineUdine33100Italy

A dietary intervention study was assessed to determine if different sources of starch in homemade diets could significantly modify fecal microbiome of ***-seven adult dogs were enrolled and fed a diet based on a mixture of rice and pasta with fresh raw meat(CD).After 90 d,8 dogs continued to receive CD diet,10 dogs received a diet made of a raw meat and a complementary food with rice as the main source of starch(B1),and 9 dogs were fed a diet with the same raw meat and a complementary food with potato as the main source of starch(B2).Samples of feces were collected from each dog in the mornings at the beginning of the study and after 15 d and analyzed for pH,ammonia N(N-NH3)and total N,short chain fatty acids(SCFA)and lactic *** abundance of fecal microbiota was assessed by sequencing and annotating the V3-V4 regions of the 16S *** starch intake was similar between diets but differed in the in vitro rate digestion and in the resistant starch,which was higher in B2 than in B1 and CD *** fed B2 diet showed lower(P<0.05)N-NH3 and pH but higher(P<0.05)molar proportion of lactic *** discriminant analysis of the genera relative abundances indicated a significant(P<0.01)increase of SMB53 genus at the end of the study in B1 diet and of Megamonas genus in B1 and B2 diets in comparison to CD *** results suggest that changes of starch source in a raw meat-based diet have limited effects on fecal microbiome in healthy dogs,but underline a high variability of microbiota among dogs.

关键词： Diets Starch fraction Microbiome Nutrition Canis lupus familiaris

Conservative management of an early abdominal complication during a Tullio percutaneous endoscopic excision of renal pelvis urothelial carcinoma:A case report

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World Journal of Clinical Urology 2024年第1期13卷 1-6页

作者： Massimiliano Bernabei NicolòFabbri Danila Romeo elisa Paiolo Martina Bandi Maurizio Simone Department of Urology Azienda USL di FerraraFerrara 44100Italy Department of Surgery University of FerraraAzienda USL of FerraraAzienda USL of FerraraFerrara 44100FerraraItaly Local Health Agency of Ferrara Ferrara 44100Italy

BACKGROUND Upper tract urothelial carcinoma(UTUC)representing only a small fraction of all urothelial *** predominantly affects the renal pelvis in men,often coexisting with bladder *** displays a more aggressive genetic profile compared to bladder neoplasms,with the majority of patients presenting with advanced ***,about a quarter of UTUC cases exhibit high-grade subtypes,associated with a worse *** use and past exposure to aromatic amines are significant risk factors for *** modalities such as Uro-computed tomography and magnetic resonance imaging play crucial roles in *** is vital for direct visualization and biopsy sampling,but its limited sampling capacity presents challenges in determining tumor depth and ***,nephroureterectomy with bladder cuff excision has been the gold-standard treatment for *** conservative treatment has recently emerged as a viable option for selected patients,offering comparable oncological outcomes to radical *** access is also feasible for larger intrarenal *** SUMMARY We present a case of an 84-year-old woman who underwent percutaneous endoscopic excision of a renal pelvis neoplasm using the Tullio *** successful tumor removal,the patient experienced a postoperative complication with abdominal fluid *** management effectively resolved the *** the patient's age and refusal for radical surgery,the conservative approach proved to be a valid therapeutic *** Overall,UTUC remains a diagnostic and therapeutic challenge due to its ***,advances in endoscopic and percutaneous techniques provide valuable alternatives for selected patients,warranting further exploration in this evolving field.

关键词： Upper tract urothelial carcinoma Endoscopic treatment Damage management Case report