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Julolidine-labelled fluorinated block copolymers for the development of two-layer films with highly sensitive vapochromic response

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Science China Chemistry 2018年第8期61卷 947-956页

作者： Camillo Sorgi elisa martinelli Giancarlo Galli Andrea Pucci Department of Chemistry and Industrial Chemistry University of Pisa 56124 Pisa Italy National Interuniversity Consortium of Materials Science and Technology UdR Pisa 56124 Pisa Italy

Fluorinated block copolymers composed of a polystyrene(Sx) first block and a polyacrylate second block carrying hydrophobic/lipophobic perfluorohexyl side chains(AF) were prepared by atom transfer radical polymerization(ATRP). Fluorescence emission properties were imparted to the copolymers by incorporation in the second block of a julolidine-based fluorescent molecular rotor(JCBF). The synthesized block copolymers were used as the fluorescent low-surface energy thin top-layer onto a polystyrene bottom-layer to produce novel two-layer film vapochromic sensors. Contact angle and X-ray photoelectron spectroscopy(XPS) measurements revealed that the two-layer film surfaces were hydrophobic and lipophobic at the same time and highly enriched in fluorine content as a result of the effective segregation of the perfluorinated tails to the polymer-air *** fluorescence intensity of the two-layer films decreased significantly when they were exposed to vapours of organic solvents,including tetrahydrofurane, chloroform, and trifluorotoluene. However, an AF content-dependent sensing behaviour was also observed, with the two-layer films containing the copolymer with the shorter fluorinated block giving a more rapid and almost quantitative decrease in fluorescence variation. Fluorescence emission of the films was also proved to vary with *** the vapochromic and thermochromic responses were reversible after successive solicitation cycles. The fluorescence variation of the two-layer films was much more marked than that of the corresponding PS/JCBF blend, thus providing a system potentially applicable as highly sensitive volatile organic compound(VOC) sensor, thanks to the active role of the fluorinated block in promoting the migration of the fluorophore to the outermost surface layers.

关键词： fluorinated block copolymers fluorescent molecular rotors vapochromism

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Altered Expression in Patients with Heart Failure of Circulating MicroRNAs Related to Lipoprotein Metabolism

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Journal of Pharmacy and Pharmacology 2018年第5期6卷 466-474页

作者： Priscila O. Carvalho Fatima R. Freitas Ana elisa M. martinelli Bruna M. O. Silva Milena N. C. Curiati Roberto Kalil-Filho Antonio C. Pereira Barretto Raul C. Maranhao Lipid Metabolism Laboratory Heart Institute (InCor) Medical School Hospital University of Sao Paulo Sao Paulo 05403-000Brazil Santa Marcelina Hospital Sao Paulo 08270-070 Brazil Prevention and Rehabilitation Service Heart Institute (InCor) Medical School Hospital University of Sao Paulo So Paulo 05403-000 Brazil Faculty of Pharmaceutical Sciences University of Sao Paulo Sao Paulo 05508-000 Brazil

Objective： This study aimed to investigate, for the first time, the expression of circulating miRNAs （microRNAs） related to lipoprotein metabolism in patients with HF （heart failure）. Medlods： Twenty patients with HF and 10 controls without HF were included. BNP （brain natxiuretic peptide）, a marker of HF severity, plasma lipid parameters and the expression of circulating miRNAs were determined. Key findings： Total, LDL-, non-HDL- and HDL-cholesterol, txiglycerides, and apo A-I did not differ between both groups, but apo B was lower in the HF group compared to controls （p = 0.007）. In respect to miRNAs, miR-33a, miR-144, miR-125, miR-30c, miR-122, miR-26a, miR-185, miR-758 and miR-106b were higher, from ten- to 25-fold, and miR-10b was lower about 4-fold, in HF group compared to controls. In HF patients a negative correlation between miR-26a and BNP, the marker of disease severity, was found （r = -0.552; p = 0.041）. Conclusions： Plasma levels of miRNAs involved in HDL and LDL metabolism regulation were strikingly changed in HF patients. The negative correlation between miR-26a and BNP values may suggest the possibility of the rise of a novel biomarker or therapeutic target in HF.

关键词： Lipids and lipoprotein metabolism HDL (high-density lipoprotein) LDL (low-density lipoprotein) HF BNP miRNAs miR-26a.

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Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

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Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria martinelli Jessica Mandrioli Andrea Ghezzi elisabetta Zucchi Giulia Gianferrari Cecilia Simonini Francesco Cavallieri Franco Valzania Department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental Medicine Ph.D.Program University of Modena and Reggio EmiliaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory SOD1 superoxide dismutase 1 urinary vocal cord palsy

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Geofluids Hosted in the Deep Crust: From Systematics to Parametrization of their Significance

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Acta Geologica Sinica(English Edition) 2021年第S1期95卷 31-33页

作者： Giovanni martinelli INGV Istituto Nazionale di Geofisica e Vulcanologia Department of PalermoPalermoItaly Northwest Institute of Eco-Environment and Resources Chinese Academy of SciencesLanzhouChina Key Laboratory of Petroleum Resources Gansu Province/Key Laboratory of Petroleum Resources ResearchInstitute of Geology and GeophysicsChinese Academy of SciencesLanzhouChina

Earthquake is a sudden release of energy due to fault *** severity of the damages can be minimized by development of a culture of prevention which includes the Seismic Hazard Assessment,microzonation studies and appro... 详细信息

关键词： probabilistic seismic hazard assessment deterministic seismic hazard assessment helium isotopes geochemical prospection earthquake precursors

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MPM simulations of dam-break floods

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Journal of Hydrodynamics 2017年第3期29卷 397-404页

作者： Xuanyu Zhao Dongfang Liang Mario martinelli Department of Engineering University of CambridgeCambridgeUK Deltares DelftThe Netherlands

Owing to its ability of modelling large deformations and the ease of dealing with moving boundary conditions,the material point method is gaining popularity in geotechnical engineering *** this paper,this promising Lagrangian method is applied to hydrodynamic problems to further explore its *** collapse of water columns with different initial aspect ratios is simulated by the material point *** order to test the accuracy and stability of the material point method,simulations are first validated using experimental data and results of mature numerical ***,the model is used to ascertain the critical aspect ratio for the widely-used shallow water equations to give satisfactory *** the comparisons between the simulations based on the material point method and the shallow water equations,the critical aspect ratio for the suitable use of the shallow water equations is found to be 1.

关键词： Material point method dam-break floods Lagrangian method shallow water equations

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Numerical Boundary Conditions for Specular Reflection in a Level-Sets-Based Wavefront Propagation Method

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Communications in Computational Physics 2013年第7期14卷 509-536页

作者： Sheri L.martinelli Torpedo Systems Department Naval Undersea Warfare Center1176 Howell StreetNewportRhode Island 02841USA Division of Applied Mathematics Brown UniversityProvidenceRhode Island 02912USA

We study the simulation of specular reflection in a level set method implementation for wavefront propagation in high frequency acoustics using WENO spatial *** implement WENO efficiently andmaintain convergence rate,a rectangular grid is used over the physical *** the physical domain does not conformto the rectangular grid,appropriate boundary conditions to represent reflection must be derived to apply at grid locations that are not coincident with the reflecting boundary.A related problem is the extraction of the normal vectors to the boundary,which are required to formulate the reflection condition.A separate level set method is applied to pre-compute the boundary normals which are then stored for use in the wavefront *** approaches to handling the reflection boundary condition are proposed and studied:one uses an approximation to the boundary location,and the other uses a local reflection *** second method is shown to produce superior results.

关键词： Boundary conditions reflection level setmethod wavefrontmethods high-frequency acoustic propagation WENO

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An Application of the Level Set Method to Underwater Acoustic Propagation

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Communications in Computational Physics 2012年第10期12卷 1359-1391页

An algorithm for computing wavefronts,based on the high frequency approximation to the wave equation,is *** technique applies the level set method to underwater acoustic wavefront propagation in the time *** level set method allows for computation of the acoustic phase function using established numerical techniques to solve a first order transport equation to a desired order of *** methods for solving the eikonal equation directly on a fixed grid limit one to only the first arrivals,so these approaches are not useful when multi-path propagation is *** the level set model to the problem allows for the time domain computation of the phase function on a fixed grid,without having to restrict to first arrival *** implementation presented has no restrictions on range dependence or direction of travel,and offers improved efficiency over solving the full wave equation which under the high frequency assumption requires a large number of grid points to resolve the highly oscillatory *** conditions are discussed,and an approach is suggested for producing good results in the presence of boundary *** efficientmethod to compute the amplitude from the level set method solutions is also *** to analytical solutions are presented where available,and numerical results are validated by comparing results with exact solutions where available,a full wave equation solver,and with wavefronts extracted from ray tracing software.

关键词： Geometric acoustics level set method high-frequency acoustic propagation WENO method

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Rhynchophorus ferrugineus attack affects a group of compounds rather than rearranging Phoenix canariensis metabolic pathways

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Journal of Integrative Plant Biology 2016年第4期58卷 388-396页

作者： Antonio Giovino Federico martinelli Sergio Saia Consiglio per la Ricerca in Agricoltura e l'analisi dell'economia agraria(CREA) Unita di ricerca per il recupero e la valorizzazione delle Specie Floricole Mediterranee(CREA-SFM)90011 Bagheria(PA)Italy Dipartimento di Scienze Agrarie e Forestali(SAF) University of PalermoViale delle ScienzeEdif.490128 PalermoItaly Istituto Euromediterraneo di Scienza e Tecnologia(IEMEST) Via E.Amari 12390139 PalermoItaly

The red palm weevil（RPW; Rhynchophorus ferrugineus） is spreading worldwide and severely harming many palm species. However, most studies on RPW focused on insect biology, and little information is available about the plant response to the attack. In the present experiment, we used metabolomics to study the alteration of the leaf metabolome of Phoenix canariensis at initial（1^（st） stage） or advanced（2^（nd） stage）attack by RPW compared with healthy（unattacked） *** leaf metabolome significantly varied among treatments. At the 1^（st） stage of attack, plants showed a reprogramming of carbohydrate and organic acid metabolism; in contrast, peptides and lipid metabolic pathways underwent more changes during the 2^（nd） than 1^（st） stage of attack. Enrichment metabolomics analysis indicated that RPW attack mostly affected a particular group of compounds rather than rearranging plant metabolic pathways. Some compounds selectively affected during the 1^（st） rather than 2^（nd） stage（e.g. phenylalanine; tryptophan; cellobiose;xylose; quinate; xylonite; idonate; and iso-threonate; cellobiotol and arbutine） are upstream events in the phenylpropanoid,terpenoid and alkaloid biosynthesis. These compounds could be designated as potential markers of initial RPW attack. However,further investigation is needed to determine efficient early screening methods of RPW attack based on the concentrations of these molecules.

关键词： Early detection Mediterranean environment metabolomics palms plant borer

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Simulation of Propagating Acoustic Wavefronts with Random Sound Speed

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Communications in Computational Physics 2014年第9期16卷 1081-1101页

作者： Sheri L.martinelli Undersea Warfare Weapons Vehiclesand Defensive Systems DepartmentNaval Undersea Warfare CenterNewportRhode Island 02841USA.

A method for simulating acoustic wavefronts propagating under random sound speed conditions is *** approach applies a level set method to solve the Eikonal equation of high frequency acoustics for surfaces of constant phase,instead of tracing *** Lagrangian nature often makes full-field ray solutions difficult to *** level set method captures multiple-valued solutions on a fixed *** is straightforward to represent other sources of uncertainty in the input data using this model,which has an advantage over Monte Carlo approaches in that it yields an expression for the solution as a function of random variables.

关键词： Level set method wavefront methods high-frequency acoustic propagation stochastic collocation.

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NOTE COMPLEMENTARI SU Orotrechus schwienbacheri GROTTOLO E martinelli,1991(Coleoptera Carabidae Trechinae)DEL MASSICCIO DEL MONTE CAVALLO(Prealpi Venete)

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Natural Disaster Reduction in China 1993年第1期 185-192页

作者： MARIO GROTTOLO ARRIGO martinelli Centro Studi Naturalistici Bresciani Museo Civico di Rovereto

RIASSUNTO-Viene completata la descrizione di Orotrechus schwienbacheri Grottolo e martinelli,speciecavernicola del Massiccio di rifugio del Monte *** recente scoperta di questo taxon assume unparticolare significato in quanto simpatrico di ben altre ire specie di Orotrechus cavernicoli *** schwienbacheri Grottolo e martinelli from the refuge massif of Monte Cavallois completely *** discovery of the taxon assumes a particular meaning as it is sympatric withthree other species of specialized cave Orotrechus.

关键词： Pi NOTE COMPLEMENTARI SU Orotrechus schwienbacheri GROTTOLO E martinelli,1991 Prealpi Venete La Coleoptera Carabidae Trechinae)DEL MASSICCIO DEL MONTE CAVALLO

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