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Multimodal comparison of plasma proteins associated with blood-brain barrier impairment in Alzheimer’s disease

Aging Communications 2024年第1期6卷 1-9页

作者： elisa giunti Roberto Collu Joel Reisman Jong Soo Lee Noureddine Melikechi Weiming Xia Geriatric Research Education and Clinical Center Bedford VA Healthcare SystemBedfordMA 01730U.S.A Department of Pharmacology Physiology and BiophysicsBoston University Chobanian&Avedisian School of MedicineBostonMA 02118U.S.A Center for Healthcare Organization and Implementation Research Bedford VA Healthcare SystemBedfordMA 01730U.S.A Kennedy College of Science University of Massachusetts LowellLowellMA 01854U.S.A.

Background:Vascular impairment is one of the major contributors to *** aimed to identify blood biomarkers suggestive of potential impairment of the blood-brain barrier(BBB)in subjects with Alzheimer’s disease(AD).Methods:We used administrative data from the VA Informatics and Computing Infrastructure Resource Center to study both inpatients and outpatients with *** samples from healthy control and AD individuals were analyzed using enzyme-linked immunosorbent assay and proteomics approaches to identify differentially expressed *** analysis was applied to explore significantly enriched ***:In the same cohort of patients with AD,we found twice number of subjects with cerebral amyloid angiopathy in the two-year period after the onset of AD,compared to the number of subjects with cerebral amyloid angiopathy in the two-year period prior to AD *** pathways related to BBB,like cell adhesion,extracellular matrix organization and Wnt signaling,were activated and differentially expressed proteins such as ADAM22,PDGFR-α,DKK-4,Neucrin and RSOP-1 were ***,matrix metalloproteinase-9,which is implicated in causing degradation of basal lamina and BBB disruption,was significantly increased in the plasma of AD ***:Alteration of proteins found in AD subjects could provide new insights into biomarkers regulating permeability and BBB integrity.

关键词： Alzheimer’s disease blood-brain barrier peripheral biomarkers matrix metalloproteinases cerebral amyloid angiopathy

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Singing on the wings! Male wing fanning performances affect female willingness to copulate in the aphid parasitoid Lysiphlebus testaceipes （Hymenoptera： Braconidae： Aphidiinae）

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Insect Science 2016年第4期23卷 603-611页

作者： Giovanni Benelli Nickolas G. Kavallieratos elisa Donati Giulia giunti Cesare Stefanini Angelo Canale Insect Behavior Group Department of Agriculture Food and Environment University of Pisa Pisa Italy Laboratory of Agricultural Entomology Department of Entomology and Agricultural Zoology Benaki Phytopathological Institute Kifissia Attica Greece The BioRobotics Institute Sant'Anna School of Advanced Studies Pontedera Pisa Italy

Lysiphlebus testaceipes （Hymenoptera： Braconidae： Aphidiinae） is a generalist endoparasitoid attacking more than 100 aphid species. In L. testaceipes, wing fanning is a main male courtship display evoked by a female-borne sex pheromone. However, no information is available on the characteristics and behavioral role of male fanning during courtship in this parasitoid. Here, the courtship behavior of a wild strain ofL. testaceipes was quantified and the male wing fanning performances were analyzed through high-speed video recordings and examined in relation to mating success. Courtship sequence of wild L. testaceipes did not substantially differ from that previously reported for other populations mass reared on aphids. We observed that the male courtship duration did not affect mating success. However, video analysis revealed that the males producing high-frequency fanning signals achieved higher mating success over those that display low-frequency fanning. Wing fanning before successful and unsuccessful courtship differed in amplitude of wing movements and alignment toward the mate, highlighting that frontal courtship positively influence the female mating decisions. This study increases knowledge on sexual behavior in a key parasitoid of aphids, highlighting the importance of wing fanning among the range of sensory modalities used in the sexual communication ofL. testaceipes. From a practical point of view, this information is useful in L. testaceipes-based biocontrol strategies, since it can help to establish parameters for quality checking of mass-reared wasps over time.

关键词： biocontrol agent courtship mating success parasitic wasp sensory ecology sexual communication

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Can gender predict virological response to standard antiviral therapy for chronic hepatitis C? A retrospective study

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Hepatoma Research 2016年第1期2卷 122-130页

作者： Paola Belci Alessandro Collo Maria Martorana Andrea Evangelista Sara giunti Roberto Gambino Maurizio Cassader Simona Bo Marilena Durazzo Department of Medical Sciences University of Turin10126 TurinItaly Department of Economics and Statistics“Cognetti de Martiis” University of Turin10153 TurinItaly

Aim:The liver is a sexually dimorphic organ presenting gender differences in its metabolism,functions,enzyme activity,membrane lipid composition and immune *** paper aimed to assess whether gender may predict virological response to standard antiviral therapy in subjects with chronic hepatitis C(CHC).Methods:The authors retrospectively analyzed 100 patients with genotype 1 CHC(55 men,45 women),who performed standard antiviral therapy(interferon and ribavirin for 12 months)in the period 2002-2012,evaluated with blood tests and abdominal ultrasound to compare different virological and biochemical response in both ***:Rate of substained virological response(SVR)was higher,but not significant,in women than men(46.7%vs.34.5%,P=0.05);difference became significant after stratification by age(<50 and≥50 years).Specifically in the group aged under 50 years,rate of SVR was significantly higher in women than in men(66.7%vs.38.2%,P<0.05).Conclusion:Female gender may predict virological response to standard antiviral therapy in subjects with CHC aged below 50 *** new potent and more expensive antiviral drugs actually available for HCV treatment,it could be useful to identify candidates firstly eligible to therapy.

关键词： Liver gender antiviral therapy

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QT间期离散度增加可有效预测2型糖尿病患者超远期心血管病死亡风险

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心血管病学进展 2013年第2期 296-297页

作者： giunti S Amione C Gruden G 袁志敏四川省第五人民医院

糖尿病为心血管病的公认危险因素之一,并将增加心血管病的罹患和死亡风险。然而既往关于心电图表现尤其是校正后QT间期(QTc)和QT间期离散度(QTd)与2型糖尿病者超远期总死亡风险及心血管病死亡风险关系远不清楚,现就此进行分析。受检对象... 详细信息

糖尿病为心血管病的公认危险因素之一,并将增加心血管病的罹患和死亡风险。然而既往关于心电图表现尤其是校正后QT间期(QTc)和QT间期离散度(QTd)与2型糖尿病者超远期总死亡风险及心血管病死亡风险关系远不清楚,现就此进行分析。受检对象为1 357例2型糖尿病患者,女性居多。研究中均经心电图测算各自基线QTc和QTd,凡QTc>0.44 s均视为QTc间期延长,和QTd>0.08 s皆纳为QTd异常增加。人均随访15年,观察分析基线QTc延长和QTd异常增加与继后随访期内总死亡风险和心血管病死亡风险间相关关系,尤其是在校

关键词：死亡风险 QTc QTd 心血管病心脏血管疾病糖尿病患者 QT 间期静止期(细胞学) 离散度

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