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Heterozygous nucleotide-binding oligomerization domain-2 mutations affect monocyte maturation in Crohn's disease

World Journal of Gastroenterology 2007年第46期13卷 6191-6196页

作者： Marilena Granzotto elisa fabbro Massimo Maschio Stefano Martelossi Sara Quaglia Alberto Tommasini Gianni Presani Alessandro Ventura Institute for Child Health Burlo Garofolo Trieste 34137Italy Department of Sciences of Reproduction and Development University of TriesteTriesteItaly Supported by the Italian Ministry of HealthNo.150/03

AIM： To investigate the function of monocytes in Crohn＇s disease （CD） patients and to correlate this with disease- associated nucleotide-binding oligomerization domain-2 （NOD2） gene variants. METHODS： Monocytes from 47 consecutively referred CD patients and 9 healthy blood donors were cultured with interleukin （IL）-4 and granulocyte-macrophage colony-stimulating factor （GM-CSF）, and stimulated with lipopolysaccharide （LPS） or muramyldipeptide （MDP）, the putative ligand of NOD2. RESULTS： We found that monocytes from CD patients differentiated in vitro to mature dendritic cells （DCs）, as determined by immunophenotype and morphology. IVOD2 genotype was assessed in all subjects, and we observed high CD86 expression on immature and LPS-stimulated DCs in IVOD2 mutated CD patients, as compared with wtlVOD2 CD patients and controls. By contrast, CD86 expression levels of DCs induced to maturity with MDP derived from IVOD2-mutated subjects were comparable to those of normal subjects. The amount of IL-12p70 in patient-cell cultures was larger than in controls aEer LPS treatment, but not aEer treatment with MDR CONCLUSION： Our results suggest that DCs obtained from patients with mutations in the IVOD2 gene display an activated phenotype characterized by high CD86 expression, but have a diminished response to MDP when compared to the terminal differentiation phase. We speculate that the altered differentiation of monocytes might lead to an imbalance between inflammation and the killing ability of monocytes, and may be relevant to the pathogenesis of CD.

关键词： Crohn's disease Dendritic cells Immun-ophenotype Muramyldipeptide Nucleotide-bindingoligomerization domain-2

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Investigation on laser brazing AA6056 Al alloy to XC18 low-carbon steel

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Chinese Optics Letters 2005年第1期3卷 31-34页

作者：丁健君李飞群瞿丰 Patrice Peyre Remy fabbro College of Materials Science and Engineering Shanghai Jiao Tong University Shanghai 200030 Cooperation Laser Franco-Allemande 94114 ARCUEIL France

Based on the studies of influence of YAG laser heating conditions for Al alloy melt and steel on wettability, the mechanics of the laser overlap braze welding of 6056 Al and XC18 steel sheet has been investigated. Under the temperature range which is above the melting point of the Al alloy and below the melting point of the steel, two dissimilar metals can be joined by means of laser braze welding. There is no crack observed in the joining area, i.e. Al-Fe intermetallic phase (Fe3Al/FeAl/FeAl3/Fe2Al5) layer formed by solution and diffusion between liquid-solid interface. The temperature range can be defined as the process temperatures of laser braze welding of Al-Fe materials. Selecting a higher laser heating temperature can improve the wettability of Al melt to steel surface, but the intermetallic phase layer is also thicker. When the laser heating temperature is so high that the joining surface of steel is melted, there is a crack trend in the joining area.

关键词： Aluminum alloys Brazing Carbon steel Temperature

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Synthetic high-density lipoprotein(sHDL):a bioinspired nanotherapeutics for managing periapical bone inflammation

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International Journal of Oral Science 2024年第3期16卷 460-470页

作者： Renan Dal-fabbro Minzhi Yu Ling Mei Hajime Sasaki Anna Schwendeman Marco C.Bottino Department of Cariology Restorative Sciencesand EndodonticsSchool of DentistryUniversity of MichiganAnn ArborMIUSA Department of Pharmaceutical Sciences College of Pharmacy and Biointerfaces InstituteUniversity of MichiganAnn ArborMIUSA Department of Biomedical Engineering College of EngineeringUniversity of MichiganAnn ArborMIUSA

Apical periodontitis(AP)is a dental-driven condition caused by pathogens and their toxins infecting the inner portion of the tooth(i.e.,dental pulp tissue),resulting in inflammation and apical bone resorption affecting 50%of the worldwide population,with more than 15 million root canals performed annually in the United *** treatment involves cleaning and decontaminating the infected tissue with chemo-mechanical approaches and materials introduced years ago,such as calcium hydroxide,zinc oxide–eugenol,or even formalin ***,we present,for the first time,a nanotherapeutics based on using synthetic highdensity lipoprotein(sHDL)as an innovative and safe strategy to manage dental bone *** application in concentrations ranging from 25μg to 100μg/mL decreases nuclear factor Kappa B(NF-κB)activation promoted by an inflammatory stimulus(lipopolysaccharide,LPS).Moreover,sHDL at 500μg/mL concentration markedly decreases in vitro osteoclastogenesis(P<0.001),and inhibits IL-1α(P=0.027),TNF-α(P=0.004),and IL-6(P<0.001)production in an inflammatory ***,sHDL strongly dampens the Toll-Like Receptor signaling pathway facing LPS stimulation,mainly by downregulating at least 3-fold the pro-inflammatory genes,such as Il1b,Il1a,Il6,Ptgs2,and *** vivo,the lipoprotein nanoparticle applied after NaOCl reduced bone resorption volume to(1.3±0.05)mm^(3) and attenuated the inflammatory reaction after treatment to(1090±184)cells compared to non-treated animals that had(2.9±0.6)mm^(3)(P=0.0123)and(2443±931)cells(P=0.004),thus highlighting its promising clinical potential as an alternative therapeutic for managing dental bone inflammation.

关键词： inflammation lipoprotein markedly

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Surgical treatment of synchronous colorectal liver and lung metastases： the usefulness of thoracophrenolaparotomy for single stage resection

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Hepatobiliary & Pancreatic Diseases International 2016年第2期15卷 216-219页

作者： Daniele Del fabbro Marco Alloisio Fabio Procopio Matteo Cimino Matteo Donadon Angela Palmisano Luca Viganò Guido Torzilli Department of Hepatobiliary Surgery Humanitas Research HospitalUniversity of Milan School of MedicineRozzanoMilanItaly Department of Thoracic Surgery Humanitas Research HospitalUniversity of Milan School of MedicineRozzanoMilanItaly

When suitable, surgery still remains the therapeutic option to be preferred for patients carrier of colorectal liver and lung metastases. Since thoracophrenolaparotomy should be helpful during liver resection for some of these patients, simultaneous removal of right lung metastases can be proposed through this approach. Eleven consecutive patients（median age of 53 years） carrier of colorectal liver and lung metastases, underwent single session surgical resection of both liver and right lung lesions by means of J-shaped thoracophrenolaparotomy. The median number of liver metastases removed was 5（range 2-30） and of lung metastases removed was 2（range 1-3）. Lung metastases were located in the upper lobe in 1 patient, in the middle lobe in 2, in the lower lobe in 6, and in the upper and lower lobe in 2. Mortality and major morbidity were nil. Two patients had a minor morbidity： one had wound infection and bile leakage treated conservatively and the other had transient fever. Mean overall survival was 24.4 months. An aggressive surgical approach should be undertaken for colorectal metastases： in case of multifocal liver disease with complex presentations, J-shaped thoracophrenolaparotomy could be considered as safe approach for combined liver and right lung metastasectomies.

关键词： colorectal carcinoma liver metastases lung metastases thoracophrenolaparotomy

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Prolegomena for a Living Architecture

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Journal of Civil Engineering and Architecture 2019年第2期13卷 88-95页

作者： Armando Dal fabbro Department of Architecture Construction Conservation Università IUAV di VeneziaDorsoduro 220630123VeniceItaly

Rational and intuitive can be considered as two sides of the same coin? If they coexist in the design process,what do they refer to and what do they stand out for? What kind of relationship can be established between the act of prefiguring the work and of putting it into operation,according to procedures and techniques that are coherent and necessary for its construction? The value of an architectural project is shown by its being a continuous search for expression of art,even if,as we know,architecture also has a social function and plays a civil *** universal meanings and the cultural reference context,which have always been the heritage of the architectural project,are increasingly taking on a secondary *** and concepts such as:tradition,memory,modernity,invention and location seem to have lost any research prerogative at the expense of the meaning and use attributed to the architectural and urban composition in the overall design process.

关键词： Architectural composition rational architecture expression of art the universal meanings

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Intraoperative cholangio-ultrasonography(IOCUS)during hepatectomy with resection of the biliary confluence:An effective alternative to intraoperative cholangiography

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 417-420页

作者： Daniele Del fabbro Fabio Procopio Jacopo Galvanin Guido Costa Simone Famularo Angela Palmisano Matteo Donadon Guido Torzilli Division of Hepatobiliary Surgery Department of SurgeryIRCCS Humanitas Research HospitalVia A.Manzoni 56Rozzano 20089MilanItaly Department of Biomedical Sciences Humanitas UniversityVia Rita Levi Montalcini 4Pieve Emanuele 20072MilanItaly

Intraoperative ultrasonography(IOUS)in hepatobiliary surgery is well known as an essential tool for radical and safe hepatectomies,allowing to perform parenchymal sparing surgery and,as consequence,to expand the surgical indications for patients otherwise considered ***,since many years,despite its effectiveness in the study of vascular anatomy of the liver,the gold standard for the assessment of biliary anatomy during surgery is intraoperative cholangiography(IOC),which is used for the validation of preoperative imaging as well as for guiding reconstruction in case of bile duct injury or resection.

关键词： anatomy biliary ultrasonography

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Salivary biomarkers: novel noninvasive tools to diagnose chronic inflammation

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International Journal of Oral Science 2023年第2期15卷 229-240页

作者： Paola Dongiovanni Marica Meroni Sara Casati Riccardo Goldoni Douglas Vieira Thomaz Nermin Seda Kehr Daniela Galimberti Massimo Del fabbro Gianluca MTartaglia Medicine and Metabolic Diseases Fondazione IRCCS CàGranda Ospedale Maggiore Policlinico Department of Biomedical Surgical and Dental SciencesUniversity of Milan Department of Electronics Information and Bioengineering(DEIB) Istituto di Elettronica e di Ingegneria dell'Informazione e delle Telecomunicazioni CNR Laboratory of Medicinal Pharmaceutical Chemistry Faculty of PharmacyFederal University of Goiás Department of Chemistry ?zmir Institute of TechnologyGülbah?e Kampüsü Neurology-Neurodegenerative Diseases Fondazione IRCCS CàGrandaOspedale Maggiore Policlinico UOC Maxillo-Facial Surgery and Dentistry Fondazione IRCCS CàGranda Ospedale Maggiore Policlinico

Several chronic disorders including type 2 diabetes(T2D),obesity,heart disease and cancer are preceded by a state of chronic lowgrade *** for the early assessment of chronic disorders encompass acute phase proteins(APP),cytokines and chemokines,pro-inflammatory enzymes,lipids and oxidative stress *** substances enter saliva through the blood flow and,in some cases。

关键词： inflammation acute chronic

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Reply to： Surgical treatment of metachronous rectal liver andlung metastases： A combined videolaparoscopic and videothoracoscopic approach

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Hepatobiliary & Pancreatic Diseases International 2018年第3期17卷 282-282页

作者： Daniele Del fabbro Guido Torzilli department of hepatobiliary surgery humanitas research hospitalRozzano Milan Italy humanitas university school of medicineRozzano Milan Italy

The Author Reply：We thank Dr. Sucameli et al. for the interest toward our article[1] and for the opportunity for further discussing on this issue,providing a case report of single metastastic fore sites in the liverand lung both treated in a minimal access fashion. However, giventhe interest of the authors insight, it appears misleading when related to that discussed in our report which was clearly referred toother patients＇ profiles. Indeed, they described a case with a singleperipheral nodule in the right lung and a single liver metastasesin segment 5. This uncommon situation （less than 2% of patientsaccording to the LiverMetSurvey registry [2]）, is obviouslya more than reasonable indication for a mini-invasive ***, our patients received surgery for complex oncological involvementof the liver： as described, this means large and/or multiplelesions, in contact or invading the hepatic veins at caval *** such conditions we have introduced original surgicalapproaches [3,4]： in such conditions we would select a J-shapedthoracophrenolaparotomy for the liver per se [5]. This incision forsuch complex conditions other than allowing the liver clearance in a single operation rather than in staged approach [6], allows justin case the removal of lung nodules. Therefore, we thank again theauthors for their interest to our report, and furthermore we congratulatefor the original management of the shared clinical ***, the condition recalled by the authors is related to a scenariooncologically and surgically at the opposite side of that discussedin our paper and for that somehow suggesting a comparisonis misleading.

关键词： Reply to:Surgical treatment of metachronous rectal liver and lung metastases:A combined videolaparoscopic and videothoracoscopic approach

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达涅利供货的全新短流程设施：MMK Iskenderun厂300t巨型FastArc电炉

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钢铁 2009年第5期44卷 92-95页

作者： Romano Setlan Maurizio fabbro Paolo Burin 苏宏蕾达涅利森特罗冶金公司不详

介绍了达涅利供货的全新短流程设施,即MMKIskenderun厂(土耳其)300 t巨型FastArc电炉。主要包括:电炉设计特点,工艺设计,所用原料,二次精炼冶金设备主要特点,烟气处理厂主要特点,以及电气自动化系统等。

关键词： FastArc电炉二次冶金烟气处理电气自动化系统

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The Efficiency of the Moire Technique for Three-Dimensional Measures of Grape Bunches

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Journal of Agricultural Science and Technology(B) 2016年第4期6卷 244-249页

作者： Juliana Aparecida Fracarolli Katia Cristina Suzigan Inacio Maria Dal fabbro Department of Postharvest Technology School of Agricultural Engineering University of Campinas Campinas 13083-875 SP Brazil Department of Pre-processing Agricultural Products School of Agricultural Engineering University of Campinas Campinas 13083-875 SP Brazil Department of Farm Machinery School of Agricultural Engineering University of Campinas Campinas 13083-875 SP Brazil

This study was carried out in the University of Campinas to study the three-dimensional reconstruction of grape bunches through the application of the Moire technique as an alternative and innovative method, using low-cost equipment for data acquisition. This study proposed the three-dimensional visualization of grapes and topography on Xi axes through the Moire projection technique. The artificial grapes with a 20 cm long bunch and 18.45 mm average diameter for each grape were used. A projector was used to generate a grid with light and dark lines. The grape bunch was placed on a holder, illuminated by a sinusoidal grid and photographed. After processing the images, a three-dimensional map of the fruit and topography on Xi axes were obtained. The three-dimensional fruit observation allows the visualization of the higher and lower regions of the three-dimensional configuration through a color map. This result makes it possible to obtain size and shape of the grape bunch, allowing for the process automation of product selection and classification.

关键词： Vitis vinifera L. grape bunches Moire technique three-dimensional visualization

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