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Psycho-gastroenterological profile of an Italian population of children with disorders of gut-brain interaction:A case-control study

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World Journal of Clinical Pediatrics 2025年第1期14卷 69-77页

作者： Valentina Giorgio Ilaria Venezia Licia Pensabene elisa blasi Donato Rigante Paolo Mariotti Giuseppe Stella Gaia Margiotta Giovanna Quatrale Giuseppe Marano Marianna Mazza Antonio Gasbarrini Eleonora Gaetani Pediatric Unit Department of WomenChildren and Public Health SciencesFondazione Policlinico Universitario“A.Gemelli”IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Child Neuropsychiatry Unit ASST Santi Paolo e CarloSan Paolo HospitalMilan 20142Italy Child Neuropsychiatry Unit Department of WomenChildren and Public Health SciencesFondazione Policlinico Universitario“A.Gemelli”IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Department of Medical and Surgical Sciences Pediatric UnitUniversity Magna GraeciaCatanzaro 88100Italy Unit of Psychiatry Fondazione Policlinico Universitario“A.Gemelli”IRCCSRome 00168Italy Department of Neurosciences UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Internal Medicine and Gastroenterology Fondazione Policlinico Universitario"A.Gemelli"IRCCSRome 00168Italy Department of Medical and Surgical Sciences Fondazione Policlinico Universitario"A.Gemelli"IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy

BACKGROUND Disorders of gut-brain interaction(DGBI)are common,but knowledge about their physiopathology is still poor,nor valid tools have been used to evaluate them in *** To develop a psycho-gastroenterological questionnaire(PGQ)to assess the psycho-gastroenterological profile and social characteristics of a pediatric population with and without *** One hundred and nineteen Italian children(age 11-18)were included:28 outpatient patients with DGBI(Rome IV criteria)and 91 healthy *** filled the PGQ,faces pain scale revised(FPS-R),Bristol stool chart,ga-strointestinal symptoms rating scale,state-trait anxiety inventory,Toronto alexithymia scale 20,perceived self-efficacy in the management of negative emotions and expression of positive emotions(APEN-G,APEP-G),irritable bowel syndrome-quality of life questionnaire,school performances,tobacco use,early life events,degree of *** Compared to controls,patients had more medical examinations(35%of them went to the doctor more than five times),a higher school performance(23%vs 13%,P<0.05),didn’t use tobacco(never vs 16%,P<0.05),had early life events(28%vs 1%P<0.05)and a higher percentage of pain classified as 4 in the FPS-R during the examination(14%vs 7%,P<0.05).CONCLUSION Pediatric outpatients with DGBI had a higher prevalence of early life events,a lower quality of life,more medical examinations rising health care costs,lower anxiety levels.

关键词： Disorders of gut-brain interaction Functional gastrointestinal disorders Psycho-gastroenterological profile Gut-brain axis Rome IV criteria Pediatric patients

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Coagulopathy in liver disease:Lack of an assessment tool

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World Journal of Gastroenterology 2015年第35期21卷 10062-10071页

作者： Annabel blasi Anesthesia Department Hospital ClínicInstitut d'investigacions Biomediques Agustí Pi i Sunyer

There is a discrepancy between the information from clotting tests which have routinely been used in clinical practice and evidence regarding thrombotic and bleeding events in patients with liver disease. This discrepancy leads us to rely on other variables which have been shown to be involved in haemostasis in these patients and/or to extrapolate the behaviour of these patients to other settings in order to decide the best clinical approach. The aims of the present review are as follows:(1) to present the information provided by clotting tests in cirrhotic patients;(2) to present the factors that may influence clotting in these patients;(3) to review the clinical evidence; and(4) to put forward a clinical approach based on the first 3 points.

关键词： Cirrhosis Coagulation test Assessment Coagulopathy

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Carbon sequestration in a bamboo plantation:a case study in a Mediterranean area

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Journal of Forestry Research 2024年第3期35卷 231-238页

作者： Tommaso Chiti Emanuele blasi Maria Vincenza Chiriaco Department for Innovation in Biological Agro-Food and Forest Systems(DIBAF)University of TusciaVia San C.De Lellis snc01100 ViterboItaly Foundation Euro-Mediterranean Center on Climate Change(CMCC) Division on Climate Change Impacts on AgricultureForests and Ecosystem Services(IAFES)Via Garbini5101100 ViterboItaly

In the Mediterranean region,despite bamboo being an alien species that can seriously alter plant and ani-mal biocoenosis,the area occupied by bamboo plantations continues to increase,especially for the purpose to seques-ter carbon(C).However,the C dynamics in the soil-plant system when bamboo is grown outside its native area are poorly *** we investigated the C mitigation potential of the fast-growing Moso bamboo(Phyllostachys edulis)introduced in Italy for climate-change *** analyzed aboveground(AGB)and belowground(as root/shoot ratio)biomass,litter and soil organic C(SOC)at O-15-and 15-30-cm depths in a 4-year-old bamboo plantation in comparison with the former annual cropland on which the bamboo was *** have an idea of the maximum C stored at an ecosystem level,a natural forest adjacent the two sites was also *** the plantation,C accumulation as AGB was stimulated,with 14.8±3.1 Mg C ha^(-1) stored in 3 years;because thinning was done to remove culms from the first year,the mean sequestration rate was 4.9 Mg C ha^(-1) a^(-1).The sequestration rates were high but comparable to other fast-growing tree species in Italy(e.g.,Pinus nigra).SOC was significantly higher in the bamboo plantation than in the cropland only at the 0-15 cm depth,but SOC stock did not *** 4 years were not enough time for a clear increase in SOC,or the high nutrient uptake by bamboos might have depleted the soil nutrients,thus inhibiting the soil organic matter formation by *** comparison,the natural forest had significantly higher C levels in all the *** C dynamics at an ecosystem level,the bamboo plantation on the former annual cropland led to substantial C removal from the atmosphere(about 12 Mg C ha^(-1) a^(-1)).However,despite the promising C sequestration rates by bamboo,its introduction should be carefully considered due to potential ecological problems caused by this species in overexploited environments such as the Med

关键词： Carbon sequestration Climate change mitigation Mediterranean area Moso bamboo Soil organic carbon

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Comment on: Early recovery pathway for hepatectomy: data-driven liver resection care and recovery

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Hepatobiliary Surgery and Nutrition 2018年第1期7卷 63-64页

作者： Annabel blasi Joan Beltran Department of Anesthesia Clinic HospitalBarcelonaSpain

We read with great interest the paper"Early recovery pathway for hepatectomy:data-driven liver resection care and recovery"by Warner et al.,in which the authors review the data behind enhanced recovery pathways preceding and following *** article formulates a pathway for practice based on data and allows a rational order set for an efficient practice(1).

关键词： hepatectomy al. liver

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Multi-family therapy for veteran and refugee families: a Delphi study

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Military Medical Research 2019年第1期6卷 39-44页

作者： elisa van Ee Psychotraumacentrum Zuid Nederland Behavioural Science Institute Radboud University

Background: Research indicates that Posttraumatic stress disorder(PTSD) has an extensive impact on family relationships. Nevertheless, there is a dearth of empirically supported interventions addressing family functioning and PTSD. In the Netherlands, it is considered good clinical practice to offer multi-family therapy(MFT) to veteran and refugee families. MFT for traumatized families aims to address the dysfunctional family patterns that have evolved to address the consequences with ***: The aim of this study is to generate a common framework for the practical impact and active ingredients of MFT in families confronted with trauma. The Delphi method was used to study the expert opinion of 11 therapists in Dutch expert trauma ***: The results indicate that MFT is a promising treatment for families dealing with the consequences of trauma. According to experts, positive outcomes include an increased understanding between family members,particularly visible in the de-escalation of conflicts within the family, and improved parenting. One explanation for the effectiveness of MFT with these target groups is its defining feature of therapy with several ***: The findings support the importance of considering family relationships and the family context in interventions for traumatized individuals.

关键词： PTSD Veteran Refugee Multi-family therapy Parenting Expert opinion

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Effect of steam-pretreatment combined with hydrogen peroxide on lignocellulosic agricultural wastes for bioethanol production：Analysis of derived sugars and other by-products

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Journal of Energy Chemistry 2018年第2期27卷 535-543页

作者： Alessandra Verardi Alessandro blasi Tiziana Marino Antonio Molino Vincenza Calabrò Laboratory of Transport Phenomena and Biotechnology Department of Computer Engineering Modeling Electronics and Systems Science (DIMES) University of Calabria Via Pietro Bucci Cube 39/A 1st Floor 1-87036 Arcavacata di Rende Cosenza (CS) Italy ENFA Italian National Agency for New Technologies Energy and Sustainable Economic Development CR Trisaia S.S. 106 lonica km 419+500-75026 Rotondella Matera (MT) Italy Institute on Membrane Technology ITM-CNR Via P. Bucci Cuba 17/c 1-87036 Arcavacata di Rende CS Italy ENEA. Italian National Agency for New Technologies Energy and Sustainable Economic Development CR Portici P.. Enrico Fermi 1 80055 Portici NA Italy

The hydrogen peroxide, a green impregnating agent suitable for lignocellulosic biomass to bioethanol process, was used to pretreat sugarcane bagasse by steam explosion. Two different concentrations of hydrogen peroxide（0.2% and 1%） were investigated. Then, the biomass was hydrolyzed after pretreatment using cellulase. The amount released of：（i） cellobiose;（ii） monosaccharides, as glucose, xylose, arabinose and mannose and（iii） lignocellulose derived by-products, as furans and small organic acids（acetic, formic,and levulinic acid）, was evaluated in the hydrolysate samples, previously pretreated both in the presence and absence of impregnating agent. By adding of hydrogen peroxide in steam-pretreatment, the average yield increase was 12% for glucose and as high as 34% for xylose, and cellobiose yield was decreased of about 30%. No significant increase has been observed in arabinose and mannose yield. Furthermore,the hydrogen peroxide seems not increased the formation of lignocellulose derived by-products during pretreatment process, with the exception of the levulinic acid.

关键词： Lignocellulose Hydrogen peroxide Steam explosion Enzymatic hydrolysis Bioethanol

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On a Fixed Point Theorem of Ky Fan

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Acta Mathematica Sinica,English Series 2002年第2期18卷 363-374页

作者： DE blasi Francesco S. GEORGIEV Pando Gr. Department of Mathematics.University of Roma Ⅱ'Tor Vergata.Via della Ricerca Scientifica.00133 Roma.Italy Department of Mathematics and Informatics SofiaUniversity"St.Kl.Ohridski"5 James Bourchier Blvd.1126 Sofia.Bulgaria and Laboratory for Advanced Brain Signal Processing.Brain Science Institute.The Institute of Physical and Chemical Research(RIKEN)2-1HirosawaWako-shiSaitama.351-0198.Japan

We generalize a theorem of Ky Fan about the nearest distance between a closed convex set D in a Banach space E and its image by a function f:D→E,in several directions:(1)for noncompact sets *** f(D)precompact:(2)for compact D and upper semicontinuous multifunction f:and more generally,(3)for noncompact D and upper semicontinuous multifunction f with f(D)Hausdorff precompact. In particular,we prove a version of the fixed point theorem of Kakutani-Ky Fan for multifunctions. whose values are convex closed bounded,thus not necessarily compact.

关键词： Ky Fan Compact h-compact Upper semicontinuous Multifunction

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Over-specialization versus synergy in neuroscience:professionals’integration is more than the sum of its parts

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Neural Regeneration Research 2021年第11期16卷 2232-2233页

作者： elisa Cainelli Luca Vedovelli Department of General Psychology University of PadovaPadovaItaly Unit of Biostatistics Epidemiology and Public HealthDepartment of CardiacThoracicVascular Sciencesand Public HealthUniversity of PadovaPadovaItaly

Health care systems in industrialized countries are built around acute health problems(Etzwiler,1997).This approach is successful when the goal is to improve or overcome pathologies that result in severe health issues or *** the recent tremendous improvement of the treatments of life-threatening conditions,the clinical focus has moved from short term results to the overall expected quality of life and longterm ***,the new objectives imply to consider a multitude of interacting processes and *** fact,a complex interplay of biological systems(nervous,immune,and endocrine)works together in an integrated and synergistic way to deal with a constantly evolving environment,determining our physical,behavioral,and psychological/subjective *** interplay is the mechanism that allows us to adapt promptly and appropriately to circumstances,the key feature for successful living.

关键词： overcome synergistic determining

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How do stream processes affect hazard exposure on alluvial fans? Insights from an experimental study

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Journal of Mountain Science 2020年第4期17卷 753-772页

作者： Bruno MAZZORANA elisa GHIANDONI Lorenzo PICCO Universidad Austral de Chile Faculty of SciencesInstituto de Ciencias de la Tierra5090000 ValdiviaChile Universidad Austral de Chile RINA–Natural and Anthropogenic Risks Research Center5090000 ValdiviaChile Universidad Austral de Chile Laboratory of HydromorphologyFaculty of Forest Sciences and Natural Resources5090000 ValdiviaChile University of Padova Department of LandEnvironmentAgriculture and Forestry35020 LegnaroItaly

Alluvial fans are among the most privileged settlement areas in many mountain regions. These landforms are particularly dynamic being episodically affected by distributary processes generated by extreme flood events. Addressing risk assessment entails determining hazard exposure and unravelling how it might be related to process loading and to process dynamics once the flow becomes unconfined on the surface of alluvial fans. By following a ‘similarity of process concept’, rather than by attempting to scale a real-world prototype, we performed a set of 72 experimental runs on an alluvial fan model. Thereby, we considered two model layouts, one without a guiding channel and featuring a convex shape and the other one with a guiding channel, a bridge, and inclined but planar overland flow areas as to mirror an anthropic environment. Process magnitude and intensity parameters were systematically varied, and the associated biphasic distributary processes video recorded. For each experiment, the exposure was detected by mapping the exposed area in a GIS, thereby discerning between areas exposed to biphasic flows and the associated depositional phenomena or to the liquid flow phase only. Our results reveal that total event volume, sediment availability and stream power in the feeding channel, as well as depositional effects, avulsion, and channelization on the alluvial fan concur to determine the overall exposure. Stream process loading alone, even when rigorously defined in terms of its characterizing parameters, is not sufficient to exhaustively determine exposure. Hence, further developing reliable biphasic simulation models for hazard assessment on settled alluvial fans is pivotal.

关键词： Alluvial fan Hazard Exposure Flood risk Experimental model Process similarity

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Biomarkers for pancreatic cancer:Recent achievements in proteomics and genomics through classical and multivariate statistical methods

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World Journal of Gastroenterology 2014年第37期20卷 13325-13342页

作者： Emilio Marengo elisa Robotti Department of Sciences and Technological Innovation University of Piemonte Orientale

Pancreatic cancer(PC) is one of the most aggressive and lethal neoplastic diseases. A valid alternative to the usual invasive diagnostic tools would certainly be the determination of biomarkers in peripheral fluids to provide less invasive tools for early diagnosis. Nowadays, biomarkers are generally investigated mainly in peripheral blood and tissues through high-throughput omics techniques comparing control vs pathological samples. The results can be evaluated by two main strategies:(1) classical methods in which the identification of significant biomarkers is accomplished by monovariate statistical tests where each biomarker is considered as independent from the others; and(2) multivariate methods, taking into consideration the correlations existing among the biomarkers themselves. This last approach is very powerful since it allows the identification of pools of biomarkers with diagnostic and prognostic performances which are superior to single markers in terms of sensitivity, specificity and robustness. Multivariate techniques are usually applied with variable selection procedures to provide a restricted set of biomarkers with the best predictive ability; however, standard selection methods are usually aimed at the identification of the smallest set of variables with the best predictive ability and exhaustivity is usually neglected. The exhaustive search for biomarkers is instead an important alternative to standard variable selection since it can provide information about the etiology of the pathology by producing a comprehensive set of markers. In this review, the most recent applications of the omics techniques(proteomics, genomics and metabolomics) to the identification of exploratory biomarkers for PC will be presented with particular regard to the statistical methods adopted for their identification. The basic theory related to classical and multivariate methods for identification of biomarkers is presented and then, the most recent applications in this f

关键词： Pancreatic cancer Biomarker identification Multivariate analysis Principal component analysis Ranking principal component analysis

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