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语言教学与研究 1992年第4期 158-159页

作者： mc

为贯彻落实邓小平同志重要讲话精神,加速语文报刊的改革步伐,“中国语文报刊代表大会”于1992年8月16—18日在北京召开。国家语委常务副主任伸哲明、新闻出版署期刊司司长张伯海和报纸司司长梁衡出席大会指导。

关键词：语文知识语言文字标准化语文教学改革中国语文贯彻落实代表大会中学语文教学报刊讲话精神

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Void fill techniques for stabilizing roof conditions during longwall recovery

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International Journal of Mining Science and Technology 2016年第1期26卷 119-122页

作者： Oldham Robin Dickerson Craig mc Henry Rusty Underground Coal GMS Mine Repair and Maintenance Bailey Mine CONSOL Energy

It has been proven that longwall faces can be moved safely and efficiently. However,abutment pressures and poor ground control conditions can halt operations and be hazardous to coal miners. Recently at a mine in Southwestern Pennsylvania,roof material collapsed above shields that created two large voids and caused major challenges for shield recovery. A unique,engineering solution was developed that utilized a modified concrete material to fill the voids,creating stability in the affected area. The many phases of this project included the construction phase,void pumping,cutting out,and bolting of the concrete material. This project eliminated the hazards associated with bolting the recovery face and removing shields in adverse conditions,making it possible for the mine operator to safely complete the longwall move.

关键词： Longwall miningLongwall recoveryVoid fillNon-traditional recovery

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Up-regulation of PIK3CA promotes metastasis in gastric carcinoma

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World Journal of Gastroenterology 2010年第39期16卷 4986-4991页

作者： Liu JF Zhou XK Chen JH Yi G Chen HG Ba mc Lin SQ Qi YC. Institute of Cancer Research Affiliated Tumor Hospital of Guangzhou Medical College Guangzhou 510095 Guangdong Province China. zxkstar@***

AIM:To explore expressions of PIK3CA in the progression of gastric cancer from primary to metastasis and its effects on activation of phosphatidylinositol 3-kinase(PI3K)/Akt ***:mRNA and protein levels of PIK3CA were assessed,respectively,by real-time quantitative polymerase chain reaction and immunohistochemistry in specimens of normal gastric mucosa,primary foci and lymph node and distant metastasis of gastric *** and phosphorylated Akt protein were also examined by Western blotting in these tissues,in order to analyze the effect of PIK3CA expression level changes on the activation of PI3K/Akt signaling ***:PIK3CA mRNA in lymph node metastasis were approximately 5 and 2 folds higher,respectively,than that in the corresponding normal gastric mucosa and primary gastric cancer tissues(P<0.05),while no statistical significance was found compared with distant ***,PIK3CA protein expression was discovered in 7(35%)specimens of 20 primary foci vs 10(67%)of 15 of lymph node metastasis or 11(61%)of 18 of distant metastasis(35%vs 67%,P=0.015;35%vs 61%,P=0.044).With the increased level of PIK3CA expression,the total Akt protein expression remained almost unchanged,but p-Akt protein was upregulated ***:Increased expression of PIK3CA is expected to be a promising indicator of metastasis in gastric ***-regulation of PIK3CA may promote the metastasis of gastric cancer through aberrant activation of PI3K/Akt signaling.

关键词： PIK3CA Phosphatidylinositol 3-kinase/Akt pathway Metastasis Gastric cancer Akt

Painful intervertebral disc degeneration and inflammation:from laboratory evidence to clinical interventions

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Bone Research 2021年第1期9卷 1-14页

作者： Feng-Juan Lyu Haowen Cui Hehai Pan Kenneth mc Cheung Xu Cao James C.Iatridis Zhaomin Zheng School of Medicine South China University of TechnologyGuangzhouChina Department of Spine Surgery The First Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Breast Tumor Center Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Orthopedics&Traumatology The University of Hong KongHong KongSARChina Department of Orthopedic Surgery Johns Hopkins UniversityBaltimoreMDUSA Leni and Peter W.May Department of Orthopedics Icahn School of Medicine at Mount SinaiNew YorkNYUSA Pain Research Center Sun Yat-sen UniversityGuangzhouChina

Low back pain(LBP),as a leading cause of disability,is a common musculoskeletal disorder that results in major social and economic *** research has identified inflammation and related signaling pathways as important factors in the onset and progression of disc degeneration,a significant contributor to *** mediators also play an indispensable role in discogenic *** suppression of LBP is a primary goal of clinical practice but has not received enough attention in disc research ***,an overview of the advances in inflammation-related pain in disc degeneration is provided,with a discussion on the role of inflammation in IVD degeneration and pain *** models,mechanical models,and spontaneous models as the main animal models to study painful disc degeneration are discussed,and the underlying signaling pathways are ***,potential drug candidates,either under laboratory investigation or undergoing clinical trials,to suppress discogenic LBP by eliminating inflammation are *** hope to attract more research interest to address inflammation and pain in IDD and contribute to promoting more translational research.

关键词： degeneration eliminating enough

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Final anatomic and visual outcomes appear independent of duration of silicone oil intraocular tamponade in complex retinal detachment surgery

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 83-88页

作者： Maedbh Rhatigan Elizabeth mc Elnea Patrick Murtagh Kirk Stephenson Elaine Harris Paul Connell David Keegan Department of Ophthalmology Mater Misericordiae University Hospital

AIM： To report anatomic and visual outcomes following silicone oil removal in a cohort of patients with complex retinal detachment, to determine association between duration of tamponade and outcomes and to compare patients with oil removed and those with oil in situ in terms of demographic, surgical and visual factors. METHODS： We reported a four years retrospective case series of 143 patients with complex retinal detachments who underwent intraocular silicone oil tamponade. Analysis between anatomic and visual outcomes, baseline demographics, duration of tamponade and number of surgical procedures were carried out using Fisher＇s exact test and unpaired two-tailed t-test. RESULTS： One hundred and six patients（76.2%） had undergone silicone oil removal at the time of review with 96 patients（90.6%） showing retinal reattachment following oil removal. Duration of tamponade was not associated with final reattachment rate or with a deterioration in best corrected visual acuity（BCVA）. Patients with oil removed had a significantly better baseline and final BCVA compared to those under oil tamponade（P=0.0001, 〈0.0001 respectively）. CONCLUSION： Anatomic and visual outcomes in this cohort are in keeping with those reported in the literature. Favorable outcomes were seen with oil removal but duration of oil tamponade does not affect final attachment rate with modern surgical techniques and should be managed on a case by case basis.

关键词： silicone oil tamponade proliferative vitreoretinopathy retinal detachment

Sediment transport trends and cross-sectional stability of a lagoonal tidal inlet on the Central Coast of Vietnam

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International Journal of Sediment Research 2019年第4期34卷 322-334页

作者： Do Minh Duc Tran Thanh Tung Patrick mc Laren Tran Ngoc Anh Dinh Thi Quynh Faculty of Geology VNU University of Science Vietnam National University Faculty of Marine and Coastal Engineering Thuyloi University Sed Trend Analysis Limited 4. Faculty of Meteorology Hydrology and Oceanography VNU University of Science Vietnam National University

Lagoonal tidal inlets are a typical morphology of the Central Coast of Vietnam. Recently, navigation channels in these inlets have become increasingly threatened by siltation. This study analyses the relations between sediment distribution and transport trends(using the technique of Sediment Trend Analysis-STAs) in the lagoonal system of the De Gi inlet and then proposes appropriate countermeasures against sand deposition in the navigation channel. The STA identified three types of transport trends in the De Gi inlet, namely dynamic equilibrium, net accretion, and net erosion. Processes associated with the tidal prism have resulted in trends of sediment transport and deposition across the flood and ebb tidal shoals, which maintain a present cross-sectional area of about 1000 m~2. However, longshore sediment transport from north to south resulting from northeast waves cause additional sand deposition in the channel. In addition, the effects of refraction associated with a nearby headland and jetty also increase sedimentation. These processes provide the main reasons for sediment deposition in the De Gi inlet. Short term and regular dredging helps to maintain the navigation channel. A system comprised of three jetties(north, south, and weir) is necessary to ensure the longterm cross-sectional stability of the navigation channel.

关键词： Lagoon Tidal inlet Sediment Trend Analysis (STA) Tidal prism Cross-sectional stability

Short turn radius colonoscope in an anatomical model: Retroflexed withdrawal and detection of hidden polyps

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World Journal of Gastroenterology 2015年第2期21卷 593-599页

作者： Sarah K mc Gill Shivangi Kothari Shai Friedland Ann Chen Walter G Park Subhas Banerjee Division of Gastroenterology and Hepatology Stanford University School of MedicineStanfordCA 94305United States

AIM: To evaluate the new Retro View^(TM) colonoscope and compare its ability to detect simulated polyps "hidden" behind colonic folds with that of a conventional colonoscope, utilizing anatomic colon ***: Three anatomic colon models were prepared,with twelve simulated polyps "hidden" behind haustral folds and five placed in easily viewed locations in each model. Five blinded endoscopists examined two colon models in random order with the conventional or Retro View^(TM) colonoscope, utilizing standard withdrawal technique. The third colon model was then examined with the Retro View^(TM) colonoscope withdrawn initially in retroflexion and then in standard withdrawal. Polyp detection rates during standard and retroflexed withdrawal of the conventional and Retro View^(TM) colonoscopes were determined. Polyp detection rates for combined standard and retroflexed withdrawal(combination withdrawal) with the Retro View^(TM) colonoscope were also ***: For hidden polyps, retroflexed withdrawal using the Retro View^(TM) colonoscope detected more polyps than the conventional colonoscope in standard withdrawal(85% vs 12%, P = 0.0001). For hidden polyps, combination withdrawal with the Retro View^(TM) colonoscope detected more polyps than the conventional colonoscope in standard withdrawal(93% vs 12%, P ≤ 0.0001). The Retro View^(TM) colonoscope in "combination withdrawal" was superior to other methods in detecting all(hidden + easily visible) polyps, with successful detection of 80 of 85 polyps(94%) compared to 28(32%) polyps detected by the conventional colonoscope in standard withdrawal(P < 0.0001) and 67(79%) polyps detected by the Retro View^(TM) colonoscope in retroflexed withdrawal alone(P < 0.01). Continuous withdrawal of the colonoscope through the colon model while retroflexed was achieved by all endoscopists. In a post-test survey, four out of five colonoscopists reported that manipulation of the colonoscope was easy or very ***: In

关键词： Colonoscopy Adenoma detection Polyp detection Colo

Management of hepatocellular carcinoma with portal vein tumor thrombosis: Review and update at 2016

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World Journal of Gastroenterology 2016年第32期22卷 7289-7300页

作者： Stephen L Chan Charing CN Chong Anthony WH Chan Darren mc Poon Kenneth SH Chok State Key Laboratory in Oncology of South China Institute of Digestive Disease The Chinese University of Hong Kong Department of Clinical Oncology Sir YK Pao Center for Cancer Hong Kong Cancer Institute The Chinese University of Hong Kong Prince of Wales Hospital Department of Surgery Prince of Wales Hospital The Chinese University of Hong Kong State Key Laborator in Oncology of South China Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong Department of Surgery Queen Mary Hospital The University of Hong Kong

Portal vein tumor thrombosis(PVTT) is a common phenomenon in hepatocellular carcinoma(HCC). Compared to HCC without PVTT, HCC with PVTT is characterized by an aggressive disease course, worse hepatic function, a higher chance of complications related to portal hypertension and poorer tolerance to treatment. Conventionally, HCC with PVTT is grouped together with metastatic HCC during the planning of its management, and most patients are offered palliative treatment with sorafenib or other systemic agents. As a result, most data on the management of HCC with PVTT comes from subgroup analyses or retrospective series. In the past few years, there have been several updates on management of HCC with PVTT. First, it is evident that HCC with PVTT consists of heterogeneous subgroups with different prognoses. Different classifications have been proposed to stage the degree of portal vein invasion/thrombosis, suggesting that different treatment modalities may be individualized to patients with different risks. Second, more studies indicate that more aggressive treatment, including surgical resection or locoregional treatment, may benefit select HCC patients with PVTT. In this review, we aim to discussthe recent conceptual changes and summarize the data on the management of HCC with PVTT.

关键词： Liver cancer Vascular invasion Targeted agent Surgery Radiotherapy

Antitussive activity of Triclisia dictyophylla of the family Menispermecae

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Asian Pacific Journal of Tropical Medicine 2009年第4期2卷 33-40页

作者： Azikiwe CCA Unekwe PC Amazu LU Luechai Srigernyaung Ezeani mc Nwosu PJC Ajugwo A Department of Pharmacology Madonna UniversityElele CampusNigeria Department of Microbiology/Immunology Madonna UniversityEleleRivers State Nigeria

Objective:To verify through a scientific mean the therapeutic use of the plant as an anti-tussive agent,by traditional medicine healers and also aid in the search for new drugs developments from ***:The roots of Triclisia dictyophylla were investigated for their antitussive *** plant was uprooted in the month of June 2003 at Igbodo,Delta State,Nigeria and was taken to the university of Nigeria Nsukka for taxonomy. The roots were chopped,ground and immersed in pure drinking water for 24 *** filtration, extraction was carried out using a Rotary evaporator,preliminary phytochemistry and acute toxicity studies were carried *** study was carried out using a total of 42 young rats of average weight of 72.2 *** rats were housed in standard animal house of the university and were allowed access to feeds and water but, were fasted for 12 hours prior to commencement of *** and appropriate dosage of the crude extract and Codeine re - dissolved in water were administered orally 30 minutes prior to induction of cough. Cough was induced by exposing the animals to Sulphure dioxide gas for 3- *** was taken as number of Head-nods per minute,Stethoscope aided audible sounds and,or tears *** cough inhibition for crude extract and,or Codeine treated rats were compared with reference to control *** were subjected to statistical analysis using SPSS ***:A 10.2%extraction yield was got from a starting root initial weight of 320 *** preliminary phytochemistry of the aqueous root extract revealed the presence of alkaloids,saponins,flavonoids,proteins,reducing sugars,steroids,resins fats/oils and glycosides. The Median lethal dose(LD_(50)) based on Lorke's 1983 method was 548 mg/kg The aqueous root extract at concentrations of 10 mg/kg,50 mg/kg,100 mg/kg and 200 mg/kg orally administered,inhibited cough in rats induced by sulphure dioxide gas by 16.67%,33.33%,50.00%and 83.33%respec

关键词： Antitussive Cough Rats/Mice Triclisia dictyophylla Menispermaceae Moonseed Sulphure dioxide gas Codeine

Perspectives of Taiwan Tectonics from TAIGER Project

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地质学报 2013年第S1期 84-85页

作者： Francis T Wu Hao Kuo-Chen Kirk mc Intosh Luc Lavier SUNY Binghamton University of Southern California National Central University University of Texas

Taiwan is one of the youngest and most active orogenies in the world. It can be taken as a good "present" for us to use as the "key" to understand other older orogenies in China and around the world. Through the TAIGER project we have obtained a large amount of geophysical data. Being young and active the Taiwan orogen provides an environment for detailed studies of ongoing orogenic processes.

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