检索结果-南通市图书馆

Development of a chronic compression spinal cord injury model in neonatal and adult rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2024年第05期 758-768页

作者： Reggie Ridlen Victoria Marsters Elizabeth Clarke Kristine mc Grath Catherine A.Gorrie School of Life Sciences University of Technology Sydney Kolling Institute of Medical Research Sydney Medical School University of Sydney

Background: Spinal cord injury presents a significant burden globally, with traumatic spinal cord injury being the predominant cause historically. However, nontraumatic spinal cord injury(NTSCI) is emerging as a significant contributor, particularly in developed nations, yet it remains poorly understood due to underreporting and misclassification. NTSCI, spanning various etiologies such as bony growths, vascular conditions,infections, neoplastic conditions, and immune disorders, poses unique challenges in diagnosis and treatment, often resulting in lifelong morbidity. This study addresses the lack of suitable animal models for NTSCI research, especially in neonatal ***: Utilizing a solid spacer approach, we developed a compression NTSCI model applicable to both neonatal and adult Sprague–Dawley ***: Through anatomical measurements and in vivo experiments, we confirmed the feasibility and safety of the spacer insertion procedure and observed no acute off-target ***: The versatility of this model lies in its adaptability to different ages of rats,offering a cost-effective and reproducible means to induce graded injuries. Moreover,behavioral assessments demonstrated observable hindlimb function, validating the model' s utility for studying functional outcomes. Although challenges persist, particularly in accounting for spinal column growth in neonatal animals, this model fills a crucial gap in pediatric NTSCI research. By providing a platform to investigate pathophysiological mechanisms and test potential treatments, it offers promising avenues for advancing our understanding and management of pediatric NTSCI.

关键词：

Artificial light at night(ALAN) pollution alters bat lunar chronobiology:insights from broad-scale long-term acoustic monitoring

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Ecological Processes 2024年第1期13卷 176-187页

作者： Han Li Pauline Allen Saige Boris Samantha Lagrama Jade Lyons Christina Mills Pauline Moussi Casey Nichols Carter Tacosik mc Kenzie Tsaousis Nyzaya Livingston Wilson John F.Grider Kevin A.Parker Matina C.Kalcounis-Rueppell Department of Biology University of Nebraska Omaha Department of Biology University of North Carolina Greensboro Colorado Parks and Wild-life Parker Ecology LLC Department of Biological Sciences University of Alberta

Background The timing of behavior and habitat use of nocturnal animals can be influenced by the lunar cycle in nature. The prevalence of artificial light at night(ALAN) has been recognized as a source of environmental pol-lution. The interaction between ALAN and the lunar cycle on bat behavior is important for understanding anthro-pogenic effects on bats. We utilized a decade(2012–2022) of acoustic monitoring data collected in North Carolina, United States, to investigate the relationship between bat activity, lunar cycle, and light pollution. We examined whether the amount of lunar illumination affected species-specific nightly activity and whether hourly bat activity patterns varied between nights with different moon phases. We further investigated if the relationship between bat activity and the lunar cycle might be altered by light *** We found that seven bat species showed activity variation across nights in relation to the amount of moon illumination when ALAN was absent. In general, bats were less active on full moon nights compared to new moon nights. Light pollution interacted with the bat–lunar relationship in five of the seven species, masking the effect of the lunar cycle. We identified delayed bat activity patterns on nights with a full or waxing moon in seven species, and light pollution altered that pattern in four species. Overall, ALAN was associated with decreased bat activity inde-pendent of lunar cycle *** Our study demonstrated that at a broad spatial scale, ALAN negatively affected many North American temperate bat species and altered their lunar chronobiology. As light pollution is spreading to historically dark areas and habitats, ALAN might couple with other threats, such as the white-nose syndrome or climate change, to cause cascading damage in the environment that depends on ecosystem services such as pest control provided by bats. We argue that further research and conservation actions are needed to mitigate

关键词： Artificial light at night ALAN Bats Chiroptera Chronobiology Light pollution Lunar cycle Moonlight

Photoionisation detection of a single Er3+ ion with sub-100-ns time resolution

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2024年第4期11卷 38-45页

作者： Yangbo Zhang Wenda Fan Jiliang Yang Hao Guan Qi Zhang Xi Qin Changkui Duan Gabriele G.de Boo Brett C.Johnson Jeffrey C.mc Callum Matthew J.Sellars Sven Rogge Chunming Yin Jiangfeng Du CAS Key Laboratory of Microscale Magnetic Resonance and School of Physical Sciences University of Science and Technology of China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of China Hefei National Laboratory University of Science and Technology of China Centre of Excellence for Quantum Computation and Communication Technology School of Physics University of New South Wales Centre of Excellence for Quantum Computation and Communication Technology School of Engineering RMIT University Centre of Excellence for Quantum Computation and Communication Technology School of Physics University of Melbourne Centre of Excellence for Quantum Computation and Communication Technology Research School of Physics and Engineering Australian National University

Efficient detection of single optical centres in solids is essential for quantum information processing, sensing and single-photon generation *** this work,we use radio-frequency（RF） reflectometry to electrically detect the photoionisation induced by a single Er3+ion in *** high bandwidth and sensitivity of the RF reflectometry provide sub-100-ns time resolution for the photoionisation *** this technique,the optically excited state lifetime of a single Er3+ion in a Si nano-transistor is measured for the first time to be 0.49±0.04μ*** results demonstrate an efficient approach for detecting a charge state change induced by Er excitation and *** approach could be used for fast readout of other single optical centres in solids and is attractive for large-scale integrated optical quantum systems thanks to the multi-channel RF reflectometry demonstrated with frequency multiplexing techniques.

关键词： single optical centres erbium ions RF reflectometry photoionisation detection

专为电动汽车市场的轮胎和橡胶制品设计的炭黑

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

橡塑技术与装备 2024年第10期50卷 82-86页

作者：章羽 Abegayl Thomas-mc Millan Wesley Wampler Leszek Nikiel Michael Widmor Peter Cameron 全国橡塑机械信息中心北京100143 Tokai Carbon CB Ltd.

本文探讨了特种炭黑材料EV 800在电动汽车轮胎和橡胶制品中的应用。EV 800具有可持续性、高结构和适宜的表面积,且已通过ISCC Plus认证,它能增强轮胎强度和耐久性,减少滚动阻力,提升电动汽车的能效。本文总结了EV 800对轮胎性能的积极影... 详细信息

本文探讨了特种炭黑材料EV 800在电动汽车轮胎和橡胶制品中的应用。EV 800具有可持续性、高结构和适宜的表面积,且已通过ISCC Plus认证,它能增强轮胎强度和耐久性,减少滚动阻力,提升电动汽车的能效。本文总结了EV 800对轮胎性能的积极影响,并通过实验对比确认了其作为电动汽车轮胎材料的适宜性,强调了其强度、能效提升和可持续性特点。

关键词： EV 800 炭黑材料滚动阻力可持续性

Novel advancements in threedimensional neural tissue engineering and regenerative medicine

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2015年第3期10卷 352-354页

作者： Richard J.mc Murtrey Institute of Neural Regeneration & Tissue Engineering Institute of Biomedical Engineering Department of Engineering ScienceOld Road Campus Research BuildingUniversity of Oxford

Neurological diseases and injuries present some of the great- est challenges in modern medicine, often causing irrevers- ible and lifelong burdens in the people whom they afflict. Conditions of stroke, traumatic brain injury, spinal cord injury, and neurodegenerative diseases have devastating con- sequences on millions of people each year, and yet there are currently no therapies or interventions that can repair the structure of neural circuits and restore neural tissue function in the brain and spinal cord. Despite the challenges of over- coming these limitations, there are many new approaches under development that hold much promise. Neural tissue engineering aims to restore and influence the function of damaged or diseased neural tissue generally through the use of stem cells and biomaterials. Many types of biomaterials may be implemented in various designs to influence the survival, differentiation, and function of developing stem cells, as well as to guide neurite extension and morphological architecture of cell cultures. Such designs may aim to reca- pitulate the cellular interactions, extracellular matrix char- acteristics, biochemical factors, and sequences of events that occur in neurodevelopment, in addition to supporting cell survival, differentiation, and integration into innate neural tissue.

关键词： Novel advancements in threedimensional neural tissue engineering and regenerative medicine

维普期刊数据库

Natural products:Perspectives in the pharmacological treatment of gastrointestinal anisakiasis

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 604-609页

作者： Valero A Romero mc Gómez-Mateos M Hierro I Navarro mc Department of Parasitology.Faculty of Pharmacy.University of Granada Department of Pharmacology.Faculty of Pharmacy.University of Granada

Objective: To evaluate the activity of different natural products against L3 larvae of Anisakis type I. Methods: Information on investigations into the activity of natural products against the L3 larvae of Anisakis simplex was collected from scientific journals, books, theses and reports via a library and electronic search(using Pubmed, Scopus, Medline, Web of Science and Science Direct). The search terms included: natural products, medicinal plants, essential oils, terpenic derivatives, Anisakis, antinematodal activity. Results: In the literature reviewed numerous papers were found concerning the in vitro and in vivo activity against Anisakis type I of various natural products(plant extracts, essential oils and their major components). Analysis of the results showed that in vitro tests the Melaleuca alternifolia essential oil and the ar-turmerone isolated from Curcuma longa displayed the greatest activity. In vivo, the most active compound was perillaldehyde, the main component of Perilla frutescens essential oil. Conclusions: This study shows that some natural products exhibited promising antianisakis properties.

关键词： Anisakis Anisakiasis Natural products Essential oils Terpenic derivatives

Characterization of six tumorsuppressor genes and microsatellite instability in hepatocellular carcinomain southern African blacks

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 1999年第6期5卷 470-476页

作者： Martins C Kedda MA Kew mc MRC/CANSA/University Molecular Hepatology Research Unit Department of Medicine University of the Witwatersrand Medical School 7 York Road Parktown 2193 Johannesburg South Africa

AIM To analyse cumulative loss of heterozygosity (LOH) of chromosomal regions and tumor suppressor genes in hepatocellular carcinomas (HCCs) from 20 southern African blacks. METHODS p53, RB1, BRCA1, BRCA2, WT1 and E cadherin genes were analysed for LOH, and p53 gene was also analysed for the codon 249 mutation, in tumor and adjacent non tumorous liver tissues using molecular techniques and 10 polymorphic microsatellite markers. RESULTS p53 codon 249 mutation was found in 25% of the subjects, as was expected, because many patients were from Mozambique, a country with high aflatoxin B 1 exposure. LOH was found at the RB1, BRCA2 and WT1 loci in 20%(4/*!20) of the HCCs, supporting a possible role of these genes in HCC. No LOH was evident in any of the remaining genes. Reports of mutations of p53 and RB1 genes in combination, described in other populations, were not confirmed in this study. Change in microsatellite repeat number was noted at 9/*!10 microsatellite loci in different HCCs, and changes at two or more loci were detected in 15%(3/*!20) of subjects. CONCLUSION We propose that microsatellite/genomic instability may play a role in the pathogenesis of a subset of HCCs in black Africans.

关键词： carcinoma, hepatocellular southern African blacks cumulative LOH tumor suppressor genes microsatellite genomic instability liver neoplasms

Foraminifera in Cenozoic Paleoenvironments

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of China University of Geosciences 2005年第3期16卷 200-218页

作者： Brian mc Gowran School of Earth & Environmental Sciences Mawson Building DP313 The University of Adelaide Adelaide SA 5005 Australia

Paleontologists search the fossil record for evidence of age, ancient environments, phylogenetic reconstructions and ancient communities. Cenozoic foraminifera preserve evidence for all of these simultaneously from the water column and from at, above and below the sediment/water interface. As our understanding of foraminiferal assemblages and their place in the strata （biofacies） becomes more sophisticated, so are foraminiferal biofacies challenged to contribute to more subtle problems in Cenozoic earth and life history. Progress is described as a series of five ＂integrations＂. （Ⅰ） The quantification of foraminiferal biofacies was an advance on simple presences and absences of species meeting such questions as marine or nonmarine, or shallow or deep. （Ⅱ） Foraminiferal shells carry geochemical signals especially isotopes of oxygen （temperature, ice volume）, carbon （nutrition and the carbon cycle）, and strontium （seawater ratios through time）. （Ⅲ） From modern foraminiferal biology we have lifestyle insights leading to a model of oceans and paleo-oceans called the trophic resource continuum, a valuable way into greenhouse-icehouse comparisons and contrasts. （Ⅳ） Biofacies changes in space and time are sometimes abrupt with little evidence of diachrony, and sometimes gradual. These patterns are clarified in the context of sequence stratigraphy （which they enrich in turn）. （Ⅴ） The paleobiological counterpart of sequence stratigraphy is evolutionary paleoecology, reconstructing communities in deep time. The foraminifera are perfectly suited to investigate the possibility （or likelihood） that global environmental shifts have controlled community turnover in the pelagic, neritic and terrestrial realms.

关键词： foraminifera biofacies stratigraphy paleoecology paleoenvironment evolution Cenozoic trophic resource continuum

维普期刊数据库

Progress in research of liver surgery in China

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2000年第6期6卷 773-776页

作者： Wu mc Shen F Second Mil Med Univ Eastern Hepatobiliary Surg Hosp Shanghai 200438 Peoples R China

INTRODUCTIONLiver surgery,was started in the late 1950s in Chinaand has developed rapidly in the past 40 *** study on the diagnosis and treatment of primaryliver cancer in China underwent four stages:①Inthe 1950s,the... 详细信息

关键词： liver neoplasms/surgery liver transplantation liver neoplasms/diagnosis liver neoplasms/therapy biopsy needle genes suppressor tumor