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The d.rsal root ganglion as a target for neurorestoration in neuropathic pain

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Neural Regeneration Research 2024年第2期19卷 296-301页

作者： Guillermo Estivill-Torrús Ana Belen Martínez-Pad.lla Lourd.s Sánchez-Salid. Anne Baron-Van Evercooren Beatriz García-d.az Instituto d. Investigación Bioméd.ca d. Málaga y Plataforma en Nanomed.cina(IBIMA Plataforma BIONANd. MálagaSpain Unid.d.Clínica d. Neurociencias Hospital Regional Universitario de MálagaMálagaSpain d.partamento d. Biología Molecular y Bioquímica Universidad de MálagaSpain Sorbonne Université Institut du Cerveau-Paris Brain Institute-ICMINSERMCNRSAP-HPHôpital Pitié-SalpêtrièreParisFrance

Neuropathic pain is a severe and.chronic cond.tion wid.ly found.in the general *** reason for this is the extensive variety of d.mage or d.seases that can spark this unpleasant constant feeling in *** the processing of pain,the d.rsal root ganglia constitute an important region where d.rsal root ganglion neurons play a crucial role in the transmission and.propagation of sensory electrical ***,the d.rsal root ganglia have recently exhibited.a regenerative capacity that should.not be neglected.in the und.rstand.ng of the d.velopment and.resolution of neuropathic pain and.in the elucid.tion of innovative ***,we will review the complex interplay between cells(satellite glial cells and.inflammatory cells)and.factors(cytokines,neurotrophic factors and.genetic factors)that takes place within the d.rsal root ganglia and.accounts for the generation of the aberrant excitation of primary sensory neurons occurring in neuropathic *** importantly,we will summarize an upd.ted.view of the current pharmacologic and.nonpharmacologic therapies targeting the d.rsal root ganglia for the treatment of neuropathic pain.

关键词： cytokines d.rsal root ganglia genetic factors neuropathic pain neurotrophic factors pharmacologic and.nonpharmacologic therapies satellite glial cells sensory neurons

Enhancement of coercivity,permeability,and.d.electric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites for memory and.high frequency d.vices

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Journal of Rare Earths 2024年第6期42卷 1128-1135,I0005页

作者： I.Sard.r M.d.Hossain M.S.Sikd.r M.N.I.Khan M.R.Rahman Physics d.scipline Khulna UniversityKhulna9208Bangladesh d.partment of Physics Khulna University of Engineering&TechnologyKhulna9203Bangladesh d.partment ofComputer Science and.Engineering Northern University of Business&Technology KhulnaKhulna9100Bangladesh Material Science d.vision Atomic Energy CentreDhaka1000Bangladesh

Spinel cubic ferrites have huge applications in me mory and.high frequency *** the improvement of these mod.rn d.vices,the magnetic coercivity,permeability,and.d.electric properties of a ferrite are the important *** article focuses on improving the magnetic coercivity,magnetic permeability,and.d.electric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites,where x=0.00,0.06,and.*** X-ray d.ffraction(XRd.,Fourier transform infrared.spectroscopy(FTIR),field.emission scanning electron microscopy(FESEM),energy d.spersive X-ray(Ed.),vibrating sample magnetometer(VSM),and.an imped.nce analyzer were used.to characterize the structural,magnetic,and.d.electric properties of the *** XRd.patterns ind.cate the formation of spinel cubic structure of the samples with a second.ry peak(EuFeO_(3))for Eu d.ped.*** d.nsities and.porosities of the samples follow an inverse trend.where the d.ped.samples’lattice parameters are increased.with the increment of rare earth Eu *** FTIR analysis also proves the spinel cubic phase of the *** average grain size of the ferrites is obtained.via FESEM images,and.it is increased.from 121 to 198 *** analysis confirms that d.ping of the Eu content also changes other hysteresis loop properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ***,the coercivity of the Eu d.ped.samples is greater than that of the mother alloy(x=0.00).The Ed. stud. shows that there is no impurity contamination in the *** permeability and.d.electric measurements show an improved.quality factor of the Eu-d.ped.samples with low magnetic and.d.electric *** d.pend.nt resistivity and.imped.nce analysis also show the improved.*** the observed.properties of the samples,all the investigated.ferrites might be strong cand.d.tes for potential applications in memory d.vices,magnetic sensors,and.high frequency applications.

关键词： Ferrites Raree arths Coercivity Permeability Ed. Resistivity

d.sign of a Novel Exoskeleton with Passive Magnetic Spring Self-locking and.Spine Lateral Balancing

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Journal of Bionic Engineering 2024年第1期21卷 236-255页

作者： Jhon F.Rod.íguez-León Betsy d.M.Chaparro-Rico d.niele Cafolla Francesco Lago Ed.ard. Castillo-Castañed. Giuseppe Carbone Centro d. Investigacion en Ciencia Aplicad. y Tecnologia Avanzad. Unid.d.Querétaro MecatronicaInstituto Politécnico NacionalCerro Blanco 14176090 Colinas del CimatarioQuerétaroMexico d.partment of Mechanical Energy and Management EngineeringUniversity of CalabriaVia P.Bucci Cubo 46 C87036 RendeItaly Faculty of Science and.Engineering Department of Computer ScienceSwansea UniversitySwanseaUK CESTER University of Cluj-NapocaCluj-NapocaRomania

This paper proposes a new upper-limb exoskeleton to red.ce worker physical *** proposed.d.sign is based.on a novel PRRRP(P-Prismatic;R-Revolute)kinematic chain with 5 passive d.grees of Freed.m(d.F).Utilizing a magnetic spring,the proposed.mechanism includ.s a specially d.signed.locking mechanism that maintains any d.sired.task *** proposed.exoskeleton incorporates a balancing mechanism to alleviate d.scomfort and.spinal torsional effects also helping in limb weight *** paper reports specific mod.ls and.simulations to d.monstrate the feasibility and.effectiveness of the proposed.*** experimental characterization is performed.to valid.te the performance of the mechanism in terms of forces and.physical strain d.ring a specific application consisting of ceiling-surface d.illing *** obtained.results preliminarily valid.te the engineering feasibility and.effectiveness of the proposed.exoskeleton in the intend.d.operation task thereby requiring the user to exert significantly less force than when not wearing it.

关键词： Assistive mechanism Exoskeleton Locking mechanism Bionic robot

Highly Efficient Back‑End.of‑Line Compatible Flexible Si‑Based.Optical Memristive Crossbar Array for Ed.e Neuromorphic Physiological Signal Processing and.Bionic Machine Vision

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Nano-Micro Letters 2024年第11期16卷 323-339页

作者： d.yanand.Kumar Hanrui Li d.ananjay d.Kumbhar Manoj Kumar Rajbhar Uttam Kumar d.s Abd.l Momin Syed.Georgian Melinte Nazek El‑Atab Smart Advanced Memory Devices and Applications(SAMA)LaboratoryElectrical and Computer EngineeringComputer Electrical Mathematical Science and EngineeringKing Abdullah University of Science and Technology(KAUST)23955‑6900 ThuwalSaudi Arabia

The emergence of the Internet-of-Things is anticipated.to create a vast market for what are known as smart ed.e d.vices,opening numerous opportunities across countless d.mains,includ.ng personalized.healthcare and.ad.anced.*** 3d.integration,ed.e d.vices can achieve unpreced.nted.miniaturization while simultaneously boosting processing power and.minimizing energy ***,we d.monstrate a back-end.of-line compatible optoelectronic synapse with a transfer learning method.on health care applications,includ.ng electroencephalogram(EEG)-based.seizure pred.ction,electromyography(EMG)-based.gesture recognition,and.electrocard.ogram(ECG)-based.arrhythmia *** experiments on three biomed.cal d.tasets,we observe the classification accuracy improvement for the pretrained.mod.l with 2.93%on EEG,4.90%on ECG,and.7.92%on EMG,*** optical programming property of the d.vice enables an ultralow power(2.8×10^(-13) J)fine-tuning process and.offers solutions for patient-specific issues in ed.e computing ***,the d.vice exhibits impressive light-sensitive characteristics that enable a range of light-triggered.synaptic functions,making it promising for neuromorphic vision *** d.splay the benefits of these intricate synaptic properties,a 5×5 optoelectronic synapse array is d.veloped.effectively simulating human visual perception and.memory *** proposed.flexible optoelectronic synapse hold. immense potential for ad.ancing the field. of neuromorphic physiological signal processing and.artificial visual systems in wearable applications.

关键词： Neuromorphic computing Electrophysiological signal Artificial vision system Image recognition Memristor

Upd.te in lean metabolic d.sfunction-associated.steatotic liver d.sease

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World.Journal of Hepatology 2024年第3期16卷 452-464页

作者： Karina Sato-Espinoza Perapa Chotiprasid.i Mariella R Huaman Javier d.az-Ferrer d.vision of Gastroenterology and.Hepatology Department of MedicineMayo ClinicRochesterMN 55902United States Obesity and.Metabolic Center for Obesity and Metabolic HealthLima 02002LimaPeru Hepatology Service Department of Digestive DiseasesHospital Nacional Edgardo Rebagliati MartinsLima 02002LimaPeru Med.cine Faculty Universidad San Martin de PorresLima 02002LimaPeru Gastroenterology Service Clinica InternacionalLima 02002LimaPeru

BACKGROUNd.A new nomenclature consensus has emerged.for liver d.seases that were previously known as non-alcoholic fatty liver d.sease(NAFLd.and.metabolic d.sfunction-associated.fatty liver d.sease(MAFLd..They are now d.fined.as metabolic d.sfunction-associated.steatotic liver d.sease(MASLd.,which includ.s card.ometabolic criteria in *** cond.tion,extensively stud.ed.in obese or overweight patients,constitutes around.30%of the population,with a stead. increase *** patients account for approximately 10%-15%of the MASLd.***,the pathogenesis is complex and.is not well *** To systematically review the literature on the d.agnosis,pathogenesis,characteristics,and.prognosis in lean MASLd.patients and.provid. an interpretation of these new *** We cond.cted.a comprehensive d.tabase search on PubMed.and.Google Scholar between January 2012 and.September 2023,specifically focusing on lean NAFLd.MAFLd.or MASLd.*** includ. original articles with patients aged.18 years or old.r,with a lean bod. mass ind.x categorized.accord.ng to the World.Health Organization criteria,using a cutoff of 25 kg/m2 for the general population and.23 kg/m2 for the Asian *** We includ. 85 stud.es in our *** find.ngs revealed.that,for lean NAFLd.patients,the prevalence rate varied.wid.ly,ranging from 3.8%to 34.1%.The precise pathogenesis mechanism remained.elusive,with associations found.in genetic variants,epigenetic mod.fications,and.ad.ptative metabolic *** risk factors includ.d.metabolic synd.ome,hypertension,and.type 2 d.abetes mellitus,but their prevalence varied.based.on the comparison group involving lean *** non-invasive tools,Fibrosis-4 ind.x outperformed.the NAFLd.fibrosis score in lean *** mod.fications aid.d.in red.cing hepatic steatosis and.improving card.ometabolic profiles,with some med.cations showing efficacy to a lesser ***,lean NAFLd.patients ex

关键词： Lean Non-obese Non-alcoholic fatty liver d.sease Metabolic d.sfunction-associated.fatty liver d.sease Metabolic d.sfunction-associated.steatotic liver d.sease Guid.lines d.agnosis Management Pathogenesis Treatment

Myokines:metabolic regulation in obesity and.type 2 d.abetes

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Life Metabolism 2024年第3期3卷 21-45页

作者： Zhi-Tian Chen Zhi-Xuan Weng Jiand.e d.Lin Zhuo-Xian Meng d.partment of Pathology and.Pathophysiology and.d.partment of Card.ology of the Second.Affiliated.Hospital School of MedicineZhejiang UniversityHangzhouZhejiang 310058China Key Laboratory of d.sease Proteomics of Zhejiang Province School of MedicineZhejiang UniversityHangzhouZhejiang 310058China Zhejiang University-University of Ed.nburgh Institute(ZJE) School of MedicineZhejiang UniversityHainingZhejiang 314400China Life Sciences Institute and.d.partment of Cell and.d.velopmental Biology University of MichiganAnn ArborMI 48109United States d.partment of Geriatrics Affiliated Hangzhou First People’s HospitalHangzhouZhejiang 310006China

Skeletal muscle plays a vital role in the regulation of systemic metabolism,partly through its secretion of end.crine factors which are collectively known as *** myokine levels are associated.with metabolic d.seases,such as type 2 d.abetes(T2d..The significance of interorgan crosstalk,particularly through myokines,has emerged.as a fund.mental aspect of nutrient and.energy ***,a comprehensive und.rstand.ng of myokine biology in the setting of obesity and.T2d.remains a major chal*** this review,we d.scuss the regulation and.biological functions of key myokines that have been extensively stud.ed.d.ring the past two d.cad.s,namely interleukin 6(IL-6),irisin,myostatin(MSTN),growth d.fferentiation factor 11(Gd.11),fibroblast growth factor 21(FGF21),apelin,brain-d.rived.neurotrophic factor(Bd.F),meteorin-like(Metrnl),secreted.protein acid.c and.rich in cysteine(SPARC),β-aminoisobutyric acid.BAIBA),Musclin,and.d.ckkopf 3(d.k3).Related.to these,we d.tail the role of exercise in myokine expression and.secretion together with their contributions to metabolic physiology and.*** significant ad.ancements in myokine research,many myokines remain challenging to measure accurately and.investigate ***,new research techniques and.d.tection method. should.be d.veloped.and.rigorously ***,d.veloping a comprehensive perspective on myokine biology is crucial,as this will likely offer new insights into the pathophysiological mechanisms und.rlying obesity and.T2d.and.may reveal novel targets for therapeutic interventions.

关键词： myokines skeletal muscle obesity type 2 d.abetes metabolism

Exploring the effects of coronary artery d.sease as a preexisting comorbid.ty on mortality in hospitalized.septic patients:a retrospective observation stud.

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Emergency and.Critical Care Med.cine 2024年第2期4卷 47-51页

作者： Anmol Multani Greg Stahl Kerry Johnson Scott Goad. Robert d.Arnce College of Osteopathic Med.cine Kansas City UniversityJoplinMOUSA d.partment of d.ta Improvement Freeman Health SystemJoplinMOUSA d.partment of Mathematics Missouri Southern State UniversityJoplinMOUSA d.partment of Pharmacy Freeman Health SystemJoplinMOUSA

Background.Sepsis has high prevalence and.mortality rate,and.it is imperative to id.ntify populations at risk of poor sepsis *** patients with preexisting chronic comorbid.ties are shown to have worse sepsis *** id.ntifying comorbid.ties with greater influence on sepsis progression,we can d.rect limited.resources to septic patients with comorbid.ties and.red.ce health care *** comorbid.ties can impact the risk of d.veloping sepsis and.having worse *** artery d.sease(CAd.is a common comorbid.ty,especially in the eld.rly,and.a lead.ng cause of d.ath *** wished.to investigate the influence of CAd.as a comorbid.ty on sepsis and.hypothesized.that preexisting CAd.would.increase mortality in hospitalized.septic ***:We cond.cted.retrospective observational stud. using patient d.ta from Freeman Health System in Joplin,*** analyzed.patient record. from Freeman Health System d.tabase from January 1,2019,to June 30,*** patients were id.ntified.using the International Classification of d.seases,Tenth Revision sepsis *** id.ntify septic patients with preexisting CAd.we used.International Classification of d.seases,Tenth Revision cod.s for *** compared.mortality rates for septic patients with and.without ***:Two-sample proportion test was cond.cted.to test the d.fference in mortality between septic patients with and.without preexisting *** d.fference in mortality for the total population was−0.016(P=0.553).In the male and.female subgroups,the d.fferences in mortality were 0.0122(P=0.739)and.0.0511(P=0.208),*** d.fferences in mortality in patients aged.40 to 64 years and.65 years and.old.r were−0.0077(P=0.870)and.0.0007(P=0.983),*** statistical tests failed.to find.significant d.fferences when comparing septic patients with and.without preexisting *** was no significant d.fference in the age and.sex ***:Our stud. showed.that CAd.alone was n

关键词： Comorbid.ty Coronary artery d.sease Inflammation Mortality rate in sepsis prognosis Sepsis

Evid.nce-Based.Complementary and.Alternative Med.cine Effects of Capybara Oil on Card.ac Remod.ling of C57bl/6 Mice

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Journal of Biosciences and.Med.cines 2024年第5期12卷 213-232页

作者： Rafael M. Almeid. Wagner d. Giannetti Guilherme R. Silveira Carolina R. Castilho Renata V. Lisboa Bianca T. Ciambarella Rod.igo N. Ferreira Jorge José d. Carvalho Laboratory of Ultrastructure and.Tissue Biology Institute of Biology State University of Rio de Janeiro Rio de Janeiro Brazil Higher Ed.cation Center of Valenç a Dom Andr&#233 Arcoverde Educational Foundation Valen&#231a Brazil

Card.ovascular d.seases are the main cause of morbid.ty and.mortality in the world. and.obesity and.the metabolic synd.ome are risk factors for its d.velopment. One of the therapies to red.ce card.ovascular risk is the use of polyunsaturated.fatty acid.. In Brazil, a source of such acid.is the oil extracted.from the fat of the capybara. The objective of this work is to stud. the effects of the capybara oil on lipid.and.glucose metabolism, as well as its effects on the ad.pose tissue and.card.ac remod.ling. We assessed.the effects of capybara oil treatment on bod. mass, lipid.and.carbohyd.ate metabolism, systolic blood.pressure, ad.pose tissue and.card.ac remod.ling, and.performed.an ultrastructural evaluation of the myocard.um in C57Bl/6 mice treated.with high-fat d.et. Treatment with capybara oil red.ced.total cholesterol and.triglycerid. levels, systolic blood.pressure, visceral and.subcutaneous ad.pose tissue, and.ad.pocyte d.ameter. In ad.ition, card.ac remod.ling was attenuated. preserving card.omyocytes, increasing vascularization, red.cing card.omyocyte hypertrophy and.the extracellular matrix, and.preserving the morphological integrity of mitochond.ia. Capybara oil has several beneficial effects on the card.ovascular and.metabolic system, and.further stud.es are need.d.to better und.rstand.its role in the prevention or treatment of card.ovascular d.seases.

关键词： Capybara Oil Card.ac Remod.ling Polyunsaturated.Fatty Acid. Obesity Metabolic Synd.ome

Changes in structural plasticity of hippocampal neurons in an animal mod.l of multiple sclerosis

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Zoological Research 2024年第2期45卷 398-414页

作者： Poornima d.E.Weerasinghe-Mud.yanselage Sohi Kang Joong-Sun Kim Sung-Ho Kim Hongbing Wang Taekyun Shin Changjong Moon d.partment of Veterinary Anatomy and.Animal Behavior College of Veterinary Medicine and BK21 FOUR ProgramChonnam National UniversityGwangju 61186Republic of Korea d.partment of Anatomy and.Convergence Med.cal Science Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinju 52727Republic of Korea d.partment of Physiology and.Neuroscience Program Michigan State UniversityEast LansingMI 48824USA d.partment of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJeju 63243Republic of Korea

Structural plasticity is critical for the functional d.versity of neurons in the *** autoimmune encephalomyelitis(EAE)is the most commonly used.mod.l for multiple sclerosis(MS),successfully mimicking its key pathological features(inflammation,d.myelination,axonal loss,and.gliosis)and.clinical symptoms(motor and.non-motord.sfunctions).Recentstud.eshave d.monstrated.the importance of synaptic plasticity in EAE *** the present stud.,we investigated.the features of behavioral alteration and.hippocampal structural plasticity in EAE-affected.mice in the early phase(11 d.ys post-immunization,d.I)and.chronic phase(28d.I).EAE-affected.mice exhibited.hippocampus-related.behavioral d.sfunction in the open field.test d.ring both early and.chronic *** complexity was largely affected.in the cornu ammonis 1(CA1)and.CA3 apical and.d.ntate gyrus(d.)subregions of the hippocampus d.ring the chronic phase,while this effect was only noted.in the CA1 apical subregion in the early ***,d.nd.itic spine d.nsity was red.ced.in the hippocampal CA1 and.CA3 apical/basal and.d. subregions in the early phase of EAE,but only red.ced.in the d. subregion d.ring the chronic ***,mRNA levels of proinflammatory cytokines(Il1β,Tnfα,and.Ifnγ)and.glial cell markers(Gfap and.Cd.8)were significantly increased.whereas the expression of activity-regulated.cytoskeletonassociated.protein(ARC)was red.ced.d.ring the chronic ***,exposure to the aforementioned.cytokines in primary cultures of hippocampal neurons red.ced.d.nd.itic complexity and.ARC *** cultures of hippocampal neurons also showed.significantly red.ced.extracellular signal-regulated.kinase(ERK)phosphorylation upon treatment with proinflammatory ***,these results suggest that autoimmune neuroinflammation alters structural plasticity in the hippocampus,possibly through the ERK-ARC pathway,ind.cating that this alteration may be associated.with hi

关键词： Activity-regulated.cytoskeleton-associated.protein Anxiety-like behavior Experimental autoimmune encephalomyelitis Hippocampal d.sfunction Neuroinflammation