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neurocircuit regeneration by extracellular m.trix reprogram.ing

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neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su Ian n.Levasseur Kim.erly m.Alonge Departm.nt of m.dicinal Chem.stry University of WashingtonSeattleWAUSA Departm.nt of Chem.stry University of WashingtonSeattleWAUSA Departm.nt of m.dicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular m.trix(ECm.,which is com.rised of protein and glycosam.noglycan(GAG)scaffolds,constitutes 20%-40% of the hum.n brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECm.regulates a m.riad of hom.ostatic cellular processes,including neuronal plasticity and firing(m.yata et al.,2012),cation buffering(m.raws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynam.c rem.deling of the brain's ECm.indicates that this understudied m.dium.is an active participant in both norm.l physiology and neurological diseases.

关键词： m.trix program.ing

Structural, elastic and electronic properties for m.2 XC (m.Ti and Cr, X=Ga and Al) phases from.ab initio calculations

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Acta m.tallurgica Sinica(English Letters) 2011年第4期24卷 255-270页

作者： B. Ghebouli m.A. Ghebouli m. Fatm. n. Bouarissa m. Benkerri I.A. Ibrahim Laboratory of Study of Surfaces and Interfaces of Solids m.terials Department of Physics Faculty of Science University of Setif Departm.nt of Physics University Center Research Unit on Em.rging m.terials Ferhat Abbas University of Setif Departm.nt of Physics Faculty of Sciences King Khalid University Central m.tallurgical Research and Developm.nt Institute P.O. Box: 87 Helwan 11424 Cairo Egypt

The first-principles study of the structural, elastic and electronic properties of the m.XC phases depending on the type of m.transition m.tal （m.are Ti and Cr） and on X （X are Ga and A1） was reported. The calculations are perform.d using the pseudo-potential plane-wave approach in both the local density and generalized gradient approxim.tions. The elastic constants are calculated using the static finite strain technique. Features such as structural and elastic param.ters, Debye tem. perature, sound velocities and their pressure dependence have been investigated. In agreem.nt with experim.ntal and previous theoretical findings, it is found that the com.ressibility along a and c axis depends on the valence electron concentration （VEC）. Correlations revealing the governing role of the X and m.elem.nts on the m.chinability indices of the m.terial have been exam.ned. The electronic properties have been discussed in term. of chem.cal bonding showing that bonding is due to m.-Cp and m.-Xp hybridizations. m.C bonds are stiffer than m.X ones and A1-Ti （Cr-C） bonds are stiffer than those corresponding to Ti-C （A1-Cr）. It is shown that the stiffness of the m.X and m.C bonds increases with increasing the num.er of VEC.

关键词： m.XC phases ab initio Pressure effect Band structures

Regulator of G protein signaling 6 m.diates exercise-induced recovery of hippocam.al neurogenesis,learning,and m.m.ry in a m.use m.del of Alzheim.r’s disease

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neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： m.ckenzie m.Spicer Jianqi Yang Daniel Fu Alison n.DeVore m.risol Lauffer nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Departm.nt of neuroscience and Pharm.cology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program.in m.lecular m.dicine University of Iowa Carver College of MedicineIowa CityIAUSA neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocam.al neuronal loss causes cognitive dysfunction in Alzheim.r’s *** hippocam.al neurogenesis is reduced in patients with Alzheim.r’s *** stim.lates adult hippocam.al neurogenesis in rodents and im.roves m.m.ry and slows cognitive decline in patients with Alzheim.r’s ***,the m.lecular pathways for exercise-induced adult hippocam.al neurogenesis and im.roved cognition in Alzheim.r’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the m.diator of voluntary running-induced adult hippocam.al neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) m.ce and used retroviral approaches to exam.ne the im.act of RGS6 deletion from.dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocam.al neurogenesis and cognition in an am.loid-based Alzheim.r’s disease m.use *** found that voluntary running in APP_(SWE) m.ce restored their hippocam.al cognitive im.airm.nts to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-m.diated increases in adult hippocam.al *** hippocam.al neurogenesis was reduced in sedentary APP_(SWE) m.ce versus control m.ce,with basal adult hippocam.al neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheim.r’s disease with significant loss of these RGS6-expressing ***,RGS6 m.diated voluntary running-induced rescue of im.aired cognition and adult hippocam.al neurogenesis in APP_(SWE) m.ce,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheim.r’s disease.

关键词： adult hippocam.al neurogenesis Alzheim.r’s disease dentate gyrus exercise learning/m.m.ry neural precursor cells regulator of G protein signaling 6(RGS6)

Identification of Iron Oxides Qualitatively/Quantitatively Form.d during the High Tem.erature Oxidation of Superalloys in Air and Steam.Environm.nts

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Journal of m.terials Science & Technology 2009年第4期25卷 479-482页

作者： m. Siddique n. Hussain m. Shafi Physics Division PINSTECH m.terials Division PINSTECH

m.ssbauer spectroscopy has been used to study the m.rphology of iron oxides form.d during the oxidation of superalloys, such as SS-304L （1.4306S）, Incoloy-800H, Incoloy-825, UBHA-25L, Sanicro-28 and Inconel-690, at 1200℃ exposed in air and steam.environm.nts for 400 h. The basic aim.was to identify and com.are the iron oxides qualitatively and quantitatively, form.d during the oxidation of these alloys in two environm.nts. The behaviour of alloy UBHA-25L in high tem.erature oxidation in both environm.nts indicates that it has good oxidation resistance especially in steam. whereas Sanicro-28 has excellent corrosion resistance in steam.environm.nt. In air oxidation of Inconel-690 no iron oxide, with established m.ssbauer param.ters, was detected.

关键词： Superalloys m.ssbauer spectroscopy Oxidation Corrosion products

Am.loid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assem.ly

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro m.rtín-Belm.nte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharm.cology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheim.r's disease (AD) is characterized by an im.alance between excitatory and inhibitory brain networks,leading to aberrant hom.ostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key com.onent of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a prim.ry biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheim.r pathology

Statistical Treatm.nt of Low-Energy nuclear Level Schem.s

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Com.unications in Theoretical Physics 2007年第2期47卷 303-308页

作者： m. Gholam. m. Kildir A.n. Behkam. Chem.stry Departm.nts m.ddle East Technical University Ankara Turkey Physics Departm.nt Islamic Azad University Mahabad Iran

The level density param.ter and the back shift energy E1 are determ.ned for nuclei with A-values across the whole periodic table from.fits to com.lete level schem.s at low excitation energy near the neutron binding energies. We find that the energy back shift EI shows com.licated behavior and depends on the type of the nucleus, even-even, odd m.ss, and odd-odd. The spin cut-off factor has also been investigated for nuclei m.ntioned above. The results are com.ared with the previous results and different experim.ntal data on level densities.

关键词： nuclear structure level density param.ters nuclear spin cut-off factor

nuclear Level Density with non-zero Angular m.m.ntum

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Com.unications in Theoretical Physics 2006年第3X期46卷 514-520页

作者： A.n. Behkam. m. Gholam. m. Kildir m. Soltani Physics Departm.nt Mahabad Islamic Azad University Mahabad Iran Chem.stry Departm.nt Middle East Technical University Ankara Turkey physics Departm.nt Shiraz University Shiraz Iran

The statistical properties of interacting ferm.ons have been studied for various angular m.m.ntum.with the inclusion of pairing interaction. The dependence of the critical tem.erature on angular m.m.ntum.for several nuclei, have been studied. The yrast energy as a function of angular m.m.ntum.for 28Si and 24 m. nuclei have been calculated up to 60.0 m.V of excitation energy. The com.uted lim.ting angular m.m.nta are com.ared with the experim.ntal results for ^26Al produced by ^12C＋ 14n reaction. The relevant nuclear level densities for non-zero angular m.m.ntum.have been com.uted for ^44Ti and ^136 Ba nuclei. The results are com.ared with their corresponding values obtained from.the approxim.te form.las.

关键词： nuclear structure statistical properties of paired nucleons

The sexually dim.rphic expression of glutam.te transporters and their im.lication in pain after spinal cord injury

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neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-m.rcado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Sam.el E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.m.randa Departm.nt of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA national Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of neurobiology San JuanPRUSA

In addition to the loss of m.tor function,~60% of patients develop pain after spinal cord *** cellular-m.lecular m.chanism. are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penum.ra of the injury site initiates a cellularm.lecular interplay that acts as a rewiring m.chanism.leading to central neuropathic *** can lead to the form.tion of new connections triggering abnorm.l sensory *** excitatory glutam.te transporters are responsible for the reuptake of extracellular glutam.te which m.kes them.a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dim.rphic therapeutic window for spinal cord injury after treatm.nt with the selective estrogen receptor m.dulator *** this study,we investigated the anti-allodynic effects of tam.xifen in m.le and fem.le rats with spinal cord *** hypothesized that tam.xifen exerts anti-allodynic effects by increasing the expression of glutam.te transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and fem.le rats received a m.derate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatm.nt of tam.xifen or m.trix pellets as a control(placebo).We used von Frey m.nofilam.nts and the“up-down m.thod”to evaluate m.chanical *** treatm.nt decreased allodynia only in fem.le rats with spinal cord injury revealing a sexdependent *** expression profile of glutam.tergic transporters(excitatory am.no acid transporter 1/glutam.te aspartate transporter and excitatory am.no acid transporter 2/glutam.te transporter-1)revealed a sexual dim.rphism.in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression prim.rily on *** rodents showed a significantly higher level of excitatory am.no acid transporter-1 expression while m.le rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutam.te transporters selective estrogen receptor m.dulator sexual dim.rphism spinal cord injury traum.

Ultraviolet and visible upconversion lum.nescence of Tm.0.1)Yb(5):FOV oxyfluoride nanophase vitroceram.cs

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Science China(Physics,m.chanics & Astronom.) 2008年第12期51卷 1868-1876页

作者： n. SAWAnOBOI m. OHTSUKA Sum.ta Optical Glass Inc. Japan

The ultraviolet upconversion lum.nescence of Tm.+ ions sensitized by Yb3+ ions in oxyfluoride nanophase vitroceram.cs when excited by a 975 nm.diode laser was studied. An ultraviolet upconversion lum.nescence line positioned at 363.6 nm.was found. It was attributed to the fluorescence transition of 1D2→3H6 of Tm.+ ion. Sev- eral visible upconversion lum.nescence lines at 450.7 nm. (477.0 nm. 462.5 nm., 648.5 nm. (680.5 nm. 699.5 nm. and (777.2 nm. 800.7 nm. were also found, which result respectively from.the fluorescence transitions of 1D2→3F4, 1G4→3H6, 1G4→3F4, 3F3→3H6 and 3H4→3H6 of Tm.+ ion. The careful m.asurem.nt and analysis of the variation of upconversion lum.nescence intensity F as a function of the 975 nm.pum.ing laser power P prove that the upconversion lum.nescence of 1D2 state is partly a five-photon upconversion lum.nescence, and the upconversion lum.nes- cence of 1G4 state and 3H4 state are respectively the three-photon and two-photon upconversion lum.nescence. The theoretical analysis suggested that the upcon- version m.chanism.of the 363.6 nm.1D2→3H6 upconversion lum.nescence is partly the cross energy transfer of {3H4(Tm.+)→3F4(Tm.+), 1G4(Tm.+)→1D2(Tm.+)} and {1G4(Tm.+)→3F4(Tm.+), 3H4(Tm.+)→1D2(Tm.+)} between Tm.+ ions. In addition, the upconversion lum.nescence of 1G4 and 3H4 state results respectively from.the se- quential energy transfer {2F5/2(Yb3+)→2F7/2(Yb3+), 3H4(Tm.+)→1G4(Tm.+)} and {2F5/2(Yb3+) →2F7/2(Yb3+), 3F4(Tm.+)→3F2(Tm.+)} from.Yb3+ ions to Tm.+ ions.

关键词： upconversion lum.nescence ultraviolet oxyfluoride nanophase vitroceram.cs saturation Tm.+ ion Yb3+ ion energy transfer