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BRCA1在人类肿瘤细胞中的表达(英文)

实验生物学报 2001年第1期34卷 55-64页

作者：孟庆慧袁仁起 Itzhak D.Goldberg eliot m rosen 樊赛军纽约长岛犹太人医学中心放射肿瘤系分子肿瘤学研究室纽约爱因斯坦医学院长岛附属医院

人类乳癌易感基因1(BRCA1)是乳癌,卵巢癌和前列腺癌的危险因素之一,而且表现出许多的生物功能。采用Western Blotting和半定量RT-PCR的方法,我们检测了内源性BRCA1蛋白质和mR-NA在从十一种人类肿瘤组织中建立的四十三种肿瘤细胞系的表... 详细信息

人类乳癌易感基因1(BRCA1)是乳癌,卵巢癌和前列腺癌的危险因素之一,而且表现出许多的生物功能。采用Western Blotting和半定量RT-PCR的方法,我们检测了内源性BRCA1蛋白质和mR-NA在从十一种人类肿瘤组织中建立的四十三种肿瘤细胞系的表达水平。在不同的肿瘤细胞中BRCA1的表达水平是各不一样的。而且并没有发现BRCA1的表达和细胞的内源性p53基因状况有明显的相关性。通过采用细胞转染乳头状瘤病毒-E6致癌基因或采用畸变的p53基因(143Ala→Va1)而导致的p53基因功能失活并不对内源性BRCA1本底表达水平产生任何的影响,但两种与p53功能有关p21(-/-)和Gadd45基因剔除则轻微地增加BRCA1蛋白质的表达。因此,虽然我们目前还不清楚BRCA1在人类肿瘤细胞中不同表达的功能意义,但本文的结果为进一步研究BRCA1在不同肿瘤细胞系的生物功能提供了有价值的背景资料。

关键词： BRCA1 p53 肿瘤细胞基因人类

The role of undifferentiated adipose-derived stem cells in peripheral nerve repair

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Neural Regeneration Research 2018年第5期13卷 757-763页

作者： Rui Zhang Joseph m.rosen Dartmouth Geisel School of medicine Dartmouth-Hitchcock Medical Center

Peripheral nerve injuries impose significant health and economic consequences, yet no surgical repair can deliver a complete recovery of sensory or motor function. Traditional methods of repair are less than ideal： direct coaptation can only be performed when tension-free repair is possible, and transplantation of nerve autograft can cause donor-site morbidity and neuroma formation. Cell-based therapy delivered via nerve conduits has thus been explored as an alternative method of nerve repair in recent years. Stem cells are promising sources of the regenerative core material in a nerve conduit because stem cells are multipotent in function, abundant in supply, and more accessible than the myelinating Schwann cells. Among different types of stem cells, undifferentiated adipose-derived stem cell（uASC）, which can be processed from adipose tissue in less than two hours, is a promising yet underexplored cell type. Studies of uASC have emerged in the past decade and have shown that autologous uASCs are non-immunogenic, easy to access, abundant in supply, and efficacious at promoting nerve regeneration. Two theories have been proposed as the primary regenerative mechanisms of uASC： in situ trans-differentiation towards Schwann cells, and secretion of trophic and anti-inflammatory factors. Future studies need to fully elucidate the mechanisms, side effects, and efficacy of uASC-based nerve regeneration so that uASCs can be utilized in clinical settings.

关键词： peripheral nerve injury adipose-derived stem cells Schwann cells cell therapy nerve conduits axonal regeneration stem cell differentiation neurotrophic factors anti-apoptosis immunosuppression

A note on circle packing

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第8期13卷 559-564页

作者： Young Joon AHN Christoph m. HOFFmANN Paul rosen Department of mathematics Education Chosun University Gwangju 501-759 Korea Department of Computer Science Purdue University West Lafayette IN 47907 USA Scientific Computing and Imaging Institute University of Utah Salt Lake City UT 84112 USA

The problem of packing circles into a domain of prescribed topology is considered. The circles need not have equal radii. The Collins-Stephenson algorithm computes such a circle packing. This algorithm is parmlelized in two different ways and its performance is reported for a triangular, planar domain test case. The implementation uses the highly parallel graphics processing unit （GPU） on commodity hardware. The speedups so achieved are discussed based on a number of experiments.

关键词： Circle packing Algorithm performance Parallel computation Graphics processing unit (GPU)

BRCA mutated pancreatic cancer:A change is coming

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World Journal of Gastroenterology 2021年第17期27卷 1943-1958页

作者： michael N rosen Rachel A Goodwin michael m Vickers Faculty of medicine The University of OttawaOttawa K1H 8L6OntarioCanada The Ottawa Hospital Cancer Center The University of OttawaOttawa K1H 8L6OntarioCanada

Pancreatic cancer remains a leading cause of cancer-related death with few available therapies for advanced ***,patients with germline BRCA mutations have received increased attention due to advances in the management of BRCA mutated ovarian and breast *** BRCA mutations significantly increase risk of developing pancreatic cancer and can be found in up to 8%of patients with sporadic pancreatic *** patients with germline BRCA mutations,platinum-based chemotherapies and poly(ADP-ribose)polymerase inhibitors are effective treatment options which may offer survival *** review will focus on the molecular biology,epidemiology,and management of BRCA-mutated pancreatic ***-more,we will discuss future directions for this area of research and promising active areas of research.

关键词： Pancreatic cancer Systemic therapy Platinum chemotherapy BRCA Deoxyribonucleic acid repair Poly(ADP-ribose)polymerase inhibitors

Finding stable multi-component materials by combining cluster expansion and crystal structure predictions

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npj Computational materials 2023年第1期9卷 2137-2146页

作者： Adam Carlsson Johanna rosen martin Dahlqvist materials Design Department of PhysicsChemistryand Biology(IFM)Linköping UniversitySE-58183 LinköpingSweden

A desired prerequisite when performing a quantum mechanical calculation is to have an initial idea of the atomic positions within an approximate crystal *** atomic positions combined should result in a system located in,or close to,an energy ***,designing low-energy structures may be a challenging task when prior knowledge is scarce,specifically for large multi-component systems where the degrees of freedom are close to *** this paper,we propose a method for identification of low-energy crystal structures within multi-component systems by combining cluster expansion and crystal structure predictions with density-functional theory *** structure prediction searches are applied to the mo_(2)AlB_(2) and Sc2AlB_(2) ternary systems to identify candidate structures,which are subsequently used to explore the quaternary(pseudo-binary)(mo_(x)Sc_(1–x))2AlB_(2) system through the cluster expansion formalism utilizing the ground-state search ***,we show that utilizing low-energy structures found within the cluster expansion ground-state search as seed structures within crystal structure predictions of(mo_(x)Sc_(1–x))2AlB_(2) can significantly reduce the computational *** this combined approach,we not only correctly identified the recently discovered mo_(4/3)Sc_(2/3)AlB_(2) i-mAB phase,comprised of in-plane chemical ordering of mo and Sc and with Al in a Kagomélattice,but also predict additional low-energy structures at various *** result demonstrates that combining crystal structure prediction with cluster expansion provides a path for identifying low-energy crystal structures in multi-component systems by employing the strengths from both frameworks.

关键词： structure cluster crystal

Green's function solution for transient heat conduction in annular fin during solidification of phase change material

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Applied mathematics and mechanics(English Edition) 2012年第10期33卷 1265-1274页

作者： A.H.mOSAFFA F.TALATI m.A.rosen H.BASIRAT-TABRIZI Faculty of mechanical Engineering University of Tabriz Faculty of Engineering and Applied Science University of Ontario Institute of TechnologyL1H 7K4 OshawaOntarioCanada Department of mechanical Engineering Amirkabir University of Technology

The Green＇s function method is applied for the transient temperature of an annular fin when a phase change material （PCm） solidifies on it. The solidification of the PCms takes place in a cylindrical shell storage. The thickness of the solid PCm on the fin varies with time and is obtained by the megerlin method. The models are found with the Bessel equation to form an analytical solution. Three different kinds of boundary conditions are investigated. The comparison between analytical and numerical solutions is given. The results demonstrate that the significant accuracy is obtained for the temperature distribution for the fin in all cases.

关键词： annular fin analytical solution Green's function phase change material(PCm) solidification thermal energy storage

The European registry of quality outcomes for cataract and refractive surgery(EUREQUO):a database study of trends in volumes,surgical techniques and outcomes of refractive surgery

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Eye and Vision 2015年第1期2卷 76-84页

作者： mats Lundström Sonia manning Peter Barry Ulf Stenevi Ype Henry Paul rosen Department of Clinical Sciences OphthalmologyFaculty of MedicineLund UniversityLundSweden Department of Ophthalmology Mater Misericordiae University HospitalDublinIreland Department of Ophthalmology St.Vincent’s University HospitalDublinIreland Department of Ophthalmology Sahlgren’s University HospitalMolndalSweden Department of Ophthalmology VumcAmsterdamThe Netherlands Oxford Eye Hospital OxfordUK.

Background:A European web-based registry for refractive surgery was established in 2008;The European Registry of Quality Outcomes for Cataract and Refractive Surgery(EUREQUO).The aim of the registry was to improve treatment and standards of care for refractive *** aims were to offer a tool for benchmarking by establishing a reference database and for surgeons to enter and analyze their own *** purpose of this study was to characterize the registry and analyze the data collected during its first ***:The characteristics of the web-based registry are *** collected from February 4^(th) 2004 until June 30th 2014 are included in the *** database is analyzed in terms of surgical technique,indications for surgery,complications,and refractive and visual ***:Data have been reported from 47 centers in 14 countries until *** 4,000 procedures were reported *** most frequent procedure was laser-assisted in-situ keratomileusis(LASIK)with 11697 reported *** time in the database,LASIK declined(pmy(PRK)and refractive lens exchange(RLE)increased(pms of preoperative refraction and age,were stable over time,for all types of *** complications were reported infrequently and with a well-known relationship to the type of surgical *** reported refractive outcomes were *** visual outcomes indicate a significant increase of visual acuity after high myopia treatment by phakic intraocular lens in the anterior(phakic IOL AC)and the posterior(phakic IOL PC)chamber and a poorer visual outcome,after both myopia and hyperopia treatment,by epithelial LASIK(Epi-LASIK).Conclusions:We describe the establishment of a European registry for refractive *** database increases at a rate of approximately 4000 refractive procedures per *** most frequent procedure is LASIK,but

关键词： Refractive surgery Registry European database Outcomes

Thick Electrodes of a Self-Assembled mXene Hydrogel Composite for High-Rate Energy Storage

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Energy & Environmental materials 2024年第4期7卷 255-261页

作者： Leiqiang Qin Jianxia Jiang Lintao Hou Fengling Zhang Johanna rosen Department of Physics Chemistry and Biology(IFM)LinkEoping UniversityLinkEoping SE-58183Sweden Flexible Electronics Innovation Institute(FEII) Jiangxi Key Laboratory of Flexible ElectronicsJiangxi Science and Technology Normal UniversityNanchang 330013China Guangzhou Key Laboratory of Vacuum Coating Technologies and New Energy materials Physics DepartmentJinan UniversityGuangzhou 510632China

Supercapacitors based on two-dimensional mXene(Ti_(3)C_(2)T_(z))have shown extraordinary performance in ultrathin electrodes with low mass loading,but usually there is a significant reduction in high-rate performance as the thickness increases,caused by increasing ion diffusion *** limitations include restacking of the nanosheets,which makes it challenging to realize the full potential of these electrode ***,we demonstrate the design of a vertically aligned mXene hydrogel composite,achieved by thermal-assisted self-assembled gelation,for high-rate energy *** highly interconnected mXene network in the hydrogel architecture provides very good electron transport properties,and its vertical ion channel structure facilitates rapid ion *** resulting hydrogel electrode show excellent performance in both aqueous and organic electrolytes with respect to high capacitance,stability,and high-rate capability for up to 300μm thick electrodes,which represents a significant step toward practical applications.

关键词： energy storage high-rate hydrogel mXene self-assemble

Colorless-to-colorful switching of electrochromic mXene by reversible ion insertion

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Nano Research 2022年第4期15卷 3587-3593页

作者： Jianxia Jiang Leiqiang Qin Joseph Halim Per O.Å.Persson Lintao Hou Johanna rosen Guangzhou Key Laboratory of Vacuum Coating Technologies and New Energy materials Physics DepartmentJinan UniversityGuangzhou 510632China Department of Physics Chemistry and Biology(IFM)Linköping UniversityLinköping SE-58183Sweden

Electrochromic(EC)materials that change color with voltage have been widely studied for use in dynamic ***,colorless-to-colorful switching with high contrast ratio is generically unattainable,especially for colorless-to-black electrochromic materials with an ultrahigh contrast ratio over the entire visible *** this work,we developed Nb_(1.33)C mXene-based dynamic windows with colorless-to-black switching of up to 75%reversible change in transmittance from 300 to 1,500 *** exploring the electrochromic effects of different electrolytes through in situ optical changes and electrochemical quartz crystal microbalance(EQCm),it is found that electrochromic behavior is greatly influenced by the extent of reversible Li^(+)insertion/deinsertion between the two-dimensional Nb_(1.33)C mXene *** addition,a colorless-to-black EC device based on Nb_(1.33)C with an overall integrated contrast ratio over 80%was successfully constructed by a solution-processable spin coating *** work enables a simple route to fabricate mXene-based high-performance electrochromic smart windows,which is important for further expanding the application of mXenes to optoelectronic and photonic applications.

关键词： mXenes electrochromic materials colorless-to-black switching high contrast ratio reversible Li^(+)insertion