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Antibiotic ciprofloxacin removal from aqueous solutions by electrochemically activated persulfate process:Optimization,degradation pathways,and toxicology assessment

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Journal of Environmental Sciences 2024年第9期143卷 85-98页

作者： elif Yakamercan Ahmet Aygün Halis Simsek Environmental Engineering Department Bursa Technical UniversityBursaTurkey Agricultural and Biological Engineering Department Purdue UniversityWest LafayetteINUSA

Ciprofloxacin(CIP)is a commonly used antibiotic in the fluoroquinolone group and is widely used in medical and veterinary medicine disciplines to treat bacterial *** CIP is discharged into the sewage system,it cannot be removed by a conventional wastewater treatment plant because of its recalcitrant *** this study,boron-doped diamond anode and persulfate were used to degrade CIP in an aquatic solution by creating an electrochemically activated persulfate(EAP)*** added to the system as a coactivator and the process was called EAP+*** effects of independent variables,including pH,Fe^(2+),persulfate concentration,and electrolysis time on the systemwere optimized using the response surface *** results showed that the EAP+Fe process removed 94%of CIP under the following optimum conditions:A pH of 3,persulfate/Fe^(2+)concentration of 0.4 mmol/L,initial CIP concentration 30 mg/L,and electrolysis time of 12.64 *** removal efficiency was increased from 65.10%to 94.35%by adding Fe^(2+)as a transition *** degradation products,7 pathways,and 78 intermediates of CIP were studied,and three of those intermediates(m/z 298,498,and 505)were *** toxicological analysis based on toxicity estimation software results indicated that some degradation products of CIP were toxic to targeted animals,including fathead minnow,Daphnia magna,Tetrahymena pyriformis,and *** optimumoperation costswere similar in EAP and EAP+Fe processes,approximately 0.54€/m^(3).

关键词： Ciprofloxacin Response surface methodology Electrochemically activated persulfate Electrooxidation

A Comparative Study of Metaheuristic Optimization Algorithms for Solving Real-World Engineering Design Problems

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 1039-1094页

作者： elif Varol Altay Osman Altay Yusuf Ovik Department of Software Engineering Manisa Celal Bayar UniversityManisa45400Turkey

Real-world engineering design problems with complex objective functions under some constraints are relatively difficult problems to *** design problems are widely experienced in many engineering fields,such as industry,automotive,construction,machinery,and interdisciplinary ***,there are established optimization techniques that have shown effectiveness in addressing these types of *** research paper gives a comparative study of the implementation of seventeen new metaheuristic methods in order to optimize twelve distinct engineering design *** algorithms used in the study are listed as:transient search optimization(TSO),equilibrium optimizer(EO),grey wolf optimizer(GWO),moth-flame optimization(MFO),whale optimization algorithm(WOA),slimemould algorithm(SMA),harris hawks optimization(HHO),chimp optimization algorithm(COA),coot optimization algorithm(COOT),multi-verse optimization(MVO),arithmetic optimization algorithm(AOA),aquila optimizer(AO),sine cosine algorithm(SCA),smell agent optimization(SAO),and seagull optimization algorithm(SOA),pelican optimization algorithm(POA),and coati optimization algorithm(CA).As far as we know,there is no comparative analysis of recent and popular methods against the concrete conditions of real-world engineering ***,a remarkable research guideline is presented in the study for researchersworking in the fields of engineering and artificial intelligence,especiallywhen applying the optimization methods that have emerged *** research can rely on this work for a literature search on comparisons of metaheuristic optimization methods in real-world problems under similar conditions.

关键词： Metaheuristic optimization algorithms real-world engineering design problems multidisciplinary design optimization problems

Evaluation of Industrial IoT Service Providers with TOPSIS Based on Circular Intuitionistic Fuzzy Sets

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Computers, Materials & Continua 2024年第7期80卷 715-746页

作者： elif Çalo˘glu Büyükselçuk Industrial Engineering Department Fenerbahçe University˙Istanbul34758Turkey

Industrial Internet of Things(IIoT)service providers have become increasingly important in the manufacturing industry due to their ability to gather and process vast amounts of data from connected devices,enabling manufacturers to improve operational efficiency,reduce costs,and enhance product *** platforms provide manufacturers with real-time visibility into their production processes and supply chains,allowing them to optimize operations and make informed *** addition,IIoT service providers can help manufacturers create new revenue streams through the development of innovative products and services and enable them to leverage the benefits of emerging technologies such as Artificial Intelligence(AI)and machine ***,the implementation of IIoT platforms in the manufacturing industry is crucial for companies seeking to remain competitive and meet the ever-increasing demands of customers in the digital *** this study,the evaluation criteria to be considered in the selection of IIoT service provider in small andmedium-sized(SME)manufacturing enterprises will be determined and IIoT service providers alternatives will be evaluated using the technique for order preference by similarity to an ideal solution(TOPSIS)method based on circular intuitionistic fuzzy *** on the assessments conducted in accordance with the literature review and expert consultations,a set of 8 selection criteria has been *** criteria encompass industry expertise,customer support,flexibility and scalability,security,cost-effectiveness,reliability,data analytics,as well as compatibility and *** evaluating these criteria,it was observed that the security criterion holds the highest significance,succeeded by cost-effectiveness,data analytics,flexibility and scalability,reliability,and customer support criteria,in descending order of *** the evaluation of seven distinct alternatives against these criteria,it was deduced tha

关键词： IIoT manufacturing TOPSIS circular intuitionistic fuzzy sets

Detecting early changes in choroidal vascularity and thickness using optical coherence tomography in patients with corneal crosslinking for keratoconus

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1267-1272页

作者： Selim Doganay Mehmet Omer Kiristioglu Derya Doganay elif Kacmaz Department of Ophthalmology Bursa Uludag University School of MedicineBursa 16059Turkey Department of Ophthalmology University of Health Sciences Bursa Yuksek Ihtisas Training and Research HospitalBursa 16310Turkey

AIM:To investigate changes in choroidal thickness and vascularity in keratoconus patients treated with corneal ***:This study evaluated 28 eyes of 22 patients with keratoconus who underwent corneal *** choroidal thicknesses were evaluated on enhanced depth imaging optical coherence tomography at the preoperative and postoperative 3d,1,and *** thickness in the four cardinal quadrants and the fovea were *** choroidal vascularity index was also ***:There was no significant difference in central choroidal thickness between the preoperative and postoperative 3d,1mo(P>0.05).There was a significant increase in the 3mo(P=0.034)and a significant decrease in the horizontal choroidal vascularity index on the postoperative 3d(P=0.014),there was no statistically significant change in vertical axes and other visits in horizontal sections(P>0.05).CONCLUSION:This study sheds light on choroidal changes in postoperative corneal crosslinking for *** it suggests the procedure’s relative safety for submacular choroid,more extensive research is necessary to confirm these findings and their clinical significance.

关键词： keratoconus corneal crosslinking choroidal vascularity index enhanced depth imaging optical coherence tomography

Evaluation of the mental health of COVID-19 patients discharged from the intensive care unit

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World Journal of Clinical Cases 2024年第33期12卷 6587-6590页

作者： elif Sarac Ministry of National Defense General Directorate of Management ServicesAnkara 06000Türkiye

In this editorial,I address the mental health status of patients who have been discharged from intensive care units(ICUs)after battling coronavirus disease 2019(COVID-19).An ICU admission is generally a stressful experience,and for severe COVID-19 survivors prolonged treatment in the ICU can lead to significant psychological *** individuals may experience psychiatric distress,including symptoms such as insomnia,anxiety,depression,and even posttraumatic psychological *** indicates that during the first 6 months to 1 year following an ICU stay,nearly one-third of survivors exhibit symptoms similar to those of depression and post-traumatic stress *** factors may have contributed to the development of depressive and anxious symptoms during the COVID-19 pandemic,particularly for those who underwent an ICU *** ICU environment itself is inherently stressful,filled with the constant noise of various medical *** have provided strong evidence that the prolonged need for ventilation support and the loss of freedom of movement are key factors in the development of psychological problems among COVID-19 patients who had been treated in the ICU.

关键词： COVID-19 Patient Post-intensive care unit Discharge Mental health

Impact of parenting styles on preschoolers’behaviors

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World Journal of Clinical Cases 2024年第23期12卷 5294-5298页

作者： elif Sarac Ministry of National Defense General Directorate of Management ServicesAnkara 06000Türkiye

In this editorial,I comment on the article“Association of preschool children behavior and emotional problems with the parenting behavior of both parents”which was published in the latest issue of“World Journal of Clinical Cases”that demonstrates the prevalence of behavioral disorders in preschool *** I am focused on parenting which is the most effective factor shown to affect the development and continuity of these *** management of child behavior problems is *** in early ages,especially preschoolers who are in the first 5 years of life,are influenced by dramatic changes in various aspects of development,such as social,emotional,and ***,children experience many changes linked to different developmental tasks,such as discovering themselves,getting new friendships,and adapting to a new *** this period,parents have a critical role in supporting child *** parents do not manage and overcome their child’s misbehavior,it could be transformed into psychosocial problems in *** is the most powerful predictor in the social development of preschool *** studies have shown that to reduce the child’s emotional and behavioral problems,a warm relationship between parents and children is *** addition,recent studies have demonstrated significant relationships between family regulation factors and parenting,as well as with child behaviors.

关键词： Behavioral problems Children Emotional problems Parenting style Preschool

Harnessing photosynthetic microorganisms for enhanced bioremediation of microplastics:A comprehensive review

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Environmental Science and Ecotechnology 2024年第4期20卷 63-78页

作者： Giovanni Davide Barone Andres Rodríguez-Seijo Mattia Parati Brian Johnston elif Erdem Tomislav Cernava Zhi Zhu Xufeng Liu Ilka MAxmann Peter Lindblad Iza Radecka Institute of Biology University of GrazUniversitatsplatz 28010GrazAustria Area de Edafoloxía Departamento de Bioloxía Vexetal e Ciencia Do SoloFacultade de CienciasUniversidade de Vigo32004OurenseSpain Agroecology and Food Institute(IAA) University of Vigo e Campus Auga32004OurenseSpain School of Life Sciences Faculty of Science and EngineeringUniversity of WolverhamptonWolverhamptonWV11LYUnited Kingdom FlexSea Ltd. LondonEC2A4NEUnited Kingdom Department of Chemical and Biochemical Engineering Technical University of Denmark2800Kongens LyngbyDenmark Institute of Environmental Biotechnology Graz University of Technology8010GrazAustria The Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province School of Life SciencesJiangsu Normal University221116XuzhouChina Department of ChemistrydÅngstrom Laboratory Uppsala UniversitySE-75120UppsalaSweden Synthetic Microbiology Department of BiologyHeinrich Heine University Düsseldorf40225DüsseldorfGermany Cluster of Excellence on Plant Sciences(CEPLAS) Heinrich HeineUniversity DüsseldorfD-40001DüsseldorfGermany

Mismanaged plastics,upon entering the environment,undergo degradation through physicochemical and/or biological *** process often results in the formation of microplastics(MPs),the most prevalent form of plastic debris(<1 mm).MPs pose severe threats to aquatic and terrestrial ecosystems,necessitating innovative strategies for effective *** photosynthetic microorganisms can degrade MPs but there lacks a comprehensive *** we examine the specific role of photoautotrophic microorganisms in water and soil environments for the biodegradation of plastics,focussing on their unique ability to grow persistently on diverse polymers under ***,these cells utilise light and CO_(2) to produce valuable compounds such as carbohydrates,lipids,and proteins,showcasing their multifaceted environmental *** address key scientific questions surrounding the utilisation of photosynthetic microorganisms for MPs and nanoplastics(NPs)bioremediation,discussing potential engineering strategies for enhanced *** review highlights the significance of alternative biomaterials and the exploration of strains expressing enzymes,such as polyethylene terephthalate(PET)hydrolases,in conjunction with microalgal and/or cyanobacterial ***,we delve into the promising potential of photo-biocatalytic approaches,emphasising the coupling of plastic debris degradation with sunlight *** integration of microalgal-bacterial consortia is explored for biotechnological applications against MPs and NPs pollution,showcasing the synergistic effects in wastewater treatment through the absorption of nitrogen,heavy metals,phosphorous,and *** conclusion,this review provides a comprehensive overview of the current state of research on the use of photoautotrophic cells for plastic *** underscores the need for continued investigation into the engineering of these microorganisms and the development of innovative approaches

关键词： Environmental biotechnology Microplastic Nanoplastic Microalgae Cyanobacteria

Prognostic significance of tumor budding,desmoplastic reaction,and lymphocytic infiltration in patients with gastric adenocarcinoma

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World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 9-25页

作者： Aysen Yavuz Kubra Simsek Anil Alpsoy Busra Altunay elif Ocak Gedik Betul Unal Cumhur Ibrahim Bassorgun Ali Murat Tatli Gulsum Ozlem Elpek Department of Pathology Akdeniz University Medical SchoolAntalya 07070Türkiye Department of Medical Oncology Akdeniz University Medical SchoolAntalya 07070Türkiye

BACKGROUND Recent studies have shown that the tumor microenvironment significantly influences the behavior of solid *** this context,Accumulated data suggests that pathological evaluation of tumor budding(TB),desmoplastic reaction(DR),and tumor-infiltrating lymphocytes(TILs)may be crucial in determining tumor behavior in the gastrointestinal *** gastric adenocarcinoma(GAC),although some results suggest that TB and TILs may be effective in determining the course of the disease,the data do not ***,very few studies have investigated the relationship between DR and *** present,the associations between tumor TB,DR and TILs in GAC patients have not been *** To establish the relationships between TB,DR,and TILs in patients with GAC and to assess their influence on *** Our study group comprised 130 patients diagnosed with *** definition of TB was established based on the International TB Consensus *** DR was categorized into three groups according to the level of tumor stroma *** assessment of TILs was conducted using a semiquantitative approach,employing a cutoff value of 5%.The statistical analysis of the whole group and 100 patients with an intestinal subtype of GAC was performed using SPSS version *** A significant correlation between peritumoral budding(PTB)and intratumoral budding(ITB)was noted(r=0.943).Tumors with high PTBs and ITBs had a greater incidence of immature DRs and low TILs(P<0.01).PTB and ITB were associated with histological subtype,lymph node metastasis(LNM),and stage(P<0.01).ITB,PTB,LNM,DR,and stage were significant risk factors associated with poor *** multivariate Cox regression analysis identified ITB,PTB,and LNM as independent prognostic variables(P<0.05).In intestinal-type adenocarcinomas,a positive correlation between PTB and ITB was noted(r=0.972).While univariate analysis revealed that LNM,stage,PTB,ITB,and DR were strong parameters for pred

关键词： Gastric cancer Tumor budding Desmoplastic stroma Tumor-infiltrating lymphocytes Prognosis

A novel mutation of SGK-1 gene in central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 23-28页

作者： Mahmut Akyol Muhammet Kazιm Erol Ozdemir Ozdemir Deniz Turgut Coban Ahmet Burak Bilgin Esin Sogutlu sari elif Betul Turkoglu Department of Medical Biology and Genetics Akdeniz University Faculty of Medicine Department of Ophthalmology Antalya Education and Research Hospital Department of Ophthalmology Zekai Tahir Burak Women's Health Education and Research Hospital Department of Ophthalmology Akdeniz University Faculty of Medicine Department of Ophthalmology Balιkesir University Faculty of Medicine

AIM: To investigate the association of serum glucocorticoid kinase gene-1(SGK-1) DNA variants with chronic central serous chorioretinopathy(CSC).METHODS: We enrolled 32 eyes of 32 patients who were diagnosed with chronic CSC and composed 32 normal eyes as a control group. Peripheral blood was used for DNA extraction and polymerase chain reaction amplification. SGK1 gene was sequenced by using Big Dye Terminator v3.1 cycle sequencing Kit(Applied Biosystems, Foster City, CA, USA). The SGK-1 gene and its variants were investigated in CSC patient group and control ***: We identified a new polymorphism M32 V in two person in the patient group [Minor allele frequency(MAF) =0.009] on the region of 1-60 amino acids. The rs1057293 was located in the encoder region of the SGK- 1 gene but not associated with CSC(P =0.68). An intrinsic rs1743966 is also not associated(P =0.28).CONCLUSION: The new polymorphism M32 V is located on the region of 1-60 amino acids which is necessary for localization to the mitochondria in CSC patient. This mutation is probably important for the energy metabolism and plays an important role in the cellular response to hyperosmotic stress and other stress stimuli. Both rs1057293 and rs1743966 are not associated with CSC.

关键词： central serous chorioretinopathy mutation polymerase chain reaction serum glucocorticoid kinase gene-1