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Development of gluten-free tarhana formulations:Part *** of legume composite flours and baker’s yeast

Food Bioscience 2022年第3期47卷 802-809页

作者： Hatice Kılıç Keskin Nermin Bilgiçli elif Yaver Department of Food Engineering Engineering FacultyNecmettin Erbakan UniversityKöyceğiz Campus42090KonyaTurkey

Many gluten-free foods are prepared from starch-rich ingredients with low protein and fiber content,resulting in poor nutritional and functional *** this study,five different composite legume flours which are prepared from different levels of chickpea,lentil,common bean,soybean and lupin flours were used at 75%level in gluten-free tarhana formulations to improve nutritional ***,effect of baker’s yeast(Saccharomyces cerevisiae)at different levels(2.5%and 5.0%)on physicochemical and sensory attributes of the samples containing composite flours was *** inclusion of composite flours(75%)resulted in lower L^(*) and hue values in tarhana than gluten-free sample without composite *** viscosity of tarhana soup containing“25%chickpea+50%lentil”composite flour(F2)was similar to traditional wheat tarhana soup(p>0.05).The utilization of composite flours containing“50%chickpea+25%lentil”(F1),F2,and“25%chickpea+25%lentil+25%common bean”(F3)in tarhana revealed comparable oil absorption capacity to wheat ***,pH and foaming capacity values of the samples containing composite flours were greater than wheat tarhana and gluten-free tarhana without composite *** addition of composite flours elicited markedly higher ash,protein,fat,and mineral *** phytic acid concentration of tarhana enhanced with the incorporation of composite flour,the use of 5.0%yeast considerably decreased phytic acid content and enriched ash,protein,total phenolic content,Ca,Cu,K,Mg,and P concentrations of tarhana in comparison with tarhana containing 2.5%*** inclusion of F1,F2,and F3 elicited acceptable sensory scores in *** was concluded that gluten-free tarhana prepared from legume composite flours(especially F1,F2,and F3)+5.0%yeast could offer a nutritious and acceptable alternative for gluten-free diet with greater protein and mineral *** on the findings,further studies may evaluate the use of hydrocolloids to improve the tec

关键词： Gluten-free Legumes Yeast(Saccharomyces cerevisiae) Tarhana Phytic acid Functional properties

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Effects of COVID-19 fear and anxiety on attitudes towards complementary and alternative medicine use in women with gynecological cancer during the COVID-19 pandemic

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Journal of Integrative Medicine 2023年第4期21卷 377-384页

作者： Fatma Uslu-Sahan Ilknur Yesilcınar Gonul Kurt elif Hancer Gulten Guvenc Department of Obstetrics and Gynecologic Nursing Faculty of NursingHacettepe UniversityAnkara 06100Turkey Department of Obstetrics and Gynecologic Nursing Faculty of Health SciencesIzmir Katip Celebi UniversityIzmir 35620Turkey Department of Obstetrics and Gynecology Nursing Gulhane Faculty of NursingUniversity of Health SciencesAnkara 06018Turkey Department of Obstetrics and Gynecology Gynecologic Oncology ClinicHacettepe University Faculty of MedicineAnkara 06800Turkey

Objective:Patients with gynecological cancer commonly use complementary and alternative medicine(CAM)methods to cope with the ***,despite the existence of treatment strategies,the effect of fear and anxiety caused by coronavirus disease 2019(COVID-19)pandemic on attitudes about CAM use is *** study was carried out to investigate the effect of fear and anxiety experienced by patients with gynecological cancer during the COVID-19 pandemic on their attitudes towards the use of ***:This is a cross-sectional and descriptive study that included 177 women with gynecological cancer;participants were recruited from a social networking site for cancer patients in Turkey between June and December *** were collected using an online survey that included the Personal Information Form,the Fear of COVID-19 Scale,the Coronavirus Anxiety Scale,and the Attitude Towards Holistic Complementary and Alternative Medicine *** statistics,t-test,Pearson’s correlation test,and simple linear and multiple regression analyses were performed to analyze the ***:During the pandemic,55.4%of the participants reported using CAM methods,but only 22.6%were using CAM before the *** participants who used CAM during the pandemic also scored higher on the fear of COVID-19 and coronavirus anxiety scales(20.69±5.37 and 13.09±6.29,respectively)compared to the participants who did not use CAM(9.29±2.72 and 6.35±2.06,respectively).Fear of COVID-19 accounted for 52%of the CAM attitude score,while coronavirus anxiety accounted for 15%of the CAM attitude *** of COVID-19 and coronavirus anxiety together accounted for 53%of CAM ***:Gynecological cancer patients with high levels of COVID-19-related anxiety and fear during the pandemic used CAM *** that the psychological effects of the pandemic will continue in the coming years,CAM use should be evaluated as a coping strategy,especially due to the COVID-19-related anxiety an

关键词： Complementary and alternative medicine Anxiety COVID-19 Fear Gynecological cancer

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PCP-Ed: Parallel coordinate plots for ensemble data

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Visual Informatics 2023年第1期7卷 56-65页

作者： elif E.Firat Ben Swallow Robert S.Laramee University of Nottingham UK University of Glasgow UK

The Parallel Coordinate Plot(PCP)is a complex visual design commonly used for the analysis of high-dimensional *** data size and complexity may make it challenging to decipher and uncover trends and outliers in a confined space.A dense PCP image resulting from overlapping edges may cause patterns to be *** develop techniques aimed at exploring the relationship between data dimensions to uncover trends in dense *** introduce correlation glyphs in the PCP view to reveal the strength of the correlation between adjacent axis pairs as well as an interactive glyph lens to uncover links between data dimensions by investigating dense areas of edge *** also present a subtraction operator to identify differences between two similar multivariate data sets and relationship-guided dimensionality reduction by collapsing axis *** finally present a case study of our techniques applied to ensemble data and provide feedback from a domain expert in epidemiology.

关键词： Parallel coordinates Overplotting Ensemble data

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Detecting early changes in choroidal vascularity and thickness using optical coherence tomography in patients with corneal crosslinking for keratoconus

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1267-1272页

作者： Selim Doganay Mehmet Omer Kiristioglu Derya Doganay elif Kacmaz Department of Ophthalmology Bursa Uludag University School of MedicineBursa 16059Turkey Department of Ophthalmology University of Health Sciences Bursa Yuksek Ihtisas Training and Research HospitalBursa 16310Turkey

AIM:To investigate changes in choroidal thickness and vascularity in keratoconus patients treated with corneal ***:This study evaluated 28 eyes of 22 patients with keratoconus who underwent corneal *** choroidal thicknesses were evaluated on enhanced depth imaging optical coherence tomography at the preoperative and postoperative 3d,1,and *** thickness in the four cardinal quadrants and the fovea were *** choroidal vascularity index was also ***:There was no significant difference in central choroidal thickness between the preoperative and postoperative 3d,1mo(P>0.05).There was a significant increase in the 3mo(P=0.034)and a significant decrease in the horizontal choroidal vascularity index on the postoperative 3d(P=0.014),there was no statistically significant change in vertical axes and other visits in horizontal sections(P>0.05).CONCLUSION:This study sheds light on choroidal changes in postoperative corneal crosslinking for *** it suggests the procedure’s relative safety for submacular choroid,more extensive research is necessary to confirm these findings and their clinical significance.

关键词： keratoconus corneal crosslinking choroidal vascularity index enhanced depth imaging optical coherence tomography

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Clinical significance of low transaminase levels in children with inflammatory bowel disease

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World Journal of Pediatrics 2019年第2期15卷 143-147页

作者： Murat Cakir elif Sag Guzide Dogan Fatih Unal Erhun Kasirga Department of Pediatric Gastroenterology Hepatology and Nutrition Faculty of MedicineKaradeniz Technical UniversityTrabzonTurkey Department of Pediatric Gastroenterology Hepatology and Nutrition Faculty of MedicineManisa Celal Bayar UniversityManisaTurkey Department of Pediatric Gastroenterology Hepatology and Nutrition BursaTurkey

Background Low alanine aminotransaminase (LALT) levels may be seen in patients with inflammatory bowel disease (IBD),but there has been no study about the frequency and its clinical *** aimed to analyze the frequency of LALT,and its clinical significance in children with *** The study included the 89 patients with IBD without hepatobiliary *** was defined as ALT levels < 5 U/*** and clinical findings and outcome of the patients with and without LALT were *** LALT was found 47.1% of the *** initial examination,it was more common in female patients (92.3 vs.41.3%,P < 0.001) and patients with CD (57.7 vs.30.2%,P=0.01).75% of the patients with penetrating Crohn's disease (CD) had LALT (P=0.002).Hemoglobin (10.4±2.1 vs.11.7± 1.9 g/dL,P=0.01),folic acid (5.2±3.3 vs.8.6±5.9 ng/mL,P =0.02) and serum albumin levels (3.6 ± 0.8 vs.4.7 ± 5 g/dL,P =0.002) were significantly low in patients with *** was associted with the disease relapse within 2 weeks in 12 of the 16 patients with LALT whereas it was seen in 16 of the 73 patients without LALT during the follow-up (75 vs.21.9%,P < 0.001).Additionally,steroid dependency was more common in patients with LALT during the follow-up (62.5 vs.12.3%,P<0.001).Conclusions LALT is common in children with IBD especially in CD and associated with low hemoglobin,albumin and folic acid *** may be a marker of relapse and steroid dependency.

关键词： Children Inflammatory bowel disease Low transaminase levels Vitamin B6

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A case of mediastinal mesenchymal tumor resembling hemopericardium

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Journal of Geriatric Cardiology 2021年第7期18卷 591-594页

作者： Aynur Acibuca Mustafa Yilmaz elif Karadeli Emine Tuba Canpolat Tansel Erol Department of Cardiology Baskent University School of MedicineDr Turgut Noyan Practice and Research CenterAdanaTurkey Department of Radiology Baskent University School of MedicineDr Turgut Noyan Practice and Research CenterAdanaTurkey Department of Pathology Baskent University School of MedicineDr Turgut Noyan Practice and Research CenterAdanaTurkey

Mediastinal neoplasms are rare in the elderly,and clinical suspicion is the first and most important step of differential *** tumors can be misdiagnosed because their symptoms or signs can overlap with cardiovascular diseases,which have a higher prevalence among the older *** diagnostic process should be managed with multimodality imaging and clinical ***,the case of a 74-year-old male patient,who presented with shortness of breath,is examined.A chest X-ray revealed an increased cardiothoracic ratio,and he was diagnosed with hemopericardium following an emergent chest computed *** the echocardiography,it was suspected that a hyperechogenic area adjacent to the heart might be due to a mass,and further examinations confirmed a mediastinal neoplasm.A surgical biopsy was performed,and it was determined to be a mesenchymal *** conclude,clinicians should keep in mind the possibility of paracardiac neoplasm in the elderly,as well as in other age groups,when encountering mediastinal widening so that the patient can be protected from unnecessary interventions such as pericardiocentesis.

关键词： neoplasms neoplasm media

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Prolonged QT dispersion in inflammatory bowel disease

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World Journal of Gastroenterology 2013年第1期19卷 65-71页

作者： elif Yorulmaz Aslihan Sezgin Gupse Adali Hatice Yorulmaz Hilmi Ciftci Department of Gastroenterology Goztepe Training and Research Hospital34470 IstanbulTurkey Department of Ⅲ Internal Medicine Goztepe Training and Research Hospital34470 IstanbulTurkey School of Nursing Halic University34394 IstanbulTurkey

AIM:To investigate the frequency and factors of prolonged QT dispersion that may lead to severe ventricular arrhythmias in patients with inflammatory bowel disease(IBD).METHODS:This study included 63 ulcerative colitis(UC) and 41 Crohn's disease(CD) ***-seven healthy patients were included as the control *** rate was calculated using electrocardiography,corrected QT dispersion(QTcd) and the Bazett's *** model assessment(HOMA) was used to determine insulin resistance(IR).HOMA values 2.5 indicated a high probability of ***:Prolonged QTcd was found in 12.2% of UC patients,and in 14.5% of CD patients compared with the control group(P < 0.05).A significant difference was found between the insulin values(CD:10.95 ± 6.10 vs 6.44 ± 3.28,P < 0.05;UC:10.88 ± 7.19 vs 7.20 ± 4.54,P < 0.05) and HOMA(CD:2.56 ± 1.43 vs 1.42 ± 0.75,P < 0.05;UC:2.94 ± 1.88 vs 1.90 ± 1.09,P < 0.05) in UC and CD patients with and without prolonged *** behavior types were determined in CD patients with prolonged *** systolic arterial pressure(125 ± 13.81 vs 114.09 ± 8.73,P < 0.01) and age(48.67 ± 13.93 vs 39.57 ± 11.58,P < 0.05) in UC patients were significantly associated with prolonged ***:Our data show that IBD patients have prolonged QTcd in relation to *** routine followup of IBD patients should include determination of HOMA,insulin values and electrocardiogram examination.

关键词： Crohn’s disease Homeostasis model assessment Insulin QT dispersion Ulcerative colitis

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Effects of glycaemic management on diabetic kidney disease

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World Journal of Diabetes 2017年第5期8卷 172-186页

作者： Richard J MacIsaac George Jerums elif I Ekinci Department of Endocrinology and Diabetes St Vincent’s Hospital Department of Medicine University of Melbourne Endocrine Centre Austin Health

Hyperglycaemia contributes to the onset and progression of diabetic kidney disease(DKD). Observational studies have not consistently demonstrated a glucose threshold, in terms of HbA1c levels, for the onset of DKD. Tight glucose control has clearly been shown to reduce the incidence of micro-or macroalbuminuria. However, evidence is now also emerging to suggest that intensive glucose control can slow glomerular filtration rate loss and possibly progression to end stage kidney disease. Achieving tight glucose control needs to be balanced against the increasing appreciation that glucose targets for the prevention of diabetes related complications need be individualised for each patient. Recently, empagliflozin which is an oral glucose lowering agent of the sodium glucose cotransporter-2 inhibitor class has been shown to have renal protective effects. However, the magnitude of empagliflozin's reno-protective properties are over and above that expected from its glucose lowering effects and most likely largely result from mechanisms involving alterations in intra-renal haemodynamics. Liraglutide and semaglutide, both injectable glucose lowering agents which are analogues of human glucagon like peptide-1 have also been shown to reduce progression to macroalbuminuria through mechanisms that remain to be fully elucidated. Here we review the evidence from observational and interventional studies that link good glucose control with improved renal outcomes. We also briefly review the potential reno-protective effects ofnewer glucose lowering agents.

关键词： Diabetic nephropathy Albuminuria Glucose control Glomerular filtration rate Diabetes Chronic kidney disease Empagliflozin Liraglutide Semaglutide

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Radiotherapy for Gastrointestinal Stromal Tumors

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Chinese Medical Journal 2018年第2期131卷 235-240页

作者： Emine elif Ozkan Department of Radiation Oncology Suleyman Demirel University Isparta 32260 Turkey

Objective： Gastrointestinal stromal tumors （GISTs） are rare mesenchymal tumors of the gastrointestinal tract, which fiequently cause intraabdominal metastases. The current standard of care is surgery for localized cases, and adjuvant imatinib is recommended for tumors with a high risk of recurrence. To date. radiotherapy has not been commonly accepted as a part of l-nultimodality treatment approach other than palliation. However, recently published case reports and some small series suggest that radiotherapy is a valuable option for controlling locally progressive, drug-resistant disease. The aim of this review is to provide a viewpoint from a radiation oncologist concerning the management of GISTs, especially rectal GIST, and clarify the role and technical aspects of radiotherapy in the treatment approach. Data Sources： A comprehensive search in PubMed using the keywords ＂＇radiotherapy for rectal GIST＂ and ＂＇rectal GIST＂ was undertaken. The literature search included the related articles after 1995. Study Selection： The main articles including rectal GIST case reports and GIST series containing rectal cases were the primary references. Results： Surgery is tile mainstay of treatment, However, to date, radiotherapy is included in the multidisciplinary treatment strategy of rectal GISTs in some circumstances with palliative, adjuvant, or definitive intent using different treatment doses and fields. Conchlsions： Recently reported Iong-terrn local control rates indicate that GIST is a radiosensitive disease. This makes radiotherapy a valuable alternative in GIST management with curative intent, especially in patients who （ I ） cannot tolerate or are resistant to chemotherapy agents. （2） have an unresectable disease, （3） have a gross or microscopic residual disease after surgery, and （4） have a recurrent disease.

关键词： Gastrointestinal Stromal Tumor Radiotherapy: Rectum

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Thermal conductivity of reinforced soils: A literature review

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Research in Cold and Arid Regions 2014年第4期6卷 409-414页

作者： Muge elif Orakoglu JianKun Liu School of Civil Engineering Beijing Jiaotong University Technical Education Faculty Department of Construction Firat UniversityElazig Turkey

This paper aims a review of the literature related to soil reinforcements to achieve lower soil thermal conductivity （2）. The use of various natural and synthetic fibers, polymers, geosynthetics, agricultural waste/materials, and nanoclays is discussed and existing prediction models that have been thought to affect low thermal conductivity are presented.

关键词： reinforced soil heat flux thermal conductivity

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