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Effects of glycaemic management on diabetic kidney disease

World Journal of Diabetes 2017年第5期8卷 172-186页

作者： Richard J Macisaac George Jerums elif i ekinci Department of Endocrinology and Diabetes St Vincent’s Hospital Department of Medicine University of Melbourne Endocrine Centre Austin Health

Hyperglycaemia contributes to the onset and progression of diabetic kidney disease(DKD). Observational studies have not consistently demonstrated a glucose threshold, in terms of HbA1c levels, for the onset of DKD. Tight glucose control has clearly been shown to reduce the incidence of micro-or macroalbuminuria. However, evidence is now also emerging to suggest that intensive glucose control can slow glomerular filtration rate loss and possibly progression to end stage kidney disease. Achieving tight glucose control needs to be balanced against the increasing appreciation that glucose targets for the prevention of diabetes related complications need be individualised for each patient. Recently, empagliflozin which is an oral glucose lowering agent of the sodium glucose cotransporter-2 inhibitor class has been shown to have renal protective effects. However, the magnitude of empagliflozin's reno-protective properties are over and above that expected from its glucose lowering effects and most likely largely result from mechanisms involving alterations in intra-renal haemodynamics. Liraglutide and semaglutide, both injectable glucose lowering agents which are analogues of human glucagon like peptide-1 have also been shown to reduce progression to macroalbuminuria through mechanisms that remain to be fully elucidated. Here we review the evidence from observational and interventional studies that link good glucose control with improved renal outcomes. We also briefly review the potential reno-protective effects ofnewer glucose lowering agents.

关键词： Diabetic nephropathy Albuminuria Glucose control Glomerular filtration rate Diabetes Chronic kidney disease Empagliflozin Liraglutide Semaglutide

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Evaluation of the mental health of COViD-19 patients discharged from the intensive care unit

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World Journal of Clinical Cases 2024年第33期12卷 6587-6590页

作者： elif Sarac Ministry of National Defense General Directorate of Management ServicesAnkara 06000Türkiye

in this editorial,i address the mental health status of patients who have been discharged from intensive care units(iCUs)after battling coronavirus disease 2019(COViD-19).An iCU admission is generally a stressful experience,and for severe COViD-19 survivors prolonged treatment in the iCU can lead to significant psychological *** individuals may experience psychiatric distress,including symptoms such as insomnia,anxiety,depression,and even posttraumatic psychological *** indicates that during the first 6 months to 1 year following an iCU stay,nearly one-third of survivors exhibit symptoms similar to those of depression and post-traumatic stress *** factors may have contributed to the development of depressive and anxious symptoms during the COViD-19 pandemic,particularly for those who underwent an iCU *** iCU environment itself is inherently stressful,filled with the constant noise of various medical *** have provided strong evidence that the prolonged need for ventilation support and the loss of freedom of movement are key factors in the development of psychological problems among COViD-19 patients who had been treated in the iCU.

关键词： COViD-19 Patient Post-intensive care unit Discharge Mental health

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impact of parenting styles on preschoolers’behaviors

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World Journal of Clinical Cases 2024年第23期12卷 5294-5298页

作者： elif Sarac Ministry of National Defense General Directorate of Management ServicesAnkara 06000Türkiye

in this editorial,i comment on the article“Association of preschool children behavior and emotional problems with the parenting behavior of both parents”which was published in the latest issue of“World Journal of Clinical Cases”that demonstrates the prevalence of behavioral disorders in preschool *** i am focused on parenting which is the most effective factor shown to affect the development and continuity of these *** management of child behavior problems is *** in early ages,especially preschoolers who are in the first 5 years of life,are influenced by dramatic changes in various aspects of development,such as social,emotional,and ***,children experience many changes linked to different developmental tasks,such as discovering themselves,getting new friendships,and adapting to a new *** this period,parents have a critical role in supporting child *** parents do not manage and overcome their child’s misbehavior,it could be transformed into psychosocial problems in *** is the most powerful predictor in the social development of preschool *** studies have shown that to reduce the child’s emotional and behavioral problems,a warm relationship between parents and children is *** addition,recent studies have demonstrated significant relationships between family regulation factors and parenting,as well as with child behaviors.

关键词： Behavioral problems Children Emotional problems Parenting style Preschool

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Harnessing photosynthetic microorganisms for enhanced bioremediation of microplastics:A comprehensive review

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Environmental Science and Ecotechnology 2024年第4期20卷 63-78页

作者： Giovanni Davide Barone Andres Rodríguez-Seijo Mattia Parati Brian Johnston elif Erdem Tomislav Cernava Zhi Zhu Xufeng Liu ilka MAxmann Peter Lindblad iza Radecka institute of Biology University of GrazUniversitatsplatz 28010GrazAustria Area de Edafoloxía Departamento de Bioloxía Vexetal e Ciencia Do SoloFacultade de CienciasUniversidade de Vigo32004OurenseSpain Agroecology and Food institute(iAA) University of Vigo e Campus Auga32004OurenseSpain School of Life Sciences Faculty of Science and EngineeringUniversity of WolverhamptonWolverhamptonWV11LYUnited Kingdom FlexSea Ltd. LondonEC2A4NEUnited Kingdom Department of Chemical and Biochemical Engineering Technical University of Denmark2800Kongens LyngbyDenmark institute of Environmental Biotechnology Graz University of Technology8010GrazAustria The Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province School of Life SciencesJiangsu Normal University221116XuzhouChina Department of ChemistrydÅngstrom Laboratory Uppsala UniversitySE-75120UppsalaSweden Synthetic Microbiology Department of BiologyHeinrich Heine University Düsseldorf40225DüsseldorfGermany Cluster of Excellence on Plant Sciences(CEPLAS) Heinrich HeineUniversity DüsseldorfD-40001DüsseldorfGermany

Mismanaged plastics,upon entering the environment,undergo degradation through physicochemical and/or biological *** process often results in the formation of microplastics(MPs),the most prevalent form of plastic debris(ic and terrestrial ecosystems,necessitating innovative strategies for effective *** photosynthetic microorganisms can degrade MPs but there lacks a comprehensive *** we examine the specific role of photoautotrophic microorganisms in water and soil environments for the biodegradation of plastics,focussing on their unique ability to grow persistently on diverse polymers under ***,these cells utilise light and CO_(2) to produce valuable compounds such as carbohydrates,lipids,and proteins,showcasing their multifaceted environmental *** address key scientific questions surrounding the utilisation of photosynthetic microorganisms for MPs and nanoplastics(NPs)bioremediation,discussing potential engineering strategies for enhanced *** review highlights the significance of alternative biomaterials and the exploration of strains expressing enzymes,such as polyethylene terephthalate(PET)hydrolases,in conjunction with microalgal and/or cyanobacterial ***,we delve into the promising potential of photo-biocatalytic approaches,emphasising the coupling of plastic debris degradation with sunlight *** integration of microalgal-bacterial consortia is explored for biotechnological applications against MPs and NPs pollution,showcasing the synergistic effects in wastewater treatment through the absorption of nitrogen,heavy metals,phosphorous,and *** conclusion,this review provides a comprehensive overview of the current state of research on the use of photoautotrophic cells for plastic *** underscores the need for continued investigation into the engineering of these microorganisms and the development of innovative approaches

关键词： Environmental biotechnology Microplastic Nanoplastic Microalgae Cyanobacteria

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Exploration of the shared pathophysiological mechanisms of gestational diabetes and large for gestational age offspring

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World Journal of Diabetes 2019年第6期10卷 333-340页

作者： Sofia Nahavandi Sarah Price Priya Sumithran elif ilhan ekinci The Royal Children’s Hospital Melbourne Parkville VIC 3052 Australia Department of Endocrinology Austin Health Repatriation Campus Heidelberg West Melbourne VIC 3081 Australia Department of Medicine Austin Health and the University of Melbourne (Austin Campus) Parkville Melbourne VIC 3084 Australia

Gestational diabetes mellitus (GDM) and large for gestational age (LGA) offspring are two common pregnancy complications. Connections also exist between the two conditions, including mutual maternal risk factors for the conditions and an increased prevalence of LGA offspring amongst pregnancies affected by GDM. Thus, it is important to elucidate potential shared underlying mechanisms of both LGA and GDM. One potential mechanistic link relates to macronutrient metabolism. indeed, derangement of carbohydrate and lipid metabolism is present in GDM, and maternal biomarkers of glucose and lipid control are associated with LGA neonates in such pregnancies. The aim of this paper is therefore to reflect on the existing nutritional guidelines for GDM in light of our understanding of the pathophysiological mechanisms of GDM and LGA offspring. Lifestyle modification is first line treatment for GDM, and while there is some promise that nutritional interventions may favourably impact outcomes, there is a lack of definitive evidence that changing the macronutrient composition of the diet reduces the incidence of either GDM or LGA offspring. The quality of the available evidence is a major issue, and rigorous trials are needed to inform evidence-based treatment guidelines.

关键词： Gestational diabetes mellitus Large for gestational age Metabolism Biomarkers Glucose Lipids

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Optimization of constitutive parameters of foundation soils k-means clustering analysis

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Research in Cold and Arid Regions 2013年第5期5卷 626-636页

作者： Muge elif Orakoglu Cevdet Emin ekinci Firat University Technical Education FacultyDepartment of Construction Education Beijing Jiaotong University School of Civil Engineering Firat University Technology FacultyDepartment of Civil Engineering

The goal of this study was to optimize the constitutive parameters of foundation soils using a k-means algorithm with clustering analysis. A database was collected from unconfined compression tests, Proctor tests and grain distribution tests of soils taken from three different types of foundation pits： raft foundations, partial raft foundations and strip foundations. k-means algorithm with clustering analysis was applied to determine the most appropriate foundation type given the un- confined compression strengths and other parameters of the different soils.

关键词： foundation soil regression model k-means clustering analysis

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Production of nanocrystalline silver particles by hydrogen reduction of silver nitrate aerosol droplets

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Transactions of Nonferrous Metals Society of China 2013年第3期23卷 841-848页

作者： Burak EBiN elif YAZiC i Sebahattin GüRMEN Department of Metallurgical & Materials Engineering Ist anbul Technical University34469IstanbulTurkey

Nanocrystalline silver particles were produced by hydrogen reduction of silver nitrate aerosol droplets formed by high frequency ultrasonic *** dependences of the particle size,morphology and crystallite size on the precursor concentration and the reaction temperature were *** spray pyrolysis process was combined with hydrogen reduction to research the effects on the silver particle *** silver particles including slight oxide structure were prepared at temperature as low as 200 ℃ from silver nitrate under hydrogen atmosphere.X-ray diffraction（XRD） studies showed that pure silver particles were obtained above 200 ℃ reaction *** crystallite sizes of the samples ranged from 29 to 47 *** results indicate that the crystallite sizes hardly ever depended on the reaction *** slightly enlarged by increasing precursor *** observations showed that particles were obtained in spherical morphology with particle sizes between 210 and 525 *** temperature and precursor concentration strongly influenced the particle size.

关键词： silver particles nanocrystalline materials aerosol process hydrogen reduction

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Radiotherapy for Gastrointestinal Stromal Tumors

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Chinese Medical Journal 2018年第2期131卷 235-240页

作者： Emine elif Ozkan Department of Radiation Oncology Suleyman Demirel University Isparta 32260 Turkey

Objective： Gastrointestinal stromal tumors （GiSTs） are rare mesenchymal tumors of the gastrointestinal tract, which fiequently cause intraabdominal metastases. The current standard of care is surgery for localized cases, and adjuvant imatinib is recommended for tumors with a high risk of recurrence. To date. radiotherapy has not been commonly accepted as a part of l-nultimodality treatment approach other than palliation. However, recently published case reports and some small series suggest that radiotherapy is a valuable option for controlling locally progressive, drug-resistant disease. The aim of this review is to provide a viewpoint from a radiation oncologist concerning the management of GiSTs, especially rectal GiST, and clarify the role and technical aspects of radiotherapy in the treatment approach. Data Sources： A comprehensive search in PubMed using the keywords ＂＇radiotherapy for rectal GiST＂ and ＂＇rectal GiST＂ was undertaken. The literature search included the related articles after 1995. Study Selection： The main articles including rectal GiST case reports and GiST series containing rectal cases were the primary references. Results： Surgery is tile mainstay of treatment, However, to date, radiotherapy is included in the multidisciplinary treatment strategy of rectal GiSTs in some circumstances with palliative, adjuvant, or definitive intent using different treatment doses and fields. Conchlsions： Recently reported iong-terrn local control rates indicate that GiST is a radiosensitive disease. This makes radiotherapy a valuable alternative in GiST management with curative intent, especially in patients who （ i ） cannot tolerate or are resistant to chemotherapy agents. （2） have an unresectable disease, （3） have a gross or microscopic residual disease after surgery, and （4） have a recurrent disease.

关键词： Gastrointestinal Stromal Tumor Radiotherapy: Rectum

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Bietti crystalline dystrophy and choroidal neovascularization in childhood

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international Journal of Ophthalmology(English edition) 2019年第9期12卷 1514-1516页

作者： Sabiha Gungor Kobat Fatih Cem Gul elif Yusufoglu Department of Ophthalmology Elazig Health Sciences UniversityElazig 23000Turkey

Dear Editor,i am *** Gungor Kobat,from the Department of Ophthalmology,Elazig Health Sciences University,Elazig,Turkey.i am writing to present an exceedingly rare case of two siblings,one of whom developed Bietti crystalline dystrophy(BCD)with choroidal neovascularization at the age of 13 years,and the other has asymptomatic BCD at 8 years old.

关键词： RPE BCD Bietti crystalline dystrophy and choroidal neovascularization in childhood

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Antimicrobial activity against periodontopathogenic bacteria,antioxidant and cytotoxic effects of various extracts from endemic Thermopsis turcica

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Asian Pacific Journal of Tropical Biomedicine 2014年第7期4卷 505-514页

作者： elif Burcu Bali Leyla Acik Glin Akca Meral Sarper Mualla Pinar Eli Ferit Avcu Mecit Vural Health Services Vocational School.University of Gazi Department of Biology Faculty of Science.University of Gazi Department of Medical Microbiology Faculty of DentistryUniversity of Gazi Cancer and Stem Cell Research Center Gulhane Military Medical School Department of Hematology Cancer and Stem Cell Research Center.Gulhane Military Medical School

Objective:To investigate the in vitro antimicrobial potential of Thermopsis turcica Kit Tan,Vural&Kckdk against periodoutopathogenie bacteria,its antioxidant activity and cytotoxic effect on various cancer cell ***:in vitro antimicrobial activities of ***,ethyl acetate(ElAc,n-hexane and water extracts of Thermopsis turcica herb against periodontopathogenic bacteria,Aggregatibacter actinnmycelemconilans ATCC 29523 and Porphyromonas gingivalis ATCC 33277 were tested by agar well diffusion,minimum inhibitory concentration(MiC)and minimal bactericidal concentration(MBC),Antioxidant properties of the extracts were evaluatod by 1,1-diphenyl-2-picryl-hydrazyl radical scavenging activity and p-carotene bleaching *** of phenolic contents of the extracts were also analysed by using the Folin-Ciocalteu ***,cytotoxic activity of the extracts on androgcn-insensilivc prostate cancer,androgen—sensitive prostate cancer,chronic myelogenous leukemia and acute promyelocytic leukemia bunian cancer cell lines were determined by 3-4,5-dimelhylthiazol-2-yh-2,5-diphenyltclrazolium bromide *** gingival fibroblast cells were used as a ***:Our data showed that ELAc extract had the highest antimicrobial effect on Aggregatibacter actinomycetemitans(MiC:1.562 mg/ml_MHC:3.124 mg/ml.)and Porph yromonas gingiralis(MiC:0.781 mg/mL,MBC:1.562 mg/mL).in antioxidant *** extract exhibited also the highest radical scavenging activity[iC_(50)=(30.0±0.3)μg/ml.]and the highest inhibition[(74.35±0.30)%]|against lineloic acide *** amount of phenolic content of it was also the highest[(l62.5±l.2)μg/mg gallic acid].in cytotoxic assay,only etbanol[iC_(50)=(80.00±1.21)μg/ml.]and EtAc extract[iC_(50)=(70.0±0.9)μg/ml]were toxic on acute promyeloeytic leukemia cells at 20—100μg/mL.P.However,no toxic effect was observed on human gingival fibroblast ***:According to our findings,owing to its antioxidant and

关键词： Thermopsis turcica Antimicrobial activity Periodontopathogenic bacteria Antioxidant effect Phenolic content Cytotoxic effect Human gingival fibroblast Acute promyelocytic leukemia

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