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An Investigation of Postmortem Urotensin II Receptor Levels in Brain and Kidney Tissues in a Rat Model of Cardiac Ischemia

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Journal of Forensic Science and Medicine 2018年第1期4卷 1-6页

作者： Mustafa Talip Sener Erol Akpinar elif Cadirci Zekai Halici Irfan Cinar Ahmet Nezih Kok Departments of Forensic Medicine and Pharmacology Faculty of MedicineAtaturk UniversityErzurum 25240Turkey

This study aimed to investigate changes in postmortem urotensin Ⅱ receptor(UTR)levels in brain and kidney tissues in a rat model of cardiac *** rats were divided into two groups:a control group and a cardiac ischemia-induced *** ischemia was created by an intraperitoneal injection of a single lethal dose of isoproterenol(ISO;850 mg/kg).Plasma UT,blood urea nitrogen,and creatinine levels were determined 0 h *** and kidney UTR mRNA expression levels were determined 0,1,3,6,12,24,4&and 72 h *** histopathological appearance of brain and kidney tissues was also *** UT and plasma creatinine levels were increased in the cardiac ischemia-induced group as compared with those in the control group(P<0.001).Ischemia resulted in histopathological changes in brain and cerebellum *** morphological evaluation revealed Purkinje cell degeneration(P=0.037)and dark neurons(P=0.004).The UTR expression level decreased after 1 h postmortem in the brain and after 3 h postmortem in the kidneys in the cardiac ischemia-induced group as compared with that in the control group(P<0.001).The observed changes in UTR expression levels may be valuable in clinical practice in the field of forensic *** changes may be used as a marker in postmortem evaluations of sudden death caused by ischemia-induced cardiac shock.

关键词： Brain cardiac ischemia kidney postmortem urotensin II receptor expression

Heavy metal concentrations in macroalgae species from Sinop coasts of the Southern Black Sea

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Journal of Coastal Life Medicine 2016年第11期4卷 841-845页

作者： Levent Bat elif Arici Department of Hydrobiology Fisheries FacultySinop University57000SinopTurkey

Objective:To determine the concentrations of Fe,Zn,Ni,Cu,Mn,Pb,Cd and Co in macroalgae from Sinop coasts of the Sounthern Black ***:Chlorophyta-green algae(Chaetomorpha spp.,Cladophora spp.,Ulva linza,Ulva intestinalis,Ulva lactuca,Ulva rigida);Ochrophyta-brown alga[Cystoseira barbata(***)]and Rhodophyta-red algae(Ceramium spp.,Corallina panizzoi)were collected seasonally in the year 2010 from the upper infralittoral zone of inner harbour,outer harbour,Gerze and Ayancık of Sinop coasts of the Black *** samples were analysed by atomic absorption spectrophotometer in order to determine heavy metal levels in different algal division species along Sinop coasts and to provide information of marine environment quality as marine strategy framework directive is aimed to ensure good environmental status of the seas by 2020 in the European ***:The results showed that metal concentrations in all studied green algae,brown alga and red algae increase in the order:Cd

关键词： Heavy metals Macroalgae Black Sea Sinop Coast Marine strategy framework directive

A rare cause of chronic ataxia in childhood:ganglioneuroma

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World Journal of Pediatrics 2018年第2期14卷 204-206页

作者： elif Acar Arslan Tülay Kamasak Betül Diler Turgut ismail Saygin Haluk Sarihan Ali Cansu Department of Pediatric Neurology Karadeniz Technical University School of MedicineFarabi StreetN:6461080 TrabzonTurkey Department of Pathology Karadeniz Technical University School of MedicineFarabi StreetN:6461080 TrabzonTurkey Department of Pediatric Surgery Karadeniz Technical University School of MedicineFarabi StreetN:6461080 TrabzonTurkey

Ganglioneuroma is an extremely rare cause of ataxia in childhood,the only descriptions of which are in the form of case reports[1,2].Ganglioneuroma can be asymptomatic in the abdominal and thoracic region,or else can ... 详细信息

关键词： rare thoracic pain

The apoptotic effect of ozone therapy on mitochondrial activity of highly metastatic breast cancer cell line MDA-MB-231 using in vitro approaches

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Journal of Interventional Medicine 2022年第2期5卷 64-71页

作者： Merve Yildirim Selen Erkisi Hazal Yilmaz Naz Unsal elif inac Yldray Tanrnver Polen Kocak Departnent of Genetics and Bioenginering Facaly of Engineering and Architecture Yeditepe University26 Agustos CampusKaqrisdagt CadKaytsdag34755IstanbulTurkey Infirity Regnerative Clini Thy Sites YoluUlus34347IstanbulTurkey Department of Biomedical Engineering Faculy of Enginering Itirve Universit Vadi CampusAzerbaycan CadSariyer34396IstanbulTurkey

Ozone(O) gas is the triatomic state of oxygen and it is used as a disinfection agent due to its strong oxidizing effect, since its discovery in the mid-nineteenth century. Ozone therapy is also an alternative therapeutic approach for some diseases like circulatory disorders, AIDS, asthma, cardiovascular diseases, and certain types of cancer by increasing the oxygen levels in the blood by external addition of ozone to the body. In this study, the therapeutic potential of ozone therapy was examined by inhibiting the growth of breast cancer cells in a dose-dependent procedure. Ozone concentrations varying from 5 to 20 μg/ml were applied to the MDA-MB-231, human breast adenocarcinoma and HUVEC, human umbilical vein endothelium, cell lines, and MDA cells demonstrated an increased rate of death while its migration potential decreases. RT-PCR analysis showed mRNA expression levels of pro-apoptotic genes demonstrated higher folds in MDA cells after 10 μg/ml treatment. In the same context,Annexin V/PI and cell cycle analysis also concluded that ozone therapy causes apoptotic cell death on breast tumor cells. The use of ozone therapy for cancer treatment requires further and extensive research. However, this research has shown that ozone therapy is a promising source for cancer treatment in a way by inhibiting the proliferation of breast tumor cells.

关键词： Ozone therapy Antioxidants Apoptosis Breast cancer

Solid amine sorbents for CO_(2) capture by chemical adsorption: A review

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Petroleum 2017年第1期3卷 37-50页

作者： elif ErdalÜnveren Bahar Ozmen Monkul S¸erife Sarıoglan Nesrin Karademir Erdogan Alper Institute of Chemical Technology TUBITAK Marmara Research CenterGebze 41470KocaeliTurkey Chemical Engineering Department Hacettepe UniversityBeytepe 06800AnkaraTurkey

Amines are well-known for their reversible reactions with CO_(2),which make them ideal for CO_(2) capture from several gas streams,including flue *** this respect,selective CO_(2) absorption by aqueous alkanolamines is the most mature technology but the process is energy intensive and has also corrosion *** disadvantages can be diminished to a certain extent by chemical adsorption of CO_(2) *** most important element of the chemical adsorption of CO_(2) involves the design and development of a suitable adsorbent which consist of a porous support onto which an amine is attached or *** an adsorbent is often called as solid amine *** review covers solid amine-based studies which are developed and published in recent ***,the review examines several different types of porous support materials,namely,three mesoporous silica(MCM-41,SBA-15 and KIT-6)and two polymeric supports(PMMA and PS)for CO_(2) *** is given to the synthesis,modifications and characterizations-such as BET and PXRD data-of *** of these supports to obtain a solid amine sorbent through impregnation or grafting is reviewed *** is given to the adsorption mechanisms,material characteristics,and synthesis methods which are discussed in *** amount of original data are also presented which makes this review ***,relevant CO_(2) adsorption(or equilibrium)capacity data,and cyclic adsorption/desorption performance and stability of important classes of solid amine sorbents are critically *** include severa PEI or TEPA impregnated adsorbents and APTES-grafted systems.

关键词： Amine-impregnation Amine-grafting CO_(2)capture Chemical adsorption Mesoporous silica Solid amine sorbent Polymeric support Temperature swing adsorption

Propolis reduces bacterial translocation and intestinal villus atrophy in experimental obstructive jaundice

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World Journal of Gastroenterology 2007年第39期13卷 5226-5231页

作者： Mehmet Zafer Sabuncuoglu Kemal Kismet Sibel Serin Kilicoglu Bulent Kilicoglu Serap Erel Sabahattin Muratoglu Asli elif Sunay Esra Erdemli Mehmet Ali Akkus 4th General Surgery Department Ankara Training and Research Hospital Ulucanlar Ankara 06340 Turkey Department of Histology and EmbriologyUfuk University School of Medicine Ankara 06520 Turkey Microbiology Department Ankara Training and Research Hospital Ulucanlar Ankara 06340 Turkey Food Engineer Balparmak Pazarlama Cekmekoy 34760 Istanbul Turkey Department of Histology and Embriology Ankara University School of Medicine 06100 Ankara Turkey

AIM： To investigate the effects of propolis on bacterial translocation and ultrastructure of intestinal morphology in experimental obstructive jaundice. METHODS： Thirty Wistar-Albino male rats were randomly divided into three groups, each including 10 animals： group Ⅰ, sham-operated; group Ⅱ, ligation and division of the common bile duct （BDL）; group Ⅲ, BDL followed by oral supplementation of propolis 100 mg/kg per day. Liver, blood, spleen, mesenteric lymph nodes, and ileal samples were taken for microbiological, light and transmission electron microscopic examination on postoperative 7^th d after sacrification. RESULTS： The mean number of villi per centimeter and mean mucosal height of the propolis group were significantly different in the BDL group （P = 0.001 and 0.012, respectively）. The electron microscopic changes were also different between these groups. Sham and BDL＋propolis groups had similar incidence of bacterial translocation （BT）. The BDL group had significantly higher rates of BT as compared with sham and BDL ＋ propolis groups. BT was predominantly detected in MLNs and the most commonly isolated bacteria was Escherichia coil CONCLUSION： Propolis showed a significant protective effect on ileal mucosa and reduced bacterial translocation in the experimental obstructive jaundice model. Further studies should be carried out to explain the mechanisms of these effects,

关键词： Obstructive jaundice Bacterial translocation Ileal morphology

A Study of Students＇ Opinions About History Subjects in the Social Studies Curriculum

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Journal of Literature and Art Studies 2017年第10期7卷 1347-1353页

作者： Hamza AKENGiN Meltem elif CENDEK Marmara University Istanbul Turkey Social Studies Teacher Istanbul Turkey

Social studies combines social sciences and the humanities, and has the purpose of raising effective citizens. There are many different areas integrated in social studies including history, geography, philosophy and psychology. Social studies is the presentation of the information produced by these areas in framework of a curriculum. Social studies curriculum is a multi-dimensional program. One of the objectives of this program is to raise individuals who know about their past and shape their future with the help of the lessons they learn from history. In this context, the aim of this study is to determine sixth grade students＇ perspective to the history subjects in social studies curriculum, learn the place of history in their lives and see how history subjects are taught in classrooms. This study is limited to the 2014-2015 academic year. The participants were identified using random sampling, a probability-based sampling method. This is a qualitative study. The study includes interviews with eight sixth graders, of whom four were female and four were male. The study data were collected in semi-structured interviews. The interviews were recorded and transcribed. The data were analyzed using descriptive analysis. The study found that the students enjoyed learning history, had positive opinions about their history grades and their teachers continued to teach history using traditional methods. They also felt that history contributed to their lives. Based on the data collected, the study makes specific suggestions.

关键词： history topics social studies students' opinions

Bullous oral lichen planus:report of two cases

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中华医学杂志(英文版) 2003年第10期 154-155页

作者： Berrin NSAL,S.elif GLTEKIN,Erol BAL,Benay TOKMAN Department of Periodentology Faculty of Dentistry Gazi University Department of Oral Pathology Faculty of Dentistry Gazi University Department of Maxillofacial Surgery Dental Clinic Air Force Hospital Etimesgut Department of Oral Pathology Faculty of Dentistry Gazi University Ankara Turkey Ankara Turkey Ankara Turkey Ankara Turkey

Effect of the COVID-19 pandemic on patients with presumed diagnosis of acute appendicitis

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World Journal of Clinical Cases 2022年第29期10卷 10487-10500页

作者： Sami Akbulut Adem Tuncer Zeki Ogut Tevfik Tolga Sahin Cemalettin Koc Emek Guldogan Ertugrul Karabulut elif Seren Tanriverdi Ali Ozer Surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatya 44280Turkey Department of Biostatistics and Medical Informatics Inonu University Faculty of MedicineMalatya 44280Turkey Department of Public Health Inonu University Faculty of MedicineMalatya 44280Turkey Department of Surgery Inonu University Faculty of MedicineMalatya 44280Turkey Department of Medical Microbiology Inonu University Medical FacultyMalatya 44280Turkey

BACKGROUND Acute appendicitis(AAp) is the most frequent cause of acute abdominal pain,and appendectomy is the most frequent emergency procedure that is performed *** coronavirus disease 2019(COVID-19) pandemic has caused delays in managing diseases requiring emergency approaches such as AAp and *** To compare the demographic,clinical,and histopathological outcomes of patients with AAp who underwent appendectomy during pre-COVID-19 and COVID-19 *** The demographic,clinical,biochemical,and histopathological parameters were evaluated and compared in patients who underwent appendectomy with the presumed diagnosis of AAp in the pre-COVID-19(October 2018-March 2020) and COVID-19(March 2020-July 2021) *** Admissions to our tertiary care hospital for AAp increased 44.8% in the COVID-19 ***-19(n = 154) and COVID-19(n = 223) periods were compared for various parameters,and we found that there were statistically significant differences in terms of variables such as procedures performed on the weekdays or weekends [odds ratio(OR):1.76;P = 0.018],presence of AAp findings on ultrasonography(OR:15.4;P < 0.001),confirmation of AAp in the histopathologic analysis(OR:2.6;P = 0.003),determination of perforation in the appendectomy specimen(OR:2.2;P = 0.004),the diameter of the appendix(P < 0.001),and hospital stay(P = 0.003).There was no statistically significant difference in terms of interval between the initiation of symptoms and admission to the hospital between the pre-COVID-19(median:24 h;interquartile range:34) and COVID-19(median:36 h;interquartile range:60) periods(P = 0.348).The interval between the initiation of symptoms until the hospital admission was significantly longer in patients with perforated AAp regardless of the COVID-19 or pre-COVID-19 status(P < 0.001).CONCLUSION The present study showed that in the COVID-19 period,the ultrasonographic determination rate of AAp,perforation rate of AAp,and duration of hospital

关键词： SARS-CoV-2 COVID-19 pandemic Acute appendicitis Perforated appendicitis Negative appendectomy