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ACCURATE ATTENUATION CORRECTION FOR ALGEBRAIC RECONSTRUCTION TECHNIQUE IN SPECT

Journal of Computational Mathematics 2010年第3期28卷 401-417页

作者： elie nasr IMB Institute of Mathematics of Bordeaux

We present a new iterative reconstruction algorithm to improve the algebraic reconstruction technique （ART） for the Single-Photon Emission Computed Tomography. Our method is a generalization of the Kaczmarz iterative algorithm for solving linear systems of equations and introduces exact and implicit attenuation correction derived from the attenuated Radon transform operator at each step of the algorithm. The performances of the presented algorithm have been tested upon various numerical experiments in presence of both strongly non-uniform attenuation and incomplete measurements data. We also tested the ability of our algorithm to handle moderate noisy data. Simulation studies demonstrate that the proposed method has a significant improvement in the quality of reconstructed images over ART. Moreover, convergence speed was improved and stability was established, facing noisy data, once we incorporate filtration procedure in our algorithm.

关键词： Single-photon emission computed tomography Attenuated radon transform,Algebraic reconstruction technique Attenuation correction.

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Optimum chemotherapy for the management of advanced biliary tract cancer

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World Journal of Gastroenterology 2015年第14期21卷 4121-4125页

作者： Marwan Ghosn Hampig Raphael Kourie elie El Rassy Ralph Chebib Fadi El Karak Colette Hanna Dolly nasr Department of Oncology Faculty of MedicineSaint Joseph University

Biliary tract cancers(BTCs) are highly fatal malignancies, which are often diagnosed at an advanced stage and have relatively poor *** treatment of patients with advanced BTC is systemic, based on chemotherapy or best supportive care, depending on their performance *** clinical trials studyingmany chemotherapeutic regimens and targeted therapies for the treatment of BTC, the standard of care for advanced BTC remains the combination of gemcitabine with *** new molecules targeting proliferation and survival pathways, the immune response and angiogenesis are currently undergoing phase Ⅰ and Ⅱ trials for the treatment of advanced BTC with promising results.

关键词： Biliary tract cancer Chemotherapy Updates Treatmen

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Where does chemotherapy stands in the treatment of ampullary carcinoma? A review of literature

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World Journal of Gastrointestinal Oncology 2016年第10期8卷 745-750页

作者： Marwan Ghosn Hampig Raphael Kourie elie El Rassy Fady Ghassan Haddad Colette Hanna Fadi El Karak Dolly nasr Department of Oncology Faculty of MedicineSaint Joseph University Department of Oncology Jules Bordet InstituteFree University of Brussels (ULB) Department of Radiation Oncology Faculty of MedicineSaint Joseph University

Ampullary carcinoma(AC) is a rare gastrointestinal tumor without clear treatment *** management of this tumor is usually extrapolated from the treatment of pancreatic,biliary duct and intestinal *** papers have studied the AC as an independent entity and yet succombs to several *** studies were retrospective single institutional experiences with limited sample sizes recruited over a long period of *** metastatic ACs where chemotherapy is the only recommended option,localized AC once excised may be approached by either chemotherapy alone or concomitant chemoradiation *** this review,we report the overall survival and recurrence factors of more than 1000 patients from all the studies treating exclusively *** also review the medical treatment of this tumor and conclude to the necessity of multi-institutional randomized controlled studies for AC exclusively.

关键词： Ampullary cancer Prognostic factors Treatment Review Novel therapies

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Management of Heart Failure with Reduced Ejection Fraction Globally and in Lebanon: Where Do SGLT-2is Stand?

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World Journal of Cardiovascular Diseases 2023年第3期13卷 138-169页

作者： Hadi Skouri Tony Abdel Massih Saiid Chaaban elie Chammas Malek Mohamad Samer nasr Fadi Turquieh Cardiology Division Department of Internal Medicine American University of Beirut Medical Center Beirut Lebanon Department of Cardiology Hôtel-Dieu de France University Medical Center Beirut Lebanon Cardiology Division Department of Internal Medicine Hammoud Hospital University Medical Center Sidon Lebanon Heart Center Clemenceau Medical Center Beirut Lebanon Department of Cardiology Sahel General Hospital Beirut Lebanon Department of Cardiology Mount Lebanon Hospital University Medical Center Hazmieh Lebanon Department of Cardiology Haykel Hospital El Koura Lebanon

Heart failure (HF) is a clinical syndrome due to structural and/or functional cardiac anomalies, accompanied by elevated natriuretic peptide levels and/or cardiogenic pulmonary or systemic congestion;severely compromising patients’ health, performance and quality of life. The advancement of novel treatment and their endorsement by international medical and scientific societies have shifted the treatment of HF with reduced ejection fraction (HFrEF) towards quadruple therapy: an angiotensin receptor-neprilysin inhibitor or an angiotensin-converting enzyme inhibitor, a beta-blocker, a mineralocorticoid receptor antagonist and a sodium/glucose co-transporter-2 inhibitor (SGLT2i). This paper reviews the available literature on state-of-the-art diagnostic and therapeutic advances in HFrEF, discusses landmark trials that shifted the paradigm towards quadruple therapy in HFrEF, visits the potential challenges in Lebanon and globally, proposes an algorithm for treatment introduction and sequencing in HFrEF and highlights clinical considerations for HFrEF management and patient education and follow-up. This practical guidance could serve cardiologists and other medical specialists in identifying clinical signs of HFrEF, diagnosing patients, referring them or prescribing the components of quadruple therapy, and offering medical advice and follow-up. We highlight the role of SGLT2is in HF management and their effectiveness in reducing rates of hospitalization for HF as well as cardiovascular deaths, with satisfactory safety profile.

关键词： Heart Failure HFrEF Management SGLT2i Clinical Guidance Quadruple Therapy

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