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Optimum chemotherapy for the management of advanced biliary tract cancer

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World Journal of Gastroenterology 2015年第14期21卷 4121-4125页

作者： Marwan Ghosn Hampig Raphael Kourie elie El Rassy Ralph Chebib Fadi El Karak Colette Hanna Dolly Nasr Department of Oncology Faculty of MedicineSaint Joseph University

Biliary tract cancers(BTCs) are highly fatal malignancies, which are often diagnosed at an advanced stage and have relatively poor *** treatment of patients with advanced BTC is systemic, based on chemotherapy or best supportive care, depending on their performance *** clinical trials studyingmany chemotherapeutic regimens and targeted therapies for the treatment of BTC, the standard of care for advanced BTC remains the combination of gemcitabine with *** new molecules targeting proliferation and survival pathways, the immune response and angiogenesis are currently undergoing phase Ⅰ and Ⅱ trials for the treatment of advanced BTC with promising results.

关键词： Biliary tract cancer Chemotherapy Updates Treatmen

Understanding myofibroblast origin in the fibrotic lung

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第3期2卷 142-150页

作者： Mahsa Zabihi Mahtab Shahriari Felordi Arun Lingampally Saverio Bellusci Xuran Chu elie El Agha Department of Medicine V Internal MedicineInfectious Diseases and Infection ControlUniversities of Giessen and Marburg Lung Center(UGMLC)German Center for Lung Research(DZL)Justus-Liebig University GiessenGiessen 35392Germany Cardio-Pulmonary Institute(CPI) Giessen 35392Germany Institute for Lung Health(ILH) Giessen 35392Germany Department of Medicine II Internal MedicinePulmonary and Critical CareUniversities of Giessen and Marburg Lung Center(UGMLC)German Center for Lung Research(DZL)Justus-Liebig University GiessenGiessen 35392Germany Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhouZhejiang 325035China

Idiopathic pulmonary fibrosis(IPF)is characterized by accumulation of myofibroblasts(MYFs)and extracellular matrix components,which leads to severe distortion and scarring of the gas exchange units of the lung,the alveoli,and ultimately respiratory ***-associated MYFs are therefore widely regarded as the culprits that compromise the architectural makeup of the lung in fibrotic *** the past decade,the cellular source of MYFs has been intensely *** rationale for such studies is that identifying the origin of these cells might help identify novel therapeutic targets and candidates to treat IPF *** advances in basic and translational research employing lineage tracing and multi-omics approaches have helped address the identity of MYF precursors,highlight the underlying heterogeneity,and to a less extent investigate MYF fate during fibrosis *** this review,we discuss the current understanding of such important aspects of MYF biology as well as recent developments in the treatment of IPF.

关键词： Idiopathic pulmonary fibrosis Myofibroblasts Fibrotic disease Myofibroblast heterogeneity Lineage tracing

Tensile Shock Physics in Compressible Thermoviscoelastic Solid Medium

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Applied Mathematics 2024年第10期15卷 719-744页

作者： Karan S. Surana elie Abboud Department of Mechanical Engineering University of Kansas Lawrence USA

This paper addresses tensile shock physics in thermoviscoelastic (TVE) solids without memory. The mathematical model is derived using conservation and balance laws (CBL) of classical continuum mechanics (CCM), incorporating the contravariant second Piola-Kirchhoff stress tensor, the covariant Green’s strain tensor, and its rates up to order n. This mathematical model permits the study of finite deformation and finite strain compressible deformation physics with an ordered rate dissipation mechanism. Constitutive theories are derived using conjugate pairs in entropy inequality and the representation theorem. The resulting mathematical model is both thermodynamically and mathematically consistent and has closure. The solution of the initial value problems (IVPs) describing evolutions is obtained using a variationally consistent space-time coupled finite element method, derived using space-time residual functional in which the local approximations are in hpk higher-order scalar product spaces. This permits accurate description problem physics over the discretization and also permits precise a posteriori computation of the space-time residual functional, an accurate measure of the accuracy of the computed solution. Model problem studies are presented to demonstrate tensile shock formation, propagation, reflection, and interaction. A unique feature of this research is that tensile shocks can only exist in solid matter, as their existence requires a medium to be elastic (presence of strain), which is only possible in a solid medium. In tensile shock physics, a decrease in the density of the medium caused by tensile waves leads to shock formation ahead of the wave. In contrast, in compressive shocks, an increase in density and the corresponding compressive waves result in the formation of compression shocks behind of the wave. Although these are two similar phenomena, they are inherently different in nature. To our knowledge, this work has not been reported in the publishe

关键词： Tensile Shock Physics Tensile Waves Elastic Viscoelastic Solids Variationally Consistent Space-Time Coupled Space-Time Residual Functional A Posteriori Finite Element Method Wave Speed Conservation and Balance Laws

First Report of a Successful Development of Yam Hybrids(Dioscorea alata L.)from Lyophilized and Long-Term Stored Pollens

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Phyton-International Journal of Experimental Botany 2023年第10期92卷 2861-2874页

作者： Erick Malédon elie Nudol Christophe Perrot Marie-Claire Gravillon Ronan Rivallan Denis Cornet Hâna Chair Komivi Dossa CIRAD UMR AGAP InstitutPetit BourgGuadeloupe97170France UMR AGAP Institut Univ MontpellierCIRADINRAEInstitut AgroMontpellierF-34398France CIRAD UMR AGAP InstitutMontpellierF-34398France

Various biological constraints including erratic and asynchronous flowering between male and female plants hinder successful hybrid development and genetic gains in greater yam breeding ***,pollen storage has gained much attention to facilitate artificial pollinations and increase the genetic *** 4-year study aimed at developing a practical long-term pollen storage technique for the successful development of yam *** pollens were collected from two Dioscorea alata males,then lyophilized(two lyophilization treatments were applied),followed by storage at room temperature(24℃–25℃)for 12 ***,the lyophilized and stored pollens were tested for viability by crossing with four female *** results showed that lyophilization is effective for achieving viable pollens after 12 months of *** 1(48 h drying)showed higher pollen germination and fertility rates than Treatment 2(72 h drying).Although we observed a reduction in viability of lyophilized pollens after 12 months of storage,we generated hybrid seedlings with success rates from 12%to 21%compared to 21%–31%when using fresh *** testing based on molecular genotyping confirmed the hybrid status of the obtained seedlings,which grew well in a *** is a practical approach for a long-term storage of greater yam pollen *** protocol will positively impact yam breeding programs particularly in developing countries.

关键词： Yam freeze-drying pollen conservation genetic gain

Assessment of the Socio-Demographic Factors Associated with the Satisfaction Related to the Childbirth Experience

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Open Journal of Obstetrics and Gynecology 2014年第10期4卷 585-611页

作者： elie Al Ahmar Samir Tarraf Faculty of Medicine and Medical Sciences Holy Spirit University of Kaslik Mount Lebanon Lebanon

Assessment of the socio-demographic factors associated with the satisfaction is related to the childbirth experience. Objective: A mother’s satisfaction with the childbirth experience may have instant and lasting effects on her wellbeing, and on the bonding with her infant. The main aim of the study was to assess which socio-demographic factors are associated with this satisfaction. Most factors that authors agree on are: Pain intensity, personal control, self-efficacy, length of labor, method of delivery and numerous other demographic factors. Design: A cross-sectional study. Data was collected using a self-reported survey. Settings: The sample consisted of 100 women, selected from St Georges Hospital and CHU-NDS, who had to speak Arabic and had given birth in the past three days prior to interview. Methods: The multiple linear regressions and the mean test were used to assess which factors were associated with a positive childbirth experience. The Mackey childbirth satisfaction scale, three items from the Wijma delivery Expectancy/Experience questionnaire, a seven item mastery scale developed by Pearlin and Schooler and a background questionnaire were filled by women. Findings: Factors that were linked to a positive birth experience were: Higher age, multiparous women, higher education, high monthly income, unemployment, childbirth preparation, high personal control and self-efficacy, high childbirth and labor pain, fulfilled expectations, shorter period of labor and instrumented delivery. Conclusion: This study demonstrates that satisfaction with the childbirth experience is multi-dimensional with diverse factors foreseeing diverse dimensions of satisfaction.

关键词： Childbirth Experience Satisfaction Personal Control Self-Efficacy Mother

Learning Experience and Satisfaction of International Students in China

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Learning Experience and Satisfaction of International Studen...

作者： elie HIRWA 山东大学

学位级别：硕士

The globalization becomes the today’s world *** has been entered in higher *** is a big competition of students seeking to study *** marketing of higher education is one tool used by educationalist in order to increase *** satisfy recruited students for retention has not been paid attention *** purpose of this research is to explore the satisfaction of international students in *** make the research more understandable and specific,we choose the case study of a comprehensive *** source of information is the questionnaire distributed to international *** are presented using SPSS and quantitative analyses are made supported by relationship analysis using regression and *** result showed that practical work（internship and field trip）resources like library and networking opportunities（for employment）are too *** their performance are still low,there is a high gap in those *** performs better in areas of digital resources（soft materials）.The class participation is good confirmed by a good mean of importance and performance of interaction in class,class presentation and attending class on *** data confirmed by the relationship between importance of learning satisfaction;learning methods and learning *** research concludes with recommendation to increase library service,and explore the minimization of the gap in practical work.

关键词：国际教育学生满意度全球化学习经验

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蒿甲醚伍用伯氨喹治疗恶性疟的研究

中国寄生虫学与寄生虫病杂志 2001年第5期19卷 308-309页

作者：黄建荣高英起 Nganawei elie 浙江大学医学院附属一院杭州310003 浙江杭州中医医院杭州310006 中非共和国友谊医院

目的　观察蒿甲醚伍用伯氨喹治疗恶性疟的疗效和副作用。　方法　在中非共和国选择恶性疟12 1例 ,随机分为两组。伍用组 :口服蒿甲醚 80mg ,qd× 5d ,首日蒿甲醚 16 0mg加服伯氨喹 3片 (含基质 7 5mg ,qd× 3～ 4d)治疗 32例 ;肌注蒿甲... 详细信息

目的　观察蒿甲醚伍用伯氨喹治疗恶性疟的疗效和副作用。　方法　在中非共和国选择恶性疟12 1例 ,随机分为两组。伍用组 :口服蒿甲醚 80mg ,qd× 5d ,首日蒿甲醚 16 0mg加服伯氨喹 3片 (含基质 7 5mg ,qd× 3～ 4d)治疗 32例 ;肌注蒿甲醚加服伯氨喹 ,治疗 2 9例 ;对照组 :单用口服蒿甲醚治疗 33例和肌注蒿甲醚治疗 2 7例 ,B组、C组和D组所用剂量与疗程均同A组。上述病例于用药前及后 6、 14、 2 1、及 2 8d各随访1次 ,密切观察病例的临床症状与体征变化。　结果　A组、B组、C组和D组病例的平均退热时间分别为(47 6± 15 7)、 (36 9± 10 7)、 (48 5± 18 4 )和 (42 2± 9 5 )h。其临床治愈率依次为 84 4 %、 10 0 %、 90 1和96 3% ,其复燃率依次为 6 3%、 3 4 %、 2 1 2 %和 18 5 %。 4组药物副作用均轻。　结论　蒿甲醚伍用伯氨喹及单用蒿甲醚 (口服或肌注 )对恶性疟治疗作用均良好。

关键词：疟疾恶性疟抗疟药物蒿甲醚伯氨喹临床疗效

Advancing critical care recovery:The pivotal role of machine learning in early detection of intensive care unit-acquired weakness

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World Journal of Clinical Cases 2024年第21期12卷 4455-4459页

作者： Georges Khattar elie Bou Sanayeh Department of Medicine Staten Island University HospitalStaten IslandNY 10305United States

This editorial explores the significant challenge of intensive care unit-acquiredweakness(ICU-AW),a prevalent condition affecting critically ill patients,characterizedby profound muscle weakness and complicating patient *** paradox of modern medical advances,it emphasizes the urgent needfor early identification and intervention to mitigate ICU-AW's ***,the study by Wang et al is showcased for employing a multilayer perceptronneural network model,achieving high accuracy in predicting *** advancement underscores the potential of neural network models inenhancing patient care but also calls for continued research to address limitationsand improve model *** editorial advocates for the developmentand validation of sophisticated predictive tools,aiming for personalized carestrategies to reduce ICU-AW incidence and severity,ultimately improving patientoutcomes in critical care settings.

关键词： Critical illness myopathy Critical illness polyneuropathy Early detection Intensive care unit-acquired weakness Neural network models Patient outcomes Personalized intervention strategies Predictive modeling

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刚果民主共和国青年就业政策评估研究

刚果民主共和国青年就业政策评估研究

作者： MATUMA MOZANIMU elie 西南大学

学位级别：硕士

本研究评估了民主刚果(DRC)青年就业政策和计划的有效性,并确定了改进的方向。DRC拥有庞大且不断增长的青年人口,但青年失业率和就业不足率均较高。本研究评估了当前政策和计划对青年就业结果的影响,确定了DRC青年就业的主要挑战和障碍... 详细信息

本研究评估了民主刚果(DRC)青年就业政策和计划的有效性,并确定了改进的方向。DRC拥有庞大且不断增长的青年人口,但青年失业率和就业不足率均较高。本研究评估了当前政策和计划对青年就业结果的影响,确定了DRC青年就业的主要挑战和障碍,并审查了当前政策和计划的设计和实施。本研究利用了一系列定性和定量数据来源,包括调查、焦点小组讨论以及与关键利益相关者的访谈。研究结果提供了基于其他国家和背景的证据和最佳实践,以改善DRC青年就业政策和计划有效性的建议。该研究为低收入国家有效青年就业干预的全球证据库做出了贡献,并为DRC的政策和计划设计和实施提供了信息。

关键词：民主刚果青年就业政策评估挑战机遇