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Artificial Intelligence in Healthcare:Review and Prediction Case Studies

Engineering 2020年第3期6卷 291-301页

作者： Guoguang Rong Arnaldo Mendez elie bou assi Bo Zhao Mohamad Sawan School of Engineering Westlake UniversityHangzhou 310024China Institute of Advanced Study Westlake Institute for Advanced StudyHangzhou 310024China Polystim Neurotech Laboratory Polytechnique MontréalMontréalQC H3T1J4Canada Institute of VLSI Design College of Information Science and Electronic EngineeringZhejiang UniversityHangzhou 310027China

Artificial intelligence(AI)has been developing rapidly in recent years in terms of software algorithms,hardware implementation,and applications in a vast number of *** this review,we summarize the latest developments of applications of AI in biomedicine,including disease diagnostics,living assistance,biomedical information processing,and biomedical *** aim of this review is to keep track of new scientific accomplishments,to understand the availability of technologies,to appreciate the tremendous potential of AI in biomedicine,and to provide researchers in related fields with *** can be asserted that,just like AI itself,the application of AI in biomedicine is still in its early *** progress and breakthroughs will continue to push the frontier and widen the scope of AI application,and fast developments are envisioned in the near *** case studies are provided to illustrate the prediction of epileptic seizure occurrences and the filling of a dysfunctional urinary bladder.

关键词： Artificial intelligence Machine learning Deep learning Neural network Biomedical research Healthcare applications Epileptic seizure Urinary bladder filling

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医疗保健中的人工智能——综述与预测性案例研究

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Engineering 2020年第3期6卷 189-211页

作者：荣国光 Arnaldo Mendez elie bou assi 赵博 Mohamad Sawan School of Engineering Westlake University Institute of Advanced Study Westlake Institute for Advanced Study Polystim Neurotech Laboratory Polytechnique Montréal Institute of VLSI Design College of Information Science and Electronic EngineeringZhejiang University

近年来,人工智能在软件算法、硬件实现和应用等领域得到了迅速发展。本文综述了人工智能在生物医学中应用的最新进展,包括疾病诊断、生活辅助、生物医学信息处理和生物医学研究。综述的目的是跟踪新的科学成就,了解人工智能在生物医学... 详细信息

近年来,人工智能在软件算法、硬件实现和应用等领域得到了迅速发展。本文综述了人工智能在生物医学中应用的最新进展,包括疾病诊断、生活辅助、生物医学信息处理和生物医学研究。综述的目的是跟踪新的科学成就,了解人工智能在生物医学中的巨大潜力和相关技术的适用性,并为相关领域的研究人员提供启示。可以断言,正如人工智能本身一样,人工智能在生物医学中的应用尚处于早期阶段。新的进展和突破将继续推进,不断深入并扩大广度,并在不久的将来迅速发展。本文以人工智能在癫痫发作和膀胱功能失调预测方面的应用的两个案例来说明其在生物医疗等方面的应用。

关键词：人工智能机器学习深度学习神经网络生物医学研究医疗保健应用癫痫发作膀胱充盈

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Dilemma of first line regimens in metastatic pancreatic adenocarcinoma

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World Journal of Gastroenterology 2016年第46期22卷 10124-10130页

作者： Marwan Ghosn Tony Ibrahim Tarek assi elie El Rassy Hampig Raphael Kourie Joseph Kattan Department of Oncology Faculty of Medicine Saint Joseph University

Pancreatic cancer is one of the deadliest cancers,ranking fourth among cancer-related deaths. Despite all the major molecular advances and treatment breakthroughs, mainly targeted therapies, the cornerstone treatment of metastatic pancreatic cancer(m PC) remains cytotoxic chemotherapy. In 2016, more than 40 years after the introduction of gemcitabine in the management of m PC, the best choice for first-line treatment has not yet been fully elucidated. Two main strategies have been adopted to enhance treatment efficacy. The first strategy is based on combining non-cross resistant drugs, while the second option includes the development of newer generations of chemotherapy. More recently, two new regimens, FOLFIRINOX and gemcitabine/nab-paclitaxel(GNP), have both been shown to improve overall survival in comparison with gemcitabine alone, at the cost of increased toxicity. Therefore, the best choice for first line therapy is a matter of debate. For some authors, FOLFIRINOX should be the first choice in patients with an Eastern Cooperative Oncology Group score(0-1) given its lower hazard ratio. However, others do not share this opinion. In this paper, we review the main comparison points between FOLFIRINOX and GNP. We analyze the two pivotal trials to determine the similarities and differences in study design. In addition, we compare the toxicity profile of the two regimens as well as the impact on quality of life. Finally, we present studies revealing real life experiences and review the advantages and disadvantages of possible second-line therapies including their cost effectiveness.

关键词： Review Metastatic pancreatic cancer FOLFIRINOX Gemcitabine/nab-paclitaxel Pivotal trials

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