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Effect of Aqueous Extract of Boscia senegalensis on Hyperglycemia, Hyperlipidemia and Oxidative Stress Induced in Rats

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Journal of Diabetes Mellitus 2024年第1期14卷 49-68页

作者： Faustin Dongmo elie baudelaire Djantou Alcherif Hamid Mahamat Selestin Sokeng Dongmo Nicolas Njintang Yanou Department of Biological Sciences Faculty of Science University of Ngaoundere Ngaoundere Cameroon Department of Food Science and Nutrition ENSAI University of Ngaoundere Ngaoundere Cameroon Department of Biomedical and Pharmacetical Sciences National Higher Institute of Science and Techniques of Abeche Abeche Chad

Boscia aqueous extract. senegalensis on hyperglycemia, hyperlipidemia and oxidative stress induced in rats. The aqueous extract was prepared from B. senegalensis seed powders under the extraction conditions: time (10 min), temperature (55˚C) and the ratio of mass of flour/volume of water (3/10 g/mL). Male wistar rats aged 6 to 8 weeks were acclimated and divided into 8 groups of 5 rats each: two normal control groups which received a normal standard diet (3810 kcal/kg), and six test groups which were subjected to a hyperlipidemic diet (5310 Kcal/kg). All groups of animals were fed in this manner for 8 weeks to induce hyperglycemia, hyperlipidemia and oxidative stress. After induction the animals were treated either with distilled water for the normal and negative control groups or with atorvastatin for the positive control group or with the extract of B. senegalensis. (125, 250 and 500 mg/kg) for the test groups. Fasting blood glucose was taken every 7 days during induction. After sacrifice, biochemical and oxidative stress parameters were measured. The aqueous extract of B. senegalensis significantly decreased (p B. senegalensis at a dose of 500 mg/kg has the capacity to reduce blood sugar, improve the quality of the lipid profile and reduce oxidative stress. Thus, the results reveal that the aqueous extract of B. senegalensis has powerful hypoglycemic, hypolipidemic and antioxidant properties.

关键词： Boscia Senegalensis Hypoglycemic Hypolipidemic Hyperlipidemic Diet An-tioxidant

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Particle Size Effects on Antioxydant and Hepatoprotective Potential of Essential Oil from Eucalyptus camaldulensis Leaves against Carbon Tetrachloride-Induced Hepatotoxicity in Rats

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Pharmacology & Pharmacy 2022年第8期13卷 253-272页

作者： Venant Donald Noumi Markusse Deli Richard Marcel Nguimbou elie baudelaire Sandrine Rup-Jacques Dicko Amadou Selestin Sokeng Nicolas Yanou Njintang Department of Biological Sciences Faculty of Sciences University of Ngaoundere Ngaoundere Cameroon Department of Biological Sciences Faculty of Sciences University of Maroua Maroua Cameroon Department of Food Sciences and Nutrition ENSAI University of Ngaoundere Ngaoundere Cameroon AGRITECH Nancy France Université de Lorraine ICPM Metz Cedex France Université de Lorraine UR-AFPA Metz Cedex France

Particle size fractionation by sieving is used to optimize antioxydant potential of natural substances. The aim of the present study was to evaluate particle size effects on antioxidant and hepatoprotective potential of Eucalyptus camaldulensis essential oils (EO) on CCl4-induced hepatic damage in Wistar rats. Animals were daily orally treated with the EOs extracted by hydrodistillation from powder sieved at four particle sizes (≥355, 200 - 355, 100 - 200, ≤100 μm) and those of the unsieved powder at dose of 50 mg/Kg for 7 days. Compounds that are evaluated for these activities are hydrocarbons and oxygenated terpenes that were identified and quantified by GC/MS. Activities of enzymes markers of hepatocellular damage in serum and antioxidant enzymes in the liver homogenates were measured. In this research, EOs significantly prevented the increase in serum ALT and AST (p 4 and significant increase level of plasma HDL-cholesterol. Also, significantly (p < 0.05) decreased the extent of malondialdehyde (MDA) formation and elevated the activities of superoxide dismutase (SOD) and catalase (CAT) liver in comparison to negative control group. The best antioxidant and hepatoprotective activities were those of EOs from two fine powder fractions (≤100 μm and 100 - 200 μm) was correlated to their high concentration in oxygenated terpenes (70.9% and 46.4%, respectively), when compared to the large particles (200 - 355 μm and ≥355 μm, with 33.3% and 41.8%, respectively) and unsieved powder (37.4%).

关键词： Eucalyptus camaldulensis Powder Particle Size Essential Oils Hepatoprotection Oxidative Stress

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Phytochemical Profile and <i>In Vitro</i>Antioxidant Properties of Essential Oils from Powder Fractions of <i>Eucalyptus camaldulensis</i>Leaves

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American Journal of Plant Sciences 2021年第3期12卷 329-346页

作者： Venant Donald Noumi Richard Marcel Nguimbou Marthe Valentine Tsague Markusse Deli Sandrine Rup-Jacques Dicko Amadou elie Njantou baudelaire Selestin Sokeng Nicolas Yanou Njintang Department of Biological Sciences Faculty of Sciences University of Ngaoundere Ngaoundere Cameroon Department of Food Sciences and Nutrition ENSAI University of Ngaoundere Ngaoundere Cameroon Department of Biomedical Sciences Faculty of Sciences University of Ngaoundere Ngaoundere Cameroon Université de Lorraine ICPM Metz France Université de Lorraine UR-AFPA Metz France

Dried leaves of Eucalyptus camaldulensis were finely grinded and fractionated by sieving into four granulometric classes (355 μm). The obtained powder fractions were used for essential oil (EO) extraction by hydrodistillation and their phytochemical profile and in vitro antioxidant activities were evaluated. The mother powder (unsieved powder) was used for comparison. Particle size exerted a significant influence (p in vitro antioxidant properties of the EOs. Comparatively, the mother powder had the highest contents of α-pinene (55.6%), camphene (3.4%) and limonene (3.7%), while 1,8-cineole (26.6% and 22.4%), exo-fenchol (5.6% and 3.5%), α-campholenol (4.2% and 3.4%), L-trans-pinocarveol (5.5% and 2.7%), L-borneol (12.6% and 6.8%) and α-terpineol (16.4% and 7.6%) are the main compounds of EOs from the <100 μm and 100 - 200 μm fractions, respectively. The antioxidant activities of the EOs revealed higher radical-scavenging activities DPPH (90.62% and 7

关键词： Eucalyptus camaldulensis Powder Fraction Essential Oil Chemical Composition Antioxidant Activity

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Particle Size Effects on Antioxydant and Hepatoprotective Potential of Essential Oil from Eucalyptus camaldulensis Leaves against Carbon Tetrachloride-Induced Hepatotoxicity in Rats

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Pharmacology & Pharmacy（药理与制药） 2022年第8期

作者： venant donald noumi markusse deli richard marcel nguimbou elie baudelaire sandrine rup-jacques dicko amadou selestin sokeng nicolas yanou njintang

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Phytochemical Profile and In Vitro Antioxidant Properties of Essential Oils from Powder Fractions of Eucalyptus camaldulensis Leaves

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American Journal of Plant Sciences（美国植物学期刊） 2021年第3期

作者： Venant Donald Noumi Richard Marcel Nguimbou Marthe Valentine Tsague Markusse Deli Sandrine Rup-Jacques Dicko Amadou elie Njantou baudelaire Selestin Sokeng Nicolas Yanou Njintang

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