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NKR-P1B expression in gut-associated innate lymphoid cells is required for the control of gastrointestinal tract infections

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Cellular & Molecular Immunology 2019年第11期16卷 868-877页

作者： elias abou-samra Zachary Hickey Oscar A.Aguilar Michal Scur Ahmad Bakur Mahmoud Sergey Pyatibrat Megan M.Tu Jeffrey Francispillai Arthur Mortha James R.Carlyle Mir Munir A.Rahim Andrew P.Makrigiannis Department of Biochemistry Microbiology and ImmunologyUniversity of Ottawa451 Smyth RoadOttawaON K1H 8M5Canada Department of Immunology University of Toronto1 King’s College CircleTorontoON M5S 1A8Canada Sunnybrook Research Institute 2075 Bayview AvenueTorontoON M4N 3M5Canada Department of Microbiology and Immunology Dalhousie University5850 College StreetHalifaxNS B3H 4R2Canada College of Applied Medical Sciences Taibah UniversityMadinah MunawwarahSaudi Arabia Division of Anatomical Pathology Department of Pathology and Laboratory MedicineThe Ottawa HospitalUniversity of Ottawa501 Smyth RoadOttawaON K1H 8L6Canada

Helper-type innate lymphoid cells(ILC)play an important role in intestinal *** of the NKR-P1 gene family are expressed in various innate immune cells,including natural killer(NK)cells,and their cognate Clr ligand family members are expressed in various specialized tissues,including the intestinal epithelium,where they may play an important role in mucosalassociated innate immune *** this study,we show that the inhibitory NKR-P1B receptor,but not the Ly49 receptor,is expressed in gut-resident NK cells,ILC,and a subset ofγδT cells in a tissue-specific ***3 cells constitute the predominant cell subset expressing NKR-P1B in the gut lamina *** known NKR-P1B ligand Clr-b is broadly expressed in gut-associated cells of hematopoietic *** genetic deletion of NKR-P1B results in a higher frequency and number of ILC3 andγδT cells in the gut lamina ***,the function of gut-resident ILC3,NK,andγδT cells in NKR-P1B-deficient mice is impaired during gastrointestinal tract infection by Citrobacter rodentium or Salmonella typhimurium,resulting in increased systemic bacterial dissemination in NKR-P1B-deficient *** findings highlight the role of the NKR-P1B:Clr-b recognition system in the modulation of intestinal innate immune cell functions.

关键词： Innate lymphoid cells Natural killer cells Gut-associated immune cells NKR-P1B receptor Innate immunity

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