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Pathogenesis of primary biliary cirrhosis: A unifying model

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World Journal of Gastroenterology 2006年第15期12卷 2320-2327页

作者： elias Kouroumalis George Notas Laboratory of Gastroenterology and Hepatology University of Crete Faculty of MedicineHeraklion 71003Greece

Primary biliary cirrhosis （PBC） is a disease of unknown etiology leading to progressive destruction of small intrahepatic bile ducts and eventually to liver cirrhosis and failure. It is characterised by female predominance and serum auto-antibodies to mitochondrial antigens targeting the E2 components of the 2-oxoacid dehydrogenase complex. Although they are associated with disease pathogenesis, no concrete evidence has been presented so far. Epidemiological data indicate that a geographical clustering of cases and possible environmental factors are implicated in pathogenesis. A number of genetic factors play a role in determining disease susceptibility or progression, although no definitive conclusion has been reached so far. A key factor to immune pathogenesis is considered to be the breakdown of immune tolerance, either through molecular mimicry or through the so called determinant density model. In this review, the available data regarding the pathogenesis of primary biliary cirrhosis are described and discussed. A new unifying hypothesis based on early endothelin overproduction in primary biliary cirrhosis （PBC） is presented and discussed.

关键词： Primary biliary cirrhosis Pathogenesis

A New Species of Amsassia from the Ordovician of Korea and South China:Paleobiological and Paleogeographical Significance

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Acta Geologica Sinica(English Edition) 2016年第3期90卷 796-806页

作者： Mirinae LEE Heeju PARK Nguyen Viet TIEN Suk-Joo CHOH Robert J.elias Dong-Jin LEE Department of Earth and Environmental Sciences Andong National UniversityAndong36729Republic of Korea Institute of Geological Sciences-Vietnam Academy of Science and Technology(IGS-VAST) Hanoi100000Socialist Republic of Vietnam Department of Earth and Environmental Sciences Korea UniversitySeoul02841Republic of Korea Department of Geological Sciences The University of ManitobaWinnipegR3T 2N2Canada

A new species of the probable calcareous alga Amsassia, A. koreanensis, is recognized from the Duwibong Formation （Middle Ordovician, Darriwilian） of the Taebaeksan Basin in mid-eastern Korea. This is the first report of the genus from the Korean Peninsula, expanding its geographical range to the eastern Sino-Korean Block. The new species also occurs in the Xiazhen Formation （Upper Ordovician, Katian） at Zhuzhai in the South China Block. Amsassia koreanensis is the smallest species of this modular genus, having a maximum module diameter of 0.28 ram. Module increase is by bipartite, tripartite and quadripartite types of longitudinal axial fission, but unlike other species of the genus, quadripartite fission is common. The types of fission are comparable to those in some Tetradiida （now Prismostylales, florideophycean rhodophyte algae）, although the processes of fission are different. The distribution of A. koreanensis further strengthens the biogeographical connection between the Sino-Korean and South China blocks, suggesting that these two paleocontinents were located closer together during the Middle to Late Ordovician than previously speculated.

关键词： Amsassia koreanensis sp. nov. Ordovician Sino-Korean Block South China Block paleobiology paleogeography.

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Cancer drug resistance: rationale for drug delivery systems and targeted inhibition of HSP90 family proteins

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Cancer Drug Resistance 2019年第3期2卷 381-398页

作者： Clélia Mathieu Samir Messaoudi elias Fattal Juliette Vergnaud-Gauduchon Institut Galien Paris-Sud CNRSUMR 8612UniversitéParis-Sud/Paris-SaclayChâtenay-Malabry 92296France BioCIS CNRSUMR 8076UniversitéParis-Sud/Paris-SaclayChâtenay-Malabry 92296France.

Nanocarriers have been developed in order to protect drugs or to improve drugs efficiency by reaching the damaged tissue and avoiding systemic and local *** using HSP90 inhibitors,some cancer drug resistances have been overcome and the loading into nanocarriers of such drugs has shown an increase of their *** review will present some advantages of HSP90 inhibitors to treat resistant tumors;especially those targeting the mitochondrial protein *** will also focus on the targeting of the primary tumors,cancer stem cells and metastatic cells.

关键词： Heat-shock proteins cancer resistance nanoparticles

Forecasting Mental Stress Using Machine Learning Algorithms

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Computers, Materials & Continua 2022年第9期72卷 4945-4966页

作者： elias Hossain Abdulwahab Alazeb Naif Almudawi Sultan Almakdi Mohammed Alshehri M.Gazi Golam Faruque Wahidur Rahman Department of Software Engineering Daffodil UniversityDhakaBangladesh Collage of Computer Science and Information System University of NajranNajranSaudi Arabia Department of Computer Science and Engineering Khwaja Yunus Ali UniversitySirajganj 6751Bangladesh

Depression is a crippling affliction and affects millions of individuals around the *** general,the physicians screen patients for mental health disorders on a regular basis and treat patients in collaboration with psychologists and other mental health experts,which results in lower costs and improved patient ***,this strategy can necessitate a lot of buy-in from a large number of people,as well as additional training and logistical ***,utilizing the machine learning algorithms,patients with depression based on information generally present in a medical file were analyzed and *** methodology of this proposed study is divided into six parts:Proposed Research Architecture(PRA),Data Pre-processing Approach(DPA),Research Hypothesis Testing(RHT),Concentrated Algorithm Pipeline(CAP),Loss Optimization Stratagem(LOS),and Model Deployment Architecture(MDA).The Null Hypothesis and Alternative Hypothesis are applied to test the *** addition,Ensemble Learning Approach(ELA)and Frequent Model Retraining(FMR)have been utilized for optimizing the loss ***,the Features Importance Interpretation is also delineated in this *** forecasts could help individuals connect with expert mental health specialists more quickly and *** to the findings,71%of people with depression and 80%of those who do not have depression can be appropriately *** study obtained 91%and 92%accuracy through the Random Forest(RF)and Extra Tree *** after applying the Receiver operating characteristic(ROC)curve,79%accuracy was found on top of RF,81%found on Extra Tree,and 82%recorded for the eXtreme Gradient Boosting(XGBoost)***,several factors are identified in terms of predicting depression through statistical data *** the additional effort is needed to develop a more accurate model,this model can be adjustable in the healthcare sector for diagnosing depression.

关键词： Depression analysis mental health machine learning model deployment XGBoost ROC-AUC

HIV entry inhibitors: a new generation of antiretroviral drugs

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Acta Pharmacologica Sinica 2005年第10期26卷 1165-1173页

作者： elias KRAMBOVITIS Filippos PORICHIS Demetrios A SPANDIDOS Department of Applied Biochemistry and Immunology Institute of Molecular Biology and Biotechnology Vassilika Vouton Heraklion Crete Department of Applied Biochemistry and Immunology Institute of Molecular Biology and Biotechnology Vassilika Vouton Heraklion Crete Greece Greece Department of Virology Medical School University of Crete Heraklion Crete Greece Greece Department of Virology Medical School University of Crete Heraklion Crete Greece

AIDS is presently treatable, and patients can have a good prognosis due to the success of highly active antiretroviral therapy (HAART), but it is still not curable or preventable. High toxicity of HAART, and the emergence of drug resistance add to the imperative to continue research into new strategies and interventions. Considerable progress in the understanding of HIV attachment and entry into host cells has suggested new possibilities for rationally designing agents that interfere with this process. The approval and introduction of the fusion inhibitor enfuvirtide (Fuzeon) for clinical use signals a new era in AIDS therapeutics. Herewe review the crucial steps the virus uses to achieve cell entry, which merit attention as potential targets, and the compounds at pre-clinical and clinical development stages, reported to effectively inhibit cell entry.

关键词： highly active antiretroviral therapy HIV receptors HIV fusion inhibitors HIV

Key factors contributing to crash severity at highway-rail grade crossings

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Journal of Modern Transportation 2016年第3期24卷 224-235页

作者： Wei Fan Linfeng Gong Edward Matt Washing Miao Yu elias Haile Department of Civil and Environmental Engineering The University of North Carolina at Charlotte EPIC Building Room 3261 9201 University City Boulevard Charlotte NC 28223 USA 1721 Market St. # 102. Oakland CA 94607 USA

The purpose of this paper is to develop and com- pare the preferred multinomial logit （MNL） and ordered logit （ORL） model in identifying factors that are important in making an injury severity difference and exploring the impact of such explanatory variables on three different severity levels of vehicle-related crashes at highway-rail grade crossings （HRGCs） in the United States. Vehicle-rail crash data on USDOT highway-rail crossing inventory and public crossing sites from 2005 to 2012 are used in this study. Preferred MNL and ORL models are developed and marginal effects are also calculated and compared. A majority of the variables have shown similar effects on the probability of the three different severity levels in both models. In addition, based on the Akaike information criterion, it is found that the MNL model is better than the ORL model in predicting the vehicle crash severity levels on HRGCs in this study. Therefore, the researchers recommend the use of MNL model in predicting severity levels of vehicle-rail crashes on HRGCs.

关键词： Vehicle crashes Severity Highway-rail grade crossings Multinomial logit model Ordered logit model

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Minimizing Complementary Pivots in a Simplex-Based Solution Method for a Quadratic Programming Problem

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American Journal of Operations Research 2012年第3期2卷 308-312页

作者： elias Munapo Department of Decisions Sciences University of South Africa Unisa Pretoria South Africa

The paper presents an approach for avoiding and minimizing the complementary pivots in a simplex based solution method for a quadratic programming problem. The linearization of the problem is slightly changed so that the simplex or interior point methods can solve with full speed. This is a big advantage as a complementary pivot algorithm will take roughly eight times as longer time to solve a quadratic program than the full speed simplex-method solving a linear problem of the same size. The strategy of the approach is in the assumption that the solution of the quadratic programming problem is near the feasible point closest to the stationary point assuming no constraints.

关键词： Quadratic Programming Convex Karusha-Kuhn-Tucker Simplex Method

Interaction between Spermatozoa and the Different Epithelia along the Female Reproductive Tract of Mustelus schmitti

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Journal of Life Sciences 2015年第3期9卷 111-119页

作者： Femanda Gabriela elias Departamento de Biologia Bioquimica y Farmacia Universidad Nacional del Sur Bahia Blanca San Juan 670-8000 Argentina

The presence of sperm was observed in different organs of the reproductive tract of M. schmitti. These were the club, baffle and terminal zone of the oviducal gland, posterior portion of the uterus and in the cervix. This fact allowed for consideration not only its storage but its interaction with the female reproductive tract epithelia as well. SEM （microscopic observation studies） detected loose and sole spermatozoa in the club and baffle zones in a pregnant female. On the other hand, histochemical techniques showed sperm storage tubules of the terminal zone, which contain bundles of sperm, do not stain AB （alcian blue） or PAS （periodic acid schiff）. Disintegration of some of the male gametes was observed in the posterior part of the uterus with TEM （transmission electron microscopy） studies which would indicate a first uterine sperm selection. The uterine epithelial cells involved in this process showed an important level of secretion vacuoles suggesting an interaction with sperm cells. Sperm in the cervix was found without the matrix that constitutes the spermatozeugmata formed in the male tract. Some heads of the sperm were uncurled while they were interacting with the cervical cells.

关键词： Sperm uterine epithelium oviducal gland chondrichthyes.

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Die Mondkusine

德语人文研究 2008年第3期 8-11页

作者： elias Canetti

elias Canetti(geboren am *** 1905 in Bulgarien,gestorben am *** 1994 in Zrich) war ein Schriftsteller deutscher Sprache und Literatur-Nobelpreistrager 1981.

关键词： der Die Mondkusine