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Peri-nuclear antibodies correlate with survival in Greek primary biliary cirrhosis patients

World Journal of Gastroenterology 2010年第39期16卷 4938-4943页

作者： Ourania Sfakianaki Meri Koulentaki Maria Tzardi Elena Tsangaridou Panayotis A Theodoropoulos elias Castanas elias A Kouroumalis Liver Research Laboratory Medical SchoolUniversity of Crete Department of Gastroenterology University Hospital of Heraklion Department of Pathology University Hospital of Heraklion Department of Biochemistry Medical SchoolUniversity of Crete Department of Experimental Endocrinology Medical SchoolUniversity of Crete Liver ResearchLaboratory Medical SchoolUniversity of Crete

AIM:To investigate possible associations of anti-nuclear envelope antibody(ANEA)with disease severity and survival in Greek primary biliary cirrhosis(PBC)***:Serum samples were collected at diagnosis from 147 PBC patients(85%female),who were followed-up for a median 89.5 mo(range 1-240).ANEA were detected with indirect immunofluorescence on 1% formaldehyde fixed Hep2 cells,and anti-gp210 antibodies were detected using an enzyme linked immunosorbent *** were correlated with clinical data,histology,and ***:ANEA were detected in 69/147(46.9%) patients and 31/147(21%)were also anti-gp210 *** ANEA positive patients were at a more advanced histological stage(Ⅰ-Ⅱ/Ⅲ-Ⅳ56.5%/43.5% vs 74.4%/25.6%,P=0.005)compared to the ANEA negative *** had a higher antimitochondrial antibodies(AMA)titer(≤1:160/>1:160 50.7%/49.3%vs 71.8%/28.2%,P=0.001)and a lower survival time(91.7 ±50.7 mo vs 101.8±55 mo,P=0.043).Moreover,they had more advanced fibrosis,portal inflammation,interface hepatitis,and proliferation of bile ductules(P =0.008,P=0.008,P=0.019,and P=0.027,respectively).They also died more frequently of hepatic failure and/or hepatocellular carcinoma(P=0.016).ANEA positive,anti-gp210 positive patients had a difference in stage(Ⅰ-Ⅱ/Ⅲ-Ⅳ54.8%/45.2%vs 74.4%/25.6%,P= 0.006),AMA titer(≤1:160/>1:160 51.6%/48.4%vs 71.8%/28.2%,P=0.009),survival(91.1±52.9 mo vs 101.8±55 mo,P=0.009),and Mayo risk score(5.5 ±1.9 vs 5.04±1.3,P=0.04)compared to the ANEA negative *** positive,anti-gp210 negative patients had a difference in AMA titer(≤1:160/>1:160 50%/50%vs 71.8%/28.2%,P=0.002),stage(Ⅰ-Ⅱ/Ⅲ -Ⅳ57.9%/42.1%vs 74.4%/25.6%,P=0.033),fibrosis(P=0.009),portal inflammation(P=0.018),interface hepatitis(P=0.032),and proliferation of bile ductules(P=0.031).Anti-gp210 positive patients had a worse Mayo risk score(5.5±1.9 vs 4.9±1.7,P=0.038)than the anti-gp210 negative ***:The presence of ANEA and anti-gp210 identifies a subgroup of PBC pati

关键词： Primary biliary cirrhosis Antimitochondrial antibodies Antinuclear antibodies Antibodies against nuclear envelope antigens Anti-gp210 antibodies

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A Novel Integrated Learning Scheme for Predictive Diagnosis of Critical Care Patient

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Computers, Materials & Continua 2022年第11期73卷 2333-2350页

作者： Sarika R.Khope Susan elias School of Electronics Engineering Vellore Institute of TechnologyChennaiTamil NaduIndia Center for Advanced Data Science Vellore Institute of TechnologyChennaiTamil NaduIndia

Machine learning has proven to be one of the efficient solutions for analyzing complex data to perform identification and *** a large number of learning tools and techniques,the health section has significantly benefited from solving the diagnosis *** paper has reviewed some of the recent scientific implementations on learning-based schemes to find that existing studies of learning have mainly focused on predictive analysis with less emphasis on preprocessing and more inclination towards adopting sophisticated learning schemes that offer higher accuracy at the cost of the higher computational ***,the proposed method addresses the concern mentioned above by a novel computational learning model that emphasizes fine-tuning complex medical data and makes it suitable for learning to balance better classification performance and computational *** implementation is carried out using the MIMIC-III dataset,where the proposed system discretizes,the complete model using physician reports and furnished patient information as the first *** also prepares the data by choosing a specific tuple and its associated *** second step introduces a novel relatedness function where preprocessing is carried out using word quantization while adopting auto-encoders in deep learning followed by a novel learning-based *** outcome exhibits that the proposed system offers better classification performance in reduced processing time in comparison to existing learning schemes.

关键词： Machine Learning diagnosis accuracy computational complexity diagnosis deep learning classification prediction

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HIV entry inhibitors: a new generation of antiretroviral drugs

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Acta Pharmacologica Sinica 2005年第10期26卷 1165-1173页

作者： elias KRAMBOVITIS Filippos PORICHIS Demetrios A SPANDIDOS Department of Applied Biochemistry and Immunology Institute of Molecular Biology and Biotechnology Vassilika Vouton Heraklion Crete Department of Applied Biochemistry and Immunology Institute of Molecular Biology and Biotechnology Vassilika Vouton Heraklion Crete Greece Greece Department of Virology Medical School University of Crete Heraklion Crete Greece Greece Department of Virology Medical School University of Crete Heraklion Crete Greece

AIDS is presently treatable, and patients can have a good prognosis due to the success of highly active antiretroviral therapy (HAART), but it is still not curable or preventable. High toxicity of HAART, and the emergence of drug resistance add to the imperative to continue research into new strategies and interventions. Considerable progress in the understanding of HIV attachment and entry into host cells has suggested new possibilities for rationally designing agents that interfere with this process. The approval and introduction of the fusion inhibitor enfuvirtide (Fuzeon) for clinical use signals a new era in AIDS therapeutics. Herewe review the crucial steps the virus uses to achieve cell entry, which merit attention as potential targets, and the compounds at pre-clinical and clinical development stages, reported to effectively inhibit cell entry.

关键词： highly active antiretroviral therapy HIV receptors HIV fusion inhibitors HIV

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Calculations of Optical Rotation from Density Functional Theory

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Chinese Physics Letters 2007年第5期24卷 1207-1209页

作者： Antǒnio Canal Neto Francisco elias Jorge Departamento de Fisica Universidade Federal do Espírito Santo 29060-900 Vitória ES Brazil

Density function theory calculations of frequency-dependent optical rotations [α]ω for three rigid chiral molecules are reported. Calculations have been carried out at the sodium D line frequency, using the ADZP basis set and a wide variety of functionals. Gauge-invariant atomic orbitals are used to guarantee origin-independent values of [ω]D. In addition, study of geometry dependence of [ω]D is reported. Using the geometries optimized at the B3LYP/ADZP level, the mean absolute deviation of B3LYP/ADZP and experimental laiD values yields 60.1°/（dm g/cm^3）. According to our knowledge, this value has not been achieved until now with any other model.

关键词： MOLECULAR WAVE-FUNCTIONS BASIS-SETS MP2 HF

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The role of an integration identity in the analysis of the Cauchy-Leray transform

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Science China Mathematics 2017年第11期60卷 1923-1936页

作者： LANZANI Loredana STEIN elias M. Department of Mathematics Syracuse University Department of Mathematics Princeton University

The purpose of this paper is to complement the results by Lanzani and Stein(2017) by showing the dense definability of the Cauchy-Leray transform for the domains that give the counter-examples of Lanzani and Stein(2017), where L^p-boundedness is shown to fail when either the "near" C^2 boundary regularity, or the strong C-linear convexity assumption is dropped.

关键词： Hardy space Cauchy integral Cauchy-Szego projection Lebesgue space pseudoconvex domain minimal smoothness Leray-Levi measure

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Community Knowledge about Bleeding Control in Jazan, KSA: Is There a Need for First Aid Educational Programs

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Journal of Biosciences and Medicines 2024年第6期12卷 64-84页

作者： Md Mazharul Hoque Hamoud Yahya Alsuriha Mohamed E. Moukhyer Bahja Siddig Mohamed Mubarak Almaki Amna Moukhyer Fawaz Yahya Masswadi Mofareh Salman Harubi elias Yosef Modabish Talal Omar Khasawi Yaser Mohammed Hantool Mohammed Awaji Mohammed Madkhali Aziza Mukhayer Emergency Medical Services Department Faculty of Applied Medical Sciences Jazan University Jazan Saudi Arabia Emergency Room University Hospital Jazan University Jazan Saudi Arabia Public Health Programmes School of Medicine University of Limerick Limerick Ireland School of Medicine Ahfad University for Women Omdurman Sudan Department of Medical Laboratory Faculty of Applied Medical Sciences Jazan Jazan University Saudi Arabia Freelance Research Assistant Maastricht The Netherlands Department of Health Promotion University of Maastricht Maastricht The Netherland

The current study aimed to evaluate the first aid knowledge and general awareness of bleeding control, and their relations with different variables among the population of Jazan City, Saudi Arabia, in 2023. A cross-sectional study was conducted in Jazan City, Saudi Arabia between April 2023 and May 2023. Participants, >13 years old, living in Jazan City, were self-enrolled. Data collection was carried out by distributing a self-reported online survey questionnaire via email and social media apps. A validated, pretested online self-report questionnaire was used for data collection, with data analysis performed using (MS) Excel 2022 and SPSS version 26. A Chi-square test was used to determine the association of sociodemographic variables and Bleeding Control (BC) knowledge with, significance set at p about 90% being Saudi citizens. Only 53 (21.2%) participated in previous first aid training concentrating on bleeding control. Only 76 (30.4%) of participants had good knowledge, while 131 (52.4%) exhibited positive attitude towards BC first aid. There were no statistically significant associations between BC knowledge and age, gender, occupation, nationality, and education. However, a significant association was observed between previous BC training and knowledge (Chi-test = 40.373, d.f = 1, p = 0.000) at p < 0.05. Conclusion: The prevalence of poor knowledge of bleeding control among community members in Jazan City was high. The findings of this study should be carefully considered by various healthcare organizations to implement educational first-aid programs and activities aimed at enhancing community awareness and knowledge of bleeding control.

关键词： Injury Uncontrolled Bleeding First Aid Knowledge Attitude Jazan City

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NKR-P1B expression in gut-associated innate lymphoid cells is required for the control of gastrointestinal tract infections

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Cellular & Molecular Immunology 2019年第11期16卷 868-877页

作者： elias abou-Samra Zachary Hickey Oscar A.Aguilar Michal Scur Ahmad Bakur Mahmoud Sergey Pyatibrat Megan M.Tu Jeffrey Francispillai Arthur Mortha James R.Carlyle Mir Munir A.Rahim Andrew P.Makrigiannis Department of Biochemistry Microbiology and ImmunologyUniversity of Ottawa451 Smyth RoadOttawaON K1H 8M5Canada Department of Immunology University of Toronto1 King’s College CircleTorontoON M5S 1A8Canada Sunnybrook Research Institute 2075 Bayview AvenueTorontoON M4N 3M5Canada Department of Microbiology and Immunology Dalhousie University5850 College StreetHalifaxNS B3H 4R2Canada College of Applied Medical Sciences Taibah UniversityMadinah MunawwarahSaudi Arabia Division of Anatomical Pathology Department of Pathology and Laboratory MedicineThe Ottawa HospitalUniversity of Ottawa501 Smyth RoadOttawaON K1H 8L6Canada

Helper-type innate lymphoid cells(ILC)play an important role in intestinal *** of the NKR-P1 gene family are expressed in various innate immune cells,including natural killer(NK)cells,and their cognate Clr ligand family members are expressed in various specialized tissues,including the intestinal epithelium,where they may play an important role in mucosalassociated innate immune *** this study,we show that the inhibitory NKR-P1B receptor,but not the Ly49 receptor,is expressed in gut-resident NK cells,ILC,and a subset ofγδT cells in a tissue-specific ***3 cells constitute the predominant cell subset expressing NKR-P1B in the gut lamina *** known NKR-P1B ligand Clr-b is broadly expressed in gut-associated cells of hematopoietic *** genetic deletion of NKR-P1B results in a higher frequency and number of ILC3 andγδT cells in the gut lamina ***,the function of gut-resident ILC3,NK,andγδT cells in NKR-P1B-deficient mice is impaired during gastrointestinal tract infection by Citrobacter rodentium or Salmonella typhimurium,resulting in increased systemic bacterial dissemination in NKR-P1B-deficient *** findings highlight the role of the NKR-P1B:Clr-b recognition system in the modulation of intestinal innate immune cell functions.

关键词： Innate lymphoid cells Natural killer cells Gut-associated immune cells NKR-P1B receptor Innate immunity

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Predicting invasion potential of Senna didymobotrya (Fresen.) Irwin & Barneby under the changing climate in Africa

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Ecological Processes 2021年第1期10卷 89-98页

作者： elias Ch.Weldemariam Dejene Sintayehu W. Department of Geo-information Science Haramaya UniversityDire DawaEthiopia College of Agriculture and Environmental Sciences Haramaya UniversityDire DawaEthiopia

Background:Senna didymobotrya is a native African flowering *** is suspected that climate change encourages the introduction and spread of invasive alien *** possible invasion of *** across the continent is expected to increase in the future due to ongoing climate ***,there is still paucity of empirical evidence on the extent to which the changing climate contributes to the surge of the flowering *** study,therefore,investigated the present and potential invasion of *** using the species distribution model under changing climate *** two representative concentration pathways(RCP4.5 and RCP8.5)and eight bioclimatic variables and one topographic variable were used to simulate the current and future(2050s and 2070s)invasion of *** in *** model performance was assessed using the area under the receiver operating characteristic curve(AUC)and true skill statistics(TSS).Results:The results of the study showed that under the current climatic conditions,18%of Africa is suitable for the establishment and invasion of *** most suitable hotspot for *** invasion is eastern Africa,followed by southern *** predicted model showed that by 2050,3.3%and 3.12%of the continent would be highly suitable areas for the invasion of the species under RCP4.5 and RCP8.5,*** the 2070s,under RCP4.5 and RCP8.5,the highly suitable area would be 3.13%and 2.7%,*** relation to the current suitability,the cumulative projected areas of the low and moderate suitability class under RCP4.5 and RCP8.5 will rise by the years 2050 and ***,under both RCPs,the non-suitable area for *** invasion would gradually ***:From the findings,it can be concluded that the ecosystem’s vulnerability to *** invasion under future climatic conditions will proliferate ***,to prevent the projected harm to biodiversity and ecosys

关键词： Senna didymobotrya Invasive species Climate change Africa Ensemble approach

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Efficacy of soy protein concentrate replacing animal protein supplements in mucosa-associated microbiota, intestinal health, and growth performance of nursery pigs

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Animal Nutrition 2023年第3期14卷 235-248页

作者： Zixiao Deng Marcos elias Duarte Sung Woo Kim Department of Animal Science North Carolina State UniversityRaleighNC 27695USA

This study investigated the effects of using soy protein concentrate (SPC) to replace animal protein supplements on mucosa-associated microbiota,intestinal health,and growth performance of nursery ***-six newly weaned pigs (BW=6.4±0.6 kg) were allotted to 5 treatments in a randomized complete block *** were fed for 35 d in 3 phases (P;1,2,3) for 10,12,13 d,*** treatments were:(1) basal diet with fish meal (P1:4%,P2:2%,and P3:1%),poultry meal (P1:10%,P2:8%,and P3:4%),and blood plasma (P1:4%,P2:2%,and P3:1%),where SPC replacing none (NC);(2) basal diet with SPC replacing fish meal (RFM);(3) basal diet with SPC replacing poultry meal (RPM);(4) basal diet with SPC replacing blood plasma (RBP);and (5) basal diet with SPC replacing all animal protein supplements (PC).Growth performance was recorded for each *** were euthanized on d 35 to collect jejunal mucosa and tissue to evaluate intestinal health and microbiota,and ileal digesta to measure apparent ileal digestibility (AID) of *** were analyzed using the MIXED procedure of ***,RFM,RPM,and RBP did not affect growth performance,whereas PC decreased (P<0.05) ADG and *** RPM increased (P<0.05) Prevotella stercorea and decreased (P<0.05) Helicobacter *** PC decreased (P<0.05) ***,whilst increasing (P<0.05) Prevotella copri,Propionibacterium acnes,and Pelomonas *** RFM tended to increase (P=0.096) immunoglobulin A in the *** PC tended to decrease (P=0.078) jejunal crypt cell *** were no differences in the villus height,AID of nutrients,intestinal inflammation,and intestinal oxidative stress among *** conclusion,SPC can replace fish meal,poultry meal,or blood plasma individually without affecting growth performance and intestinal health,and AID of nutrients of nursery *** SPC replacing poultry meal benefitted intestinal health by reducing *** and increasing ***,SPC replac

关键词： Blood plasma Fish meal Intestinal health Nursery pigs Poultry meal Soy protein concentrate

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Thermal performance of lightweight concrete applications in building envelopes in Lebanon

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Building Simulation 2021年第5期14卷 1359-1375页

作者： Emilio Sassine elias Kinab Yassine Cherif Emmanuel Antczak Michel Nasrallah Lebanese University Habitat and Energy UnitGroup of Thermal and Renewable Energies-Laboratory of Applied Physics(LPA-GMTER)Faculty of SciencesFanar CampusLebanon Lebanese University Faculty of EngineeringRoumiehEl MetnLebanon Univ.Artois ULR4515Laboratoire de Genie Civil et geo-Environnement(LGCgE)BethuneF-62400France CC Technique Memari StreetHamraBeirutLebanon

Innovative building materials are being used in building envelopes for reducing their heating and cooling *** paper aims to assess the thermal impact of using lightweight concrete in Lebanese building constructions by pouring an 8 cm thickness of lightweight concrete on the roof and the slab and replacing traditional hollow concrete block by lightweight concrete *** properties of two different samples were experimentally determined:the first one(558 kg/m^(3))used for the roof and the slab and the second one(1074 kg/m^(3))used for the *** numerical simulations were carried out for a Lebanese traditional detached house using the characteristics of these two *** thermally improved Light Weight Concrete building(LWC)was compared to a traditional Lebanese house base case(BC)using a dynamic building energy simulation tool in the four different Lebanese climate zones:coastal,mid-mountain,mountain,and inland *** results highlight the effectiveness of integrating LWC to building envelopes by reducing energy consumption and improving thermal comfort in both winter and summer climate conditions and in the different Lebanese climatic *** paper demonstrates that the use of LWC in the vertical walls replacing the traditional hollow blocks can reduce the heating needs by up to 9%and by up to 13%for cooling *** the other hand,adding a LWC roof screed has a very high impact on cooling and heating energy consumption,which can reach up to 74%in cooling energy savings and up to 24%in heating energy savings.

关键词： lightweight concrete thermal properties building energy simulation thermal insulation climatic conditions

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