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Acta Geologica Sinica(English Edition) 2016年第3期90卷 796-806页

作者： Mirinae LEE Heeju PARK Nguyen Viet TIEN Suk-Joo CHOH Robert J.elias Dong-Jin LEE Department of Earth and Environmental Sciences Andong National UniversityAndong36729Republic of Korea Institute of Geological Sciences-Vietnam Academy of Science and Technology(IGS-VAST) Hanoi100000Socialist Republic of Vietnam Department of Earth and Environmental Sciences Korea UniversitySeoul02841Republic of Korea Department of Geological Sciences The University of ManitobaWinnipegR3T 2N2Canada

A new species of the probable calcareous alga Amsassia, A. koreanensis, is recognized from the Duwibong Formation （Middle Ordovician, Darriwilian） of the Taebaeksan Basin in mid-eastern Korea. This is the first report of the genus from the Korean Peninsula, expanding its geographical range to the eastern Sino-Korean Block. The new species also occurs in the Xiazhen Formation （Upper Ordovician, Katian） at Zhuzhai in the South China Block. Amsassia koreanensis is the smallest species of this modular genus, having a maximum module diameter of 0.28 ram. Module increase is by bipartite, tripartite and quadripartite types of longitudinal axial fission, but unlike other species of the genus, quadripartite fission is common. The types of fission are comparable to those in some Tetradiida （now Prismostylales, florideophycean rhodophyte algae）, although the processes of fission are different. The distribution of A. koreanensis further strengthens the biogeographical connection between the Sino-Korean and South China blocks, suggesting that these two paleocontinents were located closer together during the Middle to Late Ordovician than previously speculated.

关键词： Amsassia koreanensis sp. nov. Ordovician Sino-Korean Block South China Block paleobiology paleogeography.

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Cancer drug resistance: rationale for drug delivery systems and targeted inhibition of HSP90 family proteins

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Cancer Drug Resistance 2019年第3期2卷 381-398页

作者： Clélia Mathieu Samir Messaoudi elias Fattal Juliette Vergnaud-Gauduchon Institut Galien Paris-Sud CNRSUMR 8612UniversitéParis-Sud/Paris-SaclayChâtenay-Malabry 92296France BioCIS CNRSUMR 8076UniversitéParis-Sud/Paris-SaclayChâtenay-Malabry 92296France.

Nanocarriers have been developed in order to protect drugs or to improve drugs efficiency by reaching the damaged tissue and avoiding systemic and local *** using HSP90 inhibitors,some cancer drug resistances have been overcome and the loading into nanocarriers of such drugs has shown an increase of their *** review will present some advantages of HSP90 inhibitors to treat resistant tumors;especially those targeting the mitochondrial protein *** will also focus on the targeting of the primary tumors,cancer stem cells and metastatic cells.

关键词： Heat-shock proteins cancer resistance nanoparticles

Efficient genome editing in grapevine using CRISPR/LbCas12a system

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Molecular Horticulture 2023年第1期3卷 111-123页

作者： Chong Ren elias Kirabi Gathunga Xue Li Huayang Li Junhua Kong Zhanwu Dai Zhenchang Liang Beijing Key Laboratory of Grape Sciences and Enology Beijing 100093PR China State Key Laboratory of Plant Diversity and Specialty Crops Beijing 100093PR China China National Botanical Garden Beijing 100093PR China University of Chinese Academy of Sciences Beijing 100049PR China Institute of Botany the Chinese Academy of SciencesHaidian DistrictNanxin Village 20XiangshanBeijing 100093China

Clustered regularly interspaced short palindromic repeats(CRISPR)/Cas12a system,also known as CRISPR/Cpf1,has been successfully harnessed for genome engineering in many plants,but not in grapevine *** we developed and demonstrated the efficacy of CRISPR/Cas12a from Lachnospiraceae bacterium ND2006(LbCas12a)in inducing targeted mutagenesis by targeting the tonoplastic monosaccharide transporter1(TMT1)and dihydroflavonol-4-reductase 1(DFR1)genes in 41B *** of DFR1 gene altered flavonoid accumulation in dfr1 mutant *** treatment(34℃)improved the editing efficiencies of CRISPR/LbCas12a system,and the editing efficiencies of TMT1-crRNA1 and TMT1-crRNA2 increased from 35.3%to 44.6%and 29.9%to 37.3%after heat treatment,***,the sequences of crRNAs were found to be predominant factor affecting editing efficiencies irrespective of the positions within the crRNA array designed for multiplex genome *** addition,genome editing with truncated crRNAs(trucrRNAs)showed that trucrRNAs with 20 nt guide sequences were as effective as original crRNAs with 24 nt guides in generating targeted mutagenesis,whereas trucrRNAs with shorter regions of target complementarity≤18 nt in length may not induce detectable mutations in 41B *** these results provide evidence for further applications of CRISPR/LbCas12a system in grapevine as a powerful tool for genome engineering.

关键词： Vitis vinifera CRISPR LbCas12a Multiplex editing crRNA length Flavonoid

Forecasting Mental Stress Using Machine Learning Algorithms

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Computers, Materials & Continua 2022年第9期72卷 4945-4966页

作者： elias Hossain Abdulwahab Alazeb Naif Almudawi Sultan Almakdi Mohammed Alshehri M.Gazi Golam Faruque Wahidur Rahman Department of Software Engineering Daffodil UniversityDhakaBangladesh Collage of Computer Science and Information System University of NajranNajranSaudi Arabia Department of Computer Science and Engineering Khwaja Yunus Ali UniversitySirajganj 6751Bangladesh

Depression is a crippling affliction and affects millions of individuals around the *** general,the physicians screen patients for mental health disorders on a regular basis and treat patients in collaboration with psychologists and other mental health experts,which results in lower costs and improved patient ***,this strategy can necessitate a lot of buy-in from a large number of people,as well as additional training and logistical ***,utilizing the machine learning algorithms,patients with depression based on information generally present in a medical file were analyzed and *** methodology of this proposed study is divided into six parts:Proposed Research Architecture(PRA),Data Pre-processing Approach(DPA),Research Hypothesis Testing(RHT),Concentrated Algorithm Pipeline(CAP),Loss Optimization Stratagem(LOS),and Model Deployment Architecture(MDA).The Null Hypothesis and Alternative Hypothesis are applied to test the *** addition,Ensemble Learning Approach(ELA)and Frequent Model Retraining(FMR)have been utilized for optimizing the loss ***,the Features Importance Interpretation is also delineated in this *** forecasts could help individuals connect with expert mental health specialists more quickly and *** to the findings,71%of people with depression and 80%of those who do not have depression can be appropriately *** study obtained 91%and 92%accuracy through the Random Forest(RF)and Extra Tree *** after applying the Receiver operating characteristic(ROC)curve,79%accuracy was found on top of RF,81%found on Extra Tree,and 82%recorded for the eXtreme Gradient Boosting(XGBoost)***,several factors are identified in terms of predicting depression through statistical data *** the additional effort is needed to develop a more accurate model,this model can be adjustable in the healthcare sector for diagnosing depression.

关键词： Depression analysis mental health machine learning model deployment XGBoost ROC-AUC

HIV entry inhibitors: a new generation of antiretroviral drugs

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Acta Pharmacologica Sinica 2005年第10期26卷 1165-1173页

作者： elias KRAMBOVITIS Filippos PORICHIS Demetrios A SPANDIDOS Department of Applied Biochemistry and Immunology Institute of Molecular Biology and Biotechnology Vassilika Vouton Heraklion Crete Department of Applied Biochemistry and Immunology Institute of Molecular Biology and Biotechnology Vassilika Vouton Heraklion Crete Greece Greece Department of Virology Medical School University of Crete Heraklion Crete Greece Greece Department of Virology Medical School University of Crete Heraklion Crete Greece

AIDS is presently treatable, and patients can have a good prognosis due to the success of highly active antiretroviral therapy (HAART), but it is still not curable or preventable. High toxicity of HAART, and the emergence of drug resistance add to the imperative to continue research into new strategies and interventions. Considerable progress in the understanding of HIV attachment and entry into host cells has suggested new possibilities for rationally designing agents that interfere with this process. The approval and introduction of the fusion inhibitor enfuvirtide (Fuzeon) for clinical use signals a new era in AIDS therapeutics. Herewe review the crucial steps the virus uses to achieve cell entry, which merit attention as potential targets, and the compounds at pre-clinical and clinical development stages, reported to effectively inhibit cell entry.

关键词： highly active antiretroviral therapy HIV receptors HIV fusion inhibitors HIV

Air traffic monitoring using optimized ADS-B CubeSat constellation

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Astrodynamics 2024年第1期8卷 189-208页

作者： Ghulam Jaffer Rameez AMalik elias Aboutanios Nazish Rubab Ronnie Nader Hans U.Eichelberger Guy A.E.Vandenbosch Interdisciplinary Centre for Security Reliability and Trust(SnT)University of LuxembourgLuxembourg1855Luxembourg

The primary technique used for air traffic surveillance is ***,nowadays,its role in surveillance is gradually being replaced by the recently adopted Automatic Dependent Surveillance-Broadcast(ADS-B).ADS-B offers a higher accuracy,lower power consumption,and longer range than radar,thus providing more safety to *** coverage of terrestrial radar and ADS-B is confined to continental parts of the globe,leaving oceans and poles uncovered by real-time surveillance *** study presents an optimized Low-Earth Orbit(LEO)-based ADS-B constellation for global air traffic surveillance over intercontinental trans-oceanic flight *** optimization algorithm is based on performance evaluation parameters,i.e.,coverage time,satellite availability,and orbit stability(precession and perigee rotation),and communication *** results indicate that the constellation provides ample coverage in the simulated global oceanic *** constellation is a feasible and cost-effective solution for global air supervision,which can supplement terrestrial ADS-B and radar systems.

关键词： constellation automatic dependent surveillance-broadcast (ADS-B) air traffic surveillance precession perigee rotation.

Key factors contributing to crash severity at highway-rail grade crossings

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Journal of Modern Transportation 2016年第3期24卷 224-235页

作者： Wei Fan Linfeng Gong Edward Matt Washing Miao Yu elias Haile Department of Civil and Environmental Engineering The University of North Carolina at Charlotte EPIC Building Room 3261 9201 University City Boulevard Charlotte NC 28223 USA 1721 Market St. # 102. Oakland CA 94607 USA

The purpose of this paper is to develop and com- pare the preferred multinomial logit （MNL） and ordered logit （ORL） model in identifying factors that are important in making an injury severity difference and exploring the impact of such explanatory variables on three different severity levels of vehicle-related crashes at highway-rail grade crossings （HRGCs） in the United States. Vehicle-rail crash data on USDOT highway-rail crossing inventory and public crossing sites from 2005 to 2012 are used in this study. Preferred MNL and ORL models are developed and marginal effects are also calculated and compared. A majority of the variables have shown similar effects on the probability of the three different severity levels in both models. In addition, based on the Akaike information criterion, it is found that the MNL model is better than the ORL model in predicting the vehicle crash severity levels on HRGCs in this study. Therefore, the researchers recommend the use of MNL model in predicting severity levels of vehicle-rail crashes on HRGCs.

关键词： Vehicle crashes Severity Highway-rail grade crossings Multinomial logit model Ordered logit model

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Minimizing Complementary Pivots in a Simplex-Based Solution Method for a Quadratic Programming Problem

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American Journal of Operations Research 2012年第3期2卷 308-312页

作者： elias Munapo Department of Decisions Sciences University of South Africa Unisa Pretoria South Africa

The paper presents an approach for avoiding and minimizing the complementary pivots in a simplex based solution method for a quadratic programming problem. The linearization of the problem is slightly changed so that the simplex or interior point methods can solve with full speed. This is a big advantage as a complementary pivot algorithm will take roughly eight times as longer time to solve a quadratic program than the full speed simplex-method solving a linear problem of the same size. The strategy of the approach is in the assumption that the solution of the quadratic programming problem is near the feasible point closest to the stationary point assuming no constraints.

关键词： Quadratic Programming Convex Karusha-Kuhn-Tucker Simplex Method

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Die Mondkusine

德语人文研究 2008年第3期 8-11页

作者： elias Canetti

elias Canetti(geboren am *** 1905 in Bulgarien,gestorben am *** 1994 in Zrich) war ein Schriftsteller deutscher Sprache und Literatur-Nobelpreistrager 1981.

关键词： der Die Mondkusine

The Syntax and Morphology of the Negative Morphemes/s a/in Sesotho

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宏观语言学 2008年第1期2卷 105-126页

作者： elias Nyefolo Malete Department of African Languages University of the Free State - Qwaqwa Campus Private Bag X 13 Phuthaditjhaba 9866 South Africa

Sesotho is one of the African Languages where sentence negation is expressed by means of bound negative morphemes. It has only three negative morphemes which arespread across the Sesotho matrix and subordinate clauses. They are the negative morphemes /ha/, /sa/ and /se/.These morphemes are bound verbal morphemes that negate various predicate forms and only appear in restricted sentence types. The central aim of this paper is to examine sentence constructions that realize negation by means of the negative morpheme /sa/ and its syntactic distribution within copulative verbs, non - copulative verbs, deficient verbs and aspect morphemes over a full range of inflectional categories such as tense, aspect and mood. This morpheme will be examined within the general framework of the Minimalist Programme, which holds that inflectional categories occur as heads of phrasal categories. This paper will further illustrate the morphological representations of these morphemes within Beard’s (1995) Lexeme-Morpheme Base Morphology, which defines morphology as the sum of all the phonological means of expressing the relations of constituents in words, of words in phrases and of phrasal constituents in sentences. It distinguishes lexemes from bound morphemes.

关键词： syntax morphology negative Sesotho